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Cellular & Molecular Immunology 2010年第1期7卷 51-60页

作者： yun Wang Jing yu Xuezhen Luo xiaoqiu Wang Mingqing Li Ling Wang Dajin Li Laboratory for Reproductive Immunology Hospital and Institute of Obstetrics and GynecologyShanghai Medical College of Fudan UniversityShanghai 200011China Department of Obstetrics and Gynecology Affiliated Hospital of Hainan Medical CollegeHaikou 570102China

The chemokine thymus-expressed chemokine(TECK),which regulates T-cell development and tissue-specific homing,has been identified as a potential contributor to the pathogenesis and progression of ***(2,3,7,8-tetrachlorodibenzo-p-dioxin,TCDD),an air pollutant,and estrogen also appear to be involved in *** endometrial stromal cells(ESCs)and the combination of 17b-estradiol and TCDD increase the secretion of TECK in the endometriosis-associated cells and promote the invasiveness of ESCs by increasing expression of matrix metalloproteinase(MMP)-2 and ***-TECK neutralizing antibodies can effectively inhibit the invasiveness of ESCs and the expression of MMP-2 and MMP-9 in the ***,the expression of chemokine C receptor 9(CCR9)and its ligand TECK increases significantly in the endometriotic milieu of patients with ***,the over-expressed TECK interacts with CCR9 on the ESCs in the endometriotic milieu,which may contribute to the onset and progression of endometriosis.

关键词： TECK CCR9 DSC invasiveness endometriosis

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部分表型交配群体的信息熵

黑龙江八一农垦大学学报 2011年第1期23卷 91-93,99页

作者：张宏礼郭英阎善文刘振忠张鸿雁于晓秋黑龙江八一农垦大学数学系大庆163319

研究了在世代交替中群体总有50%的个体表型同型交配、50%的的个体随机交配的大孟德尔群体,推得各世代基因型频率分布、母子间基因型频率分布,给出各世代基因型信息熵、母子间基因型联合信息熵的算式,并证明二者随世代交替逐渐减少,最终... 详细信息

研究了在世代交替中群体总有50%的个体表型同型交配、50%的的个体随机交配的大孟德尔群体,推得各世代基因型频率分布、母子间基因型频率分布,给出各世代基因型信息熵、母子间基因型联合信息熵的算式,并证明二者随世代交替逐渐减少,最终趋于定值,群体最终达到一种远离Hardy-Weinberg平衡的非平衡定态。模拟结果验证了所得结论的正确性。

关键词：表型同型随机交配分布 Shannon信息熵

Analyses on the tectonic thermal evolution and influence factors in the deep-water Qiongdongnan Basin

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Acta Oceanologica Sinica 2014年第12期33卷 107-117页

作者： WANG Zhenfeng SHI Xiaobin YANG Jun HUANG Baojia SUN Zhen WANG Yahui JIANG Haiyan yu Chuanhai YANG xiaoqiu Zhanjiang Branch of China National Offshore Oil Corporation (CNOOC) Limited Key Laboratory of Marginal Sea Geology South China Sea Institute of Oceanology Chinese Academy of Sciences University of Chinese Academy of Sciences

To reveal the tectonic thermal evolution and influence factors on the present heat flow distribution, based on 154 heat flow data, the present heat flow distribution features of the main tectonic units are first analyzed in detail, then the tectonic thermal evolution histories of 20 profiles are reestablished crossing the main deep-water sags with a structural, thermal and sedimentary coupled numerical model. On the basis of the present geothermal features, the Qiongdongnan Basin could be divided into three regions： the northern shelf and upper slope region with a heat flow of 50-70 mW/m^2, most of the central depression zone of 70-85 mW/m^2, and a NE trending high heat flow zone of 85-105 mW/m^2 lying in the eastern basin. Numerical modeling shows that during the syn-rift phase, the heat flow increases generally with time, and is higher in basement high area than in its adjacent sags. At the end of the syn-rift phase, the heat flow in the deep-water sags was in a range of 60-85 mW/m^2, while in the basement high area, it was in a range of 75-100 mW/m^2. During the post-rift phase, the heat flow decreased gradually, and tended to be more uniform in the basement highs and sags. However, an extensive magmatism, which equivalently happened at around 5 Ma, has greatly increased the heat flow values, and the relict heat still contributes about 10-25 mW/m^2to the present surface heat flow in the central depression zone and the southern uplift zone. Further analyses suggested that the present high heat flow in the deep-water Qiongdongnan Basin is a combined result of the thermal anomaly in the upper mantle, highly thinning of the lithosphere, and the recent extensive magma-tism. Other secondary factors might have affected the heat flow distribution features in some local regions. These factors include basement and seafloor topography, sediment heat generation, thermal blanketing, local magmatic injecting and hydrothermal activities related to faulting and overpressure.

关键词： northern continental margin South China Sea surface heat flow magmatism

Synaptobrevin-2 facilitates the trafficking and function of atrial SK2 channel

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Science China(Life Sciences) 2018年第5期61卷 599-603页

作者： Tao Li Xuehui Fan Yiyan yu Linlin Chen Wenjun Huang Yan Yang Jimin Cao Xiaorong Zeng xiaoqiu Tan Key Laboratory of Medical Electrophysiology Ministry of Education Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research Southwest Medical University

Dear Editor,Small conductance Ca2＋-activated potassium （SK） channels are widely expressed in various tissues and play a unique role in regulating cell function by integrating cytosolic Ca2＋ levels and membrane potential （Adelman et al., 2012）. Xu et al. first identified SK channels in the heart and found that SK channels, particularly the SK2 channel, are preferentially expressed in human and mouse atrial myocytes but not in ventricular myocytes （Xu et al., 2003）. This suggests that the SK

关键词：隧道 Ca2+

Enhancement of hydrogenation kinetics and thermodynamic properties of ZrCo1-xCrx(x=0-0.1)alloys for hydrogen storage

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Chinese Physics B 2020年第8期29卷 543-552页

作者： Linling Luo xiaoqiu Ye Guanghui Zhang Huaqin Kou Renjin Xiong Ge Sang Ronghai yu Dongliang Zhao Science and Technology on Surface Physics and Chemistry Laboratory Mianyang 621907China Institute of Materials China Academy of Engineering PhysicsMianyang 621900China School of Materials Science and Engineering Beihang UniversityBeijing 100191China Department of Functional Material Research Central Iron and Steel Research InstituteBeijing 100081China

The vacuum arc melting method was used to prepare ZrCo1-xCrx(x=0,0.025,0.05,0.075,0.1)***,the crystal structure,hydrogenation kinetics,thermodynamic properties,and disproportionation performance of ZrCo1-xCrx(x=0-0.1)alloys were *** x-ray diffraction spectra demonstrated that ZrCo1-xCrx(x=0-0.1)alloys contained ZrCo and ZrCo2 phases,and their corresponding hydrides consisted of ZrCoH3 and ZrH *** activation behaviors of Cr-substituted samples were significantly *** activation time of ZrCo was 7715 s while that of ZrCo0.9Cr0.1 was 195 *** improvement of kinetics can be attributed to the catalytic hydrogenation of *** activation energy for the hydrogenation of ZrCo was 44.88-kJ·mol^-1 H2 and decreased to 40.34-kJ·mol^-1 H2 for *** plateau pressure and width of the pressure-composition-temperature curves decreased slightly as Cr content *** extent of disproportionation of ZrCo was 83.68%after being insulated at 798 K for 10 h and decreased slightly to 70.52%for *** improvement of anti-disproportionation performance can be attributed to increase in the activation energy of disproportionation from 167.46-kJ·mol^-1 H2 for ZrCo to 168.28-kJ·mol^-1 H2 for ZrCo0.95Cr0.05.

关键词： hydrogen storage ZrCo Cr substitution anti-disproportionation performance activation behaviors

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乌苏里蝮蛇血凝酶的分离纯化和质量研究

中国医药导报 2017年第1期14卷 20-23,47页

作者：张雪玲崔艳崔爱湜王超众宋运娜贾首时于晓秋贾翠英齐齐哈尔医学院附属第二医院药剂科黑龙江齐齐哈尔161006 哈尔滨市第一医院药剂科黑龙江哈尔滨100010 齐齐哈尔医学院附属第三医院药剂科黑龙江齐齐哈尔161005 齐齐哈尔市食品药品检验检测中心黑龙江齐齐哈尔161005 齐齐哈尔医学院基础学院黑龙江齐齐哈尔161005

目的建立一种分离纯化乌苏里蝮蛇血凝酶(WH)的方法并为其制定质量标准。方法先后采用分子筛层析法、离子交换色谱法、亲和层析法从乌苏里蝮蛇毒中分离纯化得到一种具有凝血活性的酶成分,并采用SDS-聚丙烯酰胺凝胶电泳法、RP-HPLC法测定... 详细信息

目的建立一种分离纯化乌苏里蝮蛇血凝酶(WH)的方法并为其制定质量标准。方法先后采用分子筛层析法、离子交换色谱法、亲和层析法从乌苏里蝮蛇毒中分离纯化得到一种具有凝血活性的酶成分,并采用SDS-聚丙烯酰胺凝胶电泳法、RP-HPLC法测定其纯度,HPSEC法测定其分子量,IEF法测定其等电点,Lowry法测定其蛋白浓度,并用标准人血浆法测定该酶的比活力。结果从乌苏里蝮蛇蛇毒中分离纯化了一种凝血酶成分,SDS-Page显示为一条带、测得分子量约为34 k D,RP-HPLC得到单一的色谱峰,HPSEC法测得该酶分子量为34.7 k D,等电点为5.25,此酶具有体外凝血活性,比活力为5.40μg/U。结论该方法可用于WH的分离纯化,制定的质量标准可用于控制该血凝酶的质量。

关键词：乌苏里蝮蛇血凝酶分离纯化质量标准

Biphenyl-Induced Superhelix in L-Phenylalanine-Based Supramolecular Self-Assembly with Dynamic Morphology Transitions

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CCS Chemistry 2022年第8期4卷 2816-2828页

作者： Laiben Gao yueyue Feng Chao Xing yu Zhao Meng Sun yunqing Zou Changli Zhao xiaoqiu Dou Chuanliang Feng State Key Lab of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240 College of Chemistry and Materials Science Shanghai Normal UniversityShanghai 200234 School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001

Dynamic transitions of supramolecular assemblies between lower-order structures and higher-order superhelical structures(e.g.,double-helical DNA,helical biopolymers)are of vital importance in many physiological processes,but still remain a great challenge to be realized in artificially assembled ***,a novel biphenyl central core symmetrically coupled with phenylalanine groups drives the construction of the dynamic superhelix.

关键词： superhelix biphenyl chirality morphological transition cell release

1982～1999年我国东部暖温带植被生长季节的时空变化

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地理学报 2007年第1期62卷 41-51页

作者：陈效逑喻蓉北京大学环境学院资源与环境地理系地表过程分析与模拟教育部重点实验室北京100871

利用1982～1996年5个站点的植物群落物候观测数据和物候累积频率拟合法,划分各站逐年的植被物候季节,并确定各季节初日对应的当地归一化差值植被指数(NDVI)阈值。在此基础上,通过对物候站各年NDVI曲线的年型聚类分析和区内所有像元逐年N... 详细信息

利用1982～1996年5个站点的植物群落物候观测数据和物候累积频率拟合法,划分各站逐年的植被物候季节,并确定各季节初日对应的当地归一化差值植被指数(NDVI)阈值。在此基础上,通过对物候站各年NDVI曲线的年型聚类分析和区内所有像元逐年NDVI曲线的空间聚类分析,实现植被物候季节的时空外推估计,从而得到我国暖温带落叶阔叶林地区1982～1999年植被物候季节初日和生长季节长度的时空格局。结果表明,多年平均的植被物候季节初日和生长季节长度呈现出主要随纬度和海拔高度变化的空间格局。在这18年中,整个区域的物候春季初日以提前为主,且以华北平原提前的趋势最为显著;夏季、秋季和冬季初日以推迟为主,也以华北平原推迟的趋势比较显著;因此,华北平原植被生长季节呈显著延长的趋势。本文揭示的植被物候季节初日的趋势变化与华北地区各季节气温的趋势变化基本吻合;植被生长季节的趋势变化特征与欧洲单种植物物候生长季节,以及欧亚大陆和我国温带遥感植被生长季节的趋势变化基本一致,但植被生长季节初、终日期和长度的趋势值明显大于后者,表明该地区植物物候对于气候变暖的响应更加敏感。

关键词：物候季节植被生长季节物候累积频率拟合归一化差值植被指数中国东部暖温带

Pollution Characteristics of PM2.5 during a Typical Haze Episode in Xiamen, China

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Atmospheric and Climate Sciences 2013年第4期3卷 427-439页

作者： Fuwang Zhang Jinsheng Chen Tianxue Qiu Liqian Yin xiaoqiu Chen Jianshuan yu Environmental Monitoring Center of Fujian Fuzhou China Environmental Monitoring Center of Xiamen Xiamen China Institute of Urban Environment Chinese Academy of Sciences Xiamen China

In this study, mass concentrations and chemical compositions of fine particles, mass concentrations of coarse particles, light extinction, and meteorological parameters in the atmosphere ofXiamenwere presented and analyzed to study the chemical and optical characteristics of a typical haze episode from Dec 25, 2010 to Jan 1, 2011. The major chemical compositions of PM2.5, such as water soluble inorganic ions (WSIIs), carbonaceous fractions (mainly composed of organic carbon (OC) and elemental carbon (EC)), and elements were determined. The results showed that with the typical haze episode process, the concentrations of PM2.5 mass, WSIIs, OC, EC, and TE first increased and then decreased. The average concentrations of PM2.5 mass in the stages of Before Haze, During Haze, and After Haze were (88.80 ± 19.97), (135.41 ± 36.20), and (96.35 ± 36.26) μg/m3, respectively. The corresponding average concentrations of secondary organic carbon (SOC) were 6.72, 8.18, and 10.39 μg/m3, accounting for 46.5%, 27.0%, and 61.0% of OC, respectively. S42- , NO3-, and NH4+ were three major WSIIs species, accounting for 31.4%, 26.0%, and 12.1% of total WSIIs. The major elements in PM2.5 were S, K, Fe, Zn, Pb, Ti, and Mn, covering 97.9% of the total elements, while the percentage of the other ten elements was only 2.1%. The average value of light extinction coefficients (bext) was 371.0 ±147.1 Mm-1 during the typical haze episode. The average percentage contributions to bext were 39.3% for organic mass, 19.9% for elemental carbon, 16.0% for ammonium sulfate, 13.0% for coarse mass, and 11.8% for ammonium nitrate.

关键词： Fine Particles Haze Water Soluble Inorganic Ions Organic Carbon Elemental Carbon Elements Light Extinction Coefficients Xiamen

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基于空间语义角色的自然语言空间概念提取

武汉大学学报（信息科学版） 2005年第12期30卷 1100-1103页

作者：乐小虬杨崇俊于文洋中国科学院遥感应用研究所遥感科学国家重点实验室北京市9718信箱100101

根据空间信息的特点,从定义的空间语义角色入手,通过语义角色标注、短语识别以及概念模式匹配等手段,具体分析了自然语言中的空间实体、实体间空间关系以及空间过程的表达与提取方法。

关键词：空间语义角色 GIS 信息提取(IE) 自然语言处理(NLP)