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Architecture and key technologies of grid geographic information system

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Science China(Technological Sciences) 2008年第S1期51卷 102-113页

作者： fang yu,HUANG zhou,CHEN Bin,WU Lun & YIN DaFei Institute of Remote Sensing and Geographic Information System,Peking University,Beijing 100871,China Institute of Remote Sensing and Geographic Information System Peking University Beijing China

The highly efficient and stable collaborative computation platform for geospatial information can be constructed on the basis of Grid computing technology,com-bined with Peer-to-Peer (P2P) computing technology and geospatial database technology. This paper proposed the architecture and key technologies of the Grid GIS (Geographic Information System) incorporated with P2P structure,and corre-spondingly a Grid GIS prototype named Nebula was designed and then imple-mented. Nebula is a suite of middleware for geospatial Grid computing,which could be deployed onto various service nodes in network. Based on Grid protocols and infrastructure,Nebula provides invocation interfaces to users in form of Grid services. By using P2P message based communication mechanism,complex geospatial computation tasks could be accomplished by Nebula in a collaborative way. This paper introduced Nebula's architecture and key modules,and according to experimental data,we discussed the Grid GIS's advantages,application scenar-ios and future directions.

关键词： Grid GIS distributed geospatial computing Peer-to-Peer computing

Performance and Application of Microcapsule Phase Change Material

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Performance and Application of Microcapsule Phase Change Mat...

2012上海纺织服装创意设计研究生学术论坛

作者： Wan-Ting Ge fang-yu zhou Ying-qi Xu Shanghai University of Engineering Science

＜正＞Phase change material（PCM） has been developed in recent years,and it has great potential development and vast prospect of market *** phase change material（MPCM） is a new kind of composite phase change material that applies MPCM technology to *** this paper MPCM and its characteristics were introduced,MPCM structure and thermal property were characterized,and its application was summarized.

关键词： phase change material microcapsules feature structure performance

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夫妻关系冲突对子女心理健康影响研究进展

中国公共卫生 2015年第4期31卷 525-528页

作者：何茹于方舟辽宁省人民医院心理科沈阳110016

随着中国离婚率的持续上升,夫妻关系冲突对子女心理健康的影响越来越受到人们的关注。本综述通过阐述社会学习理论、间接作用观点、认知-背景理论和情绪安全假设等代表性理论探讨夫妻关系冲突对子女心理健康影响的研究进展,通过关注夫... 详细信息

随着中国离婚率的持续上升,夫妻关系冲突对子女心理健康的影响越来越受到人们的关注。本综述通过阐述社会学习理论、间接作用观点、认知-背景理论和情绪安全假设等代表性理论探讨夫妻关系冲突对子女心理健康影响的研究进展,通过关注夫妻关系对子女心理健康的影响,并采取适当方式进行干预,可以提高夫妻关系质量,提高子女心理健康水平,最终促成全民心理健康。

关键词：夫妻关系冲突子女心理健康

Adaptive Variable Structure Guidance System Design of a Longitudinal Automatic Carrier Landing System

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Adaptive Variable Structure Guidance System Design of a Long...

Fructus Akebiae:A novel serotonin,norepinephrine and dopamine reuptake inhibitor

2009中国控制与决策会议

作者： Zhu Qi-dan,Wang Tong,Zhong Xun-yu,zhou fang College of Automation,Harbin Engineering University,Harbin 150001,China

＜正＞The design problem of guidance system of a longitudinal automatic carrier landing system is *** mathematic model of the landing guidance problem is created based on the analysis of the main architecture of a longitudinal automatic carrier landing *** landing guidance system is designed via adaptive variable structure sliding mode control theory and the stability of guidance system is *** chattering problem is solved via using hyperbolic *** results indicate that the guidance system has the merits of response fast and tracking precisely and validate the feasibility and reasonability of this method.

关键词： Automatic Landing Adaptive Variable Structure Control Guidance Law Chattering

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Fructus Akebiae:A novel serotonin,norepinephrine and dopamin...

髋关节置换缺血性脑卒中粒细胞胞外陷阱的作用

中国药理学会第十一次全国学术会议

作者： XU Jiang-ping,JIN Zeng-liang,CHENG yu-fang,DAN zhou (Department of Pharmacology,School of Pharmaceutical Sciences,Southern Medical University, Guangzhou 510515,China)

Fructus Akebiae(FAE) is a traditional Chinese herbal extract that has been used for the treatment of depressive disorders in *** studies demonstrated that FAE displayed a potent antidepressant-like activity in forced swim and tail suspension ***,the underlying mechanism is *** we provide evidences that FAE enhanced the signaling of central monoamines via inhibition of the reuptake of the extracellular monoamines including serotonin(5-hydroxytryptamine,5-HT) norepinephrine (NE) and dopamine(DA).In rat brain membrane preparation and HEK293 cells transfected with human serotonin transporter (SERT),NE transporter(NET) and DA transporter(DAT),we found that that FAE displayed marked affinity to rat and cloned human monoamine transporters in ex vivo and in vitro experiments,using competitive radio ligand binding *** uptake assays using rat synaptosomes and transfected cells,FAE was found to significantly inhibit all three monoamine transporters in a dose- and time-dependent manner,with a comparable or better potency to their corresponding specific *** contrast,FAE 10μmol·L, showed no significant affinity to a variety array of receptors tested from *** support of our uptake data,in vivo microdialysis study showed that administration of FAE 12.6,25 and 50 mg·kg significantly increased extracellular concentrations of 5-HT,NE and DA in frontal cortex of freely moving *** together,our current study showed for the first time that FAE is a novel triple inhibitor of monoamine transporters,which may be one the mechanisms of its antidepressant activity.

关键词： Fructus Akebiae antidepressant reuptake inhibitor

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中国矫形外科杂志 2024年第9期32卷 836-841页

作者：张吉美于芳洲耿榆杰李作伟山东中医药大学第一临床医学院山东济南250014 山东中医药大学附属医院神经内科山东济南250014

缺血性脑卒中是髋关节置换术后少见且严重的并发症之一,其致残率高,严重时危及生命,发病过程与创伤性炎症反应、血栓形成等密切相关。近十年研究发现,中性粒细胞胞外陷阱(neutrophil extracellular traps,NETs)参与动脉血栓形成。髋关... 详细信息

缺血性脑卒中是髋关节置换术后少见且严重的并发症之一,其致残率高,严重时危及生命,发病过程与创伤性炎症反应、血栓形成等密切相关。近十年研究发现,中性粒细胞胞外陷阱(neutrophil extracellular traps,NETs)参与动脉血栓形成。髋关节置换术后机体的炎症反应、血小板的活化等激活中性粒细胞,诱导NETs产生并释放,使血液处于高凝状态、血小板高效聚集、促进凝血酶产生、激活部分凝血因子、降低动脉粥样硬化斑块的稳定性,导致术后缺血性脑卒中发生。NETs相关生物标志物的检测可预测术后缺血性脑卒中发生,抑制NETs产生或促进NETs降解为术后缺血性脑卒中预防及治疗提供新的方向,为研发新的药物提供新的思路。

关键词：中性粒细胞胞外陷阱髋关节置换术缺血性脑卒中

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小剂量氯胺酮对上腹部手术术后镇痛的效应

复旦学报（医学版） 2004年第1期31卷 81-83页

作者：陈佳瑶白浪俞莹芳周守静复旦大学附属华山医院麻醉科上海200040

目的研究术中应用小剂量氯胺酮对上腹部手术有无超前镇痛的效应。方法采用随机对照双盲的前瞻性临床试验法,40例择期行上腹部手术的患者全部采用硬膜外复合全麻法,随机分为两组。氯胺酮组(KAT组)20例,手术前15 min静脉给予氯胺酮0.3 m... 详细信息

目的研究术中应用小剂量氯胺酮对上腹部手术有无超前镇痛的效应。方法采用随机对照双盲的前瞻性临床试验法,40例择期行上腹部手术的患者全部采用硬膜外复合全麻法,随机分为两组。氯胺酮组(KAT组)20例,手术前15 min静脉给予氯胺酮0.3 mg·kg^(-1),继之持续静脉输注氯胺酮3 μg·kg^(-1)·min^(-1)至手术结束前15min;对照组(NS组)20例给予同等容量的生理盐水。患者术后均采用自控硬膜外镇痛(PCEA),在麻醉恢复室和术后3、6、12、24、48 h随访PCEA用量、视觉模拟镇痛评分(VAS)及患者有无精神异常。结果KAT组术后3和6hPCEA用量显著少于NS组,VAS评分显著低于NS组,其余各时点无显著差异,两组未有精神异常发生。结论术中静脉给予小剂量氯胺酮能提高术后早期PCEA镇痛质量及减少阿片类用量。

关键词：小剂量氯胺酮上腹部手术术后镇痛麻醉自控硬膜外镇痛

Cohort study on the treatment of BRAF V600E mutant metastatic colorectal cancer with integrated Chinese and western medicine

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World Journal of Clinical Oncology 2025年第1期16卷 25-33页

作者： Jiang-yu Bian yu-fang Feng Wen-Ting He Tong Zhang Department of Oncology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Department of Oncology The Fourth Clinical Medical College of Xinjiang Medical UniversityUrumqi 830001China Department of Oncology Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical UniversityUrumqi 830001China

BACKGROUND Patients with BRAF V600E mutant metastatic colorectal cancer(mCRC)have a low incidence rate,poor biological activity,suboptimal response to conventional treatments,and a poor *** the previous cohort study on mCRC conducted by our team,it was observed that integrated Chinese and Western medicine treatment could significantly prolong the overall survival(OS)of patients with colorectal ***,we further explored the survival benefits in the population with BRAF V600E mutant *** To evaluate the efficacy of integrated Chinese and Western medicine in the treatment of BRAF V600E mutant metastatic colorectal *** A cohort study was conducted on patients with BRAF V600E mutant metastatic colorectal cancer admitted to Xiyuan Hospital of China Academy of Chinese Medical Sciences and Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Region from January 2016 to December *** patients were divided into two *** A total of 34 cases were included,with 23 in Chinese-Western medicine cohort(cohort A)and 11 in Western medicine cohort(cohort B).The median overall survival was 19.9 months in cohort A and 14.2 months in cohort B,with a statistically significant difference(P=0.038,hazard ratio=0.46).The 1-3-year survival rates were 95.65%(22/23),39.13%(9/23),and 26.09%(6/23)in cohort A,and 63.64%(7/11),18.18%(2/11),and 9.09%(1/11)in cohort B,*** analysis showed statistically significant differences in median OS between the two cohorts in the right colon,liver metastasis,chemotherapy,and first-line treatment subgroups(P<0.05).CONCLUSION Integrated Chinese and Western medicine can prolong the survival and reduce the risk of death in patients with BRAF V600E mutant metastatic colorectal cancer,with more pronounced benefits observed in patients with right colon involvement,liver metastasis,combined chemotherapy,and first-line treatment.

关键词： Metastatic colorectal cancer BRAF V600E mutation Integrated Chinese and Western medicine Cohort study

Single-cell transcriptomic profiling reveals ZEB1-mediated regulation in microglial subtypes and the impact of exercise on neuroinflammatory responses

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Traditional Medicine Research 2025年第2期10卷 55-64页

作者： Jin-fang Wu Yi-Sheng Chen yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This study aims to identify distinct cellular subtypes within brain tissue using single-cell transcriptomic analysis,focusing on specific biomarkers that differentiate cell types and the effects of traditional and exercise ***:Four samples were analyzed:older control(OC),older exercise(OE),younger control(YC),and younger exercise(YE).Single-cell RNA sequencing was used to distinguish cellular subtypes through their biomarker *** visualization included violin and t-SNE plots to illustrate biomarker expression across cell clusters such as oligodendrocytes,microglia,and ***,BV2 cells were exposed to amyloid-beta fragments to simulate Alzheimer’s disease,assessing the impact of exercise-induced cellular ***:Distinct cellular subtypes were identified:oligodendrocytes(MBP,St18),microglia(Dock8),and astrocytes(Aqp4,Gpc5).Sample OE was predominantly oligodendrocytes,while YE had more astrocytes,inhibitory neurons,and Canal-Retzius *** showed a significant presence of Olfm3+ganglion ***1 gene knockout revealed changes in SMAD family gene expression,which regulate *** stress levels were also ***:This profiling enhances our understanding of brain cellular functions and interactions,potentially informing targeted therapies in neurological *** may influence brain cell immune responses and cell death pathways by regulating specific gene expressions,offering new insights for treating neuroinflammation and degeneration.

关键词： single-cell transcriptomics brain tissue cellular subtypes biomarker expression neuronal diversity