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Clinical associations of corneal neuromas with ocular surface diseases

Neural Regeneration Research 2024年第1期19卷 140-147页

作者： Charmaine Jan Li Toh Chang Liu Isabelle Xin yu Lee Molly Tzu yu Lin Louis Tong yu-chi Liu Lee Kong chian School of Medicine Nanyang Technological UniversitySingapore Singapore Eye Research Institute Singapore Department of Cornea and External Eye Disease Singapore National Eye CentreSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Corneal neuromas,also termed microneuromas,refer to microscopic,irregula rly-shaped enlargements of terminal subbasal nerve endings at sites of nerve damage or *** formation of corneal neuromas results from damage to corneal nerves,such as following corneal pathology or corneal or intraocular surge ***,denervated areas of sensory nerve fibers become invaded by sprouts of intact sensory nerve fibers,and later injured axons regenerate and new sprouts called neuromas *** recent years,analysis of corneal nerve abnormalities including corneal neuromas which can be identified using in vivo confocal microscopy,a non-invasive imaging technique with microscopic resolution,has been used to evaluate corneal neuropathy and ocular surface *** neuromas have been shown to be associated with clinical symptoms of discomfort and dryness of eyes,and are a promising surrogate biomarker for ocular surface diseases,such as neuropathic corneal pain,dry eye disease,diabetic corneal neuropathy,neurotrophic keratopathy,Sjogren's syndrome,bullous keratopathy,post-refra ctive surgery,and *** this review,we have summarized the current literature on the association between these ocular surface diseases and the presentation of corneal microneuromas,as well as elaborated on their pathogenesis,visualization via in vivo confocal microscopy,and utility in monitoring treatment *** current quantitative analysis on neuromas mainly relies on manual annotation and quantification,which is user-dependent and labor-intensive,future direction includes the development of artificial intelligence software to identify and quantify these potential imaging biomarkers in a more automated and sensitive manner,allowing it to be applied in clinical settings more *** imaging and molecular biomarkers may also help elucidate the associations between corneal neuromas and ocular surface diseases.

关键词： cornea corneal diseases corneal nerve corneal neuropathy in vivo confocal microscopy microneuroma neuroma ocular surface diseases

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Bipolar hip arthroplasty using conjoined tendon preserving posterior lateral approach in treatment of displaced femoral neck fractures

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World Journal of Clinical Cases 2024年第6期12卷 1076-1083页

作者： Ting-Xin Yan Sheng-Jie Dong Bo Ning yu-chi Zhao Department of Joint Surgery Yantaishan HospitalYantai 264003Shandong ProvinceChina Department of Joint Surgery Dongying People's HospitalDongying 257091Shandong ProvinceChina

BACKGROUND Hip fractures account for 23.8%of all fractures in patients over the age of 75 *** than half of these patients are older than 80 *** hemiarthroplasty(BHA)was established as an effective management option for these *** approaches can be used for the BHA ***,there is a high risk of postoperative *** conjoined tendon-preserving posterior(CPP)lateral approach was introduced to reduce postoperative dislocation *** To evaluate the effectiveness and safety of the CPP lateral approach for BHA in elderly *** We retrospectively analyzed medical data from 80 patients with displaced femoral neck fractures who underwent *** patients were followed up for at least 1 *** the 80 patients,57(71.3%)were *** time to operation averaged 2.3 d(range:1-5 d).The mean age was 80.5 years(range:67-90 years),and the mean body mass index was 24.9 kg/m^(2)(range:17-36 kg/m^(2)).According to the Garden classification,42.5%of patients were typeⅢand 57.5%of patients were typeⅣ.Uncemented bipolar hip prostheses were used for all *** conjoined tendons,dislocations,and adverse complications during and after surgery were *** The mean postoperative follow-up time was 15.3 months(range:12-18 months).The average surgery time was 52 min(range:40-70 min)with an average blood loss of 120 mL(range:80-320 mL).The transfusion rate was 10%(8 of 80 patients).The gemellus inferior was torn in 4 patients(5%),while it was difficult to identify in 2 patients(2.5%)during *** posterior capsule was punctured by the fractured femoral neck in 3 patients,but the conjoined tendon and the piriformis tendon remained *** patients had stem varus greater than 3 degrees or femoral *** were no patients with stem subsidence more than 5 mm at the last *** postoperative dislocations were observed throughout the follow-up *** significance was found between preoperative an

关键词： Conjoined tendon preserving Bipolar hip arthroplasty Femoral neck fractures Postoperative dislocation Posterolateral approach

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo En Ning Chang Liu yu-chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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Optimized online filter stack spectrometer for ultrashort X-ray pulses

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Nuclear Science and Techniques 2024年第5期35卷 85-98页

作者： Jia-Xing Wen Ge Ma Ming-Hai yu yu-chi Wu Yong-Hong Yan Shao-Yi Wang Huai-Zhong Gao Lu-Shan Wang yu-Gang Zhou Qiang Li yue Yang Fang Tan Xiao-Hui Zhang Jie Zhang Wen-Bo Mo Jing-Qin Su Wei-Min Zhou yu-Qiu Gu Ming Zeng Zong-Qing Zhao Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterCAEPMianyang 621900China Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China School of Information Engineering Southwest University of Science and TechnologyMianyang 621010China

Currently,with the advent of high-repetition-rate laser-plasma experiments,the demand for online diagnosis for the X-ray spectrum is increasing because the laser-plasma-generated X-ray spectrum is very important for characterizing electron dynamics and *** this study,scintillators and silicon PIN(P-type–intrinsic-N-type semiconductor)diodes were used to construct a wideband online filter stack *** X-ray sensor and filter arrangement was optimized using a genetic algorithm to minimize the condition number of the response ***,the unfolding error was significantly reduced based on numerical *** detector responses were quantitatively calibrated by irradiating the scintillator and PIN diode with various nuclides and comparing the measuredγ-ray peaks.A prototype 15-channel spectrometer was developed by integrating an X-ray detector with front-and back-end *** prototype spectrometer could record X-ray pulse signals at a repetition rate of 1 ***,an optimized spectrometer was employed to record the real-time spectra of laser-driven bremsstrahlung *** optimized spectrometer offers a compact solution for spectrum diagnostics of ultrashort X-ray pulses,exhibiting improved accuracy in terms of spectrum measurements and repetition rates,and could be widely used in next-generation high-repetition-rate high-power laser facilities.

关键词： Filter stack spectrometer Laser plasma diagnostics X-ray diagnostics Scintillator PIN diode

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基于内置式声发射装置的金刚滚轮磨损在线监测方法

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科学技术与工程 2024年第26期24卷 11253-11262页

作者：于光宁史慧楠迟杰迟玉伦中国航发哈尔滨轴承有限公司哈尔滨150027 上海理工大学机械工程学院上海200093

为解决金刚滚轮修整磨损情况难以准确在线判断难题。设计开发了一套内置式声发射在线监测金刚滚轮磨损装置。基于Shannon信息熵理论与小波包模型,提出了一种对金刚滚轮修整声发射信号处理方法。该方法计算每一层小波包系数的信息熵,并... 详细信息

为解决金刚滚轮修整磨损情况难以准确在线判断难题。设计开发了一套内置式声发射在线监测金刚滚轮磨损装置。基于Shannon信息熵理论与小波包模型,提出了一种对金刚滚轮修整声发射信号处理方法。该方法计算每一层小波包系数的信息熵,并根据信息熵变化规律可确定小波包最佳分解层数。然后,利用主成分分析对该小波包分解特征参数进行降维,提取出最能表征金刚滚轮磨损的特征参数。最后,基于该特征参数建立粒子群优化算法支持向量机(particle swarm optimization-support vector machin,PSO-SVM),对金刚滚轮磨损状态进行实验监测研究。结果表明PSO-SVM模型分类精度最高,平均正确率高达95.24%以上,并通过大量实验验证了PSO-SVM的有效性。

关键词：金刚滚轮信息熵小波包分解 PSO-SVM

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Anisotropic s-Wave Gap in the Vicinity of a Quantum Critical Point in Superconducting BaFe_(2)(As_(1-x)P_(x))_(2) Single Crystals:A Study of Point-Contact Spectroscopy

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chinese Physics Letters 2024年第4期41卷 118-123页

作者：詹红星林玉尺赵宇清左海艳王兴玉马肖燕李春红罗会仟陈根富李世亮任聪 School of Physics and Astronomy Yunnan UniversityKunming 650500China Beijing National Laboratory for Condensed Matter Physics and Institute of PhysicsChinese Academy of SciencesBeijing 100190China yunnan Key Laboratory for Electromagnetic Materials and Devices Yunnan UniversityKunming 650500China

We report on soft c-axis point-contact Andreev reflection(PCAR)spectroscopy combining with resistivity measurements on BaFe_(2)(As_(0.7)P_(0.3))_(2),to elucidate the superconducting gap structure in the vicinity of the quantum critical point.A double peak at the gap edge plus a dip feature at zero-bias has been observed on the PCAR spectra,indicative of the presence of a nodeless gap in BaFe_(2)(As_(0.7)P_(0.3))_(2).Detailed analysis within a sophisticated theoretical model reveals an anisotropic gap with deep gap *** PCARs also feature additional structures related to the electron-bosonic coupling *** the extracted superconducting energy gap value,a characteristic bosonic energy Ω_(b) and its temperature dependence are obtained,comparable with the spin-resonance energy observed in neutron scattering *** results indicate a magnetism-driven quantum critical point in the BaFe_(2)(As_(1-x)P_(x))_(2) system.

关键词： quantum critical resistivity

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新型水平轴螺旋风力机气动性能分析

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兰州理工大学学报 2024年第3期50卷 58-63页

作者：宋科康宇驰昆明学院机电工程学院云南昆明650214 昆明理工大学机电工程学院云南昆明650500

为了拓展水平轴风力机的适用范围,采用计算流体力学对2种具有不同旋叶倾角的新型水平轴螺旋风力机及其加装导管后的气动性能进行了三维数值模拟研究.结果表明:相比定角螺旋风力机,变角螺旋风力机在较小尖速比(TSR)时具有更大的功率系数(... 详细信息

为了拓展水平轴风力机的适用范围,采用计算流体力学对2种具有不同旋叶倾角的新型水平轴螺旋风力机及其加装导管后的气动性能进行了三维数值模拟研究.结果表明:相比定角螺旋风力机,变角螺旋风力机在较小尖速比(TSR)时具有更大的功率系数(C_(P));同时,变角螺旋风力机在全TSR范围内具有更小的推力系数(C_(T)),且2种螺旋风力机C_(T)的差异随着TSR的增大而增大;2种螺旋风力机运行时高压区主要集中在轮毂前端、一阶和二阶旋叶的迎风端,低压区主要集中在三阶旋叶的背风端和轮毂后端;变角螺旋风力机前端旋叶的阻塞度相对较低,使其尾流恢复比定角螺旋风力机快;此外,导管可以显著增大2种螺旋风力机的C_(P)和C_(T),并拓宽C_(P)的TSR范围.研究结果揭示了水平轴螺旋风力机的气动特点,为该型风力机的优化设计和推广应用提供了一定的参考依据.

关键词：风能水平轴螺旋风力机导管气动性能计算流体力学

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西南地区不同类型植被NPP时空演变及影响因素探究

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环境科学 2024年第1期45卷 262-274页

作者：徐勇郑志威孟禹弛盘钰春郭振东张炎桂林理工大学测绘地理信息学院桂林541006 多特蒙德工业大学空间规划学院多特蒙德44135

研究植被净初级生产力(NPP)时空变化规律并探明其驱动影响因素,对于深入了解植被时空变化,指导因地制宜的生态恢复与管理工程具有重要的现实意义.以MODIS NPP数据为基础,结合基于站点的气象数据、土地利用数据和植被类型数据,通过Theil-... 详细信息

研究植被净初级生产力(NPP)时空变化规律并探明其驱动影响因素,对于深入了解植被时空变化,指导因地制宜的生态恢复与管理工程具有重要的现实意义.以MODIS NPP数据为基础,结合基于站点的气象数据、土地利用数据和植被类型数据,通过Theil-Sen Median斜率估计和Mann-Kendall显著性检验探究西南地区不同类型植被NPP时空演变特征,并结合稳定性分析和地理探测器揭示不同类型植被NPP空间分异的影响因素及影响因素间的交互作用.结果表明:(1)时间上,2000~2021年西南地区植被NPP、NPP_(Pre)(仅气候变化影响下植被NPP)和NPP_(Res)(仅人类活动影响下植被NPP)均呈波动上升趋势.在不同类型植被中,除乔木类植被NPP_(Res)以-0.183 g·(m^(2)·a)^(-1)的速率呈微弱下降趋势外,其余类型植被NPP、NPP_(Pre)和NPP_(Res)均呈上升趋势,其中,经济类植被NPP、NPP_(Pre)和NPP_(Res)上升速率均最显著,分别为5.96、3.09和2.94 g·(m^(2)·a)^(-1);空间上,下降趋势最大的乔木类植被NPP主要分布在西藏和云南南部,上升趋势最高的经济类植被NPP主要分布在四川省东部.西南地区植被NPP稳定性呈“南低北高”的空间分布格局,波动系数平均值以乔木类(0.101)、灌木类(0.105)、草本类(0.110)和经济类(0.114)的顺序依次升高.地表温度和相对湿度的交互作用是西南地区植被NPP空间分异的主要影响因素,而日照时数∩温暖指数对西南地区植被影响提升最大,提升百分比为30.91%;不同类型植被对不同气候因子需求存在差异,但对地表温度和温暖指数的需求存在高度一致性,当地表温度为21.03~28.49℃,温暖指数为106.46~167.2时,不同类型植被NPP均会达到峰值.自然演替下,气候对植被的影响程度与植被群落稳定性成反比,稳定性高的乔木类植被群落受气候影响小,稳定性低的草本类植被群落受气候影响大,而经济类植被由于受人类活动的影响,导致气候对其影响程度与稳定性成正比.研究结果可为调查区域气候变化对不同类型植被生长影响,制定因地制宜的西南地区生态恢复治理方案提供理论依据.

关键词：中国西南地区不同植被类型植被净初级生产力时空演变地理探测器

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质谱离子源内裂解和重排可能会为化学反应中间体的捕获带来错误信息

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质谱学报 2024年第1期45卷 111-122,I0004页

作者：赵玲玲梁驰予汪杰张新星南开大学化学学院天津300071

质谱法广泛应用于在线反应监测和高活性中间体捕获,极大助力了化学反应机理研究。微液滴具有极端的化学环境,有望捕获高活性中间体,与质谱联用可实现原位表征。有报道表明,微液滴表面的局部强酸环境可以稳定短寿命的碳正离子,结合在线... 详细信息

质谱法广泛应用于在线反应监测和高活性中间体捕获,极大助力了化学反应机理研究。微液滴具有极端的化学环境,有望捕获高活性中间体,与质谱联用可实现原位表征。有报道表明,微液滴表面的局部强酸环境可以稳定短寿命的碳正离子,结合在线质谱可以检测其信号。本文使用电喷雾电离质谱(ESI-MS)测定了一系列碳正离子的前体分子,在排除微液滴效应影响的前提下,检测到这些碳正离子信号。进一步的实验表明,受进样毛细管高温和管透镜电压的共同影响,在质谱的粗真空区域,前体物种会发生源内裂解产生碳正离子碎片,这些碎片可能会被误判为液滴反应中产生的高活性中间体,从而影响反应机理研究。本工作表明,在使用质谱进行反应监测和中间体捕获研究时,应谨慎地考察各仪器参数,尤其是离子光学系统所加电压对离子的影响,以避免对化学反应机制的误判。

关键词：电喷雾电离质谱(ESI-MS) 碳正离子源内裂解

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Q345qDNH桥梁耐候钢在模拟工业大气环境中的腐蚀产物膜演变规律

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腐蚀与防护 2024年第6期45卷 55-61页

作者：赵伟于驰王月香东北大学秦皇岛分校资源与材料学院秦皇岛066004 莱芜钢铁集团银山型钢有限公司技术研发中心济南271104

采用干湿交替周期浸润腐蚀试验,研究了Q345qDNH桥梁耐候钢在模拟工业大气腐蚀环境中的腐蚀行为及其腐蚀产物膜演变规律,并与Q345B钢进行了比较。结果表明:在模拟工艺大气环境中,随着浸润周期的延长,Q345qDNH钢的腐蚀质量损失量逐渐降低... 详细信息

采用干湿交替周期浸润腐蚀试验,研究了Q345qDNH桥梁耐候钢在模拟工业大气腐蚀环境中的腐蚀行为及其腐蚀产物膜演变规律,并与Q345B钢进行了比较。结果表明:在模拟工艺大气环境中,随着浸润周期的延长,Q345qDNH钢的腐蚀质量损失量逐渐降低,并在腐蚀72 h后趋于平缓,在整个试验周期内,Q345B钢的腐蚀质量损失量始终大于Q345qDNH钢;在腐蚀后期(120 h),Q345B钢发生了严重的点蚀,而Q345qDNH钢表面锈层较完整,膜层致密性较高,对金属基体的保护作用较好,耐蚀性较好;Q345B钢和Q345qDNH钢表面腐蚀产物的主要成分均为α-FeOOH、γ-FeOOH和Fe_(3)O_(4),但各组分含量及膜层厚度存在差异;随着试验时间的延长,Q345qDNH钢表面腐蚀产物内膜层厚度明显增大,Ni、Cr和Cu氧化产物富集于内膜层,这增强了氧化膜层的致密性和稳定性,从而提高了材料的耐蚀性。

关键词： Q345qDNH耐候钢工业大气环境腐蚀行为腐蚀产物膜耐蚀元素

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