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By using either endogenous or transplanted stem cells,which could you prefer for neural regeneration？

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Neural Regeneration Research 2018年第10期13卷 1731-1732页

作者： satoru matsuda yukie nakagawa kumi amano yuka ikeda ai tsuji yasuko kitagishi department of food science and nutrition nara women's University Kita—Uoya Nishimachi Nara Iapa

Neural regeneration by stem cells transplantation：Tissue regeneration and homeostasis are principally dependent on tissue stem cells which possess abilities of self-renewal and differentiation into multidirectional specialized cell *** general,stem cells are critical for normal tissue renewal as well as repair after tissue *** example,mesenchymal stromal cells and endothelial progenitor cells identified in bone marrow could.

关键词： SPINAL-CORD-INJURY ISCHEMIA

EXPLORATION　ON　THE　BASIC　ACTIVE　CENTRES　OF　KF/Al_2O_3:EFFECTOF　PRETREATMENT　TEMPERATURE

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Chinese Chemical Letters 1995年第9期6卷 811-814页

作者： Zhu, JH tsuji, H Kabashima, H Hattori, H Kita, H Nanjing Univ Dept Chem Nanjing 210093 Peoples R China Hokkaido Univ Grad Sch Environm Earth Sci Div Sci Mat Sapporo Hokkaido 060 Japan Hokkaido Univ Ctr Adv Res Energy Technol Sapporo Hokkaido 060 Japan

Abstract: KF/Al2O3 reached maxinmun activity at the pretreatment temperature(Tp) of 623K or 723K in Ibuters isomerization at 273K. according to the amount of KF loaded. Further increment of Tp lowered the activity of KF/Al2O3 due the suppression of [Al-OHF]strong basic sites through dehydroxylation. Changes in the state and function ofF caused the deactivation of KF/Al2O3 at high Tp.

关键词： KF/Al2O3 PRETREATMENT THE CENTRES BASIC ACTIVE Al

Mass screening-based case-control study of diet and prostate cancer in Changchun, China

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Asian Journal of Andrology 2008年第4期10卷 551-560页

作者： Xiao-Meng Li Jiang Li Ichiro tsuji Naoki Nakaya Yoshikazu Nishino Xue-Jian Zhao School of Life Sciences Northeast Normal University Changchun 130024 China School of Basic Medical Sciences Changchun 130041 China Dental Hospital Jilin University Changchun 130041 China Department of Public Health Tohoku University Sendai 980-8576 Japan

Aim： To investigate possible correlation factors for prostate cancer by a population-based case-control study in China. Methods： We carded out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value （〈 4.1 ng/mL） by 1：10 according to age and place of employment. A case-control study of diet and prostate cancer was then carded out. Results： After adjustment for education, body mass index （BMI）, smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio （OR） of 0.38 （95% confidence interval [CI], 0.13-1.12）. In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 （95% CI, 0.11-0.79） compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer. Conclusion： Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer.

关键词： soybean prostate cancer case-control study diet

A pedunculated polyp-shaped small-bowel lymphangioma causing gastrointestinal bleeding and treated by double-balloon enteroscopy

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World Journal of Gastroenterology 2012年第34期18卷 4798-4800页

作者： Akihiko Kida Koichiro Matsuda Satoshi Hirai Akiyoshi Shimatani yousuke Horita Katsushi Hiramatsu Mitsuru Matsuda Hidero Ogino Shin Ishizawa Yatsugi Noda Department of Internal Medicine Toyama Prefectural Central Hospital Department of Clinical Pathology Toyama Prefectural Central Hospital

We report a rare case of a small-bowel lymphangioma causing massive gastrointestinal (GI) bleeding that we successfully diagnosed and treated using double-balloon enteroscopy (DBE). An 81-year-old woman suffering from repeated GI bleeding of unknown origin underwent a capsule endoscopy at a previous hospital. She was suspected of having bleeding from the jejunum, and was referred to our department for diagnosis and treatment. An oral DBE revealed a 20 mm × 10 mm, regularly surfaced, white to yellowish, elongated, pedunculated jejunal polyp with small erosions at 10 cm distal to the ligament of Treiz. Since no other source of bleeding was identified by endoscopy in the deep jejunum, anendoscopic polypectomy (EP) was performed for this lesion. A subsequent histopathological examination of the resected polyp showed clusters of lymphatic vessels with marked cystic dilatation in the submucosa and the deep layer of the lamina propria mucosae. These characteristics are consistent with the typical features of small-bowel lymphangioma with erosions. Although clip-ping hemostasis was performed during EP, re-bleeding occurred. Finally, a complete hemostasis was achieved by performing an additional argon plasma coagulation.

关键词：小肠的淋巴管瘤胃肠的流血双汽球 enteroscopy

Imaging assessment of photosensitizer emission induced by radionuclide-derived Cherenkov radiation using charge-coupled device optical imaging and long-pass filters

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World Journal of Radiology 2023年第11期15卷 315-323页

作者： Winn Aung Atsushi B tsuji Kazuaki Rikiyama Fumihiko Nishikido Satoshi Obara Tatsuya Higashi Department of Molecular Imaging and Theranostics Institute for Quantum Medical ScienceNational Institutes for Quantum Science and TechnologyChiba 263-8555Japan Department of Advanced Nuclear Medicine Sciences Institute for Quantum Medical ScienceNational Institutes for Quantum Science and TechnologyChiba 263-8555Japan

BACKGROUND Radionuclides produce Cherenkov radiation(CR),which can potentially activate photosensitizers(PSs)in *** groups have studied Cherenkov energy transfer to PSs using optical imaging;however,cost-effectively identifying whether PSs are excited by radionuclide-derived CR and detecting fluorescence emission from excited PSs remain a *** laboratories face the need for expensive dedicated *** To cost-effectively confirm whether PSs are excited by radionuclide-derived CR and distinguish fluorescence emission from excited *** The absorbance and fluorescence spectra of PSs were measured using a microplate reader and fluorescence spectrometer to examine the photo-physical properties of *** mitigate the need for expensive dedicated equipment and achieve the aim of the study,we developed a method that utilizes a chargecoupled device optical imaging system and appropriate long-pass filters of different wavelengths(manual sequential application of long-pass filters of 515,580,645,700,750,and 800 nm).Tetrakis(4-carboxyphenyl)porphyrin(TCPP)was utilized as a model *** doses of copper-64(^(64)CuCl_(2))(4,2,and 1 mCi)were used as CR-producing *** and data acquisition were performed 0.5 h after sample *** image analysis was conducted by using ImageJ software(National Institutes of Health)to visually evaluate TCPP *** The maximum absorbance of TCPP was at 390-430 nm,and the emission peak was at 670 *** CR and CRinduced TCPP emissions were observed using the optical imaging system and the high-transmittance long-pass filters described *** emission spectra of TCPP with a peak in the 645-700 nm window were obtained by calculation and subtraction based on the serial signal intensity(total flux)difference between^(64)CuCl_(2)+TCPP and^(64)CuCl_(2).Moreover,the differential fluorescence images of TCPP were obtained by subtracting the^(64)CuCl_(2)image from the^

关键词： Tetrakis(4-carboxyphenyl)porphyrin Photosensitizer emission Radionuclide Cherenkov radiation Optical imaging Long-pass filters

Anchor-wire technique for multiple plastic biliary stents to prevent stent dislocation

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World Journal of Gastroenterology 2011年第28期17卷 3366-3368页

作者： Tsuyoshi Hamada yousuke Nakai Saburo Matsubara Hiroyuki Isayama Akiko Narita Kazuhiro Watanabe Yukihiro Koike Shigeo Matsukawa Tateo Kawase Kazuhiko Koike Department of Gastroenterology Kanto Central Hospital Department of Gastroenterology Graduate School of MedicineThe University of Tokyo

In endoscopic placement of multiple plastic biliary stents (PBSs),we sometimes experience proximal dislocation of the first PBS at the time of subsequent PBS *** describe the case of a 79-year-old male with obstructive jaundice caused by cholangiocarcinoma who needed to receive multiple PBS placements for management of *** proximal dislocation of the first PBS was observed,we prevented the dislocation via our technique of using guidewire inserted from the distal end of the first PBS to the side hole as the *** could complete this technique only by inserting guidewire through the side hole of the first PBS during the process of releasing the first PBS and pulling out the guidewire and the inner *** did not matter whether the anchor-wire went towards the third portion of the duodenum or the duodenal *** we introduce this "anchor-wire technique",which is useful for the prevention of PBS proximal dislocation in placing multiple PBSs.

关键词：技术支架错位胆道塑料锚 PBS 十二指肠

Pathogenesis of childhood idiopathic nephrotic syndrome:a paradigm shift from T-cells to podocytes

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World Journal of Pediatrics 2015年第1期11卷 21-28页

作者： Kazunari Kaneko Shoji tsuji Takahisa Kimata Tetsuya Kitao Sohsaku Yamanouchi Shogo Kato Department of Pediatrics Kansai Medical University2-5-1 Shin-machiHirakataOsaka 573-1010Japan

Background:Nephrotic syndrome is the most common cause of kidney disease in children,but its pathogenesis remains *** article reviews the novel aspects of the mechanisms underlying massive proteinuria in minimal-change disease,which is the most common form of childhood nephrotic *** sources:This article integrates the findings of a PubMed database search for English language articles published in the past 40 years(from September 1974 to February 2014)using the key words"pathogenesis","minimal change nephrotic syndrome"or"idiopathic ne phrotic syndrome".Results:Unknown humoral factors associated with T-cell dysfunction have been thought to play an important role in the pathogenesis of minimal-change ***,recent findings are changing this paradigm,i.e,visceral glomerular epithelial cells(podocytes)may be involved via expression of molecules such as CD80 and angiopoietin-like ***:Recent evidence suggests that minimal-change disease results from interactions between humoral factors and dysfunctional *** addition to immunosuppressant drugs that target lymphocytes,a biological agent such as an antibody against the abnormal molecule(S)expressed by podocytes may provide novel drug treatment for minimal-change disease.

关键词： angiopoietin-like 4 CD80 cytokine minimal change nephrotic syndrome podocyte

Effect of high pressure torsion process on the microhardness,microstructure and tribological property of Ti6Al4V alloy

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Journal of Materials Science & Technology 2021年第35期94卷 183-195页

作者： Guanyu Deng Xing Zhao Lihong Su Peitang Wei Liang Zhang Lihua Zhan Yan Chong Hongtao Zhu Nobuhiro tsuji School of Mechanical MaterialsMechatronic and Biomedical EngineeringUniversity of WollongongNSW 2500Australia Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan State Key Laboratory of High Performance Complex Manufacturing.Central South University Changsha 4W083China Stare Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400030China International Joint Laboratory for Light Alloys(MOE) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Department of Materials Science and Engineering University of California BerkeleyCA 94720United States Elements Strategy Initiative for Structural Materials(ESISM) Kyoto UniversityKyoto 606-8501Japan

In the present study,a fully lamellar Ti6Al4V alloy was severely deformed by high pressure torsion(HPT)process under a pressure of 7.5 GPa up to 10 *** results revealed that the microhardness of Ti6Al4V was increased remarkably by about~41%and saturated at about 432 Hv after the HPT process.A relatively uniform bulk nanostructured Ti6Al4V alloy with an average grain size of about52.7 nm was obtained eventually,and no obvious formation of metastableωphase was detected by XRD *** the first time,the tribological properties of the HPT processed Ti6Al4V alloy were investigated by a ball-on-disc test at room temperature under a dry *** was found that HPT process had a great influence on the friction and wear behaviors of Ti6Al4V *** increasing the number of HPT revolutions,both friction coefficient and specific wear rate were obviously decreased due to the reduction of abrasion and adhesion *** being deformed by 10 HPT revolutions,the friction coefficient was reduced from about 0.49 to 0.37,and the specific wear rate was reduced by about 48%.The observations in this study indicated that HPT processed Ti6Al4V alloys had good potential in structural applications owing to their greatly improved mechanical and tribological properties.

关键词： Severe plastic deformation High pressure torsion UFG microstructure Mechanical property Friction and wear Ti6Al4V alloy

Remnant neuromuscular junctions in denervated muscles contribute to functional recovery in delayed peripheral nerve repair

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Neural Regeneration Research 2020年第4期15卷 731-738页

作者： Leyang Li Hiroyuki Yokoyama Hidetoshi Kaburagi Takashi Hirai Kunikazu tsuji Mitsuhiro Enomoto Yoshiaki Wakabayashi Atsushi Okawa Department of Orthopedic and Spinal Surgery Graduate SchoolTokyo Medical and Dental UniversityTokyoJapan Department of Cartilage Regeneration Tokyo Medical and Dental UniversityTokyoJapan

Schwann cell proliferation in peripheral nerve injury(PNI)enhances axonal regeneration compared to central nerve ***,even in PNI,long-term nerve damage without repair induces degeneration of neuromuscular junctions(NMJs),and muscle atrophy results in irreversible *** peripheral regeneration of motor axons depends on the duration of skeletal muscle *** overcome this difficulty in nerve regeneration,detailed mechanisms should be determined for not only Schwann cells but also NMJ degeneration after PNI and regeneration after nerve ***,we examined motor axon denervation in the tibialis anterior muscle after peroneal nerve transection in thy1-YFP mice and regeneration with nerve reconstruction using *** number of NMJs in the tibialis anterior muscle was maintained up to 4 weeks and then decreased at 6 weeks after *** contrast,the number of Schwann cells showed a stepwise decline and then reached a plateau at 6 weeks after *** regeneration,we reconstructed the degenerated nerve with an allograft at 4 and 6 weeks after injury,and evaluated functional and histological outcomes for 10 to 12 weeks after grafting.A higher number of pretzel-shaped NMJs in the tibialis anterior muscle and better functional recovery were observed in mice with a 4-week delay in surgery than in those with a 6-week *** repair within 4 weeks after PNI is necessary for successful recovery in *** of synaptic acetylcholine receptor degeneration may play a key role in peripheral nerve *** animal experiments were approved by the Institutional Animal Care and Use Committee of Tokyo Medical and Dental University on 5 July 2017,30 March 2018,and 15 May 2019(A2017-311C,A2018-297A,and A2019-248A),respectively.

关键词： axon nerve allograft nerve regeneration neurodegeneration neuromuscular junction peripheral nerve injury Schwann cell skeletal muscle