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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai yuan Zhuang Shenghua Lu Qianqian Ge Hao Li yu Deng Hongbin Wu Xiaojian Xu Fei niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng lan Zheng Wu Wen-Jia Chen Xin-Ning yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics

Dimension of divergence sets for dispersive equation

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Frontiers of Mathematics in China 2020年第2期15卷 317-331页

作者： Senhua lan Tie LI Yaoming niu College of Mathematics Physics and Information EngineeringJiaxing UniversityJiaxing 314001China Faculty of Mathematics Baotou Teachers’College of Inner Mongolia University of Science and TechnologyBaotou 014030China

Consider the generalized dispersive equation defined by{iδtu+Ф(√-△)u=0,(x,t)∈R^n×R,u(x,0)=f(x),F∈F(R^n),(*)whereФ(√-△)is a pseudo-differential operator with symbolФ(|ζ|).In the present paper,assuming thatФsatisfies suitable growth conditions and the initial data in H^s(R^n),we bound the Hausdorff dimension of the sets on which the pointwise convergence of solutions to the dispersive equations(*)*** upper bounds of Hausdorff dimension shall be obtained via the Kolmogorov-Seliverstov-Plessner method.

关键词： Dispersive equation Hausdorff dimension maximal operator

Robust reliable guaranteed cost control for uncertain singular systems with time-delay

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Journal of Systems Engineering and Electronics 2010年第1期21卷 110-117页

作者： Qixun lan yuxiao Liu Huawei niu Jiarong Liang Department of Mathematics and Physics Henan University of Urban Construction Pingdingshan 467001 P. R. China Pingdingshan Institute of Education Pingdingshan 467000 E R. China School of Computer and Electronic Information Guangxi University Nanning 530004 E R. China

The robust reliable guaranteed cost control for uncertain singular delay systems with actuator failures and a given quadratic cost function is studied. The system under consideration involves constant time-delay and norm-bounded parameter uncertainties. The purpose is to design state feedback controllers which can tolerate actuator failure, such that the closed-loop system is stable, and the specified cost function has an upper bound for all admissible uncertainties. The sufficient conditions for the solvability of this problem are obtained by a linear matrix inequality （LMI） method. Furthermore, a numerical example is given to demonstrate the applicability of the proposed approach.

关键词： singular system reliable control guaranteed cost control actuator failure linear matrix inequality time-delay.

Photosensitizing metal-organic layers for photocatalysis,artificial photosynthesis and fluorescence imaging

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Science China Chemistry 2023年第12期66卷 3372-3382页

作者： An Li yufeng Zhang Zichen Sun Zhiyang niu Guangxu lan Beijing National Laboratory for Molecular Science State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100084China

In recent years,metal-organic layers(MOLs)with high-density and accessible open sites have emerged as a two-dimensional version of metal-organic frameworks(MOFs)with various potential ***,MOLs represent a promising platform for photocatalysis,artificial photosynthesis,and fluorescence imaging through the hierarchical assembly of photosensitizers and catalysts or other functional groups into *** review provides an overview of the structural design and synthesis strategies of MOLs with a particular emphasis on the applications of photosensitizing MOLs,illustrating the advantages of the MOLs-based *** final part discusses perspectives on the challenges encountered in this field and the emerging developments that can be expected.

关键词： metal-organic layers metal-organic frameworks photocatalysis artificial photosynthesis

Weaknesses and improvements of a remote user authentication scheme using smart cards

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The Journal of China Universities of Posts and Telecommunications 2007年第3期14卷 91-94页

作者： HU lan-lan niu Xin-xin YANG Yi-xian Information Security Center State Key Laboratory of Networking andSwitching Technology Beijing University of Posts and TelecommunicationsBeijing 100876 China

In 2005, Liu et al. proposed an improvement to Chien et al.＇s remote user authentication scheme, using smart cards, to prevent parallel session attack. This article, however, will demonstrate that Liu et al.＇s scheme is vulnerable to masquerading server attack and has the system＇s secret key forward secrecy problem. Therefore, an improved scheme with better security strength, by using counters instead of timestamps, is proposed. The proposed scheme does not only achieve their scheme＇s advantages, but also enhances its security by withstanding the weaknesses just mentioned.

关键词： authentication security smart cards

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巴西龟代谢性骨病CT诊断病例报告

动物医学进展 2025年第1期46卷 141-144页

作者：孙嘉徐甘靖宇江蓝刘波俞峰中国农业大学北京100193

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检... 详细信息

代谢性骨病(MBD)是一种因钙缺乏或维生素D 3摄入不足引起的骨骼代谢障碍疾病,其临床表现为骨折、脊椎异常、难产、脱垂等症状。计算机断层扫描(CT)在兽医临床中应用的逐渐增加为龟、鳖类MBD提供了新的诊断方式。该病例中红耳巴西龟血检结果提示其肾脏、肝脏功能损害,钙磷代谢异常。CT扫查提示患龟全身组织大面积矿化、背甲凹陷,定量测量患龟背椎骨、神经骨和胸膜骨3处的骨骼密度远低于正常龟,诊断患龟有严重的MBD。治疗方案为对症治疗、改善饲养管理条件,同时对该龟补充维生素D 3。该病例报告系统陈述了龟鳖MBD的诊疗流程,同时表明了CT扫查可为龟鳖MBD精确诊断、治疗和预后提供新的参考。

关键词：龟代谢性骨病计算机断层扫描骨密度

Composition and morphology of the thermal decomposition products of 3Mg（OH）2·MgCl2·8H2O nanowires

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Particuology 2017年第1期15卷 129-134页

作者： Bo yu lan Xiang Department of Chemical Engineering Tsinghua University Beijing 100084 China

The thermal decomposition of 3Mg（OH）2·MgCl2·8H2O （318MHCH） nanowires synthesized from agglom- erated Mg（OH）2 microspheres was investigated. The influence of heating rate and temperature on the composition and morphology of the products was investigated. Thermogravimetric-differential scan- ning calorimetry, field-emission scanning electron microscopy, high-resolution transmission electron microscopy, and X-ray diffraction showed that increasing the heating rate from I to 20 ℃/min promoted the escape of crystalline water from the 318MHCH nanowires. 318MHCH nanowires were dehydrated stepwise to 310MHCH porous nanowires from room temperature to 320℃, and then to MgO cubic nanoparticles from 420 to 700 ℃. The nanowires retained their one-dimensional morphology, until the phase changed to MgO. The immediate collapse of the one-dimensional structure was attributed to the presence of Mg-O/Cl chains.

关键词： Magnesium hydroxide chloride hydrates Thermal decomposition Nanowires Immediate collapse Mg-O/Cl chains

An integrative mathematical model of microwave ion thruster for mHz-frequency thrust noise analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 121-136页

作者： Xiang niu Hui LIU Daren yu Plasma Propulsion Laboratory Harbin Institute of TechnologyHarbin 150001China

Many high-precision space missions need thrusters to produce thrust with low noise to compensate for disturbances and ensure satellite platform stability. Microwave ion thruster is characterized with a wide thrust range and potential for these missions. A cost-effective and accurate mathematical model is crucial for mHz-frequency thrust noise analysis and feedback controller design. The Particle-In-Cell(PIC) and global models are two common simulation tools. The PIC model is characterized with high accuracy but huge computation cost, which is difficult to analyze long-time performance characteristics. Now, the global model is only used for the discharge chamber with low accuracy and cannot reflect ion extraction properties. In this paper, an integrative mathematical model is built for a 1-cm microwave ion thruster and can reflect ion beamlet divergence and impingement on the Accelerator Grid(AG). Simulation results show good agreement with experiments at 0.06 sccm. However, the model demonstrates worse consistency with experiments when the flux increases to 0.1 sccm, which may be because the influence of neutral gas on the Electron Cyclotron Resonance(ECR) is not considered in the model. A long-time(1000 s) simulation is conducted with this model under 35 μN. It takes 3 hrs, and the thrust noise reaches 1 μN/Hz^(0.5) at 1 mHz.

关键词： Electric propulsion Microwave ion thruster Integrative model Sheath property Ion beamlet divergence Thrust noise Plasma