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Paleogene transgression process and environmental evolution in the deepwater area of the Baiyun Depression in the northern South China Sea

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Acta Oceanologica Sinica 2024年第4期43卷 15-24页

作者： Peijun Qiao yuchi Cui Qiong Ma qiang yu Lei Shao State Key Laboratory of Marine Geology Tongji UniversityShanghai 200092China CNOOC Energy Technology&Services-Drilling&Production Co. CNOOC Central Laboratory Shenzhen BranchGuangdong 516000China

Multiple borehole samples are collected from the Baiyun Depression in deep-water area of the northern South China Sea(SCS)in an effort to reconstruct transgression processes during the Paleogene based on palynalgal *** study indicates that the Baiyun Depression generated a large group of palynopore assemblages and fluvial/lacustrine-related algae during the early and middle Eocene when the Wenchang Formation was *** entire depression was dominated by fluvial and lacustrine facies before *** eastern and southeastern sags transitioned to shallow marine environment by generating a large abundance of marine dinoflagellates during the Enping deposition of the late ***,the southern uplift zone simply yielded fluvial/lacustrine-related palynopores and algae,and was dominated by the fluvial and lacustrine environment during the early stage of the Enping Formation,prior to shifting into transitional setting in the later *** sags remained extensive fluvial and delta facies without existence of marine *** was until the depositional stage of the Zhuhai Formation(Oligocene)that the overall depression was strongly impacted from transgression *** eastern and southeastern sags were mainly under deep marine setting on a continental slope while northwestern and southern areas developed transitional *** distribution and accumulation patterns varied greatly among sub-sags,the overall Baiyun Depression was characterized by widespread development of marine *** should be noted that the northwestern sag also partly generated large-scale river delta *** to the eustatic rise and change of SCS spreading axis,the overall Baiyun Depression was mostly influenced by the deep marine environment on a continental slope during the early *** northwestern sag and southern uplift zone were found plentiful marine *** summary,transgression initiated from the ea

关键词： South China Sea Paleogene transgression sedimentary environment plant ecology

Machine Learning-based Identification of Contaminated Images in Light Curve Data Preprocessing

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Research in Astronomy and Astrophysics 2024年第4期24卷 287-295页

作者： Hui Li Rong-Wang Li Peng Shu yu-qiang Li yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Space Object and Debris Observation Chinese Academy of SciencesNanjing 210023China

Attitude is one of the crucial parameters for space objects and plays a vital role in collision prediction and debris *** light curves to determine attitude is the most commonly used *** photometric observations,outliers may exist in the obtained light curves due to various ***,preprocessing is required to remove these outliers to obtain high quality light *** statistical analysis,the reasons leading to outliers can be categorized into two main types:first,the brightness of the object significantly increases due to the passage of a star nearby,referred to as“stellar contamination,”and second,the brightness markedly decreases due to cloudy cover,referred to as“cloudy contamination.”The traditional approach of manually inspecting images for contamination is time-consuming and ***,we propose the utilization of machine learning methods as a *** Neural Networks and SVMs are employed to identify cases of stellar contamination and cloudy contamination,achieving F1 scores of 1.00 and 0.98 on a test set,*** also explore other machine learning methods such as ResNet-18 and Light Gradient Boosting Machine,then conduct comparative analyses of the results.

关键词： techniques:image processing methods:data analysis light pollution

Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways

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Food Science and Human Wellness 2024年第1期13卷 115-123页

作者： yue yu Haibin Zhu Mingyue Shen qiang yu Yi Chen Shiru Mo Jianhua Xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China International Institute of Food Innovation Nanchang UniversityNanchang 330200China

The biological activity of plant polysaccharides can be enhanced by sulfated *** this study,the immunomodulatory effect of sulfated Cyclocarya paliurus polysaccharides(SCP3)on macrophages RAW264.7 and its potential molecular mechanism were *** showed that SCP3 at 25-100μg/m L increased viability and improved phagocytosis of RAW264.7 ***,SCP3 could activate mitogen-activated protein kinase(MAPK)and nuclear factor kappa B(NF-κB)signaling pathways,which increased the phosphorylation of Erk1/2,JNK,p38 and NF-κB p65,promoting secretion of cytokines tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and nitric oxide(NO)as well as the production of reactive oxygen species(ROS).In addition,Toll-like receptor 4(TLR4)receptor inhibitors were able to block the production of NO and TNF-αby SCP3-stimulated *** on Western blot analysis and validation using specific inhibitors against MAPK and NF-κB signaling pathways,the results demonstrated that SCP3 induced macrophages activation and enhanced TNF-αand NO production via TLR4-mediated MAPK and NF-κB *** summary,SCP3 has significant immunomodulatory *** underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production,which in turn activates the downstream MAPK/NF-κB signaling pathway and then increases the secretion levels of cytokines and NO.

关键词： Cyclocarya paliurus Sulfated polysaccharides Macrophages Immunomodulatory Mechanism

Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2024年第10期30卷 1393-1404页

作者： Ming-Hui Zeng Qi-yu Shi Liang Xu yu-qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Gastroenterology Cangzhou People’s HospitalCangzhou 061000Hebei ProvinceChina Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Tianjin Research Institute of Liver Diseases Tianjin 300192China

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,affecting about 1/4th of the global population and causing a huge global economic *** date,no drugs have been approved for the treatment of NAFLD,making the correction of unhealthy lifestyles the principle method of *** patients with poor adherence to lifestyle correction and attempting to improve their adherence are therefore very *** To develop and validate a scale that can rapidly assess the adherence of patients with NAFLD to lifestyle *** The Exercise and Diet Adherence Scale(EDAS)was designed based on com-pilation using the Delphi method,and its reliability was subsequently *** and laboratory indicators were measured,and patients completed the EDAS questionnaire at baseline and after 6 *** efficacy of the EDAS was evaluated in the initial ***,the efficacy of the EDAS was internally verified in a validation *** The EDAS consisted of 33 items in six dimensions,with a total of 165 *** EDAS score correlated significantly with daily number of exercise and daily reduction in calorie intake(P500 kacl/d),(sensitivity/specificity was 100.0%/75.8%),while patients score below 97 could nearly rule out the possibility of daily exercise(sensitivity/specificity was 89.5%/44.4%).Total EDAS scores≥116,97-115,and<97 points were indicative of good,average,and poor adherence,respectively,to diet and exercise *** The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.

关键词： Fatty liver Lifestyle intervention Behavioral change Patient adherence Compliance

Analysis of mechanical strengths of extreme line casing joint considering geometric, material, and contact nonlinearities

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Petroleum Science 2024年第3期21卷 1992-2004页

作者： Ji-yun Zhang Chi Peng Jian-Hong Fu Quan Cao yu Su Jian-yun Pang Zi-qiang yu Petroleum Engineering School Southwest Petroleum UniversityChengdu610500SichuanChina Engineering Technology Research Institute of CNPC Southwest Oil and Gas Field Company Chengdu610017SichuanChina

To address the challenges associated with difficult casing running,limited annular space,and poor cementing quality in the completion of ultra-deep wells,the extreme line casing offers an effective solution over conventional ***,due to its smaller size,the joint strength of extreme line casing is reduced,which may cause failure when running in the *** address this issue,this study focuses on the CST-ZTΦ139.7 mm×7.72 mm extreme line casing and employs the elastic-plastic mechanics to establish a comprehensive analysis of the casing joint,taking into account the influence of geometric and material nonlinearities.A finite element model is developed to analyze the forces and deformations of the extreme line casing joint under axial tension and external collapse *** model investigates the stress distribution of each thread tooth subjected to various tensile forces and external ***,the tensile strength and crushing strength of the extreme line casing joint are determined through both analytical and experimental *** findings reveal that,under axial tensile load,the bearing surface of each thread tooth experiences uneven stress,with relatively high equivalent stress at the root of each thread *** end thread teeth are valuable spots for *** is observed that the critical fracture axial load of thread decreases linearly with the increase of thread tooth *** external pressure,the circumferential stress is highest at the small end of the external thread,leading to yield *** tensile strength of the joint obtained from the finite element model exhibits a relative error of less than 7%compared to the analytical and experimental values,proving the reliability of the finite element *** tensile strength of the joint is 3091.9 k ***,in terms of anti-collapse capability,the joints demonstrate higher resistance to collapse compared to the casing body,which is consistent with the test resul

关键词： Extreme line casing Elastic-plastic mechanics Finite element analysis Tensile strength Collapse strength

Suspected coexistence of perianal necrotizing sweet syndrome in chronic myelomonocytic leukemia:A case report

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1176-1183页

作者： Ke-qiang yu Hui-Xiang Li Jing Wu Clinical Medicine School Chengdu University of Chinese MedicineChengdu 610072Sichuan ProvinceChina Institute of Integrated Traditional Chinese and Western Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Chronic myelomonocytic leukemia(CMML)complicated with Sweet syndrome(SS)is a rare hematological ***,cases of concomitant development of perianal necrotizing SS(NSS)have not been *** SUMMARY We report a case of a 49-year-old male patient who underwent sequential procedures for hemorrhoids and perianal *** developed postoperative incision infection and was referred to the department where the authors ***,perianal necrotizing fasciitis secondary to incision infection after perianal abscess surgery was *** receiving antibiotic therapy and undergoing surgical debridement,deeper necrotic areas formed in the patient’s perianal wounds,accompanied by persistent high *** and fungal cultures yielded negative *** final diagnosis was corrected to be CMML with suspected concomitant perianal *** CMML with perianal NSS is a rare condition,often misdiagnosed as perianal abscess or perianal necrotizing *** antibiotic therapy and surgical debridement are ineffective in managing this condition.

关键词： Chronic myelomonocytic leukemia Sweet syndrome Necrotizing fasciitis Perianal abscess Case report

A Plasma Membrane Polarity Sensor Harnessing Conjoined Twisted Intramolecular Charge Transfer Modulation and Charge Number Control Strategy

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CCS Chemistry 2024年第3期6卷 733-748页

作者： yu-qiang Zhao Le yu Liping Zhu Jinsong Liang Ying Zhou Jong Seung Kim College of Chemical Science and Technology Yunnan UniversityKunming 650091 Department of Chemistry Korea UniversitySeoul 02841 TheranoChem Incorporation Seoul 02856

Polarity is a critical microenvironmental factor of the plasma membrane,which can offer valuable insights into various biological ***,we proposed a novel strategy for the construction of fluorescent agents to measure plasma membrane polarity by conjoining twisted intramolecular charge transfer(TICT)modulation and charge number *** is shown that compounds with a stronger TICT tendency are more sensitive to polarity shifts due to the number of dialkylated amino groups present(from 1 to 3),and the molecules with two or more charged centers remain in the plasma ***,we developed two fluorescent agents with high polarity sensitivity,excellent turn-on ratios,and superior ability,to target the plasma *** the wash-free fluorescence imaging and fluorescence lifetime tests,our designed agent could detect plasma membrane polarity with high precision,allowing effective distinction between cancer cells and normal cells based on their differences in plasma membrane ***,both fluorescence and fluorescence lifetime changes of the plasma membrane in the ferroptosis model established by Sorafenib confirmed an increase in plasma membrane polarity during cell ferroptosis.

关键词： membrane polarity fluorescence agents fluorescence imaging fluorescence lifetime imaging

Identification and functional analysis of CG3526 in spermatogenesis of Drosophila melanogaster

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Insect Science 2024年第1期31卷 79-90页

作者： Qihao Hu Yanhong Xiao Runnan Wei Ting Tang Liang Wen yuzhen Lu Xiao-qiang yu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou510631 China

Spermatogenesis is a critical part of reproduction in insects;however,its molecular mechanism is still largely *** this study,we identified a testis-specific gene CG3526 in Drosophila *** analysis showed that CG3526 contains a zinc binding domain and 2 C2H2 type zinc fingers,and it is clustered to the vertebrate really interesting new gene(RING)family E3 ubiquitin-protein *** CG3526 was knocked down by RNA interference(RNAi),the testis became much smaller in size,and the apical tip exhibited a sharp and thin end instead of the blunt and round shape in the control *** importantly,compared to the control flies,only a few mature sperm were present in the seminal vesicle of C587-Gal4>CG3526 RNAi *** staining of the testis from CG3526 RNAi flies showed that the homeostasis of testis stem cell niche was disrupted,cell distribution in the apical tip was scattered,and the process of spermatogenesis was not ***,we found that the phenotype of CG3526 RNAi flies’testis was similar to that of testis of Stat92E RNAi flies,the expression level of CG3526 was significantly downregulated in the Stat92EF06346 mutant flies,and the promoter activity of CG3526 was upregulated by *** together,our results indicated that CG3526 is a downstream effector gene in the JAK-STAT signaling pathway that plays a key role in the spermatogenesis of Drosophila.

关键词： CG3526 JAK-STAT spermatogenesis STAT92E testis

XOR spin logic operated by unipolar current based on field-free spin-orbit torque switching induced by a lateral interface

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Rare Metals 2024年第8期43卷 3868-3875页

作者： Yan-Ru Li Mei-Yin Yang Guo-qiang yu Bao-Shan Cui Jin-Biao Liu Yong-Liang Li Qi-Ming Shao Jun Luo Key Laboratory of Microelectronic Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences(IMECAS)Beijing 100029China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou UniversityLanzhou 730000China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

Spin logics have emerged as a promising avenue for the development of logic-in-memory *** particular,the realization of XOR spin logic gates using a single spin-orbit torque device shows great potential for low-power stateful logic circuits in the next *** this study,we successfully obtained the XOR logic gate by utilizing a spin-orbit torque device with a lateral interface,which was created by local ion implantation in the Ta/Pt/Co/Ta Hall device exhibiting perpendicular magnetic *** angle of the lateral interface is set at 45°relative to the current direction,leading to the competition between symmetry breaking and current-driven Néel-type domain wall ***,the field-free magnetic switching reversed is realized by the same sign of current amplitude at this *** on this field-free magnetic switching behavior,we successfully proposed an XOR logic gate that could be implemented using only a single spin-orbit torque Hall *** study provides a potentially viable approach toward efficient spin logics and in-memory computing architectures.

关键词： Filed-free magnetic switching Spin-orbit torque XOR logic gate Lateral interface