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Updates on management of gliomas in the molecular age

World Journal of Clinical Oncology 2024年第2期15卷 178-194页

作者： Ali Ahmed mohamed Rakan Alshaibi Steven Faragalla youssef mohamed Brandon Lucke-Wold Charles E.Schmidt College of Medicine Florida Atlantic UniversityBoca RatonFL 33431United States Herbert Wertheim College of Medicine Florida International UniversityMiamiFL 33199United States College of Osteopathic Medicine Kansas City UniversityJoplinMO 64804United States Department of Neurosurgery University of FloridaGainesvilleFL 32611United States

Gliomas are primary brain tumors derived from glial cells of the central nervous system,afflicting both adults and children with distinct characteristics and therapeutic *** developments have ushered in novel clinical and molecular prognostic factors,reshaping treatment paradigms based on classi-fication and grading,determined by histological attributes and cellular *** review article delves into the diverse treatment modalities tailored to the specific grades and molecular classifications of gliomas that are currently being discussed and used clinically in the year *** adults,the therapeutic triad typically consists of surgical resection,chemotherapy,and *** contrast,pediatric gliomas,due to their diversity,require a more tailored *** complete tumor excision can be curative based on the location and grade of the glioma,certain non-resectable cases demand a chemotherapy approach usually involving,vincristine and ***-tionally,if surgery or chemotherapy strategies are unsuccessful,Vinblastine can be *** recent advancements in treatment methodologies,there remains a need of exploration in the literature,particularly concerning the efficacy of treatment regimens for isocitrate dehydrogenase type mutant astrocytomas and fine-tuned therapeutic approaches tailored for pediatric *** review article explores into the therapeutic modalities employed for both adult and pediatric gliomas in the context of their molecular classification.

关键词： Gliomas Chemotherapy Radiotherapy Isocitrate dehydrogenase type mutant Pediatric gliomas Astrocytoma Oligodendroglioma 1p/19q-codeleted

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Experimental study and numerical modeling of the thermal behavior of an industrial prototype ceramic furnace:Energy and environmental optimization

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Energy and Built Environment 2024年第2期5卷 244-254页

作者： Lahcen BALLI mohamed HLIMI youssef ACHENANI Adil ATIFI Bachir HAMRI Engineering Sciences and Applications Laboratory(LSIA) National School of Applied Sciences(ENSAH)Abdelmalek Essaadi UniversityTetouanMorocco Faculty of Sciences and Techniques Moulay Ismaïl UniversityP.O.Box 509-BoutalamineErrachidiaMorocco Engineering and Health Sciences and Technologies Research Center M2SMENSAMMohammed.V UniversityRabatMorocco Research Team Quality Maintenance Safety QSMMechanical EngineeringDepartment Mohammadia School of EngineersMohammed V UniversityRabatMorocco

This article focuses on the experimental and numerical study of an industrial prototype furnace intended for the production of ceramics in order to improve the energy efficiency and therefore optimize the fuel consumption and the corresponding carbon dioxide *** order to understand the thermal behavior from which stems the energy efficiency of the experimental prototype,we establish in this work,a simplified modeling allowing to establish a mathematical model describing the thermal behavior of the *** model is able to accurately predict the spatial and temporal distribution of the temperature at each point of the furnace to control the firing of the refractory product so that the final product is of good quality in terms of resistance and *** addition,the power consumed by the prototype must be optimized in order to reduce energy and environmental *** particular,this efficient technology has allowed us to save 83% of energy used in the traditional furnace and to reduce 87.36% of the relative carbon dioxide *** simulation of the mathematical model made it possible to compare the numerical results with the experimental measurements obtained by the prototype as well as to validate the model and to adjust the heat transfer parameters.

关键词： Numerical modeling Thermal behavior Ceramic furnace Refractory materials Energy efficiency

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Landslide susceptibility mapping using machine learning algorithms and comparison of their performance at Abha Basin,Asir Region,Saudi Arabia

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Geoscience Frontiers 2021年第2期12卷 639-655页

作者： Ahmed mohamed youssef Hamid Reza Pourghasemi Geology Department Faculty of ScienceSohag UniversityEgypt Geological Hazards Department Applied Geology SectorSaudi Geological SurveyP.O.Box 54141Jeddah21514Saudi Arabia Department of Natural Resources and Environmental Engineering College of AgricultureShiraz UniversityShirazIran

The current study aimed at evaluating the capabilities of seven advanced machine learning techniques(MLTs),including,Support Vector Machine(SVM),Random Forest(RF),Multivariate Adaptive Regression Spline(MARS),Artificial Neural Network(ANN),Quadratic Discriminant Analysis(QDA),Linear Discriminant Analysis(LDA),and Naive Bayes(NB),for landslide susceptibility modeling and comparison of their *** machine learning algorithms with spatial data types for landslide susceptibility mapping is a vitally important *** study was carried out using GIS and R open source software at Abha Basin,Asir Region,Saudi ***,a total of 243 landslide locations were identified at Abha Basin to prepare the landslide inventory map using different data *** the landslide areas were randomly separated into two groups with a ratio of 70%for training and 30%for validating *** landslide-variables were generated for landslide susceptibility modeling,which include altitude,lithology,distance to faults,normalized difference vegetation index(NDVI),landuse/landcover(LULC),distance to roads,slope angle,distance to streams,profile curvature,plan curvature,slope length(LS),and *** area under curve(AUC-ROC)approach has been applied to evaluate,validate,and compare the MLTs *** results indicated that AUC values for seven MLTs range from 89.0%for QDA to 95.1%for *** findings showed that the RF(AUC=95.1%)and LDA(AUC=941.7%)have produced the best performances in comparison to other *** outcome of this study and the landslide susceptibility maps would be useful for environmental protection.

关键词： Landslide susceptibility Machine learning algorithms Variables importance Saudi Arabia

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Paleoecology of Benthic Foraminifera in Coral Reefs Recorded in the Jurassic Tuwaiq Mountain Formation of the Khashm Al-Qaddiyah Area, Central Saudi Arabia

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Journal of Earth Science 2015年第2期26卷 224-235页

作者： mohamed youssef Abdelbaset S.El-Sorogy Department of Geology and Geophysics College of Science King Saud University Department of Geology Faculty of Science South Valley University Department of Geology Faculty of Science Zagazig University

Thirty three benthic foraminiferal species belong to 23 genera and 16 families have been recorded from the coral reefs of the Callovian Tuwaiq Formation, Khashm AI-Qaddiyah area, Central Saudi Arabia. Three species： Astacolus qaddiyahensis, Nodosaria riyadhensis, Siderolites jurassica are believed to be new. Nearly all identified foraminifera are of Atlantie-Miditeranean affinity. The foraminiferal assemblage recorded in the present work is mixed of open marine, moderately deep marine conditions associations and shallow to deep lagoon. The reefal part of upper Twiaq Formation may have been deposited in shallow water of lower to middle shelf depth （20-50 m） as indicated by abundant corals and benthic foraminifera. The coral fauna and bearing benthic foraminifera indicated moderate water energy.

关键词： coral reef benthic foraminifera Jurassic Tuwaiq Formation Saudi Arabia.

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Fabrication,characterization,and electrical conductivity properties of Pr_6O_(11) nanoparticles

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Journal of Rare Earths 2013年第7期31卷 701-708页

作者： Bahaa M.Abu-Zied youssef A.mohamed Abdullah M.Asiri Chemistry Department Faculty of ScienceKing Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia Chemistry Department Faculty of ScienceAssiut University71516 AssiutEgypt Center of Excellence for Advanced Materials Research(CEAMR) King Abdulaziz UniversityP.O.Box 80203Jeddah 21589Saudi Arabia

PrrOll nanoparticles were obtained by subsequent thermal decomposition of the as-prepared precipitate formed under ambient temperature and pressure using NaOH as precipitant. The calcination process was affected, for 1 h in static air atmosphere, at 400-700 ℃ temperature range. The different samples were characterized using X-ray diffraction （XRD）, transmission electron microscopy （TEM）, field emission scanning electron microscopy （FE-SEM）, thermogravimetric analysis （TGA）, in situ electrical conductivity, and N2 adsorption/desorption. The obtained results demonstrated that nano-crystalline Pr6O11, with crystallites size of 6-12 nm, started to form at 500 ℃. Such value increased to 20-33 nm for the sample calcined at 700℃. The as-synthesized PrrOll nanoparticles presented high electrical conductivity due to electron hopping between Pr（III）-Pr（IV） pairs.

关键词： nanocrystalline praseodymium oxide Pr6O11 nano structured materials electrical conductivity rare earths

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Preparation and Reactions of 2-Methyl-7-（3-methyl-5-oxo-1- phenyl-2-pyrazolin-4-yl）-5-arylthiazolo[3,2-a]- pyrimido[4,5-d]oxazin-4（5H）-one

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Chinese Journal of Chemistry 2011年第7期29卷 1473-1482页

作者： youssef, mohamed Salah K. Abbady, mohamed S. Ahmed, Ragaa A. Omar, Ahmed A. Chemistry Department Faculty of Science Assiut University Assiut 71516 Egypt

Ethyl 7-amino-3-（3-methyl-5-oxo- 1-phenyl-2-pyrazolin-4-yl）-5-aryl-5H-thiazolo[3,2-a]pyrimidine-6-carboxy- late was hydrolyzed with an ethanolic sodium hydroxide and the sodium salt thus formed underwent cyclization with acetic anhydride to afford 2-methyl-7-（3-methyl-5-oxo-l-phenyl-2-pyrazolin-4-yl）-5-arylthiazolo[3,2-a]- pyrimido[4,5-d]oxazin-4（SH）-one. This compound was transformed to related heterocyclic systems via its reaction with various reagents. The biological activity of the prepared compounds was tested against Gram positive and Gram negative bacteria as well as yeast-like and filamentous fungi. They revealed in some cases excellent biocidal properties.

关键词： thiazolopyrimidooxazinone thiazolopyrimidopyrimidines antimicrobial activity

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Endoscopic resection of superficial bowel neoplasia:The unmet needs in the Egyptian practice

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World Journal of Gastrointestinal Endoscopy 2022年第4期14卷 235-249页

作者： mohamed H Emara Mariam Zaghloul Haidi Karam-Allah Ramadan Salem youssef mohamed Mohammed Tag-Adeen Ahmed Alzamzamy mohamed Alboraie Ahmad Madkour Ahmed youssef Altonbary Tarik I Zaher Ahmed Abo Elhassan Nermeen Abdeen Mohammed Hussien Ahmed Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversityKafr Elshiekh 33516Egypt Department of Tropical Medicine and Gastroenterology Assiut UniversityAssiut 71515Egypt Department of Internal Medicine Faculty of MedicineGastroenterology and Hepatology UnitZagazig UniversityZagazig 44519Egypt Division of Gastroenterology and Hepatology Department of Internal MedicineSouth Valley UniversityQena Faculty of MedicineQena 83523Egypt Department of Gastroenterology and Hepatology Maadi Armed Forces Medical ComplexMilitary Medical AcademyCairo 11841Egypt Department of Internal Medicine Al-Azhar UniversityCairo11884Egypt Department of Endemic Medicine Helwan UniversityCairo 11795Egypt Department of Gastroenterology and Hepatology Mansoura UniversityMansoura 35516Egypt Department of Tropical Medicine Zagazig UniversityZagazig 44519Egypt Department of Tropical Medicine Suez Canal UniversityIsmailia 41522Egypt Department of Tropical Medicine Alexandria UniversityAlexandria 21526Egypt

BACKGROUND Management of superficial bowel neoplasia(SBN)in early stages is associated with better *** last few decades experienced a paradigm shift in the management of SBN with the introduction of advanced endoscopic resection techniques(ERTs).However,there are no clear data about the aspects of ERTs in Egypt despite the growing gastroenterology *** To investigate the knowledge,attitude,and practice of ERTs toward management of SBN among Egyptian practitioners and the suitability of the endoscopy units’infrastructures toward these *** An online 2-pages questionnaire was *** first page comprised demographic data,and questions for all physicians,about the knowledge(11 questions)of and attitude(5 questions)toward ERTs as a therapeutic option for *** second page investigated the practice of ERTs by endoscopists(6 questions)and the infrastructures of their endoscopy units(14 questions).The survey was disseminated through July 2021 and the data were collected in an excel sheet and later analyzed *** The complete responses were 833/2300(36.2%).The majority of the participants were males(n=560,67.2%),middle-aged(n=366,43.9%),consultants(n=464,55.7%),gastroenterologists(n=678,81.4%),spending≥15 years in practice(n=368,44.2%),and were working in university hospitals(n=569,68.3%).The majority correctly identified the definition of SBN(88.4%)and the terms polypectomy,endoscopic mucosal resection(EMR),and endoscopic submucosal dissection(ESD)(92.1%,90.2%,and 89.1%respectively).However,26.9%,43.2%and 49.5%did not recognize the clear indication of polypectomy,EMR,and ESD *** 68.1%of physicians are convinced about the ERTs for management of SBN;only 8.9%referred all candidate cases for *** 76.5%of endoscopists had formal training in the basic polypectomy techniques while formal training for EMR and ESD was encountered only in 31.9%and 7.2%*** 71.6%and 88.4%of endoscopists did not per

关键词： Endoscopic submucosal dissection Endoscopic mucosal resection Polypectomy Superficial bowel neoplasia Egypt

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利用SRTM绘制东Sahara大型古排水盆地及其对南埃及新发展计划的影响(英文)

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Geo-Spatial Information Science 2009年第3期12卷 182-190页

作者： Ahmed mohamed youssef Geological Engineering and GIS Geology Department Faculty of Science Sohag University

In the current study, the shuttle radar topography mission (SRTM) data, with～90 m horizontal resolution, were used to delineate the paleodrainage system and their mega basin extent in the East Sahara area. One mega-drainage basin has been detected, covering an area of 256 000 km2. It is classified into two sub mega basins. The Uweinate sub mega basin, which is composed of four main tributaries, collected water from a vast catchment region and drained eastward from the north, west, and southwest, starting at highland areas. The first subwatershed basin is in the northern plateau, south of the Abu-Balas area, with a total catchment area of 25 045 km2. The second subwatershed is in the Gilf Kebir plateau and has a total catchment area of 38 257 km2. The third subwatershed drains from the Uweinate highlands and has a catchment area of 46 154 km2. The fourth subwatershed, which is known in literature as Wadi Mokhtafi in its upper reach and Wadi Arid in its lower reach, drains the northwestern highlands of Sudan and has a total catchment area of 28 653 km2. The Tushka sub mega basin includes one watershed that drains from the northeast highlands of Sudan and has a total catchment area of 63 019 km2. The Uweinate and Tushka sub mega basins are joined together to the North of the Tushka depression, which drains northward toward the Kharga depression. This study indicates that the Eastern Sahara Mega Basin is a closed hydrological system independent of the other drainage systems, such as the Nile hydrosystem and the Qena Valley system. The present research illustrates the capability of the SRTM data in mapping the paleochannel networks, as well as estimate the catchment area and direction of the water flow. Finally, the study reveals that the four areas could be potentially used for different reclamation activities due to the ground water accumulations possibilities.

关键词：测绘任务撒哈拉项目地形雷达穿梭盆地映射

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Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents

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Genes & Diseases 2017年第3期4卷 170-175页

作者： Samar Samir Abdelmajed mohamed youssef Moushira Erfan Zaki Naglaa Abu-Mandil Hassan Somaia Ismail October University for Modern Sciences and Arts(MSA) GizaEgypt Organic chemistry Department Faculty of scienceCairo UniversityEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreEgypt Medical Molecular Genetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt

Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes *** genome-wide association studies(GWAS)confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated(FTO)gene and obesity in adults and children in different ethnic *** our study,the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and *** examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases,we used the restriction fragment length polymorphism(RFLP)technique to genotype the *** current study showed that there were no significant differences(P>0.05)between the cases and controls in both variants of rs17817449 and rs9939609 ***,there were significant correlations between rs17817449 and cholesterol and between rs9939609 and *** Current Study although the two variants(rs9939609 and rs17817449)didn’t show an association with obesity,but there was a correlation between the lipid profile and these two variants.

关键词： Children Egyptians Fat mass and obesity associated gene(FTO) Obesity Variants

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Surgical Outcome of Fusion in Recurrent Lumbar Disc Herniation

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Open Journal of Modern Neurosurgery 2020年第1期10卷 157-166页

作者： Ahmed Taha mohamed youssef Neurosurgery Department Faculty of Medicine Al-Azhar University Damietta Egypt

Background Data: Recurrent lumbar disc herniation means re-herniation of disc on the same site and at the same level where a previous discectomy had been performed: recurrent lumbar disc herniation occurs in 7% to 24% of patient underwent discectomy. Tow mean surgical options after reherniated lumbar disc are revision discectomy alone or revision discectomy with fusion discectomy alone in recurrent lumbar disc herniation may not be an efficient treatment without fusion. Objective: To evaluate the efficacy and safety of revision discectomy with fusion in management of recurrent lumbar disc. Study Design: Retrospective study reviewed all patient underwent revision discectomy with fusion, they were 40 patients operated for recurrent lumbar disc from September 2014 to April 2018 in Al-Azhar University Hospital Damietta. Pre- and post-operative data collection and analysis of the outcome were completed based on the “Japanese Orthopedic Association score” (JOAs), and radiographic follow-up. Patients and Methods: 40 patients (30 male and 10 female) underwent revision discectomy with fusion as surgical management for reherniated lumbar disc from September 2014 to April 2018. All patients presented with low back pain and radicular pain with mean duration of 18 months. The patients were investigated by standard plain X-ray CT SCAN and MRI of the lumbar spine. All patients had a discectomy and postero-lateral fusion in revision surgery. These patients followed post operatively clinically for improving pain and neural function, and radiologically for disc removal stability and fusion. Results: The age ranged from 30 to 60 years, mean age was 45 years, male to female ratio 3:1. Follow-up ranged from 18 - 30 months with a mean follow-up 24 months. 30 patients had an excellent outcome, 6 patients had a good outcome, 2 patients had a fair outcome, and 2 patients had a poor outcome. Conclusion: Recurrent lumbar disc herniation occurs in 7% to 24% of patient underwent discectomy. Rev

关键词： Reherniated Lumbar Disc Postero-Lateral Fusion Revision Discectomy

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