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Halogenated Thienoacene Derivatives with Improved Emission Properties

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Chemical Research in Chinese Universities 2024年第4期40卷 699-703页

作者： ZHANG Jingmei MENG Zhihao ZHEN Yonggang HE Ping yu panpan HU Wenping Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic CompositesBeijing University of Chemical TechnologyBeijing100029P.R.China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074P.R.China State Key Laboratory of Fine Chemicals Dalian University of TechnologyDalian116024P.R.China Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province China West Normal UniversityNanchong637000P.R.China Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education Jiangxi Normal UniversityNanchang330022P.R.China MOE Key Laboratory of Organic Integrated Circuits&Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of SciencesTianjin UniversityTianjin300072P.R.China

Thienoacenes is one of most important groups of semiconducting materials due to the high stability and superior ***,there are scarce studies on the emission properties of thienoacenes to ***,we synthesized fluorinated and chlorinated dibenzo[d,d’]thieno[3,2-b;4,5-b’]dithiophenes(DBTDTs)derivatives F6-DBTDT and Cl6-DBTDT by sulfoxide cyclization,significantly lowering the energy levels relative to the parent compound *** to single crystal structure analysis,F6-DBTDT molecules adopt one-dimensional slipped stacking with closeπ-πinteractions of 3.43Å(1Å=0.1 nm),which is different from the parent compound DBTDT with herringbone stacking ***,the halogenated DBTDT derivatives exhibit enhanced emission properties both in solution and in the solid state,opening up possiblities to improve photoluminescence of thienoacences by halogenation.

关键词： Thienoacene Halogenation Photoluminescence Aggregation structure

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整体护理在重症颅脑损伤患者中的应用价值

中国伤残医学 2024年第4期32卷 96-99,104页

作者：于盼盼大连市中心医院辽宁大连116033

目的:探讨整体护理在重症颅脑损伤患者中的应用价值.方法:选取2019年10月-2020年10月我院收治的60例重症颅脑损伤患者为研究对象,并以等量电脑随机法将其分为对照组与观察组,每组30例.对照组采用常规护理干预,观察组展开整体护理干预.比... 详细信息

目的:探讨整体护理在重症颅脑损伤患者中的应用价值.方法:选取2019年10月-2020年10月我院收治的60例重症颅脑损伤患者为研究对象,并以等量电脑随机法将其分为对照组与观察组,每组30例.对照组采用常规护理干预,观察组展开整体护理干预.比较2组患者的护理干预效果.结果:护理1、2、3个月后,观察组日常生活活动能力评分分别为(49.38±7.91)分、(63.71±6.68)分、(73.17±7.79)分,均高于对照组的(42.84±6.57)分、(54.34±5.79)分、(64.27±6.54)分,组间差异有统计学意义(P<0.05).观察组护理满意度为96.67%,高于对照组的76.67%,并发症总发生率为3.33%,低于对照组的20.00%,组间差异有统计学意义(P<0.05).观察组SF-36各个维度评分均高于对照组,组间差异有统计学意义(P<0.05).护理后,观察组PaO_(2)、SpO_(2)均高于对照组,PaCO_(2)低于对照组,组间差异有统计学意义(P<0.05).结论:对重症颅脑损伤患者展开整体护理干预,不仅可以降低术后并发症发生率,改善血气分析指标,同时还有助于患者日常生活活动能力、生活质量及护理满意度的提升,值得临床借鉴及应用.

关键词：重症颅脑损伤日常生活活动能力整体护理血气分析并发症

创伤急救护理对严重创伤患者有效抢救时间及抢救成功率的作用

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中国伤残医学 2024年第7期32卷 97-100页

作者：于盼盼大连市中心医院辽宁大连116033

目的:分析创伤急救护理对严重创伤患者有效抢救时间及抢救成功率的作用。方法:选取2019年6月-2021年6月我院收治的86例严重创伤患者为研究对象,以随机抽签法将其分为对照组与观察组,每组43例。对照组实施常规护理,观察组在对照组基础上... 详细信息

目的:分析创伤急救护理对严重创伤患者有效抢救时间及抢救成功率的作用。方法:选取2019年6月-2021年6月我院收治的86例严重创伤患者为研究对象,以随机抽签法将其分为对照组与观察组,每组43例。对照组实施常规护理,观察组在对照组基础上联合创伤急救护理。分析2组不同护理方案对有效抢救时间及抢救成功率的影响,统计患者家属对抢救过程中的护理工作的满意度。结果:观察组有效抢救时间短于对照组,差异有统计学意义(P<0.05)。观察组抢救成功率及患者家属满意度均高于对照组,组间差异有统计学意义(P<0.05)。护理后,观察组焦虑、抑郁评分均低于对照组,组间差异有统计学意义(P<0.05)。观察组生活质量各个维度评分均高于对照组,组间差异有统计学意义(P<0.05)。结论:严重创伤患者采用常规护理联合创伤急救护理,能够显著缩短有效抢救时间,为患者赢得更多的治疗机会。

关键词：严重创伤创伤急救护理有效抢救时间抢救成功率

Inhibitor of DNA binding 2 accelerates nerve regeneration after sciatic nerve injury in mice

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Neural Regeneration Research 2021年第12期16卷 2542-2548页

作者： Zhong-Hai Huang Ai-Ying Feng Jing Liu Libing Zhou Bing Zhou panpan yu Guangdong-Hong Kong-Macao Institute of Central Nervous System Regeneration Ministry of Education Joint International Research Laboratory of Central Nervous System RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Interdisciplinary Innovation Institute of Medicine and Engineering Beijing Advanced Innovation Center for Big Data-Based Precision MedicineBeihang UniversityBeijingChina

Inhibitor of DNA binding 2(Id2)can promote axonal regeneration after injury of the central nervous ***,whether Id2 can promote axonal regeneration and functional recovery after peripheral nerve injury is currently *** this study,we established a mouse model of bilateral sciatic nerve crush *** weeks before injury,AAV9-Id2-3×Flag-GFP was injected stereotaxically into the bilateral ventral horn of lumbar spinal *** results showed that Id2 was successfully delivered into spinal cord motor neurons projecting to the sciatic nerve,and the number of regenerated motor axons in the sciatic nerve distal to the crush site was increased at 2 weeks after injury,arriving at the tibial nerve and reinnervating a few endplates in the gastrocnemius *** 1 month after injury,extensive neuromuscular reinnervation *** addition,the amplitude of compound muscle action potentials of the gastrocnemius muscle was markedly recovered,and their latency was *** findings suggest that Id2 can accelerate axonal regeneration,promote neuromuscular reinnervation,and enhance functional improvement following sciatic nerve ***,elevating the level of Id2 in adult neurons may present a promising strategy for peripheral nerve repair following *** study was approved by the Experimental Animal Ethics Committee of Jinan University(approval No.20160302003)on March 2,2016.

关键词： axonal regeneration functional recovery inhibitor of DNA binding 2 motor neuron neuromuscular junctions peripheral nerve reinnervation sciatic nerve injury

Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture

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Neural Regeneration Research 2018年第2期13卷 289-297页

作者： Jingyu Jin Sharada Tilve Zhonghai Huang Libing Zhou Herbert M.Geller panpan yu Guangdong-Hongkong-Macao Institute of CNS Regeneration Ministry of Education Joint International Research Laboratory of CNS Regeneration Jinan University Laboratory of Developmental Neurobiology Cell Biology and Physiology Center National Heart Lung and Blood Institute National Institutes of Health

As one major component of extracellular matrix （ECM） in the central nervous system, chondroitin sul- fate proteoglycans （CSPGs） have long been known as inhibitors enriched in the glial scar that prevent axon regeneration after injury. Although many studies have shown that CSPGs inhibited neurite out- growth in vitro using different types of neurons, the mechanism by which CSPGs inhibit axonal growth remains poorly understood. Using cerebellar granule neuron （CGN） culture, in this study, we evaluated the effects of different concentrations of both immobilized and soluble CSPGs on neuronal growth, in- cluding cell adhesion, spreading and neurite growth. Neurite length decreased while CSPGs concentration arised, meanwhile, a decrease in cell density accompanied by an increase in cell aggregates formation was observed. Soluble CSPGs also showed an inhibition on neurite outgrowth, but it required a higher concen- tration to induce cell aggregates formation than coated CSPGs. We also found that growth cone size was significantly reduced on CSPGs and neuronal cell spreading was restrained by CSPGs, attributing to an inhibition on lamellipodial extension. The effect of CSPGs on neuron adhesion was further evidenced by interference reflection microscopy （IRM） which directly demonstrated that both CGNs and cerebral cortical neurons were more loosely adherent to a CSPG substrate. These data demonstrate that CSPGs have an effect on cell adhesion and spreading in addition to neurite outgrowth.

关键词： chondroitin sulfate proteoglycans cell adhesion neurite growth interference reflection microscopy neural regeneration

A new fluorescent quinoline derivative toward the acid-responsivity in both solution and solid states

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Chinese Chemical Letters 2020年第11期31卷 2909-2912页

作者： Pu Wang Dan Liu Yongshuai Wang Pan Zhang panpan yu Mincan Wang Yonggang Zhen Huanli Dong Wenping Hu College of Chemistry and Institute of Green Catalysis Zhengzhou UniversityZhengzhou 450052China Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)&Department of Chemistry School of ScienceTianjin UniversityTianjin 300072China

In this article,an acid-responsive luminescent material,1,4-di(quinoline-6-yl)buta-1,3-diyne(DQBD)is designed and *** different pH values,gradual changes of fluorescence colors for DQBD in both solution and solid phases are demonstrated due to the protonation ***,such responsive characteristics can also be reversible,suggesting DQBD as a promising fluorescent material with great potential for reusable-and accurate-p H sensors in the future.

关键词： Quinoline derivative Stimuli-responsive Protonation effect Fluorescence switch pH sensor

依洛尤单抗联合左卡尼汀在急性ST段抬高型心肌梗死患者术后的应用效果

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实用临床医药杂志 2024年第15期28卷 76-79页

作者：王磊穆丽萍于盼盼张倩玉高光仁张军河北省沧州市中心医院心血管内五科河北沧州061000

目的探讨依洛尤单抗联合左卡尼汀在急性ST段抬高型心肌梗死(STEMI)患者行急诊经皮冠状动脉介入治疗(PCI)术后的应用效果。方法选取120例STEMI患者为研究对象,随机分为治疗组60例和对照组60例。对照组给予STEMI基本治疗方法加用左卡尼汀... 详细信息

目的探讨依洛尤单抗联合左卡尼汀在急性ST段抬高型心肌梗死(STEMI)患者行急诊经皮冠状动脉介入治疗(PCI)术后的应用效果。方法选取120例STEMI患者为研究对象,随机分为治疗组60例和对照组60例。对照组给予STEMI基本治疗方法加用左卡尼汀,治疗组在对照组基础上加用依洛尤单抗。比较2组患者治疗前后的治疗有效率、心功能指标[B型尿钠肽(BNP)、左室射血分数(LVEF)]、冠状动脉微循环情况[心肌梗死溶栓治疗临床试验(TIMI)危险评分、前蛋白转化酶枯草溶菌素9(PCSK9)和低密度脂蛋白胆固醇(LDL-C)]以及不良反应发生率。结果治疗后,治疗组总有效率高于对照组,差异有统计学意义(P0.05)。结论依洛尤单抗联合左卡尼汀对STEMI患者急诊PCI术后的心功能和冠状动脉微循环的改善效果较好,且安全性较高。

关键词：依洛尤单抗左卡尼汀急性ST段抬高型心肌梗死经皮冠状动脉介入治疗

耳软骨舒展术在轻中度耳甲腔型小耳畸形中的应用

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中国美容整形外科杂志 2024年第4期35卷 196-198,206页

作者：马博凡徐冬冬孙雯阳于盼盼黄威吕梦竹中国医科大学附属第一医院整形外科辽宁沈阳110001

目的评价耳软骨舒展术替代肋软骨部分耳郭再造术在耳甲腔型小耳畸形中的应用。方法自2023年5月至2023年12月,中国医科大学附属第一医院整形外科收治5例轻中度耳甲腔型小耳畸形患者,采用耳软骨舒展术配合耳甲腔软骨移植及游离皮片移植治... 详细信息

目的评价耳软骨舒展术替代肋软骨部分耳郭再造术在耳甲腔型小耳畸形中的应用。方法自2023年5月至2023年12月,中国医科大学附属第一医院整形外科收治5例轻中度耳甲腔型小耳畸形患者,采用耳软骨舒展术配合耳甲腔软骨移植及游离皮片移植治疗,测量术后即刻耳宽、耳周长,并对术后耳细微结构进行评分,并与术前患耳进行对比。记录了患者对再造耳的满意度及术后有无并发症发生。结果术后即刻患耳宽平均提高约31%,耳周长平均提高约28%、耳细微结构评分平均提高约35%。患耳手术前后比较,术后耳宽及耳周长均有提高,差异有统计学意义(P<0.01);术后耳细微结构评分也有提高,差异有统计学意义(P<0.05)。所有患者均对再造耳外形满意,无并发症发生。结论耳软骨舒展术配合耳甲腔软骨移植,游离皮片移植等方法可在轻中度耳甲腔型小耳畸形患者中作为肋软骨切取部分耳郭再造术的良好替代方法。

关键词：小耳畸形耳软骨舒展术小耳畸形分型小耳畸形治疗耳甲腔型小耳畸形耳再造

Long noncoding RNA(lncRNA)HOTAIR:Pathogenic roles and therapeutic opportunities in gastric cancer

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Genes & Diseases 2022年第5期9卷 1269-1280页

作者： Wencheng Kong Guang Yin Sixin Zheng Xinchun Liu Akao Zhu panpan yu Jian Zhang yuqiang Shan Rongchao Ying Huicheng Jin Department of Gastroenterological Surgery Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouZhejiang 310006PR China

Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this *** genetic and epigenetic risk factors have been identified that play a major role in gastric *** is an effective epigenetic agent known as long noncoding RNA(lncRNA).HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors,leading to genomic stability,proliferation,survival,invasion,migration,metastasis,and drug *** the present article,we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer,whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes,leading to the development of potential therapeutic strategies.

关键词： Expression Gastric cancer HOTAIR regulation Regulatory pathways