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Essential oils of Origanum compactum increase membrane permeability,disturb cell membrane integrity,and suppress quorum-sensing phenotype in bacteria

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Journal of Pharmaceutical Analysis 2019年第5期9卷 301-311页

作者： Abdelhakim Bouyahya Jamal Abrini Nadia Dakka youssef Bakri Laboratory of Human Pathologies Biology Department of Biology Faculty of Sciences and Genomic Center of Human Pathologies Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco Biology and Health Laboratory Department of Biology Faculty of Science Abdelmalek Essaadi University Tetouan Morocco

The aim of this study was to investigate antibacterial activity of Origanum compactum essential oils collected at three phenological stages on Escherichia coli and Bacillus subtilis. The antibacterial activity was evaluated using the agar-well diffusion assay. The MIC and MBC values were determined using the micro-dilution assay. The investigation of the antibacterial action was carried out by the evaluation of the effect of O. compactum essential oils on the antibacterial kinetic growth, the integrity of cell membrane and permeability of the cell membrane. The anti-quorum sensing activity was tested by the inhibition of the biofilm formation. The findings of this study showed that O. compactum essential oil has potent antibacterial activities against E. coli and B. subtilis. The lowest inhibition value against B. subtilis was obtained with O. compactum essential oil at the post-flowering stage (MIC=MBC=0.0312%(v/v)). The antibacterial mechanisms of O. compactum essential oils are related to the disturbing of the cell membrane integrity and the increasing of the membrane permeability, which leads to the leakage of genetic materials (DNA and RNA). Moreover, O. compactum essential oils inhibited the formation of the biofilms, a phenotype that has been known to be quorum sensing regulated.

关键词： Origanum compactum Essential oil Antibacterial action Cell membrane Quorum sensing inhibition

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Modelling and control of a grid-connected AC microgrid with the integration of an electric vehicle

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Clean Energy 2023年第4期7卷 707-720页

作者： youssef Akarne Ahmed Essadki Tamou Nasser Hammadi Laghridat Higher National School of Arts and Crafts(ENSAM) Mohammed V UniversityRabatMorocco National High School for Computer Science and Systems Analysis(ENSIAS) Mohammed V UniversityRabatMorocco

The purpose of this paper is to propose an efficient model and a robust control that ensures good power quality for the AC microgrid(MG)connected to the utility grid with the integration of an electric vehicle(EV).The MG consists of two renewable energy sources:a photovoltaic system(PVS)and a wind turbine system(WTS)based on a permanent magnet synchronous generator(PMSG),with the integration of an *** sources are used to supply active and reactive power to the AC bus and the utility *** power point tracking(MPPT)based on the perturb-and-observe(PO)method is used to increase the efficiency of the photovoltaic modules and improve overall *** MG system includes a 2-MW WTS,a 100-kW PVS and 12 kW provided by the *** validate the performance of the proposed system,a series of simulations were conducted using the MATLAB/Simulink?*** results demonstrate that the proposed system ensures high performance in terms of power quality,system stability,power tracking and safe integration of the EV.

关键词： microgrid wind turbine system photovoltaic system electric vehicle grid-to-vehicle vehicle-to-grid control systems

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Male genital damage in COVID-19 patients:Are available data relevant?

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Asian Journal of Urology 2021年第3期8卷 324-326页

作者： youssef Kharbach Abdelhak Khallouk Urology Department Tangier University HospitalFaculty of MedicineAbdelmalek Essaadi University90000TangierMorocco

Over the past few weeks,we have observed increasing concern about the possible impact of coronavirus disease 2019(COVID-19)which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2 virus)on male *** mechanisms of male reproductive damages are still unclear,but it seems that high temperature resulting from persistent fever and triggering a secondary autoimmune response leading to an autoimmune orchitis are the most likely involved ***,angiotensin conversion enzyme 2(ACE2)plays a highly important role in cellular entry for SARS-CoV-2 and male genital system presents high ACE2 *** these preliminary findings suggest that COVID-19 could impact men's reproductive ***,we examined available data including published and unpublished articles to assess the potential risk of COVID-19 in particular on the male reproductive system.

关键词： Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Male genital system Testis Male infertility

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Exploring physical features of anisotropic quark stars in Brans-Dicke theory with a massive scalar field via embedding approach

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Chinese Physics C 2022年第4期46卷 185-198页

作者： Abdelghani Errehymy G.Mustafa youssef Khedif Mohammed Daoud Laboratory of High Energy Physics and Condensed Matter(LPHEMaC) Department of PhysicsFaculty of Sciences Aïn ChockHassanⅡUniversity of CasablancaB.P.5366 MaarifCasablanca 20100Morocco Department of Physics Zhejiang Normal UniversityJinhua 321004China Department of Physics Faculty of SciencesUniversity of Ibn TofailB.P.133Kenitra 14000Morocco Abdus Salam International Centre for Theoretical Physics MiramareTrieste 34151Italy

The main aim of this study is to explore the existence and salient features of spherically symmetric relativistic quark stars in the background of massive Brans-Dicke *** exact solutions to the modified Einstein field equations are derived for specific forms of coupling and scalar field functions using the equation of state relating to the strange quark matter that stimulates the phenomenological MIT-Bag model as a free Fermi gas of *** use a well-behaved function along with the Karmarkar condition for class-one embedding as well as junction conditions to determine the unknown metric *** radii of strange compact stars viz.,PSR J1416-2230,PSR J1903+327,4U 1820-30,CenX-3,and EXO1785-248,are predicted via their observed mass for different values of the massive Brans-Dicke *** explore the influences of the mass of scalar field m_(ϕ),coupling parameter ωBD,and bag constant B on state determinants and perform several tests on the viability and stability of the constructed stellar ***,we find that our stellar system is physically viable and stable as it satisfies all the energy conditions and necessary stability criteria under the influence of a gravitational scalar field.

关键词： Brans-Dicke gravity karmarkar's condition exact solutions strange stars MIT bag EoS anisotropy

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On the Application of the Adomian’s Decomposition Method to a Generalized Thermoelastic Infinite Medium with a Spherical Cavity in the Framework Three Different Models

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Fluid Dynamics & Materials Processing 2019年第5期15卷 597-611页

作者： Najat A.Alghamdi Hamdy M.youssef Mathematics Department Faculty of ScienceUmm Al-Qura UniversityMakkahSaudi Arabia Mathematics Department Faculty of EducationAlexandria UniversityAlexandriaEgypt Mathematics Department Faculty of EngineeringUmm Al-Qura UniversityMakkahSaudi Arabia

A mathematical model is elaborated for a thermoelastic infinite body with a spherical cavity.A generalized set of governing equations is formulated in the context of three different models of thermoelasticity:the Biot model,also known as“coupled thermoelasticity”model;the Lord-Shulman model,also referred to as“generalized thermoelasticity with one-relaxation time”approach;and the Green-Lindsay model,also called“generalized thermoelasticity with two-relaxation times”*** Adomian’s decomposition method is used to solve the related mathematical *** bounding plane of the cavity is subjected to harmonic thermal loading with zero heat flux and *** results for the temperature,radial stress,strain,and displacement are represented *** is shown that the angular thermal load and the relaxation times have significant effects on all the studied fields.

关键词： Adomian’s decomposition method generalized thermoelasticity relaxation time iteration method

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Magnetocaloric Effect in Anisotropic Mixed Spin1/2–1 System: Pair Approximation Method

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Communications in Theoretical Physics 2019年第11期71卷 1370-1378页

作者： Abderrazak Boubekri Moulay youssef El Hafidi Mohamed El Hafidi Laboratory of Condensed Matter Physics Faculty of Sciences Ben M’sik Hassan II University of Casablanca

We use the Pair Approximation method to analyze the magnetic and magnetocaloric behaviors of diluted mixed spin SA=1 and spin SB=1/2 with the anisotropic Heisenberg model, on a cubic lattice with coordination number z=6. Our system is described in presence of an external magnetic field;the phase diagram and thermodynamic properties related to the concentration of magnetic atom(A or B) and the single ion anisotropy are constructed and *** attention is paid to magnetocaloric properties provided by isothermal entropy change as well as the cooling capacity. These cooling power keys are plotted and discussed as a function of interaction anisotropy and magnetic component concentration of two sublattices ions A and B. Numerical results show a double peak structure in the entropy change curve and the inverse magnetocaloric effect related to the presence of the negative single-ion anisotropy.

关键词： anisotropic Heisenberg model dilution entropy change mixed spin system inverse magnetocaloric effect pair approximation magnetic Gruneisen ratio

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Radiolarian and Planktic Foraminifera Biostratigraphy of the Early Albian Organic Rich Beds of Fahdene Formation,Northern Tunisia

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Journal of Earth Science 2014年第1期25卷 45-63页

作者： M Ben Fadhel T Zouaghi A Amri M Ben youssef Département de Géologie Faculté des Sciences de Gafsa-Campus Universitaire Sidi Ahmed Zarrouk–2112 Département des Géoressources CERTE–Technopole de Borj Cédria

The lower part of Fahdene Formation outcropping in northeastern Tunisia is repre- sented by pelagic sequences and characterized by an important siliciclastic fraction that includes ra- diolarian and organic-rich beds of Allam Member. Litho-biostratigraphic analysis based on planktic foraminifera and radiolaria shows that deposition of organic-rich beds of Allam Member is confined to the Microhedbergella rischi Zone through the lower part of Ticinella primula Zone. Age diagnostic radiolaria recovered from these beds has been identified to constrain a direct age of black shale depo- sition. The assemblages can be correlated with the radiolarian biochronozone U.A.10-11 indicating an Early Albian to early Middle Albian in age. Radiolarian assemblages composed of species characteris- tic of U.A.10 biochronozone （A. montisserei, D. gracilis） are associated with radiolarian taxa belonging to Costata Zone （U.A.9 Pseudoeucyrtis hanni and Thanarla pseudodecora）, which can be correlated with Dercourt Member in the Ionian Zone and Paquier level of the Vocontian Basin （southeast of France）. Biostratigraphic and abundance curves analysis has demonstrated significant diversification of cryptocephalic Nassellaria and Archaeodictyomitrae, probably adapted to eutrophic conditions that characterized the Aptian-Albian transition. Ecological conditions may have governed the stratigraphic range of many cosmopolitan taxa （i.e., Pseudodictyomitrae lodogaensis） compared with stratigraphic distributions schemes reported from other domains. The timing of black shales deposition was dia- chronic due to local geodynamic conditions and upwelling currents distribution. The Allam black shales are correlative with the oceanic anoxic event OAElb which is characterized by the widespread of supraregionnally organic-rich beds in the Mediterranean Tethys basins across the Aptian-Albian transition.

关键词： northeastern Tunisia Albian Allam Member black shale radiolaria planktic foraminifera.

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Dynamics of groundwater recharge near a semi-arid Mediterranean intermittent stream under wet and normal climate conditions

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Journal of Arid Land 2022年第7期14卷 739-752页

作者： youssef HAJHOUJI Younes FAKIR Simon GASCOIN Vincent SIMONNEAUX Abdelghani CHEHBOUNI Faculty of Sciences Semlalia Cadi Ayyad University40000MarrakechMorocco Center for Remote Sensing Application(CRSA) UM6P43150BenguerirMorocco Center for the Study of the Biosphere from Space(CESBIO) 31400ToulouseFrance

In arid and semi-arid stream-dominated systems,the temporal variability in groundwater recharge has not been widely *** questions remain about the sources of groundwater recharge,its patterns,and the appropriate measuring ***,the main objective of the present study was to assess the changes that might affect the pattern of groundwater recharge under wetter than normal surface water ***,the groundwater depth was monitored near a semi-arid Mediterranean intermittent stream on the piedmont of the High Atlas Mountains in the mountain catchment of the Wadi Rheraya over two hydrological years(2014-2016)with different climate conditions:extreme wet and normal *** recharge was assessed using the episodic master recession *** the two years,the pattern of groundwater recharge was dominated by episodic events and by a high seasonality from wet seasons to dry *** the wet year(2014-2015),the highest groundwater recharge was recorded following an extreme flood,which deeply replenished ***,an exceptional steady state of the groundwater depth was induced by a steady groundwater recharge *** several groundwater recharge events,the assessed recharge had multiple sources,mainly from streamflow at the local scale,but possibly from precipitation,underflow,deep percolation or irrigation return from the upstream part of the *** recharge by streamflow was likely to be short-lived,and lateral recharge was likely to last ***,the episodic master recession algorithm estimated the total groundwater recharge that could encompass various *** the future,more studies and multidisciplinary approaches should be carried out to partition these sources and determine their specific *** semi-arid stream-dominated systems,different groundwater recharge patterns induced by extreme hydrological events(e.g.,wet events)and various potential sources of gro

关键词： groundwater recharge water table fluctuation episodic master recession algorithm episodic recharge wet year Wadi Rheraya Citation:youssef HAJHOUJI

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Ultrafast laser dynamics of metal organic frameworks/TiO_2 nano-arrays hybrid composites for energy conversion applications

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Journal of Energy Chemistry 2019年第2期28卷 88-94页

作者： Fatma M.Ismail Daniel O'Neil Tareq youssef Souad A.Elfeky The National Institute of Laser Enhanced Sciences Cairo University Zewail City of Science and Technology Georgia Institute of Technology

Herein,we report the victorious synthesis of metal-organic frameworks(MOFs) on TiO_2 nanotubes(NTs)using a layer-by-layer(LbL) *** crystalline and homogenous thin films of MOFs were grown and characterized using XRD,SEM,FT-IR and UV/Vis ***,the utilization of the MOF films as sensitizers was probed in bespoke Graetzel type liquid junction solar *** constructed cell performance revealed an I_(sc) of 1.16 mA cm^(–2),Vocof 0.63 V,FF of 0.33,and E_(ff) of 0.42%.Further,pumpprobe transient laser spectroscopy was performed to investigate the energy and charge transfer dynamics of the MOFs/TiO_2 NTs *** results indicated 86% injection *** ultrafast pump-probe spectroscopy allows the investigation of this process and the differences between *** also showed that the relaxation of the MOF chromophores is in competition with electron injection in the Ti O2 *** this study provides a new insight into electron transfer from photoexcited metal-organic frameworks(MOFs) into titanium dioxide.

关键词： Ultrafast laser dynamics Metal-organic frameworks TiO2 nano-arrays Energy conversion Thin film

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The effect of microneedles on the skin permeability and antitumor activity of topical 5-fluorouracil

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Acta Pharmaceutica Sinica B 2014年第1期4卷 94-99页

作者： youssef W.Naguib Amit Kumar Zhengrong Cui The University of Texas at Austin College of PharmacyPharmaceutics DivisionAustinTX 78712USA

Topical 5-fluorouracil(5-FU)is approved for the treatment of superficial basal cell carcinoma and actinic ***,5-FU suffers from poor skin *** have been successfully applied to improve the skin permeability of small and large molecules,and even nanoparticles,by creating micron-sized pores in the stratum corneum layer of the *** this report,the feasibility of using microneedles to increase the skin permeability of 5-FU was *** full thickness mouse skin mounted on Franz diffusion apparatus,it was shown that the flux of 5-FU through the skin was increased by up to 4.5-fold when the skin was pretreated with microneedles(500μm in length,50μm in base diameter).In a mouse model with B16-F10 mouse melanoma cells implanted in the subcutaneous space,the antitumor activity of a commercially available 5-FU topical cream(5%)was significantly enhanced when the cream was applied on a skin area that was pretreated with microneedles,as compared to when the cream was simply applied on a skin area,underneath which the tumor cells were implanted,and without pretreatment of the skin with *** is not approved for melanoma therapy,but the clinical efficacy of topical 5-FU against tumors such as basal cell carcinoma may be improved by integrating microneedle technology into the therapy.

关键词： Microneedles 5-Fluorouracil Cytotoxicity Melanoma Immunohistochemistry Flux Transdermal Antitumor activity Skin permeability

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