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RSPSSL:A novel high-fidelity Raman spectral preprocessing scheme to enhance biomedical applications and chemical resolution visualization

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Light(Science & Applications) 2024年第2期13卷 366-386页

作者： Jiaqi Hu Gina Jinna Chen Chenlong Xue Pei Liang Yanqun Xiang Chuanlun Zhang Xiaokeng Chi Guoying Liu Yanfang Ye Dongyu Cui De Zhang xiaojun yu Hong Dang Wen Zhang Junfan Chen Quan Tang Penglai Guo Ho-Pui Ho yuchao Li Longqing Cong Perry Ping Shum State Key Laboratory of Optical Fiber and Cable Manufacture Technology Guangdong Key Laboratory of Integrated Optoelectronics IntellisenseDepartment of EEESouthern University of Science and TechnologyShenzhen 518055China College of Optical and Electronic Technology China Jiliang UniversityHangzhou 310018China Department of Nasopharyngeal Carcinoma Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangzhou 510060China Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Nephrology Chaozhou People’s HospitalChaozhou 521011China Clinical Research Design Division Sun Yatsen Memorial HospitalGuangzhouGuangdong 510120China School of Automation Northwestern Polytechnical UniversityXi’anShaanxi 710072China Department of Biomedical Engineering The Chinese University of Hong KongHong KongChina Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsJinan UniversityGuangzhou 511443China

Raman spectroscopy has tremendous potential for material analysis with its molecular fingerprinting capability in many branches of science and technology.It is also an emerging omics technique for metabolic profiling to shape precision medicine.However,precisely attributing vibration peaks coupled with specific environmental,instrumental,and specimen noise is problematic.Intelligent Raman spectral preprocessing to remove statistical bias noise and sample-related errors should provide a powerful tool for valuable information extraction.Here,we propose a novel Raman spectral preprocessing scheme based on self-supervised learning(RSPSSL)with high capacity and spectral fidelity.It can preprocess arbitrary Raman spectra without further training at a speed of~1900 spectra per second without human interference.The experimental data preprocessing trial demonstrated its excellent capacity and signal fidelity with an 88%reduction in root mean square error and a 60%reduction in infinite norm(L__(∞))compared to established techniques.With this advantage,it remarkably enhanced various biomedical applications with a 400%accuracy elevation(ΔAUC)in cancer diagnosis,an average 38%(few-shot)and 242%accuracy improvement in paraquat concentration prediction,and unsealed the chemical resolution of biomedical hyperspectral images,especially in the spectral fingerprint region.It precisely preprocessed various Raman spectra from different spectroscopy devices,laboratories,and diverse applications.This scheme will enable biomedical mechanism screening with the label-free volumetric molecular imaging tool on organism and disease metabolomics profiling with a scenario of high throughput,cross-device,various analyte complexity,and diverse applications.

关键词： spectral scheme resolution

软组织内腱鞘巨细胞瘤的诊治:附33例病例分析

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华中科技大学学报（医学版） 2024年第2期53卷 239-245页

作者：刘起昆于小钧鲍远康皓华中科技大学同济医学院附属同济医院骨科武汉430030

目的探讨罕见部位关节外型腱鞘滑膜巨细胞瘤(tenosynovial giant cell tumor,TSGCT)的临床特征、影像学表现及预后,以提高对该病的认识。方法检索文献中报道的病例,结合本院收治的2例患者资料进行回顾性分析。结果33例患者纳入本次研究... 详细信息

目的探讨罕见部位关节外型腱鞘滑膜巨细胞瘤(tenosynovial giant cell tumor,TSGCT)的临床特征、影像学表现及预后,以提高对该病的认识。方法检索文献中报道的病例,结合本院收治的2例患者资料进行回顾性分析。结果33例患者纳入本次研究,其中男性17例,女性16例,平均年龄39.8岁,肿瘤最大直径平均值为7.2 cm。发病部位多为大腿、臀部及头颈部。主要的临床表现为单纯包块(39.4%)和疼痛伴肿胀(12.1%)。CT检查表现为等密度或稍低密度的软组织肿块,病灶内无钙化或骨化。MRI主要表现为T1WI低信号或等-低信号,T2WI大部分(95.2%)为混杂信号,增强多为不均匀强化。17例获得随访的患者术后发生复发或转移的风险为17.6%。结论完全关节外型TSGCT非常罕见。对于来源于下肢及头颈部、MRI表现为混杂信号、CT显示关节外来源的软组织肿块需要考虑到该病,手术能有效控制其进展。

关键词：腱鞘滑膜巨细胞瘤关节外病变临床病理特征诊断

复方阿胶浆化学成分和药理作用研究进展及质量标志物(Q-Marker)预测

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中草药 2024年第9期55卷 3157-3167页

作者：于小钧王彬王常瞵高鹏高燕赵渤年山东中医药大学山东济南250355 山东中医药大学药物研究院山东济南250355 黄河流域特色中药生态保护和高质量发展协同创新中心山东济南250355 国家中医药管理局山东济南250355

复方阿胶浆具有补气养血的功效,临床主要用于治疗肿瘤、血液系统及妇科类疾病,但对其化学成分及药效物质基础研究较少,质量控制手段落后。通过对复方阿胶浆的化学成分和药理作用的研究进展进行综述,在此基础上,依据“五原则”对复方阿... 详细信息

复方阿胶浆具有补气养血的功效,临床主要用于治疗肿瘤、血液系统及妇科类疾病,但对其化学成分及药效物质基础研究较少,质量控制手段落后。通过对复方阿胶浆的化学成分和药理作用的研究进展进行综述,在此基础上,依据“五原则”对复方阿胶浆的质量标志物(quality marker,Q-Marker)进行预测分析,初步确定L-羟脯氨酸、甘氨酸、丙氨酸、脯氨酸、人参皂苷Rg1、人参皂苷Re、三七皂苷R2(R型)、地黄苷D、焦地黄苯乙醇苷A1、毛蕊花糖苷、异毛蕊花糖苷、党参炔苷、绿原酸、牡荆素鼠李糖苷等可作为复方阿胶浆的Q-Marker,为复方阿胶浆的质量标准提升与后续研究提供参考。

关键词：复方阿胶浆质量标志物质量控制 L-羟脯氨酸人参皂苷Re 三七皂苷R2(R型) 地黄苷D 绿原酸

计及电压幅值检测延时及相位跳变的IIDG故障电流解析计算

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中国电力 2024年第2期57卷 72-81页

作者：罗美玲马英黄伟兵孟令昆于晓军郑涛国网宁夏电力有限公司宁夏银川750001 新能源电力系统国家重点实验室(华北电力大学) 北京102206

逆变型分布式电源(inverter interfaced distributed generation,IIDG)的波动性、弱馈性及强受控性,使其在故障下具有与同步发电机不同的短路电流特性,对其进行准确解析是继电保护适应性分析与保护新原理研究的基础,具有重要意义。针对... 详细信息

逆变型分布式电源(inverter interfaced distributed generation,IIDG)的波动性、弱馈性及强受控性,使其在故障下具有与同步发电机不同的短路电流特性,对其进行准确解析是继电保护适应性分析与保护新原理研究的基础,具有重要意义。针对现有研究忽略电压幅值检测延时导致IIDG故障特性难以准确解析的问题,以新能源送出线路发生三相短路为例,综合考虑电压幅值检测延时以及相位跳变所引起锁相环动态响应特性的影响,对IIDG故障暂态过程进行精细化划分,分别针对故障暂态过程的2个阶段,建立了电压电流双环控制和电流环控制下的故障电流解析表达式,明确了电压检测延时与锁相环动态响应对IIDG故障电流暂态特性的影响机理。最后,基于Matlab/Simulink仿真平台,验证了所提故障电流解析计算模型的正确性。

关键词：逆变型分布式电源电流解析计算幅值检测延时相位跳变对称故障

过度医疗规制问题研究——以诊疗规范和法律规范为视角

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医学与法学 2024年第2期16卷 37-41页

作者：刘璟锟于晓军华东政法大学中国法治战略研究院上海201620 汕头大学医学院广东汕头515041

基于规制过度医疗的诊疗规范及法律规范之现状,分析其中诊疗规范范围不明确、法律规定有缺陷等问题,更好地预防及规制过度医疗行为、提升医疗服务质量、改善就医环境,提出应扩大规制过度医疗的诊疗规范范围、根据病情的紧急程度制定不... 详细信息

基于规制过度医疗的诊疗规范及法律规范之现状,分析其中诊疗规范范围不明确、法律规定有缺陷等问题,更好地预防及规制过度医疗行为、提升医疗服务质量、改善就医环境,提出应扩大规制过度医疗的诊疗规范范围、根据病情的紧急程度制定不同的诊疗规范、完善传统医学方面的诊疗规范以及对《民法典》第1227条进行修改和完善等建议。

关键词：过度医疗不必要的检查诊疗规范法律规制

Radiotherapy assisted with biomaterials to trigger antitumor immunity

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Chinese Chemical Letters 2022年第9期33卷 4169-4174页

作者： xiaojun yu Haitao Ma Guiying Xu Zhuang Liu Department of Thoracic Surgery Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215021China Department of Cardiothoracic Surgery Childrens Hospital of Soochow UniversitySuzhou 215021China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhou 215123China

As an extensively applied therapeutic approach to combat tumors,radiotherapy generates localized ionizing radiation to destruct tumor cells.Despite its importance in clinical oncology,radiotherapy would often cause significant organ toxicity,and its therapeutic effect is limited by tumor hypoxia.Moreover,although abscopal therapeutic effects have occasionally been observed,radiotherapy is still mostly employed as a local treatment method that could hardly control tumor metastases.In recent years,strategies involving biomaterials and nanomedicine have received increasingly high attention to enhance cancer radiotherapy.Beyond sensitizing tumors for radiotherapy via various mechanisms,many biomaterial systems with immune stimulating effects have also been introduced to boost the antitumor immunity post cancer radiotherapy.In this mini-review,we will summarize the progress of different biomaterials and nanomedicine systems in combination with radiotherapy to trigger antitumor immune responses and enhance the efficacy of immunotherapy,and discusses the perspectives and challenges of this research direction aimed at clinical translations.

关键词： Biomaterials Radiotherapy Immunotherapy

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基于模糊多判据融合的单端暂态量保护新方案

中国电力 2024年第3期57卷 60-72页

作者：罗美玲李紫肖郑涛于晓军吴建云谢海滨国网宁夏电力有限公司宁夏银川750001 新能源电力系统国家重点实验室(华北电力大学) 北京102206

针对现有单端暂态量保护方案仅依赖单一故障特征进行故障识别导致可靠性不高的问题,提出了一种基于模糊多判据融合的单端暂态量保护新方案,实现不同单端暂态量保护方案间的优势互补。首先,分析了现有基于高低频暂态能量比值、故障初始零... 详细信息

针对现有单端暂态量保护方案仅依赖单一故障特征进行故障识别导致可靠性不高的问题,提出了一种基于模糊多判据融合的单端暂态量保护新方案,实现不同单端暂态量保护方案间的优势互补。首先,分析了现有基于高低频暂态能量比值、故障初始零模/线模电压行波到达时间差以及前两个线模电压行波极性关系3种单端暂态量保护方案保护判据的特性及其动作灵敏区,在此基础上构造了相应判据的模糊隶属度函数;其次,针对不同暂态量保护方案的优缺点,基于模糊逻辑将上述3种单端暂态量保护方案进行有机融合以判别故障区段;最后,基于PSCAD/EMTDC的大量仿真,对比分析了上述3种暂态量保护方案以及所提新方案在不同故障位置、不同母线杂散电容、不同过渡电阻以及不同权重系数等条件下的适应性,验证了新方案的有效性。

关键词：暂态量保护多判据融合模糊逻辑动作灵敏区隶属度函数

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考虑新能源并网影响的零序过电压解列策略

电测与仪表 2024年第6期61卷 111-117页

作者：于晓军刘志远王洪炳胡胜宽郑涛国网宁夏电力公司有限公司银川750001 新能源电力系统国家重点实验室(华北电力大学) 北京102206

目前新能源并网故障零序过压解列判据按躲过中性点直接接地系统正常运行时的不平衡电压整定,解列时间与新能源场站的变压器间隙零序过压保护配合。然而当线路发生高阻接地短路或者线路的保护Ⅱ段范围内发生故障时,该策略存在新能源大面... 详细信息

目前新能源并网故障零序过压解列判据按躲过中性点直接接地系统正常运行时的不平衡电压整定,解列时间与新能源场站的变压器间隙零序过压保护配合。然而当线路发生高阻接地短路或者线路的保护Ⅱ段范围内发生故障时,该策略存在新能源大面积误解列问题。为此文章提出一种可靠防止新能源大面积误解列的零序过压解列策略的改进方法,并设计了解列判据,通过仿真以及实际故障验证了策略的有效性。结果表明,该解列策略具有高可靠性和实用性。

关键词：新能源并网故障解列零序过压解列策略

Experimental study on failure evolution mechanism of clastic rock considering cementation and intermediate principal stress

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1636-1650页

作者： Feiyan Wang Xia-Ting Feng Yangyi Zhou xiaojun yu Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines School of Resources and Civil EngineeringNortheastern UniversityShenyang110819China Key Laboratory of Liaoning Province on Deep Engineering and Intelligent Technology Northeastern UniversityShenyang110819China

The study of clastic rock failure evolution under true triaxial stress is an important research topic;however,it is rarely studied systematically due to the limitation of monitoring technology.In this study,true triaxial compression tests were conducted on clastic rock specimens to investigate the effect of cementation and intermediate principal stress(s2)on the failure mechanism.The complete stressestrain curves were obtained,while the acoustic emission(AE)was monitored to indirectly evaluate the evo-lution of tensile and shear cracks,and crack evolution under true triaxial compression was imaged in real time by a high-speed camera.The results showed that the deformation and failure characteristics of clastic rock were closely related to the cementation type and intermediate principal stress.On the basis of the distribution characteristics of the ratio of rise time to amplitude(RA)and the average frequency(AF)of AE signals,tensile cracks of the contact cementation specimen propagated preferentially.Meanwhile,the enhancement of specimen cementation promoted the evolution of shear cracks,and the increase inσ_(2)promoted the evolution of tensile cracks.Moreover,the mesoscale cracking mechanism of clastic rock caused by cementation andσ_(2)under true triaxial compression was analyzed.The failure patterns of clastic rock under true triaxial compression were divided into three modes:structure-induced,structure-stress-induced and stress-induced failures.This study confirms the feasibility of high-speed camera technology in true triaxial testing,and has important implications for elucidating the disaster mechanism of deep tunnels in weak rocks.

关键词： True triaxial compression Cementation Failure evolution Acoustic emission(AE) High-speed camera