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Advance on Chinese Medicine for Hypertensive Renal Damage:Focus on the Complex Molecular Mechanisms

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Chinese Journal of Integrative Medicine 2024年第10期30卷 938-948页

作者： LU Yan XIE Xue-na XIN Qi-qi yuAN Rong MIAO yu CONG Wei-hong CHEN Ke-ji Laboratory of Cardiovascular Diseases Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing100091China School of Pharmacy Macao University of Science and TechnologyTaipaMacao999078China National Clinical Research Center for Chinese Medicine Cardiology Beijing100091China

Hypertensive renal damage(HRD)is a major cause of end-stage renal *** the causes of end-stage renal disease,HRD accounts for nearly 34%of the total number of *** treatment is primarily drug-based,but therapeutic efficacy is less effective and can have serious side *** medicine(CM)has significant advantages in the treatment of *** is rich in various active ingredients and has the property of targeting multiple targets and ***,the regulatory network of CM on disease is complex.A large number of CM have been employed to treat HRD,either as single applications or as part of compound *** key possible mechanisms of CM for HRD include regulation of the renin-angiotensin-aldosterone system,antioxidation,anti-inflammation,rescue of endothelial function,regulation of vasoactive substance secretion and obesity-related factors,*** review summarized and discussed the recent advance in the basic research mechanisms of CM interventions for HRD and pointed out the challenges and future prospects.

关键词： Chinese medicine hypertensive renal damage molecular mechanisms research progress

Enhanced thermoelectric properties of Cu_(3)SbSe_(4)-based materials by synergistic modulation of carrier concentration and phonon scattering

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Journal of Materiomics 2024年第2期10卷 339-347页

作者： Sitong Wei Zhen ji Wenhao Li Shuqi Zheng Qing Wang Zhiliang Li Lu yu Sitong Luo Weiyu Song College of New Energy and Materials China University of PetroleumBeijing102249China College of Science China University of PetroleumBeijing102249China Key Laboratory of High-precision Computation and Application of Quantum Field Theory of Hebei Province College of Physics Science and TechnologyHebei UniversityBaoding071002China

Cu_(3)SbSe_(4),a copper-based sulfide free of rare earth elements,has received extensive attention in ther-moelectric ***,its low carrier concentration restricts its widespread *** this study,a microwave-assisted solution synthesis method was used to produce samples of Cu_(3)SbSe_(4),which enabled the formation of CuSe in situ and increased the *** the use of first-principles cal-culations,structural analysis,and performance evaluation,it was found that CuSe can enhance the carrier concentration and that induced nano-defects have a positive effect on reducing the lattice thermal ***,doping with Sn decreases the band gap of the system and moves the Fermi level into the valence band,increasing the carrier concentration to 1.15×10^(-20)cm^(-3).Finally,the zT value of the Cu_(3)Sb_(0.98)Sn_(0.02)Se_(4)sample was achieved at 1.05 at 623 K when the theoretical yield of a single synthesis was 10 mmol.

关键词： Cu_(3)SbSe_(4) Carrier concentration Phonon scattering Synergistic modulation

Error Estimate of Full-Discrete Numerical Scheme for the Nonlocal Allen-Cahn Model

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Journal of Mathematical Research with Applications 2024年第3期44卷 344-358页

作者： Jun ZHANG Xiaohu YANG Fulin MEI Zhimei ji yu ZHANG School of Mathematics and Statistics Guizhou University of Finance and Economics The Meteorological Disaster Prevention Center of Guizhou Province Xi'an Institute of Applied Optics Financial Department Guizhou University of Finance and Economics

In this work, we study the error estimates of the fully discrete Fourier pseudospectral numerical scheme for solving the nonlocal volume-conserved Allen-Cahn(AC) *** time marching method of the numerical scheme is based on the well-known Invariant Energy Quadratization(IEQ) method. We demonstrate that the proposed fully discrete numerical method is uniquely solvable, unconditionally energy stable, and obtain the optimal error estimate of the scheme for both space and time. Additionally, we conduct several numerical tests to verify the theoretical results.

关键词： nonlocal Allen-Cahn model uniquely solvable unconditionally energy stable error estimate numerical tests

Alendronate affects osteoprotegerin/receptor of activator of nuclear factor κB-ligand expression in human marrow stroma cells in vitro

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Journal of Pharmaceutical Analysis 2009年第4期21卷 230-233页

作者： jian-zhong Wang,Kun-zheng Wang,Zhi-bin Shi,yu-qiang ji,Ming-yu Zhang Department of Orthopedics,the Second Affiliated Hospital,Medical School of Xi’an jiaotong University,Xi’an 710004,China Department of Orthopedics Second Affiliated Hospital Medical School of Xi'an Jiaotong University Xi'an 710004 China

Objective To evaluate the effect of alendronate on osteoprotegerin(OPG)and receptor of activator of nuclear factor κB-ligand(RANKL)expression in human marrow stroma cells(hMSCs)in *** hMSCs were isolated from human marrow,cultured in vitro,and randomly divided into two groups:alendronate group,hMSCs culture fluid containing 1×10-7mol/L alendronate;control group,no special treatment but culturing hMSCs in *** weeks after treatment,the expressions of OPG and RANKL were evaluated by RT-PCR and Western *** hMSCs became uniform spindle-shaped *** cells proliferated,they formed colonies and showed whirlpool *** one week’s treatment,hMSCs in alendronate group had reduced processes and gradually showed disc shape,which did not happen in control group but kept fibroblast shape and just increased in *** RT-PCR,the ratio of OPG/RANKL in alendronate group and control group was 8.77±1.16 and 4.58±1.27,*** Western blot,the ratio of OPG/RANKL in alendronate group and control group was 2.58±0.47 and 1.52±0.32,*** ratio of OPG/RANKL was higher in alendronate group than in control group(P<0.01).Conclusion Alendronate enhances OPG expression and inhibits RANKL expression of hMSCs in vitro.

关键词： alendronate marrow stroma cell osteoprotegerin receptor of activator of NF-κB-ligand

3D printed multicore fiber-tip discriminative sensor for magnetic field and temperature measurements

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Light(Advanced Manufacturing) 2024年第1期5卷 82-92页

作者： Cong Xiong Caoyuan Wang Ruowei yu Wei ji yu Qin Yichun Shen Wei Chen Ai-Qun Liu Limin Xiao Advanced Fiber Devices and Systems Group Key Laboratory of Micro and Nano Photonic Structures(MoE)Key Laboratory for Information Science of Electromagnetic Waves(MoE)Shanghai Engineering Research Center of Ultra-Precision Optical ManufacturingSchool of Information Science and TechnologyFudan UniversityShanghaiChina Zhongtian Technology Advanced Materials Co. Ltd.NantongJiangsuChina Key laboratory of Specialty Fiber Optics and Optical Access Networks Joint International Research Laboratory of Specialty Fiber Optics and Advanced CommunicationShanghai University.ShanghaiChina Department of Electrical and Electronic Engineering The Hong Kong Polytechnic UniversityHong KongChina

Miniaturized fiber-optic magnetic field sensors have attracted considerable interest owing to their superiorities in anti-electromagnetic interference and ***,the intrinsic thermodynamic properties of the material make temperature cross-sensitivity a challenging problem in terms of sensing accuracy and *** this study,an ultracompact multicore fiber(MCF)tip sensor was designed to discriminatively measure the magnetic field and temperature,which was subsequently evaluated *** novel 3D printed sensing component consists of a bowl-shaped microcantilever and a polymer microfluid-infiltrated microcavity on the end-facet of an MCF,acting as two miniaturized Fabry-Perot *** magnetic sensitivity of the microcantilever was implemented by incorporating an iron micro ball into the microcantilever,and the microfluid-infiltrated microcavity enhanced the capability of highly sensitive temperature *** this tiny fiber-facet device in the two channels of an MCF allows discriminative measurements of the magnetic field and temperature by determining the sensitivity coefficient matrix of two *** device exhibited a high magnetic field intensity sensitivity,approximately 1805.6 pm/mT with a fast response time of~213 ms and a high temperature sensitivity of 160.3 pm/℃.Moreover,the sensor had a low condition number of 11.28,indicating high reliability in two-parameter *** proposed 3D printed MCF-tip probes,which detect multiple signals through multiple channels within a single fiber,can provide an ultracompact,sensitive,and reliable scheme for discriminative *** bowl-shaped microcantilever also provides a useful platform for incorporating microstructures with functional materials,extending multi-parameter sensing scenarios and promoting the application of MCFs.

关键词： Two-photon polymerization Multicore fiber-tip sensor Magnetic field sensing Discriminative sensing

Spatial transcriptomics reveals that metabolic characteristics define the tumor immunosuppression microenvironment via iCAF transformation in oral squamous cell carcinoma

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International Journal of Oral Science 2024年第1期16卷 110-121页

作者： Zheqi Liu Zhen Zhang yu Zhang Wenkai Zhou Xu Zhang Canbang Peng Tong ji Xin Zou Zhiyuan Zhang Zhenhu Ren Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghaiChina Department of Oral and Maxillofacial Surgery Zhongshan HospitalFudan UniversityShanghaiChina School and Hospital of Stomatology Kunming Medical UniversityKunmingChina Center for Tumor Diagnosis&Therapy Jinshan HospitalFudan UniversityShanghaiChina Department of Pathology Jinshan HospitalFudan UniversityShanghaiChina Hainan Western Central Hospital Academician Zhang Zhiyuan Team Innovation CenterDanzhouChina

Tumor progression is closely related to tumor tissue metabolism and reshaping of the microenvironment. Oral squamous cell carcinoma (OSCC), a representative hypoxic tumor, has a heterogeneous internal metabolic environment. To clarify the relationship between different metabolic regions and the tumor immune microenvironment (TME) in OSCC, Single cell (SC) and spatial transcriptomics (ST) sequencing of OSCC tissues were performed. The proportion of TME in the ST data was obtained through SPOTlight deconvolution using SC and GSE103322 data. The metabolic activity of each spot was calculated using scMetabolism,and k-means clustering was used to classify all spots into hyper-, normal-, or hypometabolic regions. CD4T cell infiltration and TGF-βexpression is higher in the hypermetabolic regions than in the others. Through CellPhoneDB and NicheNet cell-cell communication analysis, it was found that in the hypermetabolic region, fibroblasts can utilize the lactate produced by glycolysis of epithelial cells to transform into inflammatory cancer-associated fibroblasts (iCAFs), and the increased expression of HIF1A in iCAFs promotes the transcriptional expression of CXCL12. The secretion of CXCL12 recruits regulatory T cells (Tregs), leading to Treg infiltration and increased TGF-β secretion in the microenvironment and promotes the formation of a tumor immunosuppressive microenvironment. This study delineates the coordinate work axis of epithelial cells-iCAFs-Tregs in OSCC using SC, ST and TCGA bulk data, and highlights potential targets for therapy.

关键词： CXCL12 microenvironment squamous

Basic Survey Scheduling for the Wide Field Survey Telescope(WFST)

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Research in Astronomy and Astrophysics 2024年第1期24卷 59-69页

作者： Yan-Peng Chen ji-An jiang Wen-Tao Luo Xian-Zhong Zheng Min Fang Chao Yang yuan-yu Hong Zong-Fei Lü Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Astronomy University of Science and Technology of ChinaHefei 230026China National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China

Aiming at improving the survey efficiency of the Wide Field Survey Telescope, we have developed a basic scheduling strategy that takes into account the telescope characteristics, observing conditions, and weather conditions at the Lenghu site. The sky area is divided into rectangular regions, referred to as “tiles,” with a size of2°. 577 × 2°. 634 slightly smaller than the focal area of the mosaic CCDs. These tiles are continuously filled in annulars parallel to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, plays a significant role in determining the accessible survey fields. Approximately 50connected tiles are grouped into one block for observation. To optimize the survey schedule, we perform simulations by taking into account the length of exposures, data readout, telescope slewing, and all relevant observing conditions. We utilize the Greedy Algorithm for scheduling optimization. Additionally, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are located outside of the 3° field of view. This dithering pattern helps to achieve relatively uniform exposure maps for the final survey outputs.

关键词： telescopes surveys Moon

Thyroid-stimulating hormone-thyroid hormone signaling contributes to circadian regulation through repressing clock2/npas2 in zebrafish

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Journal of Genetics and Genomics 2024年第1期51卷 61-74页

作者： Cheng ji yue Ou Wangjianfei yu jiaxin Lv Fanmiao Zhang Huashan Li Zeyun Gu jiayuan Li Zhaomin Zhong Han Wang Center for Circadian Clocks Soochow UniversitySuzhouJiangsu 215123China School of Biology and Basic Medical Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

Thyroid-stimulating hormone(TSH)is important for the thyroid gland,development,growth,and *** in TSH production or the thyrotrope cells within the pituitary gland cause congenital hypothyroidism(CH),resulting in growth retardation and neurocognitive *** human TSH is known to display rhythmicity,the molecular mechanisms underlying the circadian regulation of TSH and the effects of TSH-thyroid hormone(TH)signaling on the circadian clock remain *** we show that TSH,thyroxine(T4),triiodothyronine(T3),and tshba display rhythmicity in both larval and adult zebrafish and tshba is regulated directly by the circadian clock via both E′-box and *** tshba^(−/−)mutants manifest congenital hypothyroidism,with the characteristics of low levels of T_(4)and T_(3)and growth *** or overexpression of tshba alters the rhythmicity of locomotor activities and expression of core circadian clock genes and hypothalamic-pituitary-thyroid(HPT)axis-related ***,TSH-TH signaling regulates clock2/npas2 via the thyroid response element(TRE)in its promoter,and transcriptome analysis reveals extensive functions of Tshba in ***,our results demonstrate that zebrafish tshba is a direct target of the circadian clock and in turn plays critical roles in circadian regulation along with other functions.

关键词： Thyroid-stimulating hormone subunitβa (tshba) Thyroid hormone Circadian rhythm TALEN Zebrafish

A Dielectric Ink Combining Acrylate and Cyanate Moieties for Inkjet 3D Printing with Good Thermal Stability

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Chinese Journal of Polymer Science 2024年第6期42卷 766-774页

作者： Yi-Xuan Li Liang-Ying Wu Yan Yang Yao-Zhong Lu Zhong-Ying ji yu-Xiong Guo Xiao-Long Wang Qiao-Sheng Pu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou730000China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsLanzhou730000China Lanzhou Traditional Chinese Medicine Hospital of Orthopedics and Traumatology Lanzhou730000China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai264006China

Inkjet 3D printing has potential in the additive manufacturing of electronic circuits and ***,inks that can be used for printing layers with T5%>300℃ or hardness>200 MPa have been rarely *** ester(CE)polymers have excellent thermal stability,high strength,and low shrinkage compared to other common dielectric inks for inkjet 3D printing,but cannot be quickly shaped by ultraviolet(UV)irradiation or thermal *** CEs with UV-curable monomers may be a possible way to accelerate crosslinking,but there are challenges from the adverse effects of the dilution of both *** this study,dielectric inks with acrylate and cyanate moieties were *** low viscosity and surface tension of the CE precursor(Bisphenol E cyanate ester)were combined with photocurable acrylate diluent monomers and cross-linker to realize an ink suitable for inkjet 3D *** internal dual three-dimensional cross-linked network structure resin was prepared by a combination of photocuring and thermal curing with T5%up to 326.69℃,hardness up to 431.84 MPa,dielectric constant of 2.70 at 8 GHz,and shrinkage of 1.64%.The developed dielectric inks can be applied to the 3D printing of printed circuit boards and other electronic devices that require dielectric properties.

关键词： Inkjet printing Cyanate ester resin 3D doubly cross-linked network Good thermal stability