检索结果-南通市图书馆

改良真空冷冻干燥技术在消毒剂杀菌试验菌片制备中的应用

在线全文

学校读者我要写书评

暂无评论

预防医学论坛 2024年第1期30卷 14-18,24页

作者：陈潇时玉雯尹龙崔雯刘辉济南市疾病预防控制中心细菌性疾病检验所山东250021 济南荷贝尔保健制品有限公司

目的研究一种运用改良真空冷冻干燥技术改进消毒剂杀菌试验中菌片制备的方法。方法使用改良真空冷冻干燥技术将大肠杆菌和白念珠菌固定在载体上制备真空冻干菌片,采用保存有效期监测试验、稳定性模拟试验及载体定量杀菌试验,对该真空冻... 详细信息

目的研究一种运用改良真空冷冻干燥技术改进消毒剂杀菌试验中菌片制备的方法。方法使用改良真空冷冻干燥技术将大肠杆菌和白念珠菌固定在载体上制备真空冻干菌片,采用保存有效期监测试验、稳定性模拟试验及载体定量杀菌试验,对该真空冻干菌片保存有效期、稳定性以及是否影响消毒效果进行评价。结果-20℃保存条件下,载体类型为布片、钢片时,大肠杆菌和白念珠菌菌片保存有效期均为3个月;-80℃保存条件下,大肠杆菌和白念珠菌布片保存有效期为4个月,钢片稳定性最好,保存有效期为6个月。运输温度不高于25℃、运输时间不超过4h以及中和剂浸泡温度不高于25℃、浸泡时间不超过4h,真空冻干菌片的回收菌量仍能满足试验要求。分别使用常规干燥法和真空冻干法制备菌片,使用有效氯含量为150g/L的84消毒液作用3min,两种菌片制备方法中大肠杆菌的杀灭对数值均>3.00;使用有效氯含量为150g/L的84消毒液作用5min,两种菌片制备方法中白念珠菌的杀灭对数值均>3.00;使用过氧乙酸含量为100g/L的消毒液作用1min,两种菌片制备方法中大肠杆菌的杀灭对数值均>3.00;使用过氧乙酸含量为100g/L的消毒液作用3min,两种菌片制备方法中白念珠菌的杀灭对数值均>3.00。结论改良后的真空冻干技术可明显延长真空冻干菌片的保存时间,且能保持良好的稳定性。

关键词：消毒剂杀菌试验菌片真空冷冻干燥保护剂稳定性

Experimental Studies on Cyclic Shear Behavior of Steel-Clay Interface Under Constant Normal Load

在线全文

学校读者我要写书评

暂无评论

China Ocean Engineering 2023年第3期37卷 519-524页

作者： yu shi-wen WANG Jie LIU Jun-wei WANG Teng School of Petroleum Engineering China University of Petroleum(East China)Qingdao 266580China China Communications Third Harbor Engineering Co. Ltd.ShanghaiChina School of Civil Engineering Qingdao University of TechnologyQingdao 266520China

The degradation of the shear stress between pile-clay interface caused by undrained cyclic jacking affects the jacking force.A series of large displacement monotonic shear,cyclic shear and post-cyclic monotonic steel plate-clay interface shear te sts were performed under the constant normal load(CNL)condition to inve stigate the effects of normal stre ss,cyclic amplitude,and number of cycles on a steel plate-clay interface using the GDS multi-function interface shear *** on the experimental results,in monotonic shear tests,change of shear stress took place in the specimen,the shear stress rapidly reached the peak value at shear displacement of 1 mm,and then abruptly decreased to the residual *** cyclic shear te sts,accumulated displacement was a better parameter to describe the soil degradation characteristics,and the degradation degree of shear stress became greater with the increasing of normal stress and accumulated *** stress in post-cyclic monotonic shear tests did not generate a peak value and was lower than that in monotonic shear tests under the same normal *** soil was completely disturbed and reached the residual strength when the cumulative displacement approached 6 *** empirical equation to evaluate shear stress degradation mechanism was formulated and the procedure of parameter identification was presented.

关键词： cyclic shear steel-clay interface constant normal load cumulative displacement residual strength

参莲草颗粒成型工艺优化及其理化指纹图谱建立

在线全文

学校读者我要写书评

暂无评论

中成药 2024年第4期46卷 1110-1118页

作者：刘伟朋邱智东石羽文姜孟成李钠李春雨王新蕊贾艾玲长春中医药大学药学院吉林长春130117

目的优化参莲草颗粒成型工艺,并建立其理化指纹图谱。方法湿法制粒后单因素试验筛选辅料,PB试验筛选潜在关键工艺参数。以辅(糊精)药比、乙醇体积分数、润湿剂(乙醇)用量为影响因素,成型率、吸湿率、休止角、溶化率的综合评分为评价指... 详细信息

目的优化参莲草颗粒成型工艺,并建立其理化指纹图谱。方法湿法制粒后单因素试验筛选辅料,PB试验筛选潜在关键工艺参数。以辅(糊精)药比、乙醇体积分数、润湿剂(乙醇)用量为影响因素,成型率、吸湿率、休止角、溶化率的综合评分为评价指标,Box-Behnken试验结合AHP-CRITIC混合加权法优化成型工艺。采用物理指纹图谱、HPLC指纹图谱评价不同批次样品的质量一致性,并进行化学模式识别。结果最佳条件辅药比0.98∶1,乙醇体积分数84%,润湿剂用量28%,在70℃下干燥60 min,综合评分为95.18分。10批样品物理指纹图谱相似度均大于0.95;HPLC指纹图谱中有18个共有峰,相似度均大于0.95。各批样品聚为3类,野黄芩苷、去乙酰基车叶草苷酸甲酯、木犀草素、芦丁、去乙酰基车叶草苷酸为关键质量差异物。结论该方法稳定可行,可用于评价参莲草颗粒的质量一致性,为该制剂质量标准研究奠定基础,也为同类中药制剂相关研究提供思路。

关键词：参莲草颗粒成型工艺物理指纹图谱 HPLC指纹图谱 Box-Behnken试验 AHP-CRITIC混合加权法化学模式识别

Chord length sampling correction analysis for dispersion fuel in Monte Carlo simulation

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第4期35卷 57-64页

作者： Zhao-yu Liang Ding She yu-Tong wen Lei shi Institute of Nuclear and New Energy Technology(INET) Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of EducationTsinghua UniversityBeijing 100084China

Dispersion fuels,knowned for their excellent safety performance,are widely used in advanced reactors,such as hightemperature gas-cooled *** with deterministic methods,the Monte Carlo method has more advantages in the geometric modeling of stochastic *** explicit modeling method has high computational accuracy and high computational *** chord length sampling(CLS)method can improve computational efficiency by sampling the chord length during neutron transport using the matrix chord length?s probability density *** study shows that the excluded-volume effect in realistic stochastic media can introduce certain deviations into the CLS.A chord length correction approach is proposed to obtain the chord length correction factor by developing the Particle code based on equivalent transmission *** numerical analysis against reference solutions from explicit modeling in the RMC code,it was demonstrated that CLS with the proposed correction method provides good accuracy for addressing the excludedvolume effect in realistic infinite stochastic media.

关键词： Stochastic media Monte Carlo Chord length sampling Excluded-volume effect Chord length correction

基于特征图谱和量值传递评价经典名方保元汤颗粒剂的关键生产工艺

在线全文

学校读者我要写书评

暂无评论

中国新药杂志 2024年第14期33卷 1472-1481页

作者：李钠刁元元刘伟朋石羽文姜孟成李军鸽邱智东贾艾玲长春中医药大学药学院长春130117

目的:基于特征图谱和4种指标成分的转移率评价经典名方保元汤(Baoyuan Decoction, BYD)颗粒剂的关键生产工艺,确保颗粒剂与基准样品的等效性。方法:建立BYD颗粒剂中人参皂苷Rb1、毛蕊异黄酮-7-O-葡萄糖苷、甘草酸、甘草苷的含量测定方... 详细信息

目的:基于特征图谱和4种指标成分的转移率评价经典名方保元汤(Baoyuan Decoction, BYD)颗粒剂的关键生产工艺,确保颗粒剂与基准样品的等效性。方法:建立BYD颗粒剂中人参皂苷Rb1、毛蕊异黄酮-7-O-葡萄糖苷、甘草酸、甘草苷的含量测定方法。以BYD基准样品为参比,建立3批中试样品的特征图谱,评价BYD颗粒剂制备工艺的合理性。结果:建立的4种指标成分含量测定方法稳定可行。与基准样品相比,人参皂苷Rb1、毛蕊异黄酮-7-O-葡萄糖苷、甘草酸、甘草苷从饮片到颗粒剂平均转移率分别为76.02%,63.50%,66.99%,83.54%,4种成分的转移率均在基准样品的70%~130%范围内,且均存在对应特征峰。结论:通过对特征图谱和指标成分在各环节量值传递的研究,为今后经典名方BYD颗粒剂生产和质量控制提供参考依据。

关键词：经典名方保元汤特征图谱量值传递关键生产工艺

Non-Gaussian feature of the output field from a double qubit-cavity ultrastrong coupling system

在线全文

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第7期76卷 30-36页

作者： Sheng-wen Xu shi-yu Dai Teng Zhao Center for Quantum Science and Technology Jiangxi Normal UniversityNanchang 330022China

We investigate the non-Gaussian feature of radiation in a circuit quantum electrodynamics(QED)system where two qubits are strongly coupled to a single-mode *** the regime of ultrastrong coupling(USC),the rotating-wave approximation is not valid,and the Rabi Hamiltonian contains counter-rotating wave terms,leading to level crossing and avoided crossings in the energy *** further analyze the intensity-amplitude correlation of the output field in these two novel *** the USC regime,the creation and annihilation operators in the correlation function are replaced,allowing for the identification of non-Gaussian features in the output *** findings reveal that despite the absence of squeezing effects in the output light,significant non-Gaussian characteristics are ***,we demonstrate that as the driving or coupling strength increases,the non-Gaussian features of the output field become more *** suggests that USC systems hold broad potential applications in the realms of nonlinear optics and the generation of non-Gaussian states.

关键词： ultrastrong coupling non-Gaussian intensity-amplitude correlation

Efficient and fair PPO-based integrated scheduling method for multiple tasks of SATech-01 satellite

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第2期37卷 417-430页

作者： Qi shi Lu LI Ziruo FANG Xingzi BI Huaqiu LIU Xiaofeng ZHANG wen CHEN Jinpei yu Shanghai Satellite Network Research Institute CO. LTDShanghai 201210China Innovation Academy for Microsatellites of Chinese Academy of Sciences Shanghai 201306China University of Chinese Academy of Sciences Beijing 100039China

SATech-01 is an experimental satellite for space science exploration and on-orbit demonstration of advanced *** satellite is equipped with 16 experimental payloads and supports multiple working modes to meet the observation requirements of various *** to the limitation of platform power supply and data storage systems,proposing reasonable mission planning schemes to improve scientific revenue of the payloads becomes a critical *** this article,we formulate the integrated task scheduling of SATech-01 as a multi-objective optimization problem and propose a novel Fair Integrated Scheduling with Proximal Policy Optimization(FIS-PPO)algorithm to solve *** use multiple decision heads to generate decisions for each task and design the action mask to ensure the schedule meeting the platform *** results show that FIS-PPO could push the capability of the platform to the limit and improve the overall observation efficiency by 31.5%compared to rule-based plans currently ***,fairness is considered in the reward design and our method achieves much better performance in terms of equal task *** of its low computational complexity,our task scheduling algorithm has the potential to be directly deployed on board for real-time task scheduling in future space projects.

关键词： Satellite observatories SATech-01 Multi-modes platform Scheduling algorithms Reinforcement learning Proximal Policy Optimization(PPO)

The Enhanced Period Map and Equivariant Deformation Quantizations of Nilpotent Orbits

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第3期40卷 885-934页

作者： shi Lin yu Department of Mathematics School of Mathematical SciencesXiamen UniversityXiamen 361005P.R.China

In a previous paper,the author and his collaborator studied the problem of lifting Hamil-tonian group actions on symplectic varieties and Lagrangian subvarieties to their graded deformation quantizations and apply the general results to coadjoint orbit method for semisimple Lie *** even quantizations were considered *** this paper,these results are generalized to the case of general quantizations with arbitrary *** key step is to introduce an enhanced version of the(truncated)period map defined by Bezrukavnikov and Kaledin for quantizations of any smooth sym-plectic variety X,with values in the space of Picard Lie algebroid over *** an application,we study quantizations of nilpotent orbits of real semisimple groups satisfying certain codimension condition.

关键词： Coadjoint orbit method deformation quantization Harish-Chandra modules semisimple Liegroups

Drug delivery systems for colorectal cancer chemotherapy

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第2期35卷 163-175页

作者： wen Chen Kun shi Yan yu Peipei Yang Zhongwu Bei Dong Mo Liping yuan Meng Pan yu Chen Zhiyong Qian Department of Biotherapy Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China

Colorectal cancer causes the third most common type of malignant tumors with high morbidity and *** is currently one of the most effective and common treatments for colorectal ***,the poor water solubility of some chemotherapeutics,untargeted drug delivery,and the undesirable systemic side effects of conventional treatment remain the major issues for colorectal cancer ***,drug delivery systems(DDS)based on biomaterials have been widely investigated and found to be capable of resolving those issues with good ***,the main goal of this review is to summarize and discuss the progress and potential advantages of different DDS for colorectal cancer *** not only reviewed the nanocarriers used to improve the solubility of chemotherapeutics,including liposomes,micelles,and nanoparticles,but also discussed targeted DDS based on specific ligand-receptor recognition and tumor microenvironmental stimulus ***,locally administered systems based on hydrogels and microspheres,which have been shown to increase drug accumulation at the tumor site while decreasing systemic toxicity,were also *** provides a good option for improving the efficacy of chemotherapy in the treatment of colorectal cancer.

关键词： Colorectal cancer Chemotherapy Drug delivery systems Solubility Targeted Local administration