检索结果-南通市图书馆

Changes in corneal endothelial cell density in patients with primary open-angle glaucoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第15期7卷 1978-1985页

作者： Zi-yan yu Ling Wu Bo Qu Department of Ophthalmology 4th Affiliated Hospital of China Medical UniversityEye hospital of China Medical UniversityKey Laboratory of Lens Research of Liaoning ProvinceShenyang 110005Liaoning ProvinceChina Department of Ophthalmology the 4th people’s Hospital of ShenyangShenyang 110005Liaoning ProvinceChina

BACKGROUND Glaucoma is a group of diseases characterized by a specific pattern of optic nerve neuropathy and *** evidence demonstrates glaucoma associated corneal endothelium ***-compression mechanism due to elevated intraocular pressure(IOP),cell toxicity after long term exposure to preservatives and glaucoma surgery have been reported to be the possible ***,we compare the specular endothelial microscopy in primary open-angle glaucoma(POAG)patients and healthy controls of the same age group to observe the corneal endothelium changes and the correlations to the mean IOP in a Chinese case control *** To investigate corneal endothelial cell density in Chinese patients with *** A case control study was performed on 60 eyes of 60 patients with *** criteria included history of corneal diseases,intraocular diseases,contact lens use,ocular trauma or surgery(including intraocular surgery and laser treatment),congenital abnormalities or systemic diseases such as *** pressure was measured using Goldmann *** specular microscopy(TOPCON SP-2000P)was performed on central corneas and endothelial images were *** cell density,area and cell counts were *** Endothelial cell density was 2959±236 cells/mm2 in healthy controls and 2757±262 cells/mm2 in patients with *** POAG eyes had significantly lower endothelial cell density compared to healthy control eyes(P<0.001).In the POAG group,endothelial cell density was 2686±233 cells/mm2 in the patients receiving medication and 2856±272 cells/mm2 in the untreated *** eyes receiving medication had significantly lower endothelial cell density compared to untreated *** was a negative correlation between cell density and mean IOP(r=-0.286,P=0.004),positive correlation between the average cell area and mean IOP(r=0.228,P=0.022),maximum cell area and mean IOP(r=0.218,P=0.029)and minimum cell area and

关键词： Corneal endothelium Primary open angle glaucoma Intraocular pressure

Surgery at early versus late for intermittent exotropia:a Meta-analysis and systematic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2021年第4期14卷 582-588页

作者： Yi Dong Li Nan yu—yan Liu Tianjin Eye Hospital Tianjin Key Lab of Ophthalmology and Visual ScienceTianjin Eye InstituteClinical College of Ophthalmology Tianjin Medical UniversityTianjin 300020China

AIM:To compare the outcomes between early surgery and late surgery for intermittent exotropia(IXT)with a ***:Scientific databases including PubMed,Embase,Web of Science,Cochrane and China National Knowledge Infrastructure were searched prior to December 16,*** this broad database search,we performed some Meta-analysis including eleven independent studies,to further evaluate the outcome(s)when comparing early versus late surgery for *** boundaries between early and late surgery and the surgery methods were not inconsistent,so subgroup analyses were conducted by different boundaries of age at surgery and different surgical *** pooled odds ratios(ORs)and the 95%confidence interval(CI)were estimated according to the random-effects model for high heterogeneity between ***:Eleven retrospective studies were included in this *** significant difference between early and late surgery was observed for IXT patients(OR_(First follow-up)=0.88,95%CI 0.53-1.44,P=0.61;OR_(Final follow-up)=1.48,95%CI 0.94-2.31,P=0.09).However,sensitivity analysis performed by sequentially omitting individual studies showed that the final follow-up result was not *** analyses revealed that an earlier surgical procedure could lead to a better outcome in the 4-year boundary subgroup as well as the bilateral lateral rectus recession(BLR)subgroup for the final follow-up(OR_(4y)=2.64,95%CI 1.57-4.44,P=0.00;OR_(BLR)=2.25,95%CI 1.36-3.74,P=0.00).CONCLUSION:Early surgery for IXT provides a better long term follow-up outcome when patients are younger than 4 years old or choose the BLR surgical method.

关键词： Meta-analysis intermittent exotropia surgery timing

Insights on the possibility of SARS-CoV-2 transmission through the eyes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2022年第11期15卷 1857-1863页

作者： Rui Zhu Zi-yan yu Lin Han Department of Ophthalmology the Fourth Affiliated Hospital of China Medical UniversityShenyang 110005Liaoning ProvinceChina Eye Hospital of China Medical University Shenyang 110005Liaoning ProvinceChina Key Lens Research Laboratory of Liaoning Province Shenyang 110005Liaoning ProvinceChina China Medical University Shenyang 110122Liaoning ProvinceChina

A novel coronavirus, named severe acute respiratory syndrome coronavirus 2(SARS-Co V-2 or 2019-nCOV), causing coronavirus disease 2019(COVID-19), has rapidly spread to most countries and regions worldwide since it broke out at the end of 2019. Epidemic of the virus produces a tremendous pressure on the global health systems. With progressive insight into SARS-Co V-2, the role of eye tissue has attracted wide attention in the spread of COVID-19. Whether SARS-Co V-2 can enter the human body through eyes and cause infection? The fact that unprotected exposure of the eyes to 2019-n Co V might have allowed the virus to infect the body implies that 2019-n COV can invade eye tissue and set foot in organism. Facing the severe challenge of preventing spread of the COVID-19, combined with the high-risk environment of ophthalmology, it is crucial to investigate ocular tropism of coronavirus. This paper explores the possibility of coronavirus transmission through the eye from aspects of probable mechanisms, clinical cases, detection of coronavirus;and puts forward precautions for ophthalmologists and nurses. Consequently, this review reveals our understanding of ocular tropism of coronavirus and contributes to determining risk of ocular transmission, raising awareness of necessary eye protection among medical workers and reducing further prevalence of SARS-Co V-2.

关键词： coronavirus SARS-CoV-2 ocular conjunctivitis

Sources, distribution, behavior, and detection techniques of microplastics in soil: A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Geology 2023年第4期6卷 695-715页

作者： yu-chen yan Zhong-fang yang School of Earth Sciences and Resources China University of GeosciencesBeijing 100083China

In recent years, the problem of environmental pollution caused by microplastics has attracted widespread attention. This paper reviews the latest research progress in terms of the source, content and distribution characteristics, harm, and detection technology of soil microplastics by referring to the relevant literature on soil microplastics worldwide. It concludes that:(1) Existing studies worldwide have detected the presence of microplastics in soil, water, and atmosphere, and the use of agricultural films, sewage sludge,and other man-made activities are the main sources of microplastics in soil;(2) microplastics can adsorb heavy metals, persistent organic pollutants and antibiotics in soil, change the physical and chemical properties of soil. This will result in composite pollution and harm to the ecosystem;(3) microplastics in soil not only can destroy the activity of key soil microorganisms, but also enter the body of crops and soil animals, affecting normal growth of crops and soil animals, and further threaten human health;(4) at present, there is no unified operating standard for the sampling, processing, and detection process of microplastics. Analysis methods such as visual inspection, spectroscopy, and thermal analysis have both advantages and disadvantages, and emerging detection technologies require urgent *** have become a new pollutant in soil and their distribution characteristics are closely related to human activities. They pollute the environment and threaten human health through the food *** related research on soil microplastics has just begun, it will become the focus of research in the future.

关键词： soil microplastic heavy metal organic pollutant antibiotic microorganism ecological risk composite pollution detection method

Highly sensitive fluorescence quantification of irinotecan in biological fluids with the aid of second-order advantage

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第12期21卷 1482-1486页

作者： Hai yan Fu Hai Long Wu Jin Fang Nie Yong Jie yu Hong yan Zou Ru Qin yu State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University Changsha 410082 China

A rapid,green and highly sensitive excitation-emission matrix（EEM） fluorescence method was proposed for analysis of irinotecan（CPT-11） in biological fluids including human plasma and urine samples of uncalibrated interferences with the aid of second-order *** to the serious spectral overlapping from biological matrices,the parallel factor analysis（PARAFAC） and the alternating normalization-weighted error（ANWE） have been recommended to perform directly calibration and overcome the problem which makes the traditional fluorospectrophotometer in *** results can be ***, performance of the proposed method was evaluated based on figures of merit and some statistical *** accuracy of both algorithms was validated by the elliptical joint confidence region（EJCR） *** precision and repeatability were also investigated by the relative standard deviations（RSDs） of intra-day and inter-day.

关键词： Irinotecan Biological fluids Excitation-emission matrix fluorescence PARAFAC ANWE

Free-standing vanadium pentoxide nanoribbon film as a high-performance cathode for rechargeable sodium batteries

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2017年第12期28卷 2251-2253页

作者： Yi Sun Xin Liang Hongfa Xiang yan yu Anhui Provincial Key Laboratory of Advanced Functional Materials and Devices School of Materials Science and Engineering Hefei University of TechnologyHefei 230009 China Key Laboratory of Materials for Energy Conversion Chinese Academy of Sciences Department of Materials Science and Engineering University of Scienceand Technology of China Hefei 230026 China

Vanadium pentoxide （***2O） nanoribbons are synthesized via a hydrothermal process. These ribbons are 20nm thick, 200nm to 1 μm wide and several tens of micrometers long. Free-standing binder-free films are prepared by using these nanoribbons with multi-walled carbon nanotubes （MWCNTs） and used as the cathode for rechargeable sodium batteries. The large interlayer space between the V20s5 bilayers can enhance the kinetics of sodium ion intercalation/deintercalation. In addition, the intertwining network of the V2O5. 0.34H2O film provides efficient electron conduction pathways and shortens diffusion distances of sodium ion. The electrochemical tests prove that the free- standing V2O5. 0.34H2O film cathode delivers high reversible specific capacities （190 mAh/g） and good cycling stabilities （170 mAh/g after 150 cycles） in the voltage range between 1.5V and 3.5V.

关键词： Vanadium pentoxide Cathode Free-standing electrode Rechargeable sodium batteries

Improved Cohen-Sutherland algorithm for TGS transmission imaging

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第6期34卷 91-102页

作者： yu-Cheng yan Ming-Zhe Liu Xing-yu Li yu-Ting Xiong Yao Tan Zhuo Zuo Lan Chang Cui Li State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu610059China The Engineering and Technical College of Chengdu University of Technology Leshan614000China Southwestern Institute of Physics Chengdu610225China Sichuan University of Science and Engineering Zigong643000China

Tomographic gamma scanner(TGS),an advancedγ-ray nondestructive analysis technique,can locate and analyze nuclides in radioactive nuclear waste,and TGS can be categorized into two processes:e.g.,transmission measurement and emission ***,transmission measurements provide the basis for accurate measurement of nonuniform radionuclide content in TGS *** scan data were obtained using the Monte Carlo tool Geant4 simulation,and 25 voxels were divided into five lengths and five widths in a square *** this study,an encoding cropping algorithm based on draped foot vector judgment was adopted to rapidly calculate the voxel trace matrix within a square bucket of nuclear waste,and the transmission images were reconstructed using ordered subset expectation *** results indicated that the cropping speed of the improved coding algorithm was significantly higher than that of the original algorithm,and the relative mean deviation and root-mean-square error between the reconstructed attenuation coefficient and the reference standard value tended to decrease with an increase in the cropped line segments in the voxel;the Pearson correlation coefficient tended to converge to *** image quality evaluation parameters of the high media-density materials were better than those of the low media-density materials in the above three *** reconstruction effect was relatively poor for more complex filling *** there were more than 10 cropped line segments in the voxel,the reconstruction data generally tended to be *** graphical trimming algorithm can rapidly calculate the trace matrix of the scanned voxels;it exhibits the advantages of speed and efficiency and can serve as a novel method to solve the trace matrix of TGS nuclear waste transmission scans.

关键词： TGS Cohen-Sutherland Transmission scanning Trace matrix

Synthesis and antitumor activity of 9-methyl-10-hydroxycamptothecin

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第8期19卷 918-920页

作者： Sheng Wang yu yan Li Qi Dong You Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A novel camptothecin analogue, 9-methyl-10-hydroxycamptothecin （4）, was unexpectedly synthesized from 10-hydroxycamptothecin in two steps. The key step included an efficient Mannich-type reaction. The overall yield was 47.2%. An ether analogue of 4, 9-methyl-10-benzylaminomethoxycamptothecin （5）, was also prepared. These new camptothecin analogues were evaluated for in vitro cytotoxicity against four human cancer cell lines, and exhibited more potent antitumor activities than contrals camptothecin and topotecan against several cancer cells.

关键词： Synthesis Camptothecin 10-Hydroxycamptothecin Cytotoxicity

Functionality proportion and corresponding stability study of multivariate metal-organic frameworks

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2018年第6期29卷 837-841页

作者： Jie Li Yecheng Wang yan yu Qiaowei Li Department of Chemistry iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University School of Physical Science and Technology Shanghai Tech University

Multivariate metal-organic frameworks（MTV-MOFs） with different ratios of terephthalate（BDC） linker and amino-benzenedicarboxylate（BDC-NH2） linker were synthesized through both direct synthesis from linker mixture and linker exchange of activated single-linker MOFs. Functionality proportion was impacted by the thermodynamics during the one-pot MOF construction, resulting in preference of BDC over BDC-NH2 in the MTV-MOF, in agreement with the quantum mechanics calculations. The functionality difference also affects the thermodynamics in the linker exchange process, as indicated by the more effective linker exchange in BDC-NH2-based IRMOF-3 than in BDC-based MOF-5. Furthermore,the thermal decomposition temperatures and chemical integrity upon ambient air exposure of these MOFs with variate functionalities were investigated, and it reveals that higher proportion of BDC in the MTV-MOF crystals contribute to both higher thermal and higher chemical stabilities.

关键词： Multivariate metal-organic frameworks Direct synthesis Linker exchange Functionality proportion