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Stem cell therapies in tendon-bone healing

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World Journal of Stem Cells 2021年第7期13卷 753-775页

作者： yue Xu Wan-Xia Zhang li-Na Wang yue-Qing Ming yu-lin li Guo-Xin Ni School of Sports Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China

Tendon-bone insertion injuries such as rotator cuff and anterior cruciate ligament injuries are currently highly common and *** key method of treating this kind of injury is the reconstruction *** success of this reconstructive process depends on the ability of the graft to incorporate into the ***,there has been substantial discussion about how to enhance the integration of tendon and bone through biological *** cells like bone marrow mesenchymal stem cells(MSCs),tendon stem/progenitor cells,synovium-derived MSCs,adipose-derived stem cells,or periosteum-derived periosteal stem cells can self-regenerate and potentially differentiate into different cell types,which have been widely used in tissue repair and ***,we concentrate in this review on the current circumstances of tendon-bone healing using stem cell therapy.

关键词： Tendon Bone Stem cell Anterior cruciate ligament Rotator cuff

Clinical effect of laparoscopic radical resection of colorectal cancer based on propensity score matching

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 124-133页

作者： Yang liu Xian-Xue Wang yu-lin li Wen-Tao He Hong li Hua Chen Department of General Surgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Anesthesiology Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)is increasing *** radical resection of CRC is a minimally invasive procedure preferred in clinical *** To investigate the clinical effect of laparoscopic radical resection of CRC on the basis of propensity score matching(PSM).METHODS The clinical data of 100 patients who received inpatient treatment for CRC at Changde Hospital,Xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)were analyzed *** control group included patients who underwent open surgery(n=43),and those who underwent laparoscopic surgery formed the observation group(n=57).The baseline information of both groups was equipoised using 1×1 *** in the perioperative parameters,inflammatory response,immune function,degree of pain,and physical status between the groups were *** Thirty patients from both groups were successfully *** PSM,baseline data showed no statistically significant differences between the groups:(1)Periop-erative parameters:The observation group had a longer surgery time,less intra-operative blood loss,earlier first ambulation and first anal exhaust times,and shorter gastric tube indwelling time than the control group;(2)Inflammatory response:24 h after surgery,the levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α)between groups were higher than ***-6,CRP,and TNF-αlevels in the observation group were lower than in the control group;(3)Immune function:At 24 h after surgery,counts of CD4-positive T-lymphocytes(CD4+)and CD4+/CD8-positive T-lymphocytes(CD8+)in both groups were lower than those before surgery,whereas CD8+was higher than that before *** 24 h after surgery,both CD4+counts and CD4+/CD8+in the observation group were higher than those in the control group,whereas CD8+counts were lower;(4)Degree of pain:The visual analog scale scores in the observation gro

关键词： Colorectal cancer Laparoscopic Open surgery Inflammatory reaction Immune function Propensity score

Chemerin deficiency regulates adipogenesis is depot different through TIMP1

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Genes & Diseases 2021年第5期8卷 698-708页

作者： Cheng-Long Huang liu-ling Xiao Min Xu Jun li Shu-Fen li Cui-Song Zhu yu-li lin Rui He Xi li Biology Science Institutes Chongqing Medical UniversityChongqing400016PR China Center for Translational Research in Hematologic Malignancies Houston Methodist Cancer CenterHouston Methodist Research InstituteHoustonTX 77030USA Key Laboratory of Metabolic Molecular Medicine The Ministry of EducationDepartment of Biochemistry and Molecular BiologyFudan University Shanghai Medical CollegeShanghai200032PR China Shanghai Public Health Clinical Center Fudan UniversityShanghai201508PR China Department of Immunology Fudan University Shanghai Medical CollegeShanghai200032PR China

Adipocytes and immune cells are vital for the development of adipose ***-pokines secreted by adipocytes regulate adipogenesis and body *** is one of the ***,the function and mechanism of chemerin in adipose tissue are not fully *** with wild type(WT)mice,Rarres2^(-/-)mice gained weight and significantly increased fat distribution in subcutaneous adipose tissue(SAT),rather than visceral adipose tissue(VAT)on high fat diet(HFD).PPARg and C/EBPa,the master regulators of adipogenesis,were up-regulated in SAT and down-regulated in VAT in Rarres2^(-/-)mice comparing with WT *** of chemerin deficiency or not,the ratio of adipocyte-progenitors to total cells and the differentiation capacity of adipocyte-progenitors were similar in SAT and VAT,but macrophage infiltration in VAT was more severe than in SAT in Rarres2^(-/-)***,CD45þimmune cells supernatant from Rarres2^(-/-)SAT pro-moted the differentiation of adipocyte-progenitors and 3T3-L1 *** array assay of CD45þimmune cells supernatant revealed that metalloproteinase inhibitor 1(TIMP1),an in-hibitor of adipogenesis,was reduced in Rarres2^(-/-)SAT,but increased in Rarres2^(-/-)*** we specifically knocked down chemerin in SAT,TIMP1 was down-regulated and adipogenesis was promoted with reducing infiltration of *** present study demonstrates that the effects of chemerin on adipose tissue is depot different,and specific knock down chemerin in SAT promote adipogenesis and improve glucose tolerance test(GTT)and insulin tolerance test(ITT).This suggests a potential therapeutic target for chemerin in the treatment of obesity related metabolic disorder.

关键词： Adipogenesis Adipose tissue depot Chemerin Inflammation TIMP1

Resuscitative endovascular balloon occlusion of the aorta in the treatment of severe hemorrhagic shock caused by upper gastrointestinal bleeding

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World Journal of Emergency Medicine 2023年第3期14卷 247-249页

作者： yu-lin li Jun-yang Wang Wen Han Tao Sun Kang Lyu Shan-xiang Xu Department of Emergency Medicine the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

Hemorrhagic shock is a life-threatening disease often encountered in emergency departments(EDs).Hemorrhagic shock caused by extensive bleeding from multiple sites is often associated with high mortality and *** recent years,resuscitative endovascular balloon occlusion of the aorta(REBOA)has been widely used in traumatic hemorrhagic shock and is considered to be an effective resuscitation measure.[1]Some studies reported that REBOA was also effective for non-traumatic hemorrhage.[2,3]In this study,we report a case of hemorrhagic shock caused by acute upper gastrointestinal bleeding that was successfully treated and received REBOA to obtain a transition *** report may provide feasible options for emergency physicians,gastroenterologists,or surgeons to more actively treat refractory gastrointestinal bleeding.

关键词： balloon hemorrhagic gastrointestinal

The First Total Synthesis of Five Elegan Type Natural Products

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Chinese Chemical Letters 1997年第7期8卷 595-598页

作者： Jing li Jiong LAN Zuo Sheng liU yu lin li(National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,Lanzhou Univerity, Lanzhou 730000) LANZHOU UNIV NATL LAB APPL ORGAN CHEM LANZHOU 730000 PEOPLES R CHINA LANZHOU UNIV INST ORGAN CHEM LANZHOU 730000 PEOPLES R CHINA

The first total synthesis of five linear diterpenes: eleganolone (1), eleganolone acetate (2), elegandiol (3), eleganonal (4) and epoxyeleganolone (5), was achieved from (E,E)-farnesol (6) via 4 to 6 steps. The key st... 详细信息

关键词： ppm HNMR cm IR EIMS The First Total Synthesis of Five Elegan Type Natural Products MHz

TOTAL SYNTHESIS OF(-)-3-OXOEUDESMA-1,4,11(13)-TRIEN-7αH-12-OIC ACID

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Chinese Chemical Letters 1993年第2期4卷 105-106页

作者： yu lin li Xin CHEN Si Chang SHAO Tong Shuang li State Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry Lanzhou UniversityLanzhou 730000.

The first total synthesis of(-)-3-oxoeudesma-1,4,11(13)-trien-7αH-12-oic acid 1 has been *** key step is one-pot reaction involving dehydrogenation and allylic oxidation with selenium dioxide.

关键词： TOTAL SYNTHESIS OF EIMS H-12-OIC ACID OXOEUDESMA-1,4,11 TRIEN-7

Synthetic Studies on Diarylheptanoids──Syntheses of 1,7-Bis(4-Hydroxyphenyl)-1,4,6-Heptatriene-3-One and Acetogenin G

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Chinese Chemical Letters 1997年第4期8卷 291-292页

作者： Shi Jun DA Ying li Chu Sheng HUANG Xiao Hong li and yu lin li(National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, LanZhou University, Lanzhou 730000) NATL LAB APPL ORGAN CHEM LANZHOU 730000PEOPLES R CHINA LANZHOU UNIV INST ORGAN CHEMLANZHOU 730000PEOPLES R CHINA

The two new diarylheptanoids, 1,7-bis(4-hydroxyphenyl)-1,4,6 (l) and aecrogenin G (2) were Synthesized starting from 4-hydroxybenzaldehyde (3) and acetone

关键词： Hydroxyphenyl Syntheses of 1,7-Bis Synthetic Studies on Diarylheptanoids Heptatriene-3-One and Acetogenin G

Regioselective Synthesis of Two Novel 4-alkenyloxy-2,6-dihydroxyacetophenones

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Chinese Chemical Letters 1998年第9期9卷 799-800页

作者： Chu Sheng HUANG Zhe ZHANG Shu Hua li yu lin li (National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000) Lanzhou Univ Inst Organ Chem Lanzhou 730000 Peoples R China Lanzhou Univ Natl Lab Appl Organ Chem Lanzhou 730000 Peoples R China

Two novel Acetophenones, 4-(1'-geranyloxy)-2,6-dihydroxyacetophenone 1 and 4-(1'-farnesyl)-2,6-dihydroxyacetophenone 2 isolated from the fruit of Evodia merrillii and from the aerial parts of Borronia ramosa respectiv... 详细信息

关键词： 4-alkenyl-2 6-dihydroxyacetophenones total synthesis

STUDIES ON THE PRENYLFLAVONOIDS PART Ⅳ^([1]). SYNTHESIS OF(±)LESPEDEZAFLAVANONEE

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Chinese Chemical Letters 1993年第5期4卷 393-394页

作者： Fang Jie ZHANG lian yun ZHAO yu lin li State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhon 730000

(±)Lespedezaflavanone E, 6, 8, 3'-tri (γ,γ-dimethylallyl)-5, 7, 2', 4'-tetrahydroxy-flavanone, has been synthesized by the condensation of 3, 5-di (γ,γ-dimethylallyl)-4, 6-dimethoxymethoxy-2-hydroxyacetophenone a... 详细信息

关键词： ppm OH LESPEDEZAFLAVANONEE STUDIES ON THE PRENYLFLAVONOIDS PART SYNTHESIS OF