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Lessons in bridge damage learned from the Wenchuan earthquake

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Earthquake Engineering and Engineering Vibration 2009年第2期8卷 275-285页

作者： W. Phillip Yen Genda Chen Mark Yashinski youssef Hashash Curtis Holu Wang Kehai GuoXiaodong Turner-Fairbank Highway Research Center of Federal Highway Administration （FWHA） Center for Transportation Infrastructure and Safety （CTIS） a National University Transportation Center at Missouri University of Science and Technology California Department of Transportation Representing the Earthquake Engineering Research Institute （EERI） University of Illinois at Urbana Champaign and Representing Geo-Engineering Earthquake Reconnaissance （GEER） Mid-America Earthquake Center （MAE） University of Illinois at Urbana Champaign Research Institute of Highway the Ministry of Communication of China Sichuan Province Highway Planning Survey Design and Research Institute China

A strong earthquake occurred in Wenchuan County, Sichuan Province, China, on May 12, 2008. Shortly after the earthquake, the Turner-Fairbank Highway Research Center of the Federal Highway Administration, in partnership with the Research Institute of Highways, the Ministry of Communication of China, led a reconnaissance team to conduct a post-earthquake bridge performance investigation of the transportation system in the earthquake affected areas. The U.S. transportation system reconnaissance team visited the area during July 20 24, 2008. This paper presents the findings and lessons learned by the team.

关键词： earthquake engineering bridge engineering post earthquake investigation

Dynamic connectedness between stock markets in the presence of the COVID‑19 pandemic:does economic policy uncertainty matter?

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Financial Innovation 2021年第1期7卷 273-299页

作者： Manel youssef Khaled Mokni Ahdi Noomen Ajmi College of Business Administration Northern Border UniversityArar 91431Saudi Arabia Institut Superieur de Gestion de Gabes Gabes University6002 GabesTunisia Department of Business Administration College of Science and Humanities in SlayelPrince Sattam Bin Abdulaziz UniversityAl‑KharjSaudi Arabia ESC de Tunis Manouba UniversityManoubaTunisia

This study investigates the dynamic connectedness between stock indices and the effect of economic policy uncertainty(EPU)in eight countries where COVID-19 was most widespread(China,Italy,France,Germany,Spain,Russia,the US,and the UK)by implementing the time-varying VAR(TVP-VAR)model for daily data over the period spanning from 01/01/2015 to 05/18/*** showed that stock markets were highly connected during the entire period,but the dynamic spillovers reached unprecedented heights during the COVID-19 pandemic in the first quarter of ***,we found that the European stock markets(except Italy)transmitted more spillovers to all other stock markets than they received,primarily during the COVID-19 *** analysis using a nonlinear framework showed that the dynamic connectedness was more pronounced for negative than for positive ***,findings showed that the direction of the EPU effect on net connectedness changed during the pandemic onset,indicating that information spillovers from a given market may signal either good or bad news for other markets,depending on the prevailing economic *** results have important implications for individual investors,portfolio managers,policymakers,investment banks,and central banks.

关键词： Stock markets Dynamic connectedness COVID-19 pandemic Economic policy uncertainty TVP-VAR model

Fluid Flow and Convective Heat Transfer in a Water Chemical Condenser

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Fluid Dynamics & Materials Processing 2020年第2期16卷 199-209页

作者： Mounir Kriraa Khalid Souhar Driss Achemlal youssef Ait Yassine Abdelmajid Farchi IMII Ingénierie Management et Innovation IndustriellFSTHassan 1er UniversitySettatMorocco LMPEQ National School of Applied SciencesSafiCadi Ayyad UniversityMarrakechMorocco LGEMS Laboratory National School of Applied SciencesIbn Zohr UniversityAgadir80000Morocco Engineering Sciences Laboratory Department of MathematicsPhysics and InformaticsPolydisciplinary Faculty of TazaSidi Mohamed Ben Abdellah UniversityFezMorocco Ibn Zohr University Higher School of TechnologyLaâyouneMorocco Ibn Zohr University Faculty of ScienceLaboratory of Thermodynamics and EnergyAgadirMorocco

In this paper,a detailed investigation of water(Pr=7.0)convection in a chemical condenser is carried *** openings are located along one side of the *** Navier-Stokes equations are solved in the frame of a control volume method using the SIMPLEC algorithm to implement adequate coupling of pressure and *** emphasis is given to the influence of the Reynolds number,the tilt of the channel and the Rayleigh number on the convective heat *** are presented and discussed allowing the control parameters to span relatively wide intervals:Rayleigh number(10^(4)≤Ra≤5×10^(5)),channel inclination(0°≤90°)and Reynolds number(10≤Re≤1000).On the basis of these results,a new correlation of the Nusselt number is elaborated.

关键词： Chemical condenser tilted channel convection numerical study heat transfer

Tissue-specific cancer stem/progenitor cells:Therapeutic implications

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World Journal of Stem Cells 2023年第5期15卷 323-341页

作者： Amani Yehya Joe youssef Sana Hachem Jana Ismael Wassim Abou-Kheir Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon

Surgical resection,chemotherapy,and radiation are the standard therapeutic modalities for treating *** approaches are intended to target the more mature and rapidly dividing cancer ***,they spare the relatively quiescent and intrinsically resistant cancer stem cells(CSCs)subpopulation residing within the tumor ***,a temporary eradication is achieved and the tumor bulk tends to revert supported by CSCs'resistant *** on their unique expression profile,the identification,isolation,and selective targeting of CSCs hold great promise for challenging treatment failure and reducing the risk of cancer ***,targeting CSCs is limited mainly by the irrelevance of the utilized cancer models.A new era of targeted and personalized anti-cancer therapies has been developed with cancer patient-derived organoids(PDOs)as a tool for establishing pre-clinical tumor ***,we discuss the updated and presently available tissue-specific CSC markers in five highly occurring solid ***,we highlight the advantage and relevance of the threedimensional PDOs culture model as a platform for modeling cancer,evaluating the efficacy of CSC-based therapeutics,and predicting drug response in cancer patients.

关键词： Cancer stem cells Therapy resistance Tissue-specific cancer stem cell markers Patient-derived organoids Pre-clinical cancer models

Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

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Journal of Traditional Chinese Medicine 2024年第2期44卷 408-416页

作者： LI Zhenxuan WANG Xuerui Luis Ulloa Ayman youssef BAI Yunjing XU Xiaolong LIU Qingquan Department of Infectious Diseases Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases Beijing 100010China Infection immunity laboratory Beijing Institute of Traditional Chinese MedicineBeijing 100010China Clinical College of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Center for Perioperative Organ Protection Department of AnesthesiologyDuke University Medical CenterDurhamNorth Carolina 27710USA

Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep *** is associated with higher mortality and long-term outcomes,particularly substantial declines in cognitive *** mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain,a disrupted blood–brain barrier,oxidative stress,neurotransmitter dysfunction,and severe microglial *** evidence suggests that complementary and alternative medicine,especially Traditional Chinese Medicine(TCM),is favorable in alleviating cognitive decline after ***,we summarized the studies of traditional herbal remedies,TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.

关键词： sepsis-associated encephalopathy cognitive dysfunction complementary therapies neuroinflammatory diseases medicine Chinese traditional review

Effect of rare earth on physical properties of Na_(0.5)Bi_(0.5)TiO_(3)system:A density functional theory investigation

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Journal of Rare Earths 2022年第3期40卷 473-481,I0005页

作者： Manal Benyoussef Halima Zaari Jamal Belhadi youssef El Amraoui Hamid Ez-Zahraouy Abdelilah Lahmar Mimoun El Marssi Laboratory of Physics of Condensed Matter(LPMC) University of Picardie Jules VerneScientific Pole80039Amiens Cedex 1France Laboratory of Condensed Matter and Indisciplinary Science(LaMCScI) Faculty of ScienceMohammed V UniversityBP 1014RabatMorocco National School of Arts and Crafts Moulay Ismail University50500MeknesMorocco

Na_(0.5)(Bi_(3/4)RE_(1/4))_(0.5)TiO_(3)(RENBT,RE=Nd,Gd,Dy,and Ho)compounds were investigated in the framework of first-principles calculations using the full potential linearized augmented plane wave(FP-LAPW)method based on the spin-polarized density functional theory implemented in the WIEN2k *** charge density distribution and Ti K-edge X-ray absorption spectra reveal that the RENBT compositions with high polarization values are accompanied by a higher TiO_(6)distortion,DyNBT,and NdNBT *** effect of the rare-earth elements on the polarization is confirmed experimentally with the collection of the hysteresis *** investigation of the electronic properties of the compounds highlights the emergence of a magnetization owing to the 4f orbital effect of the rare-earth ***,the investigation of the chemical ordering shows a short-range chemical ordering for the pure composition and an increased A-site disorder for dysprosium doped NBT *** increased disorder may speak for increased relaxor properties in the RE doped compositions.

关键词： Density functional theory Sodium bismuth titanate Rare earths A-site ordering Ferroelectric properties Magnetization

Molecular principles of metastasis: a hallmark of cancer revisited

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2197-2213页

作者： Jawad Fares Mohamad Y.Fares Hussein H.Khachfe Hamza A.Salhab youssef Fares Department of Neurological Surgery Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA High-Impact Cancer Research Program Harvard Medical SchoolBostonMA 02115USA Faculty of Medicine American University of BeirutBeirutLebanon Neuroscience Research Center Faculty of Medical SciencesLebanese UniversityBeirutLebanon

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-related ***,it remains poorly *** continuous evolution of cancer biology research and the emergence of new paradigms in the study of metastasis have revealed some of the molecular underpinnings of this dissemination *** invading tumor cell,on its way to the target site,interacts with other proteins and *** of these interactions improved the understanding of some of the biological principles of the metastatic cell that govern its mobility and *** with the tumor microenvironment allows invading cancer cells to overcome stromal challenges,settle,and *** characteristics of cancer cells are driven by genetic and epigenetic modifications within the tumor cell itself and its *** the biological mechanisms of the metastatic process is crucial in finding open therapeutic windows for successful *** this review,the authors explore the recent advancements in the field of metastasis and highlight the latest insights that contribute to shaping this hallmark of cancer.

关键词： metastasis overcome visited

Natural regeneration of Pinus brutia Ten. in a recreational public forest in Zawita-Kurdistan region, Iraq

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Journal of Forestry Research 2019年第5期30卷 1849-1857页

作者： Hassan Muhamed Sami youssef Ahmed Mustafa Hishyer Suliman Aree Abdulqader Hishyer Mohammed Richard Michalet Department of Forestry College of AgricultureUniversity of DuhokDuhokKurdistan RegionIraq AMAP(Botany and Modelling of Plant Architecture and Vegetation) University of Montpellier34398 Montpellier Cedex 5France Department of Ecotourism College of AgricultureUniversity of DuhokDuhokKurdistan RegionIraq Directorate of Forestry and Rangelands DuhokKurdistan RegionIraq UMR CNRS 5805 EPOC Universitede BordeauxAllee Geoffroy Saint-Hilaire CS 5002333615 Pessac CedexFrance

Zawita natural forest has recently has been subject to mass recreational activities during spring that have denuded large areas of the *** was thus essential to assess regeneration before designing optimizing *** this end,we studied the overstory canopy and microhabitat conditions for recruitment of Pinus brutia Ten in 10 plots(20×25 m)on the southern aspects where the Zawita natural forest is still *** total,1540 regenerating *** were recorded,854 seedlings,597 saplings,and 89 *** and saplings were more frequent beyond the canopy than under the canopy of the parent *** requirements differed between seedlings and *** probability of the occurrence of seedlings was negatively correlated with increasing litter depth and increasing soil *** density of saplings only showed a positive significant correlation with increasing *** nearest neighbor index showed a trend toward a positive spatial association between understory shrubs with their neighboring seedlings at a mean distance of 1.6 ***,the study highlighted the requirements for seedling regeneration as a relatively open canopy cover,a light understory litter layer,and noncompacted *** results are a step towards designing effective management and restoration programs.

关键词： Forest structure Litter depth Regeneration niche Spatial pattern Soil compaction

Hepatitis C Screening: Barriers to Linkage to Care

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 226-231页

作者： Sammy Saab youssef PChallita Lisa MNajarian Rong Guo Satvir SSaggi Gina Choi Departments of Surgery University of California at Los AngelesLos AngelesCAUSA Departments of Medicine University of California at Los AngelesLos AngelesCAUSA Departments of Medicine Statistics Core University of California at Los AngelesLos AngelesCAUSA

Background andAims:Hepatitis C(HCV)is a medical and public health *** infected individuals are identified,management includes not only education but also the use of antiviral *** screening for HCV is readily available,barriers exist which prevent assessment and treatment in individuals potentially infected with ***:This is a retrospective study of patients screened for HCV within the University of California,Los Angeles Health Care System between February 22 and July 9,*** defined linkage to care as:1)confirmatory HCV RNA test after screening HCV antibody test found a positive result;and 2)follow-up appointment for treatment was established with a *** and baseline laboratory values were *** potentially associated with prohibiting linkage of care were ***:During the study period,17,512 individuals were screened for HCV.A total of 238(1.35%)were found to have detectable HCV *** the individuals with detectable HCV antibodies,48(20%)did not undergo confirmatory testing with viral *** the 190 individuals who underwent further testing,70 patients were noted to be *** them,17 of the 70(24%)were not linked to a specialist for further *** patients(p=0.02)and people who inject drugs(p=0.02)were less likely to be referred for specialty ***:The results of our study highlight that younger patients and people who inject drugs are less likely to be referred to specialty care for HCV *** are needed to engage these populations.

关键词： Hepatitis C Screening Linkage