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Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats

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Asian Journal of Andrology 2013年第5期15卷 646-651页

作者： Wen yu Zan Wan xue-feng Qiu yun Chen yu-Tian Dai Department of Urology Affiliated Drum Tower Hospital School of Medicine Nanjing University Nanjing 210008 China

The high incidence of erectile dysfunction （ED） in diabetes highlights a need for effective treatment strategies. Resveratrol, an activator of silent information regulator 2-related enzymes 1 （sirtuinl, SIRT1）, has received attention for its valuable effects in cancer, neurodegenerative diseases, longevity and cardiovascular disease. To explore the effects of resveratrol in diabetes-induced ED, resveratrol was administered to rats with streptozocin （65 mg kg-1）-induced diabetes. Erectile function, cavernous structure, tissue protein expression of silent information regulator 2-related enzymes 1 （sirtuinl, SIRT1）, p53 and forkhead transcription factor 0 3a （FOXO3a）, superoxide dismutase （SOD） activity and malondialdehyde （MDA） levels in the corpora cavernosa were studied. We found that SIRT1 was expressed in cavernosal tissue, and it was downregulated in the corpora of diabetic rats. The administration of resveratrol upregulated the expression of SI RT1 and restored erectile function. In contrast, resveratrol downregulated the expression of p53 and FOXO3a, which regulate apoptosis and oxidative stress. Furthermore, the resveratrol-treated group showed an improvement in smooth muscle content, SOD activity and MDA levels when compared with the diabetic group. Therefore, the ability of resveratrol to improve diabetes-induced ED is likely related to its activation of SIRT1 expression, thus causing the suppression of apoptosis and resistance towards oxidative stress.

关键词： apoptosis erectile dysfunction oxidative stress resveratrol

结合ArcGIS技术探讨“气象灾害影响及风险评估”课程新模式

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教育教学论坛 2024年第2期 49-52页

作者：梁梅范伶俐薛宇峰广东海洋大学海洋与气象学院广东湛江524088 广东海洋大学南海海洋气象研究院广东湛江524088

当今社会对气象防灾减灾工作的要求越来越高,如何减少气象灾害引起的损失,加强气象灾害风险管理成了迫切的需求。“气象灾害影响及风险评估”作为一门新兴的课程,旨让学生通过理解灾害风险评估中致灾因子危险性、承灾体易损性、防灾减... 详细信息

当今社会对气象防灾减灾工作的要求越来越高,如何减少气象灾害引起的损失,加强气象灾害风险管理成了迫切的需求。“气象灾害影响及风险评估”作为一门新兴的课程,旨让学生通过理解灾害风险评估中致灾因子危险性、承灾体易损性、防灾减灾能力等组成要素,建立风险评估模型,进行气象灾害风险预警和管理,为学生从事气象应急减灾相关工作打下坚实的基础。结合ArcGIS技术,通过对课程设计、课程实施等方面进行研究,探索“气象灾害影响及风险评估”课程新模式,提出了符合风险评估本科教学要求的实践教学体系和主要内容,以提升师资队伍的实践指导水平,提高课程的教学效果,为学科设计和教学工作的开展提供参考依据。

关键词： ArcGIS 气象灾害风险评估课程模式

Fine Particulate Matter-Induced Exacerbation of Allergic Asthma via Activation of T-cell Immunoglobulin and Mucin Domain 1

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Chinese Medical Journal 2018年第20期131卷 2461-2473页

作者： yun-Xia Zhao Hui-Ran Zhang Xiu-Na Yang yu-Hao Zhang Shan feng feng-xue yu Xi-Xin Yan Department of Respiratory and Critical Care Medicine The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Respiratory Medicine The Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Department of Respiratory Medicine The Third Hospital of Shijiazhuang Shijiazhuang Hebei 050000 China Department of Emergency Jinzhou General Hospital Hebei 052260 China Department of Internal Medicine The Third Hospital of Hebei Medical University Shijiazhuang Hebei 050051 China Department of Central Laboratory The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China

Background： Fine particulate matter （PM2.5） exacerbates airway inflammation and hyperreactivity in patients with asthma, but the mechanism remains unclear. The aim of this study was to observe the effects of prolonged exposure to high concentrations of PM2.5 on the pathology and airway hyperresponsiveness （AHR） of BALB/c mice undergoing sensitization and challenge with ovalbumin （OVA） and to observe the effects of apoptosis and T-cell immunoglobulin and mucin domain 1 （TIM-1） in this process. Methods： Forty female BALB/c mice were divided into four groups： control group, OVA group, OVA/PM group, and PM group （n - 10 in each group）. Mice in the control group were exposed to filtered clean air. Mice in the OVA group were sensitized and challenged with OVA. Mice in the OVA/PM group were sensitized and challenged as in the OVA group and then exposed to PM2.5 for 4 h per day and 5 days per week for a total of 8 weeks using a nose-only ＂PM2.5 online enrichment system＂ in The Second Hospital of Hebei Medical University. Mice in the PM group were exposed to the PM2.5 online enrichment system only. AHR was detected. Bronchoalveolar lavage fluid （BALF） was collected for cell classification. The levels of interleukin-4 （IL-4）, IL-5, and IL-33 in BALF were measured using enzyme-linked immunosorbent assay. Changes in histological structures were examined by light microscopy, and changes in ultramicrostructures were detected by electron microscopy. Apoptosis was determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling （TUNEL） assay in the lung tissues. Western blotting and immunohistochemistry were utilized to analyze the expression of Bcl-2, Bax, and TIM-1 in the lungs. Results： The results showed that AHR in the OVA/PM group was significantly more severe than that in the OVA and PM groups （P 〈 0.05）. AHR in the PM group was also considerably more severe than that in the control group （P 〈 0.05）. The BALF of OVA/PM group （28.00± 6.08 vs. 12.33 ±4.51, t

关键词： Apoptosis Asthma Fine Particulate Matter T-cell Immunoglobulin and Mucin Domain 1

Distribution behavior of collector in the desilication system of bauxite flotation

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Journal of Central South University of Technology 2001年第2期8卷 125-129页

作者： JIANG yu ren,xue yu lan,CAO xue feng,XIA Zhong (Department of Mineral Engineering,Central South University, Changsha 410083,China) Department of Mineral Engineering Central South University Changsha China

The distribution behavior of the HZB collector (a kind of long chain fatty acid) in the desilication system of bauxite flotation was studied. The results show that the collector tends towards froth products in the steps of the roughing, the first cleaning and the second cleaning, while towards the tailing product in the step of the scavenging, and in each job except scavenging the collector is mainly on the surface of solids. As for the froth product in the step of the scavenging, it is mainly in solution. To the tailing products of every step, it is mainly in the respective solutions. The collector added to the flotation system is mainly taken out by the last concentrate, by which the taken one occupies 65.2% of the whole, among which, 57.8% is by solid and 7.4% by solution, respectively. And the one by the last tail occupies 34.8% of the whole, among which, 8.8% is by solid and 26.0% by solution, respectively. The sum of the collector in the solution of the last concentrate and tailing is 33.4% of the amount of addition collector, and recycling the solutions will be in favor of decreasing the dosage of collector.

关键词： distribution of collector desilication flotation of bauxite

Routinely detected indicators in plasma have a predictive effect on the identification of HIV-infected patients with non-tuberculous mycobacterial and tuberculous infections

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Infectious Diseases of Poverty 2017年第1期6卷 1172-1179页

作者： Ren-tian Cai feng-xue yu Zhen Tao xue-qin Qian Jun Chen Hong-zhou Lu Department of Infectious Diseases Nanjing First HospitalNanjing Medical UniversityNanjingChina Department of Infectious Diseases Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Department of Nephrology the Second Affiliated Hospital of the Southeast UniversityNanjingChina Department of Mycobacteria Culture Shanghai Public Health Clinical CenterFudan UniversityShanghaiChina Huashan Hospital affiliated to Fudan University ShanghaiChina Medical College of Fudan University ShanghaiChina

Background:It is difficult to quickly distinguish non-tuberculous mycobacterial(NTM)infection from tuberculosis(TB)infection in human immunodeficiency virus(HIV)-infected patients because of many similarities between these diseases.A simple and effective way to determine the differences using routine blood tests is necessary in developing ***:A retrospective cohort study was conducted to recruit HIV-infected patients with either NTM infection or TB infection diagnosed for the first time according to mycobacterial culture and microscopic identification from May 2010 to March *** data included the analysis of blood cells,liver function,renal function,C-reactive protein(CRP),and erythrocyte sedimentation rate(ESR),and were compared between the HIV/TB and HIV/NTM ***:A total of 240 patients were *** number of HIV/TB and HIV/NTM patients was 113 and 127,*** were no significant differences in the CD4 T-cell count,age,sex,percentage of patients initiating antiretroviral therapy(ART)before the explicit diagnosis of TB or NTM *** infection was more likely to be restricted in the pulmonary while TB infection also involves extra-pulmonary *** the leukocyte count(5.60×109/L)and the proportion of neutrophils in the leukocyte count(76.70%)in the HIV/TB group were significantly higher than those in the HIV/NTM group(4.40×10^(9)/L[P=0.0014]and 69.30%[P<0.001].The analysis of liver function markers indicated that the concentration of albumin but not ALT and AST was significantly lower in the HIV/TB group than in the HIV/NTM group(P<0.001).The creatinine and urea levels were not significantly different between the two *** ESR(84.00 mm/h)and the concentration of CRP(59.60 mg/L)were significantly higher in the HIV/TB group than in the HIV/NTM group(52.00 mm/h and 19.60 mg/L,respectively)(P<0.001).To distinguish TB infection from NTM infection,the best cut-off value was 69.5 mm/h for ESR,with a positive pred

关键词： HIV Tuberculosis Non-tuberculous mycobacteria

Generation and detection of squeezed state

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Optoelectronics Letters 2008年第3期4卷 231-233页

作者： SHANG Xu-dong yu Li feng xue-dong YANG Bo-jun Key Laboratory of Optical Communication and Light wave Technologies Ministry of Education Beijing University ofPosts and Telecommunications Beijing 100876 China

Soliton amplitude squeezed state is obtained and dctected by using asymmetric Sagnac interferometer and balanced homodyne detecting system. An improved photo detector circuit for quantum state detection is introduced. The circuit has a bandwidth of 10MHz and the saturation power is about 19 mW. A maximum photocurrent noise reduction of 1.1 dB below the shot noise is achieved. Taking the detection efficiency into account,the squeezing will be about 1.5 dB.

关键词：压缩态检测技术孤波不对称性

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Gitelman综合征临床特点及诊治方法

内科急危重症杂志 2024年第2期30卷 129-133,145页

作者：何晓玉张晓玲乐晗余学锋邵诗颖华中科技大学同济医学院附属同济医院内分泌内科国家代谢性疾病临床医学研究中心分中心湖北武汉430030

目的:分析Gitelman综合征的临床特点及诊治方法。方法:选取诊断为Gitelman综合征的3例患者作为研究对象,回顾性分析其临床表现、生化检查,并抽取患者的外周血进行全外显子高通量二代测序分析,结合文献报道讨论本疾病的临床特征与诊治经... 详细信息

目的:分析Gitelman综合征的临床特点及诊治方法。方法:选取诊断为Gitelman综合征的3例患者作为研究对象,回顾性分析其临床表现、生化检查,并抽取患者的外周血进行全外显子高通量二代测序分析,结合文献报道讨论本疾病的临床特征与诊治经验。结果:3例患者均为成年发病,血压均正常。病例1无明显低钾症状,由体检时偶然发现而就诊;病例2和病例3均有低钾相关临床表现,补钾后症状可缓解。病例1和病例2表现为低钾、低镁、肾性失钾、低尿钙、代谢性碱中毒,病例3轻度低钾,血镁正常,也存在肾性失钾及低尿钙,3例患者均有肾素-血管紧张素-醛固酮系统的激活。基因检测结果示病例1和病例2为SCL12A3基因复合杂合突变,病例3仅发现单杂合突变,其中病例2的移码突变c.976delG既往未被报道,致病性软件预测该变异为可能致病。本文3例患者通过补充钾和镁后症状改善,血钾、血镁水平达到治疗目标。结论:Gitelman综合征的临床表现缺乏特异性,诊断有赖于实验室检查及基因检测,预后良好。

关键词： Gitelman综合征低钾血症 SCL12A3基因

Dynamic cooperations between lattice oxygen and oxygen vacancies for photocatalytic ethane dehydrogenation by a self-restoring LaVO_(4)catalyst

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Chinese Chemical Letters 2024年第3期35卷 171-176页

作者： Fen Wei Weichao xue Zhiyang yu xue feng Lu Sibo Wang Wei Lin Xinchen Wang State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhou 350108China

Thermocatalytic nonoxidative ethane dehydrogenation(EDH)is a promising strategy for ethene production but suffers from intense energy consumption and poor catalyst durability;exploring technology that permits efficient EDH by solar energy remains a giant ***,we present that an oxygen vacancy(O_v)-rich LaVO_(4)(LaVO_(4)-O_v)catalyst is highly active and stable for photocatalytic EDH,through a dynamic lattice oxygen(O_(latt.))and O_(v)co-mediated *** by simulated sunlight at mild conditions,LaVO_(4)-O_(v)effectively dehydrogenates undiluted ethane to produce C_(2)H_(4)and CO with a conversion of 2.3%.By loading a small amount of Pt cocatalyst,the evolution and selectivity of C_(2)H_(4)are enhanced to 275μmol h^(-1)g^(-1)and 96.8%.Of note,LaVO_(4)-O_(v)appears nearly no carbon deposition after the *** isotope tracked reactions reveal that the consumed O_(latt.)recuperates by exposing the used catalyst with O_(2),thus establishing a dynamic cycle of O_(latt.)and achieving a facile catalyst regeneration to preserve its intrinsic *** refreshed LaVO_(4)-O_(v)exhibits superior reusability and delivers a turnover number of about *** O_(v)promotes photo absorption,boosts ethane adsorption/activation,and accelerates charge separation/transfer,thus improving the photocatalytic *** possible photocatalytic EDH mechanism is proposed,considering the key intermediates predicted by density functional theory(DFT)and monitored by in-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS).

关键词： Photocatalysis Ethane dehydrogenation Ethene LaVO_(4) Oxygen vacancy

Gene polymorphisms of interleukin-28, p21-activated protein kinases 4, and response to interferon-α based therapy in Chinese patients with chronic hepatitis B

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Chinese Medical Journal 2013年第9期126卷 1726-1731页

作者： yu feng-xue ZHANG Xiao-lin WANG Yan-ping MA Ning DU Hong MA Jian-min LIU Dian-wu Department of Science and Technology The Second Hospital of Hebei Medical University Shijiazhuang Hebei 050000 China Department of Epidemiology Hebei Medical University Shijiazhuang Hebei 050071 China Department of Operating Room Bethune International Peace Hospital of People's Liberaton Army Shijiazhuang Hebei 070010 China Medical Department Shunping County Hospital Shijiazhuang Hebei 070010 China

Background Peg-lnterferon-a treatment is expensive and associated with considerable adverse effects, selection of patients with the highest probability of response is essential for clinical practice. The objective of this study was to assess the relationship between the gene polymorphisms of interleukin-28 （IL-28）, p21-activated protein kinase 4 （PAK4） and the response to interferon treatment in chronic hepatitis B patients. Methods Two hundred and forty interferon-naive treatment HBeAg seropositive chronic hepatitis B patients were enrolled in the present prospective nested case-control study. Peripheral blood samples were collected, including 92 with favorable response and 148 without response to the interferon treatment. Rs8099917, rs12980602, and rs9676717 SNP was genotyped using matrix assisted laser desorption/ionization time of flight mass spectrometry （MALDI-TOF MS）. Results IL-28 genotype was not associated with response to interferon treatment （OR for GT/GG vs. TT, 0.881 （95% CI 0.388-2.002）; P=0.762; OR for CT/CC vs. TT, 0.902 （95% CI 0.458-1.778）; P=-0.766）. Rs9676717 in PAK4 genotype was independently associated with the response （OR for CT/CC vs. TT, 0.524 （95% CI 0.310-0.888）; P=0.016）. When adjusting for age, gender, smoking, drinking, levels of hepatitis B virus DNA, and alanine aminotransferase （ALT）, rs9676717 genotype TT appeared to be associated with a higher probability of response for interferon treatment （OR, 0.155 （95% CI 0.034-0.700）; P=0.015）. Conclusion Genotype TTfor rs9676717 in PAK4 gene and no drinking may be predictive of the interferon-a treatment success.

关键词： chronic hepatitis B gene polymorphisms interleukin-28 interferon-a p21-activated protein kinase 4