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Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang yuqi Liu Fangxia Xu Chengcheng Zhou Kaimei Lu Bin Fang Lijuan Wang Lina Huang zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

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RECENT ADVANCES IN RESEARCH AND FORECASTING OF TROPICAL CYCLONE TRACK, INTENSITY, AND STRUCTURE AT LANDFALL

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Tropical Cyclone Research and Review 2018年第2期7卷 85-105页

作者： MARIE-DOMINIQUE LEROUX KIMBERLY WOOD RUSSELL L.ELSBERRY ESPERANZA O.CAYANAN ERIC HENDRICKS MATTHEW KUCAS PETER OTTO ROBERT ROGERS BUCK SAMPSON zifeng yu Météo-France DIROI/EC Mississippi State University University of Colorado-Colorado Springs Philippine Atmospheric Geophysical and Astronomical Services Administration Naval Postgraduate School Joint Typhoon Warning Center Bureau of Meteorology NOAA/AOML/Hurricane Research Division Naval Research Laboratory Shanghai Typhoon Institute and Laboratory of Typhoon Forecast Technique China Meteorological Administration

This review prepared for the fourth International Workshop on Tropical Cyclone Landfall Processes(IWTCLP-4) summarizes the most recent(2015-2017) theoretical and practical knowledge in the field of tropical cyclone(TC) track, intensity, and structure rapid changes at or near landfall. Although the focus of IWTCLPIV was on landfall, this summary necessarily embraces the characteristics of storms during their course over the ocean prior to and leading up to landfall. In the past few years, extremely valuable observational datasets have been collected for TC forecasting guidance and research studies using both aircraft reconnaissance and new geostationary or low-earth orbiting satellites at high temporal and spatial resolution. Track deflections for systems near complex topography such as that of Taiwan and La Réunion have been further investigated, and advanced numerical models with high spatial resolution necessary to predict the interaction of the TC circulation with steep island topography have been developed. An analog technique has been designed to meet the need for longer range landfall intensity forecast guidance that will provide more time for emergency preparedness. Probabilistic track and intensity forecasts have also been developed to better communicate on forecast uncertainty. Operational practices of several TC forecast centers are described herein and some challenges regarding forecasts and warnings for TCs making landfall are identified. This review concludes with insights from both researchers and forecasters regarding future directions to improve predictions of TC track, intensity, and structure at landfall.

关键词： tropical cyclone track intensity structure landfall rapid intensification rapid changes

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Adaptive Fourier Decomposition of the First Three SARS-CoV-2 Infection Waves with Epidemic Intervention—London,UK,2020-2022

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China CDC weekly 2024年第21期6卷 478-486,I0006-I0008页

作者： Zige Liu Guibin Lu Cheokieng Vong Zhiqi Zeng Wei He Zhijie Lin Cuiyun Lin Kaichin Hsieh zifeng Yang Arlindo L.Oliveira Chitin Hon Department of Engineering Science Faculty of Innovation EngineeringMacao University of Science and TechnologyMacao SARChina Queen Ethelburga’s Collegiate Thorpe Underwood EstateYorkUK State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Respiratory Disease AI Laboratory on Epidemic and Medical Big Data Instrument Applications Department of Engineering ScienceFaculty of Innovation EngineeringMacao University of Science and TechnologyMacao SARChina Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Faculty of Innovation Engineering School of Computer Science and EngineeringMacao University of Science and TechnologyMacao SARChina University College London UCL Faculty of Engineering SciencesLondonUK Guangzhou Laboratory Guangzhou CityGuangdong ProvinceChina Instituto de Engenharia de Sistemas e Computadores:Investigação e Desenvolvimento em Lisboa LisboaPortugal Instituto Superior Técnico Universidade de LisboaLisboaPortugal

Background:This study provides a detailed analysis of the daily fluctuations in coronavirus disease 2019(COVID-19)case numbers in London from January 31,2020 to February 24,*** primary objective was to enhance understanding of the interactions among government pandemic responses,viral mutations,and the subsequent changes in COVID-19 case ***:We employed the adaptive Fourier decomposition(AFD)method to analyze diurnal changes and further segmented the AFD into novel multi-component groups consisting of one to three *** restructured components were rigorously evaluated using Pearson correlation,and their effectiveness was compared with other signal analysis *** study introduced a novel approach to differentiate individual components across various time-frequency scales using basis decomposition ***:Analysis of London’s daily COVID-19 data using AFD revealed a strong correlation between the“stay at home”directive and high-frequency components during the first epidemic *** indicates the need for sustained implementation of vaccination policies to maintain their ***:The AFD component method provides a comprehensive analysis of the immediate and prolonged impact of governmental policies on the spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).This robust tool has proven invaluable for analyzing COVID-19 pandemic data,offering critical insights that guide the formulation of future preventive and public health strategies.

关键词： offering sustained London

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The wheat sucrose synthase gene TaSus1 is a determinant of grain number per spike

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The Crop Journal 2024年第1期12卷 295-300页

作者： Liping Shen Lili Zhang Changbin Yin Xiaowan Xu Yangyang Liu Kuocheng Shen He Wu Zhiwen Sun Ke Wang Zhonghu He Xueyong Zhang Chenyang Hao Jian Hou Aoyue Bi Xuebo Zhao Daxing Xu Botao Ye Xuchang yu Ziying Wang Danni Liu yuanfeng Hao Fei Lu zifeng Guo Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China China National Botanical Garden Beijing 100093China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Crop Sciences Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China University of Chinese Academy of Sciences Beijing 100049China International Maize and Wheat Improvement Center(CIMMYT)China Office c/o CAASBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Some haplotypes of the sucrose synthase gene TaSus1 are associated with thousand-grain weight(TGW)in wheat(Triticum aestivum L.).However,no mutations have been identified within the gene to test this *** effects of TaSus1 on grain number per spike(GNS)also are largely *** previous genome-wide association study identified TaSus-A1 as a candidate gene controlling fertile spikelet number per spike(FSN).In the present study,we generated two independent mutants for the three TaSus1 homoeologs by CRISPR/Cas9-mediated genome *** triple mutants displayed lower FSN,GNS,grain number per spikelet(GNST),and TGW than wild-type *** 306 hexaploid wheat accessions,two single-nucleotide polymorphisms in TaSus-A1 contributed differently to *** of the two alleles into a wheat genetic background confirmed their *** alleles differed in geographical distribution among the accessions.

关键词： Domestication selection Fertile spikelet number per spike(FSN) Geographical differentiation Grain number per spike(GNS) TaSus1

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Linear-Quadratic Pareto Cooperative Game for Mean-Field Backward Stochastic System

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Journal of Systems Science & Complexity 2024年第3期37卷 947-964页

作者： WANG yu School of Control Science and Engineering Shandong UniversityJinan 250061China

This paper focuses on a Pareto cooperative differential game with a linear mean-field backward stochastic system and a quadratic form cost functional. Based on a weighted sum optimality method, the Pareto game is equivalently converted to an optimal control problem. In the first place,the feedback form of Pareto optimal strategy is derived by virtue of decoupling technology, which is represented by four Riccati equations, a mean-field forward stochastic differential equation(MF-FSDE),and a mean-field backward stochastic differential equation(MF-BSDE). In addition, the corresponding Pareto optimal solution is further obtained. Finally, the author solves a problem in mathematical finance to illustrate the application of the theoretical results.

关键词： Backward stochastic differential equation linear-quadratic control mean-field Pareto optimality

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温度对7A04铝销-50CrMo4钢盘摩擦副干滑动摩擦磨损行为的影响

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摩擦学学报 2023年第10期43卷 1189-1200页

作者：余梓枫李迪凡邵泳林屈盛官罗丹李小强华南理工大学国家金属材料近净成形工程技术研究中心广东广州510640 中国兵器工业第五九研究所重庆400039

针对7xxx铝合金温热成型过程中模具磨损等问题,本文作者研究了不同温度对7A04铝销-50CrMo4钢盘摩擦副干滑动摩擦磨损行为的影响.采用光学显微镜、3D光学轮廓仪和扫描电子显微镜等对试样的微观组织、磨痕形貌、磨损亚表层组织以及磨屑形... 详细信息

针对7xxx铝合金温热成型过程中模具磨损等问题,本文作者研究了不同温度对7A04铝销-50CrMo4钢盘摩擦副干滑动摩擦磨损行为的影响.采用光学显微镜、3D光学轮廓仪和扫描电子显微镜等对试样的微观组织、磨痕形貌、磨损亚表层组织以及磨屑形貌进行了表征.结果表明,随着试验温度的升高,摩擦系数先降低后升高.7A04铝销的磨损率先减小后增大;其磨损机制以磨粒磨损为主.50CrMo4钢盘的磨损率先增大后减小,在225℃时降至最低;其室温下的磨损机制为磨粒磨损、胶合黏着磨损和剥层磨损的混合磨损机制,温度从125℃升至175℃时转变为轻微磨粒磨损和一般黏着磨损的混合磨损机制;各温度下均存在明显的材料转移现象.7A04铝销在125℃时开始出现机械混合层,伴随有明显的氧化现象,这将导致在225℃下机械混合层结构变得疏松且易剥落.在225℃下50CrMo4钢磨损亚表面的变形晶粒区和动态再结晶区厚度增大,表面硬度下降,塑性增加,形成长条状的切屑.7A04铝销表面机械混合层的氧化及塑性变形层的变化与50CrMo4钢磨损表面动态再结晶的变化决定了在不同温度中2种材料各具有不同的磨损率与磨损形式.

关键词： 7A04铝 50CrMo4钢温度干滑动磨损磨屑

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The Impact of Medical Resources and Oral Antiviral Drugs on SARS-CoV-2 Mortality—Hong Kong SAR,China,2022

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China CDC weekly 2024年第21期6卷 469-477,I0001-I0005页

作者： Zhiqi Zeng Jingyi Liang Zhijie Lin Wenda Guan Wei He Qianying Li Lixi Liang Weiqi Pan Zige Liu Guibin Lu Xiaoyan Deng Eric HY Lau Chitin Hon zifeng Yang Guangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Macao Institute of Systems Engineering Macao University of Science and TechnologyMacao SARChina Respiratory Disease AI Laboratory on Epidemic Intelligence and Medical Big Data Instrument Applications Faculty of Innovative EngineeringMacao University of Science and TechnologyMacao SARChina State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina School of Public Health The University of Hong KongHong Kong SARChina Laboratory of Data Discovery for Health Hong Kong SARChina Guangzhou Laboratory Guangzhou CityGuangdong ProvinceChina

Introduction:The Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)demonstrates increased transmissibility compared to earlier strains,contributing to a significant number of fatalities in Hong Kong Special Administrative Region(HKSAR),*** medical resources and medications are essential in mitigating these *** study evaluates the effects of supplementary resources from the Chinese mainland during the fifth wave of the pandemic in ***:Vector autoregression(VAR)was employed to analyze data from the Oxford coronavirus disease 2019(COVID-19)Government Response Tracker to assess the effectiveness of control measures during five waves of the pandemic in ***,a transmission dynamics model was created to investigate the influence of supplementary medical resources from the Chinese mainland and oral medications on ***:In the initial four waves,workplace closures,restrictions on public events,international travel bans,and shielding the elderly significantly influenced pandemic ***,during the fifth wave,these measures showed no notable *** comparing a situation without extra medical resources or COVID-19 oral medication,there was a 17.7%decrease in COVID-19 fatalities with mainland medical resources and an additional 10.2%reduction with oral ***,they contributed to a 26.6%decline in ***:With the rapid spread of the virus,regional reallocation of medical resources may reduce mortality even when the local healthcare system is overstretched.

关键词： mainland Impact travel

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RECENT ADVANCES IN RESEARCH AND FORECASTING OF TROPICAL CYCLONE RAINFALL

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Tropical Cyclone Research and Review 2018年第2期7卷 106-127页

作者： KEVIN CHEUNG zifeng yu RUSSELL L.ELSBERRY MICHAEL BELL HAIYAN JIANG TSZ CHEUNG LEE KUO-CHEN LU YOSHINORI OIKAWA LIANGBO QI ROBERT F.ROGERS KAZUHISA TSUBOKI Macquarie University Shanghai Typhoon Institute University of Colorado Colorado Springs Colorado State University Florida International University Hong Kong Observatory Pacific Science Association RSMC Tokyo/Japan Meteorological Agency Shanghai Meteorological Service NOAA/AOML/Hurricane Research Division Nagoya University

In preparation for the Fourth International Workshop on Tropical Cyclone Landfall Processes(IWTCLP-IV), a summary of recent research studies and the forecasting challenges of tropical cyclone(TC) rainfall has been prepared. The extreme rainfall accumulations in Hurricane Harvey(2017) near Houston, Texas and Typhoon Damrey(2017) in southern Vietnam are examples of the TC rainfall forecasting challenges. Some progress is being made in understanding the internal rainfall dynamics via case studies. Environmental effects such as vertical wind shear and terrain-induced rainfall have been studied, as well as the rainfall relationships with TC intensity and structure. Numerical model predictions of TC-related rainfall have been improved via data assimilation, microphysics representation, improved resolution, and ensemble quantitative precipitation forecast techniques. Some attempts have been made to improve the verification techniques as well. A basic forecast challenge for TC-related rainfall is monitoring the existing rainfall distribution via satellite or coastal radars, or from over-land rain gauges. Forecasters also need assistance in understanding how seemingly similar landfall locations relative to the TC experience different rainfall distributions. In addition, forecasters must cope with anomalous TC activity and landfall distributions in response to various environmental effects.

关键词： tropical cyclone landfall rainfall nowcast forecast verification

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Topological Stability and Entropy for Certain Set-valued Maps

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Acta Mathematica Sinica,English Series 2024年第4期40卷 962-984页

作者： yu ZHANG yu Jun ZHU School of Mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

In this paper,the dynamics(including shadowing property,expansiveness,topological stability and entropy)of several types of upper semi-continuous set-valued maps are mainly considered from differentiable dynamical systems points of *** is shown that(1)if f is a hyperbolic endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has theε-shadowing property,and moreover,if f is an expanding endomorphism then there exists a C^(1)-neighborhood U of f such that the induced set-valued map F_(f,U)has the Lipschitz shadowing property;(2)when a set-valued map F is generated by finite expanding endomorphisms,it has the shadowing property,and moreover,if the collection of the generators has no coincidence point then F is expansive and hence is topologically stable;(3)if f is an expanding endomorphism then for eachε>0 there exists a C^(1)-neighborhood U of f such that h(F_(f,U,ε))=h(f);(4)when F is generated by finite expanding endomorphisms with no coincidence point,the entropy formula of F is ***,the dynamics of the set-valued maps based on discontinuous maps on the interval are also considered.

关键词： Set-valued map orbit space hyperbolic endomorphism perturbation shadowing expansiveness topological stability entropy

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A new liquid membrane diffusion model for characterizing the adsorption kinetics of europium by using a continuous measurement of adsorption platform

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Nuclear Science and Techniques 2024年第1期35卷 59-72页

作者： Hao-Qi yu Tao yu Jian-Hua Ye State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China CGN Cangnan Nuclear Power Co. Ltd.Cangnan 325800China Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices East China University of TechnologyNanchang 330013China School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

To explore the kinetic adsorption under continuous and nonequilibrium states, an integration of continuous measurement and adsorption platform kinetics method was proposed, which was initially called the ICM-AP kinetics method, and a corresponding kinetic adsorption experimental method was developed. Adsorption experiments of europium(Eu) on Ca-bentonite,Na-bentonite, and the D231 cation exchange resin were performed using the ICM-AP kinetics method and continuous measurements. Because the kinetic experimental results observed in this study were different from those of traditional batch adsorption data, pseudo-first-order or pseudo-second-order kinetic models were unsuitable for fitting the experimental ***, a liquid membrane diffusion(LMD) model was developed based on the assumption of simultaneous adsorption/desorption to discuss the mechanism of kinetic adsorption. The kinetic adsorption mechanism was also studied by using *** results indicated that the proposed adsorption model can fit the experimental data more suitably, and the adsorption/desorption behaviors of Eu on bentonite and the D231 resin were simultaneously observed, suggesting that the adsorption kinetics of Eu(Ⅲ) was mainly dominated by hydrated Eu(Ⅲ) ions on the liquid membrane.

关键词： ICM-AP method LMD model Adsorption mechanism Eu(Ⅲ)

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