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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer‑like social memory loss

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Military Medical Research 2025年第1期12卷 48-71页

作者： Hui-Yang Lei Gui-Lin Pi Ting He Rui Xiong Jing-Ru Lv Jia-Le Liu Dong-Qin Wu Meng-Zhu Li Kun Shi Shi-Hong Li Na-Na yu Yang Gao Hui-Ling yu Lin-yu Wei Xin Wang Qiu-Zhi Zhou Pei-Lin Zou Jia-Yang Zhou Ying-Zhou Liu Nai-Ting Shen Jie Yang Dan Ke Qun Wang Gong-Ping Liu Xi-Fei Yang jian-Zhi Wang Ying Yang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese Medicine the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Co‑Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina

Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease(AD),which is closely related to tau pathology and hippocampal *** to the heterogeneity of brain neurons,the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain ***,further investigation is ***:We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis,social behavioural tests,hippocampal electrophysiology,immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and ***,we utilized optogenetics and administered ursolic acid(UA)via oral gavage to examine the effects of these agents on social memory in ***:The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1(vCA1)under both physiological conditions and AD-like tau *** tau progressively accumulated,vCA1,especially its excitatory and parvalbumin(PV)neurons,were fully filled with mislocated and phosphorylated tau(p-Tau).This finding was not observed for dorsal hippocampal CA1(dCA1).The overexpression of human tau(hTau)in excitatory and PV neurons mimicked AD-like tau accumulation,significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within *** excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social ***,1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB(TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social ***:This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau

关键词： Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB(TFEB)

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匹莫林血清浓度和唾液浓度的相关性

新药与临床 1986年第6期 345-346页

作者：张纯王香民于嘉屏上海第二军医大学附属长征医院上海第二军医大学附属长征医院上海 200003

用高效液相色谱法（HPLC）测定5名多动综合征患儿口服匹莫林片剂后的体浓度。约服药后2h,其血药浓度和唾药浓度均可到达峰值。血药和唾药的消除半减（衰）期分别为8±3h和7±3h（n=5）;两者无显著性差异（p>0.05）。服药后24h的唾药浓... 详细信息

用高效液相色谱法（HPLC）测定5名多动综合征患儿口服匹莫林片剂后的体浓度。约服药后2h,其血药浓度和唾药浓度均可到达峰值。血药和唾药的消除半减（衰）期分别为8±3h和7±3h（n=5）;两者无显著性差异（p>0.05）。服药后24h的唾药浓度和血药浓度的比率为0.76±SD 0.17,回归方程:C血清=0.9008C唾液-0.2192,v=0.9765,p<0.001（n=30）。结果表明,用唾液浓度可替代血清浓度进行匹莫林的药物动力学研究。

关键词：匹莫林多动综合征高效液相色谱法血清浓度唾液浓度

As-cast Ti_(x)(AlVCr)_(100−x)light-weight medium entropy alloys with high strength and uniform compressive plasticity

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 194-206页

作者： Ming-jie KAI yu-jie MA Xiao-tian WANG Liang CHENG jian-bo HU Yao-yao HU Tai-ran XU Gui-jiang LI Xiang-kang MENG Zhen-hua CAO College of Materials Science and Engineering Nanjing Tech UniversityNanjing 210009China School of Intelligent Manufacturing and Information Jiangsu Shipping CollegeNantong 226010China Laboratory for Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering PhysicsMianyang 621900China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China

The effect of Ti content on the microstructure and mechanical properties of as-cast light-weight Ti_(x)(AlVCr)_(100−x)medium entropy alloys was studied by compressive tests,X-ray diffraction,scanning electron microscopy and transmission electron *** results suggest that yield strength increases and then decreases with the increment of Ti *** Ti_(60)(AlVCr)_(40)alloy has the best combination of high strength of 1204 MPa and uniform plastic strain of 70%,possessing a high specific yield strength of 255 MPa·cm^(3)/*** enhancement of strength is mainly attributed to the synergic effects of solid-solution and coherent nano-precipitation strengthening,while dislocation motion such as dislocation pinning,entanglement and dislocation cells significantly increases the strain-hardening capacity.

关键词： TiAlVCr medium entropy alloy solid solution strengthening b2 precipitate strain hardening behavior

Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia

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Zoological Research 2025年第01期 177-192页

作者： Zhou Li Yi-jian Xiang Zhi-Chuan Zou yu-Ming Feng Hui Wang Wei-Qing Chen Xie Ge Jin-Zhao Ma Jun Jing Bing Yao Department of Reproductive Medicine Jinling Hospital Affiliated Hospital of Medical School Nanjing University State Key Laboratory of Reproductive Medicine and Offspring Health Nanjing Medicine University

Increasing evidence implicates disruptions in testicular fatty acid metabolism as a contributing factor in nonobstructive azoospermia(NOA), a severe form of male infertility. However, the precise mechanisms linking fatty acid metabolism to NOA pathogenesis have not yet been fully elucidated. Multi-omics analyses, including microarray analysis, single-cell RNA sequencing(scRNA-seq), and metabolomics, were utilized to investigate disruptions in fatty acid metabolism associated with NOA using data from public databases. Results identified ACSL6, ACSBG2, and OLAH as key genes linked to fatty acid metabolism dysregulation, suggesting their potential causative roles in NOA. A marked reduction in omega-3 polyunsaturated fatty acids, especially docosahexaenoic acid(DHA), was observed, potentially contributing to the pathological process of NOA. Sertoli cells in NOA patients exhibited apparent fatty acid metabolic dysfunction, with PPARG identified as a key transcription factor(TF) regulating this process. Functional analyses demonstrated that PPARG is crucial for maintaining blood-testis barrier(BTB) integrity and promoting spermatogenesis via regulation of fatty acid metabolism. These findings reveal the pivotal role of fatty acid metabolism in NOA and identify PPARG as a potential therapeutic target.

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In vivo self-assembled bispecific fluorescence probe for early detection of bladder cancer and metastasis

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Science Bulletin 2025年第3期70卷 407-418页

作者： Da-Yong Hou Ni-yuan Zhang Peng Zhang Xiang-Peng Li Jiong-Cheng Wu Mei-yu Lv Zhi-Jia Wang Xing-Jie Hu jian-Xiao Liang Hong-Lei Wang yue-Ze Wang Hui-Hui You Hong-Wei An Hao Wang Wanhai Xu NHC Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in UrologyHarbin Medical UniversityHarbin 150001China Department of PET-CT/MRI Harbin Medical University Cancer HospitalHarbin 150001China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Beijing 100190China

Tumor metastasis accounts for over 90%of tumor-related deaths,prompting the development of fluorescently labeled tumor-specific molecular imaging agents for differentiating tumors from normal ***,early detection of metastasis lesions by tracking tumor markers alone has proven to be ***,we reported a glycopeptide-based bispecific fluorescence probe(bsProbe)for earlier detection of bladder cancer and *** simultaneously recognition(tumor&tumor microenvironment)and in vivo self-assembly,the tumor accumulation of bsProbe(12.3%ID/g)was obviously increased by∼6 fold compared with that in CXCR4 specific fluorescence probe(sProbe),indicating the obvious advantages of bsProbe over existing tumor metastasis detection ***,bsProbe substantially broadens the tumor diagnosis window and enhances the detection signal to noise ratio(SNR:approximately 9.5),permitting early diagnosis of lung micro-metastasis(∼1 mm),precise identifying of tumor boundaries and micro-tumors in orthotopic tumor *** importantly,bsProbe was demonstrated to distinguish malignant from benign specimen with a specificity of 90.48%and sensitivity of 92.22%in 195 clinical specimens of bladder cancer *** together,this novel synergetic targeting(CD206×CXCR4)strategy provides an attractive method for earlier detection of bladder cancer and metastasis,which might be further extended to the imaging-guided surgery of clinical invisible tumors.

关键词： Self-assembly Peptide Nanomaterial Fluorescence imaging Bladder cancer

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可乐猪乳头数性状全基因组关联分析

中国畜牧兽医 2016年第11期43卷 2866-2872页

作者：谢健喻昌燕许瑶牛熙冉雪琴王嘉福贵州大学生命科学学院贵阳550025 贵州大学农业生物工程研究院贵阳550025 贵州大学动物科学学院贵阳550025 铜仁学院铜仁554300

乳头数性状是猪最重要的繁殖性状之一,与养猪业的经济效益密切相关。本试验以Illunima Porcine SNP60K芯片对22头可乐猪进行基因分型,通过Plink 1.07软件,基于混合线性模型对左乳头数、右乳头数和总乳头数性状进行全基因组关联分析。经... 详细信息

乳头数性状是猪最重要的繁殖性状之一,与养猪业的经济效益密切相关。本试验以Illunima Porcine SNP60K芯片对22头可乐猪进行基因分型,通过Plink 1.07软件,基于混合线性模型对左乳头数、右乳头数和总乳头数性状进行全基因组关联分析。经过严格的质量控制和多重检验之后,共鉴定出全基因组水平潜在关联的SNPs位点4个(P<2.06E-5);染色体水平显著关联位点3个,潜在关联位点18个;在关联SNP位点可能连锁的上、下游1cM区间内检索到304个基因,其中Wnt及Fgf信号通路中的候选基因BTRC、FGF5、FGF8和BMP3、RASGEF1B、HMGB3可能影响猪的乳头数性状或繁殖性状。通过全基因组关联分析策略发掘出的关联SNP位点及潜在候选基因,将为可乐猪的选育保种奠定基础。

关键词： SNP芯片全基因组关联分析乳头数

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聚合物前驱体法制备CTNA陶瓷及其性能

电子元件与材料 2008年第2期27卷 10-12页

作者：张国清郑兴华俞建长汤德平褚夫同福州大学材料科学与工程学院福建福州350108

采用DSC-TGA、XRD和SEM对聚合物前驱体法制备的0.7CaTiO_3-0.3NdAlO_3(CTNA)陶瓷粉末进行了分析。结果表明:经550℃预烧后的粉末为无定形态;但是当预烧温度提高到600℃时,形成了钙钛矿结构的CTNA单相。这表明CTNA晶相是未经中间相而直... 详细信息

采用DSC-TGA、XRD和SEM对聚合物前驱体法制备的0.7CaTiO_3-0.3NdAlO_3(CTNA)陶瓷粉末进行了分析。结果表明:经550℃预烧后的粉末为无定形态;但是当预烧温度提高到600℃时,形成了钙钛矿结构的CTNA单相。这表明CTNA晶相是未经中间相而直接从无定形态的前驱体中结晶形成。与传统固相反应法相比,合成温度从1300℃大幅下降到600℃。经900℃预烧,1375℃烧结的样品,其εr为43.3,Q·f为34862GHz,τf为1.4×10–6℃^(–1)。

关键词：无机非金属材料微波介质陶瓷聚合物前驱体法 CTNA陶瓷钙钛矿结构

正演模拟在大平房火山岩发育区地震信息采集中的应用

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新疆石油地质 2010年第2期31卷 200-202页

作者：王海波刘兵于建华王长江中国石油东方地球物理公司辽河物探分公司辽宁盘锦124010

简要介绍了辽河大平房火山岩发育区的地质情况。在分析低频信号有利于火山岩下伏地层成像的理论基础上,以现有的地质认识为基础构建正演模型,模拟了不同频率的地震子波激发得到的单炮记录及偏移剖面。模拟结果表明,低频信号有利于辽河... 详细信息

简要介绍了辽河大平房火山岩发育区的地质情况。在分析低频信号有利于火山岩下伏地层成像的理论基础上,以现有的地质认识为基础构建正演模型,模拟了不同频率的地震子波激发得到的单炮记录及偏移剖面。模拟结果表明,低频信号有利于辽河大平房火山岩发育区中深层成像,在下一步的勘探中应加强低频信号的保护。

关键词：辽河油田火山岩正演低频

多重草稿模型视域下人工智能类意识进化的可能性探究

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科学技术哲学研究 2025年第1期42卷 92-98页

作者：孙建民杨煜东南大学人文学院南京211189

在人工智能迅速发展的背景下,哲学界对人工智能意识问题的讨论逐渐增多,但均尚无定论。为揭开意识研究的神秘面纱,建构新的人工智能类意识生成载体,文章在对以往西方关于心身关系问题研究主流路径的反思与批驳基础上,引入丹尼特的多重... 详细信息

在人工智能迅速发展的背景下,哲学界对人工智能意识问题的讨论逐渐增多,但均尚无定论。为揭开意识研究的神秘面纱,建构新的人工智能类意识生成载体,文章在对以往西方关于心身关系问题研究主流路径的反思与批驳基础上,引入丹尼特的多重草稿模型。该理论将全部人类意识现象视为在人脑乔伊斯架构串行联结中实现的虚拟机器活动,以进化论为研究视角,延伸至人工智能类意识问题的生成性研究,认为人工智能意识与人类意识的物质本质相同,区别仅在于进化程度的差异。因此,在人工智能迅速发展的背景下,人工智能进化出类人化意识是具有可能性的。

关键词：多重草稿模型人工智能类意识意识进化