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Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng Liao Sha Liao yu-Jiao gao Xi Wang Li-Hong Guo Su Zheng Wu Yang Yi-Nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

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Effect of vacuum degree and aeration rate on sludge dewatering behavior with the aeration-vacuum method

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第9期11卷 638-655页

作者： yu-feng gao Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai University Nanjing 210098 China Geotechnical Research Institute Hohai University Nanjing 210098 China The Science and Technology Division Hohai University Nanjing 210098 China

Due to large-scale dredging operations, a large amount of sludge is inevitably produced. Large areas of land are occupied when the dredged sludge is discarded in the disposal site as waste material. The sludge dewatering with aeration-vacuum (SDAV) method is suit for treating the sludge with high water content and high clay content in the disposal site. The water in the sludge can be discharged out. The volume of the sludge can be reduced quickly, and the recycling of the land can be accelerated by this method. Most importantly, this technique is an efficient way to deal with clogging problems when pumping water from high water content, high clay content dredged sludge. Vacuum degree range tests, the aeration rate range tests, and the influencing factors of sludge dewatering behavior tests were conducted with a self-developed SDAV model test device. Sludge samples were taken from the South-to-North Water Diversion East Line Project in Huai’an White-Horse Lake disposal site, Jiangsu Province, China. The optimal range of vacuum degree and aeration rate were obtained through the test results, and the mechanisms for how the two factors work and how they affect the sludge dewatering behavior were analyzed. The suitable vacuum degree range in SDAV is below 50 kPa, and the suitable aeration rate is about 1.0 m3/h. The low-vacuum degree contributes to reduce the ad-sorption effect of micro-channels on soil particles in filter material and to maintain the arch structures. Aeration has the effects of expansion, disturbance, changing Reynolds number, and dynamic sieve separating. The pump quantity of water per meter of filter tube (m) has different change rules as the vacuum degree changes under different aeration rates. The reason is that the formed arch structures’ conformation and permeability differ greatly under different combined-conditions of vacuum degree and aeration rate. The optimal combined-condition for dewatering the sludge is 35 kPa with 1.0 m3/h.

关键词： High water content dredged sludge Sludge dewatering with aeration-vacuum (SDAV) Vacuum degree Aeration rate Arch structures

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A brief report on the statistical study of net electric current in solar active regions with longitudinal fields of opposite polarity

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Research in Astronomy and Astrophysics 2013年第6期13卷 749-756页

作者： yu gao Key Laboratory of Solar Activity National Astronomical Observatories Chinese Academy ofSciences

Dynamic processes occurring in solar active regions are dominated by the solar magnetic field. As of now, observations using a solar magnetograph have supplied us with the vector components of a solar photospheric magnetic field. The two transverse components of a photospheric magnetic field allow us to compute the amount of electric current. We found that the electric current in areas with positive （negative） polarity due to the longitudinal magnetic field have both positive and neg- ative signs in an active region, however, the net current is found to be an order-of- magnitude less than the mean absolute magnitude and has a preferred sign. In particu- lar, we have statistically found that there is a systematic net electric current from areas with negative （positive） polarity to areas with positive （negative） polarity in solar ac- tive regions in the northern （southern） hemisphere, but during the solar minimum this tendency is reversed over time at some latitudes. The result indicates that there is weak net electric current in areas of solar active regions with opposite polarity, thus provid- ing further details about the hemispheric helicity rule found in a series of previous studies.

关键词： Sun: activity -- Sun: photosphere -- Sun: magnetic fields

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A quantity characterizing variation of observed magnetic twist in solar active regions

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Research in Astronomy and Astrophysics 2018年第3期18卷 37-46页

作者： yu gao Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of Sciences

An alternative parameter RJz is introduced as the ratio of one of two kinds of opposite-sign current to the total current and is used to investigate the relationship between this quantity and the hemispheric helicity sign rule（HSR） that has been established by a series of previous statistical studies. The classification of current in each hemisphere obeys the following rule： if the product of the current and the corresponding longitudinal field component contributes a consistent sign with respect to the HSR,it is called ＂HSR-compliant＂ current,otherwise it is called ＂HSR-noncompliant＂ current. Firstly,consistency between the butterfly diagram of RJz and current helicity was obtained in a statistical *** regions with RJzsmaller than 0.5 tend to obey the HSR whereas those with RJz greater than 0.5 tend to disobey it. The ＂HSR-compliant＂ current systems have a 60% probability of realization compared to 40% for ＂HSR-noncompliant＂ current systems. Overall,the HSR is violated for active regions in which the ＂HSR-noncompliant＂ current is greater than the ＂HSR-compliant＂ current. Secondly,the parameter RJz was subsequently used to study the evolution of current systems in the case analyses of flare-productive active regions NOAA AR 11158 and AR 11283. It is found that there is a ＂RJz-quasistationary＂ phase that is relatively flare quiescent and ＂RJz-dynamic＂ phase that is characterized by the occurrence of large flares.

关键词： Sun activity - Sun flares - Sun magnetic fields - Sun evolution - Sun sunspots

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HIGHLY SENSITIVE CATALASE ELECTRODE BASED ON POLYPYRROLE FILMS WITH MICROCONTAINERS

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Chinese Journal of Polymer Science 2006年第6期24卷 579-584页

作者： yu-ying gao gao-quan Shi Department of Chemistry Tsinghua University Beijing 100084 China

Highly sensitive catalase electrodes for sensing hydrogen peroxide have been fabricated based on polypyrrole films with microcontainers. The microcontainers have a cup-like morphology and are arranged in a density of 4000 units cm^-2. Catalase was immobilized into the polypyrrole films with microcontainers （Ppy-mc）, which were coated on a Pt substrate electrode. The catalase/Ppy-mc/Pt electrode showed linear response to hydrogen peroxide in the range of 0-18 mmol/L at a potential of-0.3 V （versus SCE）. Its sensitivity was measured to be approximately 3.64 μA （mmol/L） ^-1 cm^- 2, which is about two times that of the electrode fabricated from a flat Ppy film （catalase/Ppy-flat/Pt electrode）. The electrode is highly selective for hydrogen peroxide and its sensitivity is interfered by potential interferents such as ascorbic acid, urea and fructose. Furthermore, such catalase electrodes showed long-term storage stability of 15 days under dry conditions at 4℃.

关键词： Microstructured polypyrrole Catalase Electropolymerization Sensors Hydrogen peroxide.

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Spatial distribution of supra-permafrost groundwater in the Qinghai-Tibet Engineering Corridor using inversion models

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Advances in Climate Change Research 2024年第1期15卷 31-41页

作者： yu gao Ming-Tang CHAI Wei MA yu-Tao gao State Key Laboratory of Frozen Soils Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 73000China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China School of Civil and Hydraulic Engineering Ningxia UniversityYinchuan 750021China

Supra-permafrost groundwater(SPG)is a key factor that causes damage to highways and railways in the Qinghai-Tibet Engineering Corridor(QTEC).It is difficult to monitor SPG in the field due to their complex formation mechanisms and movement *** single-site field monitoring studies limit the spatial and temporal precision of SPG spatial *** determine the moisture content of shallow soils and the SPG distribution along the QTEC,this work employed the temperature vegetation dryness index and remote sensing models for groundwater table distribution *** accuracies of the models were validated using mea-surements obtained from different sites in the *** the permafrost zones of the QTEC,72%,22%and 6%of the SPG were located at depths of 0.5-1,1 m,***,79.4%of the area along the Qinghai-Tibet Highway(QTH)(Xidatan-Tanggula)section contained *** these sections with SPG,37.9%have an SPG table at depths of 0.5-0.8 *** study preliminarily explored the SPG distribution in the QTEC with a 30 m *** findings can help improve the spatial scale of SPG research,provide a basis for the analysis of the hydrothermal mechanisms,and serve as a guide in the assessment of operational risks and road structure designs.

关键词： Dryness index Landsat Soil moisture Groundwater level Qinghai-Tibet Engineering Corridor

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The global star formation law of galaxies revisited in the radio continuum

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Science China(Physics,Mechanics & Astronomy) 2012年第2期55卷 347-353页

作者： LIU LiJie gao yu Purple Mountain Observatory Chinese Academy of SciencesNanjing 210008China Graduate University of Chinese Academy of Sciences Beijing 100039China

We study the global star formation law, the relation between the gas and star formation rate （SFR） in a sample of 130 local galaxies with infrared （IR） luminosities spanning over three orders of magnitude （109-1012 Lo）, which includes 91 normal spiral galaxies and 39 （ultra）luminous IR galaxies [（U）LIRGs]. We derive their total （atomic and molecular） gas and dense molecular gas masses using newly available HI, CO and HCN data from the literature. The SFR of galaxies is determined from total IR （8-1000 μm） and 1.4 GHz radio continuum （RC） luminosities. The galaxy disk sizes are defined by the de-convolved elliptical Gaussian FWHM of the RC maps. We derive the galaxy disk-averaged SFRs and various gas surface densities, and investigate their relationships. We find that the galaxy disk-averaged surface density of dense molecular gas mass has the tightest correlation with that of SFR （scatter -0.26 dex）, and is linear in log-log space （power-law slope of N=1.03±0.02） across the full galaxy sample. The correlation between the total gas and SFR surface densities for the full sample has a somewhat larger scatter （-0.48 dex）, and is best fit by a power-law with slope 1.45±0.02. However, the slope changes from -1 when only normal spirals are considered, to -1.5 when more and more （U）LIRGs are included in the fitting. When different CO-to-H2 conversion factors are used to infer molecular gas masses for normal galaxies and （U）LIRGs, the bi-modal relations claimed recently in CO observations of high-redshift galaxies appear to also exist in local populations of star-forming galaxies.

关键词： galaxies: evolation galaxies: ISM radio lines: galaxies stars: fromation

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Single-pulse chaotic dynamics of functionally graded materials plate

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Acta Mechanica Sinica 2013年第4期29卷 593-601页

作者： yu-gao Huangfu Fang-Qi Chen College of Mathematics and Information Science Henan Polytechnic University Department of Mathematics Nanjing University of Aeronautics and Astronautics

Single-pulse chaos are studied for a functionally graded materials rectangular plate. By means of the global perturbation method, explicit conditions for the existence of a SiZnikov-type homoclinic orbit are obtained for this sys- tem, which suggests that chaos are likely to take place. Then, numerical simulations are given to test the analytical predic- tions. And from our analysis, when the chaotic motion oc- curs, there are a quasi-period motion in a two-dimensional subspace and chaos in another two-dimensional supplemen- tary subspace.

关键词： Functionally graded materials ~ Single-pulse ~Melnikov's method ~ Homoclinic orbit ~ Numerical simula-tion

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Experimental investigation of laser peening on TiAl alloy microstructure and properties

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Chinese Journal of Aeronautics 2015年第2期28卷 609-616页

作者： Qiao Hongchao Zhao Jibin gao yu Shenyang Institute of Automation Chinese Academy of Science AVIC Shenyang Liming Aero-engine (Group) Corporation Ltd.

In order to study the effect of laser peening on microstructures and properties of TiAl alloy, TiAI alloy samples were treated by Nd：YAG laser system with the wavelength of 1064 nm, pulse-width of 18 ns, and pulse-energy of 0-10J. Surface micro-hardness, roughness, and microstructural characteristics were tested with micro-hardness tester, roughness tester and scanning electron microscope. Residual stress and pole figures were tested with X-ray diffraction and its high-temperature stability was analyzed. The experimental results show that surface micro-hardness increases by up to 30%, roughness increases to 0.37 lain, compressive residual stress increases to 337 MPa, and local texture and typical lamellar microstructure are generated. Residual stress, micro-hardness, and （002） pole figures tests are conducted, compressive residual stress value drops from 337 MPa to 260 MPa, hardness value drops from 377 HV0.2 to 343 HV0.2, and the （002） poles shift back to the center slightly. Laser peening improves microstructure and properties of TiAl alloy significantly.

关键词： High temperature stabilityLaser peening Microstructure Residual stress TiAl alloy

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Phosphine-mediated enantioselective synthesis of carbocycles and heterocycles

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Chinese Chemical Letters 2017年第3期28卷 493-502页

作者： yu-Ning gao Min Shi State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China

Nucleophilic chiral phosphine catalysis has been prosperous in asymmetric synthesis over the past two decades. Various tunable chiral phosphines display excellent activity and selectivity in asymmetric transformations including acycloaddition reactions and cycloaddition reactions. Enantiomerically enriched cyclic compounds are ubiquitous in natural products and drug molecules. These phosphinecatalyzed reactions provide effective and extensive strategies for the synthesis of a series of complex cyclic compounds as well as the synthesis of chiral compounds which could be easily transformed to carbocycles and heterocycles. This minireview summarizes recent developments in this area and highlights meaningful breakthroughs.

关键词： Bifunctional phosphines Asymmetric catalysis Carbocycles Heterocycles Cycloaddition reactions

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