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Electronic structure regulation and built-in electric field synergistically strengthen photocatalytic nitrogen fixation performance on Ti-BiOBr/TiO_(2)heterostructure

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Rare Metals 2024年第3期43卷 1125-1138页

作者： Ru-Qi Li yu-Jie bian Chun-Ming Yang Li Guo Tao-Xia Ma Chuan-Tao Wang Feng Fu Dan-Jun Wang College of Chemistry and Chemical Engineering Yan’an UniversityYan’an Key Laboratory of Green Catalysis and Quality Improvement and Utilization of Low Rank CoalYan’an716000China

At present,industrial synthetic ammonia was still obtained through the Hubble-Bosch process,with large energy *** is a research hotspot to realize green synthetic ammonia by using solar *** difficulty of photocatalytic ammonia synthesis was that the photo-excited electrons have not enough energy to active N≡*** this study,Ti was doped into BiOBr by one-step hydrothermal method,which was oxidized into TiO_(2)when the doping amount reaches the maximum,in situ forming Ti_(0.31)B_(0.69)OB/TiO_(2)*** from the synergistic effect of Ti doping and S-scheme heterojunction,the synthetic ammonia efficiency of Ti_(0.31)B_(0.69)OB/TiO_(2)-11.96 reached 1.643 mmol·g_(cat)^(-1)at mild conditions and without hole scavenger for up to 7 h,the efficiency of synthetic ammonia is 115 times,10.5 times and 3.3 times of that of BiOBr,Ti_(0.31)B_(0.69)OB and TiO_(2),***,DFT calculation confirms that Ti doping accurately refine the electronic structure of BiOBr,facilitate nitrogen adsorption activation and reduce hydrogenation reaction energy barrier,thus accelerating the reaction kinetics of photocatalytic nitrogen reduction(NRR),Meanwhile,constructing S-scheme heterojunction boosts the separation and transfer of photogenerated electron-hole pairs,improving the reduction ability of electrons in the conduction band of TiO_(2)and the oxidation ability of holes in the valence band of Ti_(0.31)B_(0.69)OB.

关键词： S-scheme heterostructure Electronic structure regulation Built-in electric field Synergistical stren4gthening Photocatalytic nitrogen fixation

Treatment of a patient with aconitine poisoning using veno-arterial membrane oxygenation:A case report

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World Journal of Clinical Cases 2024年第21期12卷 4842-4852页

作者： yu-Yao bian Jin Hou Sudha Khakurel Department of Emergency Medicine Hebei Petro China Central HospitalLangfang 065000Hebei ProvinceChina Department of Internal Medicine Langfang Health Vocational CollegeLangfang 065000Hebei ProvinceChina Dallas Campus UT Health Houston School of Public HealthDallasTX 75201United States

BACKGROUND Aconitine poisoning is highly prone to causing malignant *** elimination of aconitine from the body takes a considerable amount of time,and during this period,patients are at a significant risk of death due to malignant arrhythmias associated with aconitine *** SUMMARY A 30-year-old male patient was admitted due to accidental ingestion of aconitinecontaining *** arrival at the emergency department,the patient intermittently experienced malignant arrhythmias including ventricular tachycardia,ventricular fibrillation,ventricular premature beats,and cardiac *** interventions such as cardiopulmonary resuscitation and defibrillation were promptly ***,veno-arterial extracorporeal membrane oxygenation(VA-ECMO)therapy was *** resuscitation was achieved before ECMO placement,but upon initiation of ECMO,the patient experienced recurrent malignant *** was utilized to maintain hemodynamics and respiration,while continuous blood purification therapy for toxin clearance,mechanical ventilation,and hypothermic brain protection therapy were concurrently *** the third day of VA-ECMO support,the patient’s respiratory and hemodynamic status stabilized,with only frequent ventricular premature beats observed on electrocardiographic monitoring,and echocardiography indicated recovery of cardiac contractile *** the fourth day,a significant reduction in toxin levels was observed,along with stable hemodynamic and respiratory *** a successful pump-controlled retrograde trial occlusion test,ECMO assistance was *** patient gradually improved postoperatively and achieved *** was discharged 11 days *** VA-ECMO can serve as a bridging resuscitation technique for patients with reversible malignant arrhythmias.

关键词： Poisoning Arrhythmia Blood purification Veno-arterial extracorporeal membrane oxygenation Resuscitation Case report

Single-base editing in IGF2 improves meat production and intramuscular fat deposition in Liang Guang Small Spotted pigs

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Journal of Animal Science and Biotechnology 2024年第1期15卷 108-126页

作者： Tianqi Duo Xiaohong Liu Delin Mo yu bian Shufang Cai Min Wang Ruiqiang Li Qi Zhu Xian Tong Ziyun Liang Weilun Jiang Shiyi Chen Yaosheng Chen Zuyong He State Key Laboratory of Biocontrol School of Life SciencesSun Yat-Sen UniversityGuangzhou 510275GuangdongChina Department of Pharmacology(the State‑Province Key Laboratories of Biomedicine‑Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal College of Animal Science and TechnologyHunan Agricultural UniversityChangsha 410128China

Background Chinese indigenous pigs are popular with consumers for their juiciness,flavour and meat quality,but they have lower meat ***-like growth factor 2(IGF2) is a maternally imprinted growth factor that promotes skeletal muscle growth by regulating cell proliferation and differentiation.A single nucleotide polymorphism(SNP) within intron 3 of porcine IGF2 disrupts a binding site for the repressor,zinc finger BED-type containing 6(ZBED6),leading to up-regulation of IGF2 and causing major effects on muscle growth,heart size,and backfat *** favorable mutation is common in Western commercial pig populations,but absent in most Chinese indigenous pig *** improve meat production of Chinese indigenous pigs,we used cytosine base editor 3(CBE3)to introduce IGF2 intron3-C3071T mutation into porcine embryonic fibroblasts(PEFs) isolated from a male Liang Guang Small Spotted pig(LGSS),and single-cell clones harboring the desired mutation were selected for somatic cell nuclear transfer(SCNT) to generate the founder line of IGF2^(T/T) *** We found the heterozygous progeny IGF2^(C/T) pigs exhibited enhanced expression of IGF2,increased lean meat by 18%-36%,enlarged loin muscle area by 3%-17%,improved intramuscular fat(IMF) content by 18%-39%,marbling score by 0.75-1,meat color score by 0.53-1.25,and reduced backfat thickness by 5%-16%.The enhanced accumulation of intramuscular fat in IGF2^(C/T) pigs was identified to be regulated by the PI3K-AKT/AMPK pathway,which activated SREBP1 to promote *** We demonstrated the introduction of IGF2-intron3-C3071T in Chinese LGSS can improve both meat production and quality,and first identified the regulation of IMF deposition by IGF2 through SREBP1 via the PI3KAKT/AMPK signaling *** study provides a further understanding of the biological functions of IGF2and an example for improving porcine economic traits through precise base editing.

关键词： CBE3 IGF2 Intramuscular fat Meat production PI3K-AKT/AMPK ZBED6

Business English. Xin bian shang wu Ying yu jing du. Jiao shi yong shu

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Investigating the mechanism of action of Bu-Yang-Huan-Wu decoction in treating bleomycin-Induced pulmonary fibrosis through the epithelial-mesenchymal transition pathway

2005年

作者： zong zhu bian yu Sumei.

来源：畅想之星图书光盘版（南... 评论

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Toxicology Advances 2024年第1期6卷 10-15页

作者： yu-Ming Wang Han-Zhou Li Huan-Tian Cui yu-Hong bian Graduate School Tianjin University of Traditional Chinese MedicineTianjin 301617China College of Integrated Traditional Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China The First Affiliated Hospital Yunnan University of Chinese MedicineKunming 650500China

Background:To explore the effects and mechanisms of Bu-Yang-Huan-Wu Decoction on pulmonary fibrosis in ***:Forty-five C57BL/6J mice were randomly divided into three groups:Control,Model,and Bu-Yang-Huan-Wu *** fibrosis was elicited in mice through a solitary intratracheal administration of 2.5 mg/kg *** the control group,mice were given a solitary intratracheal administration of a comparable volume of *** began on the first day after the successful model establishment and lasted for 21 *** survival rate and body weight of the mice were recorded daily,and on the 22nd day,bronchoalveolar lavage fluid was collected to determine total cells and total *** wet/dry weight ratio of lung tissue and hydroxyproline were *** tissue pathology was observed using hematoxylin and eosin staining and Masson *** mRNA expression of epithelial-mesenchymal transition-related proteins(E-cadherin and vimentin)was detected by RT-qPCR,and their protein expression was analyzed by western ***:Compared to the model group,the Bu-Yang-Huan-Wu Decoction treatment notably enhanced both the survival rate and body weight in pulmonary fibrosis mice,significantly reduced lung tissue wet/dry weight ratio,total cells,and protein in bronchoalveolar lavage fluid,and hydroxyproline *** pathological morphology of lung tissue was significantly improved,with increased expression of the epithelial cell marker E-cadherin mRNA and protein,and decreased expression of the mesenchymal cell marker vimentin mRNA and ***:Bu-Yang-Huan-Wu Decoction can improve the degree of bleomycin-induced pulmonary fibrosis in mice by inhibiting epithelial-mesenchymal transition.

关键词： pulmonary fibrosis Bu-Yang-Huan-Wu decoction epithelial-mesenchymal transition bleomycin

The role and research progress of MDSC in immune aging-related diseases

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Biomedical Engineering Communications 2024年第2期3卷 4-9页

作者： Xi-Xing Fang Han-Zhou Li Xue-Mei Piao yu-Ming Wang yu-Hong bian Medical School Hubei Minzu UniversityEnshi 445099China College of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Nursing Department People's Hospital of Longjing CityLongjing 133499China

Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous immature cells with a strong immunosuppressive function in myeloid cells,which are impeded in the differentiation of myeloid cells under the pathological conditions of hypoxia,inflammation,infection,and *** individuals age,there is a significant increase in myeloid-derived suppressor cells(MDSCs),which subsequently enhance the immunosuppressive functions of Tregs(regulatory T cells)and Bregs(regulatory B cells).Therefore,MDSC may be related to immune system remodeling,thereby preventing excessive lesions caused by *** indicates that MDSC could serve as a potent inducer of immune *** senescence,characterized by immune dysfunction with aging,is closely linked to the onset of diseases like infections,pulmonary fibrosis,and *** achieve the purpose of anti-aging by intervening in immune aging and slow down the occurrence and development of related ***,understanding the biological characteristics of MDSC and its role in immune aging is crucial for immunotherapy targeting *** article reviews the different roles of MDSC in immune aging and its relationship with pulmonary fibrosis,tumor and other related diseases to provide theoretical basis for more comprehensive targeted MDSC immunotherapy.

关键词： MDSC immunosenescence tumor progression pulmonary fibrosis immunosenescence therapy

m^(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation

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Frontiers of Medicine 2024年第3期18卷 499-515页

作者： Han Wu Weitao Jiang Ping Pang Wei Si Xue Kong Xinyue Zhang yuting Xiong Chunlei Wang Feng Zhang Jinglun Song Yang Yang Linghua Zeng Kuiwu Liu Yingqiong Jia Zhuo Wang Jiaming Ju Hongtao Diao yu bian Baofeng Yang Department of Pharmacology(National Key Laboratory of Frigid Zone Cardiovascular Diseases the State-Province Key Laboratories of Biomedicine-Pharmaceutics of ChinaKey Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin150081China

Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction(MI)can lead to heart *** N6-methyladenosine(m^(6)A)methylation has been shown to play a pivotal role in the occurrence and development of many *** investigating the biological function of the m^(6)A reader YTHDF1 in cardiac fibrosis,adeno-associated virus 9 was used to knock down or overexpress the YTHDF1 gene in mouse hearts,and MI surgery in vivo and transforming growth factor-β(TGF-β)-activated cardiac fibroblasts in vitro were performed to establish fibrosis *** results demonstrated that silencing YTHDF1 in mouse hearts can significantly restore impaired cardiac function and attenuate myocardial fibrosis,whereas YTHDF1 overexpression could further enhance cardiac dysfunction and aggravate the occurrence of ventricular pathological remodeling and fibrotic ***,zinc finger BED-type containing 6 mediated the transcriptional function of the YTHDF1 gene ***1 augmented AXL translation and activated the TGF-β-Smad2/3 signaling pathway,thereby aggravating the occurrence and development of cardiac dysfunction and myocardial ***,our data indicated that YTHDF1 was involved in activation,proliferation,and migration to participate in cardiac fibrosis in *** results revealed that YTHDF1 could serve as a potential therapeutic target for myocardial fibrosis.

关键词： cardiac fibrosis YTHDF1 AXL ZBED6 heart failure

盈余管理能否降低商业银行系统性风险?——基于中国上市银行的证据

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金融论坛 2024年第7期 37-47页

作者：顾海峰卞雨晨东华大学旭日工商管理学院上海201620

盈余管理是商业银行财务管理的常用工具,但其风险效应存在被夸大的现象。文章基于2008-2021年中国32家A股上市银行数据,就盈余管理对银行系统性风险的影响展开研究。研究表明:商业银行进行盈余管理能够降低银行系统性风险,并且该影响在... 详细信息

盈余管理是商业银行财务管理的常用工具,但其风险效应存在被夸大的现象。文章基于2008-2021年中国32家A股上市银行数据,就盈余管理对银行系统性风险的影响展开研究。研究表明:商业银行进行盈余管理能够降低银行系统性风险,并且该影响在股份制银行、高资本质量银行和信贷收缩期银行更为明显。机制检验表明:盈余管理主要通过提升银行盈利能力和盈利稳定性、降低影子银行规模和提升银行竞争度来降低银行系统性风险;经济政策不确定性增强会减弱盈余管理对银行系统性风险的抑制作用。

关键词：盈余管理银行系统性风险经济政策不确定性影子银行银行竞争

生物滤池除臭工艺在污泥发酵工程中的有效实践探讨

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黑龙江环境通报 2024年第3期37卷 166-168页

作者：边宇江西省地质局第九地质大队江西吉安343000 江西新瑞丰生化股份有限公司江西吉安343000

在努力减少污泥产生的工作中,生活污泥发酵工程是一项关键的项目,也是取得显著成果的主要举措之一,对生活污泥的处理在改善生态环境方面发挥了关键作用。然而,在污泥发酵过程中,会产生臭气,这可能对环境造成一定程度的不利影响。因此,... 详细信息

在努力减少污泥产生的工作中,生活污泥发酵工程是一项关键的项目,也是取得显著成果的主要举措之一,对生活污泥的处理在改善生态环境方面发挥了关键作用。然而,在污泥发酵过程中,会产生臭气,这可能对环境造成一定程度的不利影响。因此,需要采取措施对污泥发酵工程进行除臭处理。本文重点关注生物滤池除臭工艺在污泥发酵工程中的应用策略,旨在减轻污泥处理过程中产生的臭味问题,以确保环境和居民的健康。

关键词：生物滤池除臭工艺污泥发酵工程