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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li yu deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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历史教学实践的理论根柢与应然逻辑——基于马克思主义人学的视角

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教师教育学报 2025年第1期12卷 76-84页

作者：邓宇郑家福西南大学教师教育学院重庆400715

马克思主义人学是奠基于人的历史性实践活动之上、确证属人世界并以解放和弘扬人的主体性为主旨的思想方式与理论学说。马克思主义人学与历史及历史教学皆有着深刻的联系。马克思主义人学观照下的历史可从历史个体与历史整体两方面审视... 详细信息

马克思主义人学是奠基于人的历史性实践活动之上、确证属人世界并以解放和弘扬人的主体性为主旨的思想方式与理论学说。马克思主义人学与历史及历史教学皆有着深刻的联系。马克思主义人学观照下的历史可从历史个体与历史整体两方面审视。历史中的个人是过去“现实的人”和“社会的人”。历史的整体创造是基于“人的需要”,其发展有赖于“人的发展”。马克思主义人学关于历史个体与历史整体的观点为历史教学实践提供了理论根柢和逻辑导向。历史教学实践的应然逻辑在于:把握个体理解原则,注重历史情境建构;坚持整体认知原则,多方面呈现相关史料;重视因果解释原则,厘清历史因果关系;遵循史观统领原则,辩证地认识历史发展进程。

关键词：历史教学实践马克思主义人学个体理解整体认知因果解释史观统领

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Phase-domain blind estimation of symbol duration based on Haar wavelet transform

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Journal of Systems Engineering and Electronics 2010年第3期21卷 375-381页

作者： Zhenmiao deng yu Liu College of Information Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 P. R. China

A phase-domain blind estimator of symbol duration based on Haar wavelet transform（HWT） is *** can estimate the symbol duration of phase modulated signals,such as M-ary phase-shift keying（MPSK） signals and polyphase coded *** closed form of the spectrum of HWT is *** analysis shows the frequency of the first spectral peak is equal to the symbol rate,which is the reciprocal of symbol *** the symbol duration can be extracted from the ***,the optimum wavelet scale is determined according to the maximum output signal to noise ratio（OSNR） ***-LAB simulations show that this algorithm can blindly estimate the symbol duration without any prior *** estimator need not estimate the carrier frequency and has the characteristics of low computation complexity and high accuracy.

关键词： symbol duration M-ary phase-shift keying(MPSK) polyphase coded signal Haar wavelet.

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Effects of menopausal hormone therapy-based on the role of estrogens,progestogens,and their metabolites in proliferation of breast cancer cells

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Cancer Biology & Medicine 2022年第4期19卷 432-449页

作者： yu deng Hongyan Jin Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China

Menopausal hormone therapy(MHT)has been widely used for the clinical treatment of symptoms associated with menopause in ***,the exact nature of the relationship between MHT and the increased risk of breast cancer has not been fully *** results of the Women’s Health Initiative’s randomized controlled clinical studies showed that estrogen monotherapy was associated with a lower incidence of breast cancer as compared to estrogen-progesterone combined therapy,with an elevated risk of breast *** evidence currently available from randomized trials and observational studies is based on data from different populations,drug formulations,and routes of *** though the risks of MHT and breast cancer have received a great deal of attention,information regarding the unpredictable toxicological risks of estrogen and progestogen metabolism needs to be further ***,the diversity and complexity of the metabolic pathways of estrogen and different progestogens as well as the association of the different estrogen and progestogen metabolites with the increased risk of breast cancer need to be adequately ***,this review aimed to describe the biological effects of estrogen,progesterone,and their metabolites on the proliferation of breast cancer cells,based on relevant basic research and clinical trials,to improve our understanding of the biological functions of estrogen and progestogen as well as the safety of MHT.

关键词： Menopausal hormone therapy estrogen progestogens breast cancer

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Spatiotemporal Evolution and Influencing Factors of Landscape Ecological Vulnerability in the Three-River-Source National Park Region

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Chinese Geographical Science 2022年第5期32卷 852-866页

作者： yu Hu ZHANG Xiaoyao deng yu Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment Chinese Academy of SciencesBeijing 100049China

The increasing impact of global warming and human activities has exacerbated the ecological environment in the Three-RiverSource National Park Region(TNPR). Understanding the temporal and spatial evolution of landscape ecological vulnerability(LEV)and its influencing factors are crucial to the implementation of environmental management. Here, we aimed to: 1) construct a LEV assessment model integrating landscape structure and function;2) analyze the temporal and spatial evolution of TNPR’s LEV from 1995to 2015;3) use geographic detectors to reveal the regional influence factors of TNPR’s LEV. The main findings were: 1) grasslands, water, and bare land are important landscapes of TNPR, accounting for 98.37% of the total area. During the study period, there were significant differences in the area of different landscapes;except for desert, shrub, and urban land, the other landscape areas showed a decreasing trend. 2) During the study period, the LEV of TNPR showed a downward trend;except for grasslands, the ecological vulnerability of the other landscapes decreased steadily. Furthermore, a pattern of conversion from high to low vulnerability grade was observed in the study area. In terms of spatial distribution, the LEV level shows a trend of high at both ends(east and west) and low in the middle.3) Overall, the impact of natural factors on the ecological vulnerability of the TNPR was significantly higher than that of human *** conclusion, our study provides a scientific basis for landscape structure optimization and the management of regional ecological vulnerability.

关键词： landscape structure landscape function landscape ecological vulnerability geographical detectors influencing factors Three-River-Source National Park

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Evolutionary Pattern and Effect of Administrative Division Adjustment During Urbanization of China:Empirical Analysis on Multiple Scales

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Chinese Geographical Science 2018年第5期28卷 758-772页

作者： yu Hu deng yu XU Shan Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Science Key Laboratory of Regional Sustainable Development Modeling Chinese Academy of Science

The adjustment of administrative divisions is one of the important factors guiding China's urbanization, which has profound economic and social effects for regional development. In this paper, we comprehensively describe the process of the adjustment of administrative divisions at provincial and municipal levels in China and summarize the effects on the basic structure and patterns of the spatial development. We quantitatively assess the effects on fields such as urbanization and social economy through the use of multidimensional scaling. The results show that: 1) Upgrading county to municipality(or city-governed district) is the main way of adjusting the administrative divisions. It is also an important factor in the spatial differentiation of interprovincial urbanization. China's population urbanization can be divided into four patterns including interprovincial migration, provincial migration, natural growth, and growth caused by the adjustment of administrative divisions, which is also the main reason for the increased Chinese urbanization rate at the provincial level. 2) Taking the city of Beijing as an example, we generalize five adjustment patterns made to administrative divisions: the set-up of sub-districts, the set-up of regional offices, the upgrading of townships to sub-districts, the upgrading of townships to towns, and the set-up of towns and the addition of new regional offices. We summarize the municipal urban spatial structure, including the sub-district office area in the central urban area, the regional office area in the new urban area, the mixed area of villages, towns, and sub-district offices in the suburb area, and the township area in the outer suburb area. 3) The adjustment of administrative divisions triggers a significant circulative accumulation effect, resulting in the spatial locking of population and industrial agglomeration. It affects the evolution of the urban spatial form and plays an important role in shaping the urban spatial st

关键词： administrative division adjustment evolutionary structure effect evaluation multidimensional scaling urbanization China

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Construction of mesoporous silica-implanted tungsten oxides for selective acetone gas sensing

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Chinese Chemical Letters 2024年第11期35卷 492-498页

作者： Jichun Li Zhengren Wang yu deng Hongxiu yu Yonghui deng Xiaowei Cheng Kaiping yuan Department of Chemistry Shanghai Stomatological Hospital&School of StomatologyState Key Laboratory of Molecular Engineering of PolymersShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsiCHEMFudan UniversityShanghai 200433China Frontier Institute of Chip and System State Key Laboratory of ASIC and SystemFudan UniversityShanghai 200433China State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050China

As a key biomarker for noninvasive diagnosis of diabetes,the selective detection of trace acetone in exhaled gas using a portable and low-cost device remains a great *** metal oxide(SMO)based gas sensors have drawn signification attention due to their potential in miniaturization,user-friendliness,high cost-effectiveness and selective real-time detection for noninvasive clinical ***,we propose a one-pot solvent evaporation induced tricomponent co-assembly strategy to design a novel ordered mesoporous SMO of silica-implanted WO_(3)(Si O_(2)/WO_(3))as sensing materials for trace acetone *** controlled co-assembly of silicon and tungsten precursors and amphiphilic diblock copolymer poly(ethylene oxide)-block-polystyrene(PEO-b-PS),and the subsequent thermal treatment enable the local lattice disorder of WO_(3)induced by the amorphous silica and the formation of ordered mesoporous Si O_(2)/WO_(3)hybrid walls with a unique metastableε-phase WO_(3)*** obtained mesoporous SiO_(2)/WO_(3)composites possess highly crystalline framework with large uniform pore size(12.0-13.3 nm),high surface area(99-113 m^(2)/g)and pore volume(0.17-0.23 cm^(3)/g).Typically,the asfabricated gas sensor based on mesoporous 2.5%Si O_(2)/WO_(3)exhibits rapid response/recovery rate(5/17 s),superior sensitivity(R_(air)/R_(gas)=105 for 50 ppm acetone),as well as high selectivity towards *** limit of detection is as low as 0.25 ppm,which is considerably lower than the thresh value of acetone concentration(>1.1 ppm)in the exhaled breath of diabetic patients,demonstrating its great prospect in real-time monitoring in diabetes ***,the mesoporous 2.5%Si O_(2)/WO_(3)sensor is integrated into a wireless sensing module connected to a smart phone,providing a convenient real-time detection of acetone.

关键词： Mesoporous materials ε-Tungsten oxide Silica-implanted Acetone sensing Real-time detection

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Positively charged microporous ceramic membrane for the removal of Titan Yellow through electrostatic adsorption

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Journal of Environmental Sciences 2016年第6期28卷 204-212页

作者： Xiuting Cheng Na Li Mengfu Zhu Lili Zhang yu deng Cheng deng College of Material Science and Chemical Engineering Tianjin University of Science and Technology Institute of Medical Equipment Academy of Military Medical Sciences

To develop a depth filter based on the electrostatic adsorption principle, positively charged microporous ceramic membrane was prepared from a diatomaceous earth ceramic *** internal surface of the highly porous ceramic membrane was coated with uniformly distributed electropositive nano-Y2O3 coating. The dye removal performance was evaluated through pressurized filtration tests using Titan Yellow aqueous solution. It showed that positively charged microporous ceramic membrane exhibited a flow rate of 421 L/（m^2·hr） under the trans-membrane pressure of 0.03 bar. Moreover it could effectively remove Titan Yellow with feed concentration of 10 mg/L between pH 3 to 8. The removal rate increased with the enhancement of the surface charge properties with a maximum rejection of 99.6%. This study provides a new and feasible method of removing organic dyes in wastewater. It is convinced that there will be a broad market for the application of charged ceramic membrane in the field of dye removal or recovery from industry wastewater.

关键词： Positively charged ceramic membrane Electrostatic adsorption Organic dyes Wastewater treatment

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Pigment signatures of some diatoms isolated from China seas

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Acta Oceanologica Sinica 2006年第1期25卷 108-118页

作者： YAO Peng yu Zhigang deng Chunmei College of Chemistry and Chemical Engineering Ocean University of China Qingdao 266003 China

The photosynthetic pigments of 12 species （14 strains） of cultured diatoms from six genera under specific conditions were examined by the HPLC. The diatom genera were Skeletonema, Thalassiosira, Chaetoceros, Nitzschla, Phaeodactylum and Meuniera. All strains were isolated from China seas and most of them were from the Jiaozhou Bay, China. Fifteen pigments were identified and eight of them were various chlorophyll a derivatives. Chlorophyll a, c2 and c1 and the carotenoids fucoxanthin, diadinoxanthin, diatoxanthin and β, β-carotene existed in all species. The ratios of each pigment to chlorophyll a were compared with the results in literatures. The pigment ratios of this study generally fall within the ranges reported by the literatures although the maximum ratio of fucoxanthin to chlorophyll a was higher and the ratios of chlorophyll c and diatoxanthin to chlorophyll a were low. The pigment ratios are useful to understanding the pigment signatures of diatoms in the Jiaozhou Bay, China, and to setting up the chemotaxonomic method of phytoplankton in these sea areas.

关键词： diatoms pigment HPLC ratio Jiaozhou Bay

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Dynamics of Attractive Vesicles in Shear Flow

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Chinese Journal of Polymer Science 2016年第5期34卷 623-636页

作者： zhen-yu deng dong zhang 章林溪 Department of Physics Zhejiang University Hangzhou 310027 China

A nonequilibrium molecular dynamics（NEMD） method is employed to study the dynamics of two identical vesicles with attractive interactions immersed in shear flow. The dynamics behaviors of attractive vesicles depend on the attractive interactions and the shear rates simultaneously. There are four motion types for attractive vesicles in shear flow： a coupled-tumbling（CTB） motion, a coupled-trembling（CTR） motion, a collision/rotation mixture（CRM） motion and a separated-tank-treading（STT） motion, which are determined by the competition between the shear flow and the attractive interactions. Furthermore, the dynamics behavior of an individual vesicle shows three main motion types such as tumbling, trembling and tank-treading motions, and relies mainly on the shear rates. Meanwhile, comparisons with rigid vesicles for the dynamics behaviors are made, and the collision/rotation mixture（M） motion isn＇t observed for rigid vesicles.

关键词： vesicles attractive collision rotation contour aggregated Shear immersed separated competition

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