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Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer

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World Journal of Gastroenterology 2010年第10期16卷 1252-1257页

作者： Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato yu sasaki Shoichi Nishise Sumio Kawata Department of Gastroenterology Yamagata University Faculty of Medicine Division of Endoscopy Yamagata University Hospital

AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression ***: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced ***: A decreased level of adiponectin is str

关键词： Adenoma Early colorectal cancer Metabolic syndrome Adipokines Colonoscopy Resistin Leptin Body mass index

Synthetic high-density lipoprotein(sHDL):a bioinspired nanotherapeutics for managing periapical bone inflammation

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International Journal of Oral Science 2024年第3期16卷 460-470页

作者： Renan Dal-Fabbro Minzhi yu Ling Mei Hajime sasaki Anna Schwendeman Marco C.Bottino Department of Cariology Restorative Sciencesand EndodonticsSchool of DentistryUniversity of MichiganAnn ArborMIUSA Department of Pharmaceutical Sciences College of Pharmacy and Biointerfaces InstituteUniversity of MichiganAnn ArborMIUSA Department of Biomedical Engineering College of EngineeringUniversity of MichiganAnn ArborMIUSA

Apical periodontitis(AP)is a dental-driven condition caused by pathogens and their toxins infecting the inner portion of the tooth(i.e.,dental pulp tissue),resulting in inflammation and apical bone resorption affecting 50%of the worldwide population,with more than 15 million root canals performed annually in the United *** treatment involves cleaning and decontaminating the infected tissue with chemo-mechanical approaches and materials introduced years ago,such as calcium hydroxide,zinc oxide–eugenol,or even formalin ***,we present,for the first time,a nanotherapeutics based on using synthetic highdensity lipoprotein(sHDL)as an innovative and safe strategy to manage dental bone *** application in concentrations ranging from 25μg to 100μg/mL decreases nuclear factor Kappa B(NF-κB)activation promoted by an inflammatory stimulus(lipopolysaccharide,LPS).Moreover,sHDL at 500μg/mL concentration markedly decreases in vitro osteoclastogenesis(P<0.001),and inhibits IL-1α(P=0.027),TNF-α(P=0.004),and IL-6(P<0.001)production in an inflammatory ***,sHDL strongly dampens the Toll-Like Receptor signaling pathway facing LPS stimulation,mainly by downregulating at least 3-fold the pro-inflammatory genes,such as Il1b,Il1a,Il6,Ptgs2,and *** vivo,the lipoprotein nanoparticle applied after NaOCl reduced bone resorption volume to(1.3±0.05)mm3 and attenuated the inflammatory reaction after treatment to(1090±184)cells compared to non-treated animals that had(2.9±0.6)mm3(P=0.0123)and(2443±931)cells(P=0.004),thus highlighting its promising clinical potential as an alternative therapeutic for managing dental bone inflammation.

关键词： inflammation lipoprotein markedly

The Relationship between Neck and Shoulder Pain and the Sagittal Alignment of the Spine in Standing in Younger Generation

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Open Journal of Orthopedics 2015年第11期5卷 337-344页

作者： Tomonori Kenmoku Takane Suzuki Nobuyasu Ochiai Tatsuki Ebata Genyo Miyajima Naoshige Nagura Mitsufumi Nakawaki Ryo Tazawa Sho Hiramatsu Hironori Yamazaki yu sasaki Takeshi Yamaguchi Eiko Hashimoto Kenji Onuma Naonobu Takahira Kazuhisa Takahashi Masashi Takaso Department of Orthopedic Surgery Kitasato University School of Medicine Sagamihara Japan Sakura Orthopaedic Hospital Sakura Japan Department of Bioenvironmental Medicine Graduate School of Medicine Chiba Japan Department of Orthopaedic Surgery Chiba University Graduate School of Medicine Chiba Japan Department of Orthopedic Surgery Kitasato Medical Center Kitamoto Japan School of Allied Health Science Kitasato University Sagamihara Japan

Background: The relationship between chronic neck and shoulder pain and posture remains controversial. The purpose of this study was to investigate the relationship between chronic neck and shoulder pain and spinal sagittal alignment in standing posture in younger generation. Methods: Subjects included 57 females and 32 males (average age, 29.9 ± 5.7 years). All subjects were 20s or 30s. Spinal curvature was assessed using SpinalMouse. The subjects were also divided into a normal group (VAS zero group) and a pain group by VAS results. Statistical analysis was performed by Student’s t-test. Significance was defined as p < 0.05. Results: The normal group and pain group included 29 and 60 subjects, respectively. In terms of location of pain, thirty-one subjects felt neck pain, 50 felt pain above the scapula, and 17 felt pain between the thoracic spine and scapula. Thoracic kyphosis and lumbar lordosis in the pain group were significantly higher than those in the normal group (p = 0.013 and p = 0.020, respectively). Thoracic kyphosis in subjects with neck pain or pain above scapula was significantly higher than that in subjects without pain (p = 0.0075 and p = 0.025, respectively). Lumbar lordosis in subjects with pain above the scapula or interscapula was significantly higher than that in subjects without pain (p = 0.016).

关键词： Choronic Neck and Shoulder Pain Sagittal Alignment of the Spine Thoracic Kyphosis Lumber Lordosis

Phylogenomic resolution of Imparidentia(Mollusca:Bivalvia)diversifcation through mitochondrial genomes

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Marine Life Science & Technology 2023年第3期5卷 326-336页

作者： yu Wang Yi Yang Lingfeng Kong Takenori sasaki Qi Li Key Laboratory of Mariculture Ministry of EducationOcean University of ChinaQingdao 266003China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdao 266237China The University Museum The University of TokyoTokyo 113-0033Japan

Despite signifcant advances in the phylogenomics of bivalves over the past decade,the higher-level phylogeny of Imparidentia(a superorder of Heterodonta)remains ***,a total of fve new mitochondrial sequences(Chama asperella,Chama limbula,Chama dunkeri,Barnea manilensis and Ctena divergens)was added to provide resolution in nodes that required additional *** the monophyly of Lucinida remains less clear,the results revealed the overall backbone of the Imparidentia tree and the monophyly of ***,most relationships among the fve major Imparidentia lineages—Lucinida,Cardiida,Adapedonta,Myida and Venerida—were addressed with a well-supported *** relationships of Imparidentia recovered Lucinidae as the sister group to all remaining imparidentian *** is a sister group to other imparidentian bivalves(except Lucinidae species)which is split into Cardiida,Adapedonta and the divergent clade of *** was comprised of Venerida and Myida,the former of which now also contains Chamidae as the sister group to all the remaining venerid ***,molecular divergence times were inferred by calibrating nine nodes in the Imparidentia tree of life by extinct *** origin of these major clades ranged from Ordovician to Permian with the diversifcation through the Palaeozoic to ***,the results obtained in this study demonstrate a better-resolved Imparidentia phylogeny based on mitochondrial genomes.

关键词： Imparidentia Phylogeny Mitochondrial genome

Fabrication of initial trabecular bone-inspired three-dimensional structure with cell membrane nano fragments

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Regenerative Biomaterials 2023年第1期10卷 73-80页

作者： Koichi Kadoya Emilio Satoshi Hara Masahiro Okada yu Yang Jiao Takayoshi Nakano Akira sasaki Takuya Matsumoto Department of Biomaterials Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Department of Maxillofacial Surgery Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Division of Materials&Manufacturing Science Osaka UniversityOsaka 565-0871Japan

The extracellular matrix of trabecular bone has a large surface exposed to the bone marrow and plays important roles such as hematopoietic stem cell niche formation and *** vitro reproduction of trabecular bone microenvironment would be valuable not only for developing a functional scaffold for bone marrow tissue engineering but also for understanding its biological ***,we analyzed and reproduced the initial stages of trabecular bone formation in mouse femur *** identified that the trabecular bone formation progressed through the following steps:(i)partial rupture of hypertrophic chondrocytes;(ii)calcospherite formation on cell membrane nano fragments(CNFs)derived from the ruptured cells;and(iii)calcospherite growth and fusion to form the initial three-dimensional(3D)structure of trabecular *** reproducing the initial trabecular bone formation in vitro,we collected CNFs from cultured cells and used as nucleation sites for biomimetic calcospherite ***,almost the same 3D structure of the initial trabecular bone could be obtained in vitro by using additional CNFs as a binder to fuse biomimetic calcospherites.

关键词： trabecular bone calcospherites cell membrane nano fragments three dimensionalization bone tissue synthesis

Anisotropic fluoride nanocrystals modulated by facet-specific passivation and their disordered surfaces

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National Science Review 2020年第5期7卷 841-848页

作者： Ziyu Yang Huihui Zhang Junjie Xu Renzhi Ma Takayoshi sasaki yu-Jia Zeng Shuangchen Ruan Yanglong Hou Beijing Key Laboratory for Magnetoelectric Materials and Device(BKLMMD) Beijing Innovation Center for Engineering Science and Advanced Technology(BIC-ESAT)Department of Materials Science and Engineering College of Engineering Peking University College of Physics and Optoelectronic Engineering Shenzhen University International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)

Rutile-type fluorides have been proven to be active components in the context of emerging antiferromagnetic devices. However, controlled synthesis of low-dimensional, in particular two-dimensional (2D),fluorides in a predictable and deterministic manner remains unrealized because of a lack of efficient anisotropic control, which impedes their further development in reduced dimensions. We report here that altered passivation of{110}growing facets can direct the synthesis of rutile-type fluoride nanocrystals into well-defined zero-dimensional (0D) particulates, one-dimensional (1D) rods and 2D sheets in a colloidal approach. The obtained nanocrystals show positive exchange bias and enhanced magnetic transition temperature from the coexistence of long-range antiferromagnetic order and disordered surface spins,making them strong alternatives for flexible magnetic devices and sensors.

关键词： solution synthesis fluorides nanostructures magnetic properties exchange anisotropy surface effect

Right hepatectomy for giant cavernous hemangioma with diffuse hemangiomatosis around Glisson's capsule

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World Journal of Gastroenterology 2014年第25期20卷 8312-8316页

作者： yu Ohkura Masaji Hashimoto Seigi Lee Kazunari sasaki Masamichi Matsuda Goro Watanabe Department of Digestive Surgery Hepato Pancreato Billiary Surgery UnitToranomon HospitalTokyo 105-8470Japan

Diffuse liver hemangiomatosis with giant cavernous hemangioma in adult is extremely rare. A 35 year-old woman presented to hospital with main complaint of epigastric pain and abdominal fullness. An enhanced computed tomography scan revealed a massive liver tumor in right lobe about 150 mm in size. There was contrast enhancement at the periphery of the mass consistent with a cavernous hemangioma. She underwent right hepatectomy. Histologically, it was diagnosed as a cavernous hemangioma. And also, hemangiomatous lesions were scattered around the Glisson’s capsule on the back ground liver. These hemangiomatous lesions were not recognized preoperatively. Even if we couldn’t diagnose hemangiomatosis around the main giant hemangioma preoperatively, we need to take enough surgical margins because the giant hemangioma has the potential to have small hemangiomatous lesions around the tumor. We reported right hepatectomy for giant cavernous hemangioma with diffuse hepatic hemangiomatosis without an extrahepatic lesion in an adult.

关键词： Giant cavernous hemangioma Hemangiomatosis Right hepatectomy Around Glisson’ s capsule Surgery

Synthesis of Chl@Ti_(3)C_(2) composites as an anode material for lithium storage

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Frontiers of Chemical Science and Engineering 2021年第3期15卷 709-716页

作者： Wenxin Xu Xin Zhao Jiali Tang Chao Zhang yu Gao Shin-ichi sasaki Hitoshi Tamiaki Aijun Li Xiao-Feng Wang Key Laboratory of Physics and Technology for Advanced Batteries(Ministry of Education) College of PhysicsJilin UniversityChangchun 130012China Graduate School of Life Sciences Ritsumeikan UniversityShiga 525-8577Japan Nagahama Institute of Bio-Science and Technology Shiga 526-0829Japan

Two-dimensional(2D)titanium carbide MXene Ti_(3)C_(2) has attracted significant research interest in energy storage *** this study,we prepared Chl@Ti_(3)C_(2) composites by simply mixing a chlorophyll derivative(e.g.,zinc methyl 3-devinyl-3-hydroxymethylpyropheophorbide a(Chl))and Ti_(3)C_(2) in tetrahydrofuran,where the Chl molecules were aggregated among the multi-layered Ti_(3)C_(2) MXene or on its surface,increasing the interlayer space of Ti_(3)C_(2).The as-prepared Chl@Ti_(3)C_(2) was employed as the anode material in the lithium-ion battery(LIB)with lithium metal as the *** resulting LIB exhibited a higher reversible capacity and longer cycle performance than those of LIB based on pure Ti_(3)C_(2),and its specific discharge capacity continuously increased along with the increasing number of cycles,which can be attributed to the gradual activation of Chl@Ti_(3)C_(2) accompanied by the electrochemical *** discharge capacity of 1 wt-%Chl@Ti_(3)C_(2) was recorded to be 325 mA·h·g^(-1) at the current density of 50 mA·g^(-1) with a Coulombic efficiency of 56% and a reversible discharge capacity of 173 mA·h·g^(-1) at the current density of 500 mA·g^(-1) after 800 *** work provides a novel strategy for improving the energy storage performance of 2D MXene materials by expanding the layer distance with organic dye aggregates.

关键词： zinc chlorin aggregate Ti_(3)C_(2)MXene anode material lithium storage

High voltage-controlled magnetic anisotropy and interface magnetoelectric effect in sputtered multilayers annealed at high temperatures

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Science China(Physics,Mechanics & Astronomy) 2020年第7期63卷 114-119页

作者： LeZhi Wang Xiang Li Taisuke sasaki Kin Wong GuoQiang yu ShouZhong Peng Chao Zhao Tadakatsu Ohkubo Kazuhiro Hono WeiSheng Zhao KangLong Wang Beijing Advanced Innovation Center for Big Data and Brain Computing Beihang UniversityBeijing 100191China School of Computer Science&Engineering Beihang UniversityBejing 100191China Department of Electrical Engineering University of CaliforniaLos AngelesLos Angeles 90095USA School of Microeletronics Beihang UniversityBeijing 100191China Inston IncLos Angeles 90095USA National Institute for Materials Science(NIMS) Tsukuba 305-0047Japan Institute of Microelectronics Chinese Academy of SciencesBejing 100029China

Voltage control of magnetism promises great energy efficiency in writing magnetic memory. Here, using Cr/Mo/CoFeB/MgO multilayers stable under high annealing temperatures up to 590°C, we significantly enhance the interfacial crystallinity, thereby the interface-originated perpendicular magnetic anisotropy(PMA), voltage-controlled magnetic anisotropy(VCMA), and interface magnetoelectric(ME) effect. High interfacial PMA of 1.35 mJ/m^2, VCMA coefficient of-138 fJ/(V m), and interface ME coefficient, which is 2-3 orders of magnitude larger than ab initio calculation results are simultaneously achieved after annealing at 500°C. These promising results enabled by the industry-applicable sputtering process will pave the way for highdensity voltage-controlled spintronic devices.

关键词： voltage-controlled magnetic anisotropy(VCMA) magnetoelectric(ME)effect perpendicular magnetic anisotropy