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Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

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World Journal of Diabetes 2021年第1期12卷 19-46页

作者： Yang Zhou Xiao-yu Ma jin-yu han Min Yang Chuan Lv Ying Shao Yi-Li Wang Jia-Yi Kang Qiu-yue Wang Department of Endocrinology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Gerontology The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Clinical Laboratory The First Affiliated Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Endocrinology The People’s Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina Department of Endocrinology Shengjing Hospital of China Medical UniversityShenyang 110000Liaoning ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is significantly increasing worldwide,and the incidence of its complications is also on the *** of the main complications of T2DM is diabetic kidney disease(DKD).The glomerular filtration rate(GFR)and urinary albumin creatinine ratio(UACR)increase in the early *** the disease progresses,UACR continue to rise and GFR begins to decline until endstage renal disease *** the same time,DKD will also increase the incidence and mortality of cardiovascular and cerebrovascular *** present,the pathogenesis of DKD is not very ***,exploration of the pathogenesis of DKD to find a treatment approach,so as to delay the development of DKD,is essential to improve the prognosis of *** To detect the expression of tenascin-C(TNC)in the serum of T2DM patients,observe the content of TNC in the glomerulus of DKD rats,and detect the expression of TNC on inflammatory and fibrotic factors in rat mesangial cells(RMCs)cultured under high glucose condition,in order to explore the specific molecular mechanism of TNC in DKD and bring a new direction for the treatment of *** The expression level of TNC in the serum of diabetic patients was detected by enzyme-linked immunosorbent assay(ELISA),the protein expression level of TNC in the glomerular area of DKD rats was detected by immunohistochemistry,and the expression level of TNC in the rat serum was detected by *** glomerular mesangial cells were *** high glucose stimulation,the expression levels of related proteins and mRNA were detected by Western blot and polymerase chain reaction,*** ELISA results revealed an increase in the serum TNC level in patients with *** UACR and hypertension significantly increased the expression of TNC(P<0.05).TNC expression was positively correlated with glycosylated haemoglobin(HbA1c)level,body mass index,systolic blood pressure,and UACR(P<0.05).Immunohistochemical staining showe

关键词： Tenascin-C miR-155-5p Metformin Type 2 diabetes mellitus Diabetic kidney disease Toll-like receptor 4

Spermatozoal protein profiles in male infertility with asthenozoospermia

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Chinese Medical Journal 2010年第20期123卷 2879-2882页

作者： LI Hong-ju yu Ning ZhanG Xin-yu jin Wei LI han-zhong Department of Urology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing 100730 China

Background Infertility is a major medical and social problem, and elementary research on the spermatozoal proteins and their functions are relatively scarce and there are very few confirmed and effective options for the treatment of male infertility. Thus, it is essential to find candidate proteins that affect male infertility. This study was designed to detect the proteins with differential expression in sperm from infertile patients and normal *** Semen samples from patients with idiopathic asthenozoospermia （n=114） and from fertile men with normal spermiograms （n=37） were collected. Semen sample analysis, sperm protein extraction, SDS-PAGE electrophoresis and Western blotting analysis were performed. Results were analyzed by SPSS 16.0 statistical *** Western blotting analysis of spermatic proteins displayed a major differentially expressed protein in spermatozoa from fertile and idiopathic asthenozoospermia patients. Densities and volumes of the identified protein in the patients were significantly decreased compared to normal donors （P=0.034 and P=0.036, respectively）. The protein was identified as DEAD-box protein 4 （DDX4, VASA）. The expression and correction value （CV） of DDX4/VASA in the patients was reduced significantly compared to normal donors （P=0.037 and P=0.031, respectively）.Conclusions The expression of spermatic protein DDX4/VASA associates with spermatic motility, implying that DDX4NASA may be a candidate marker for evaluation of spermatic motility.

关键词： male infertility asthenozoospermia proteomics

传统集群低创新性形成机理——基于PFTI视角的分析

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自然辩证法研究 2015年第3期31卷 37-42页

作者：郑健壮靳雨涵浙江大学城市学院浙江杭州310015

将传统集群低创新性简单归结为其空间特征和知识产权保护力度不足,缺乏足够说服力。借助"技术创新获利理论"(简称PFTI理论),从主导设计范式、互补资产和独占性制度三个维度及相互关系出发,探究传统集群整体低创新性及集群企业创新成果... 详细信息

将传统集群低创新性简单归结为其空间特征和知识产权保护力度不足,缺乏足够说服力。借助"技术创新获利理论"(简称PFTI理论),从主导设计范式、互补资产和独占性制度三个维度及相互关系出发,探究传统集群整体低创新性及集群企业创新成果低占有性的"双低规律"。研究显示:随着主导设计范式的形成将导致集群企业创新弱化,集群内企业互补资产的结构失衡和相似性将导致集群整体的低创新性和企业创新成果的低占有性。而在低可占有性制度下,会进一步强化上述两个机理,最终又强化了"双低性"。

关键词：产业集群 PFTI理论创新成果创新占有

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不同技术水平产业集群绩效实现机理比较研究

科学学研究 2018年第9期36卷 1585-1593页

作者：靳雨涵郑健壮浙江大学管理学院浙江杭州310058 浙江大学城市学院浙江杭州310015

受Adner技术挑战理论的启发，选取杭州安防视频监控产业和温州鞋革业两类不同技术水平的集群进行跨案例比较研究，探究产业链中不同位置企业所面临的技术挑战对不同技术层次产业集群整体绩效影响的作用机制。通过实地调研、二手数据搜... 详细信息

受Adner技术挑战理论的启发，选取杭州安防视频监控产业和温州鞋革业两类不同技术水平的集群进行跨案例比较研究，探究产业链中不同位置企业所面临的技术挑战对不同技术层次产业集群整体绩效影响的作用机制。通过实地调研、二手数据搜集和权威期刊关键词分析等，描述上述两类产业集群产业链结构和技术变迁，并重点分析集群中上游组件商和下游互补件商所面临的技术挑战对集群焦点企业及其整体绩效的影响。研究发现：（1）在高技术集群中，上游组件商所面临的技术挑战对焦点企业和集群整体绩效有促进作用，而下游互补件商所面临的技术挑战对其有抑制作用；（2）在低技术集群中，上游组件商所面临的技术挑战对焦点企业和集群整体绩效无显著相关性，而下游互补件商所面临的技术挑战对其有促进作用。

关键词：产业集群技术挑战产业链集群绩效

rGO/TiO2/BiOI异质结的制备及光催化性能

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新型炭材料 2020年第4期35卷 394-400页

作者：靳玉涵李春梅张艳峰河北师范大学化学与材料科学学院国家级实验教学示范中心河北省无机纳米材料重点实验室河北石家庄050024

采用水热法制备了不同比例rGO/TiO2/BiOI三元复合物,以甲基橙为模拟污染物考察了样品的光催化性能,用扫描电子显微镜、X射线衍射仪、紫外-可见漫反射光谱仪、X射线光电子能谱仪和电化学方法对样品结构和性能进行了表征。结果表明,可见... 详细信息

采用水热法制备了不同比例rGO/TiO2/BiOI三元复合物,以甲基橙为模拟污染物考察了样品的光催化性能,用扫描电子显微镜、X射线衍射仪、紫外-可见漫反射光谱仪、X射线光电子能谱仪和电化学方法对样品结构和性能进行了表征。结果表明,可见光照射下,Bi/Ti摩尔比为80%的rGO/TiO2/BiOI复合物,在20 min时对甲基橙的降解率达到98%;表明以层状的石墨烯(rGO)为基底,TiO2纳米颗粒均匀附着在BiOI纳米片上,形成了以石墨烯为基底的异质结,异质结在可见光区有较强吸收,改善了光生载流子的分离效率,加快了载流子的迁移速率,从而提高了催化剂的光催化活性。

关键词： rGO/TiO2/BiOI 异质结光催化活性

Lichen Planus Pigmentosus Inversus:Two Case Reports

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International Journal of Dermatology and Venereology 2022年第2期5卷 116-118页

作者： Se Hoon Lee Minah Cho yu jin han yu Ri Woo Sang Hyun Cho Jeong Deuk Lee Hei Sung Kim Department of Dermatology Incheon St.Mary’s HospitalThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences The Catholic University of KoreaSeoulSouth Korea.

Introduction:Lichen planus pigmentosus inversus(LPPI)is a rare a rare variant of lichen planus characterized by hyperpigmented patches with predominating localization in intertriginous *** to its rarity,only a few LPPI cases are *** herein describe two rare cases of *** presentation:The two patients were all with a brownish macular lesion on the intertriginous area.A diagnosis of LPPI was made based on their clinical manifestations,dermoscopic features,and histopathologic features,which revealed an interface change,lichenoid infiltration,and pigmentary ***:LPPI is pruritic or asymptomatic,hyperpigmented macules and patches on the flexural *** axillae and flanks were the most commonly affected areas,followed by the groin and *** half of the female patients had inframammary fold *** shows higher female predominance than Lichen planus *** were fewer cases that lasted more than 3 years compared to ***:LPPI is a rare variant of lichen planus,with a locational characteristic and female ***,in the case of a pigmented disease occurring in the flexural folds,it should be placed in the differential diagnosis.

关键词： lichen planus pigmentosus lichen planus pigmentosus inversus

Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing Chen Chao Wu Xiaoling Liu Biao Meng Tao Chen yu han Jun Wang Shibo Xi yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Single atom catalyst Synergy effect Carbon catalyst Electrocatalysis

基于手机数据可靠性分析的旅游城市功能空间识别研究

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人文地理 2018年第3期33卷 137-144页

作者：赵莹张朝枝金钰涵中山大学旅游学院广州510275 伊利诺伊大学-中山大学国家公园(张家界)国际联合实验室广州510275

随着移动通信和移动互联网的普及,带有地理空间信息的"大数据"受到人文地理学者的关注。本文关注手机移动数据的旅游研究价值,以张家界市武陵源区、慈利县为例,首先分析了通信公司漫游用户数、基站网流量和话务量代表实际游客量的可靠... 详细信息

随着移动通信和移动互联网的普及,带有地理空间信息的"大数据"受到人文地理学者的关注。本文关注手机移动数据的旅游研究价值,以张家界市武陵源区、慈利县为例,首先分析了通信公司漫游用户数、基站网流量和话务量代表实际游客量的可靠性程度,然后探讨了漫游用户数波动对大尺度行政区的功能空间反映,最后挖掘了网流量波动对小尺度基站区的功能空间识别。结果显示,漫游用户数仅在旅游区对实际游客量具有可靠性,基站网流量比话务量的可靠性更强;漫游用户数在旅游区的波动幅度更大;基站网流量的空间因子分析识别出日常居住区、重点旅游区等功能空间。

关键词：手机数据基站网流量基站话务量可靠性功能空间

FK506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： yuhui Kou Zongxue jin yusong yuan Bo Ma Wenyong Xie Na han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma Medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

FK506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that FK506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that FK506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： FK506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons