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Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

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Oncology Research 2024年第1期32卷 101-125页

作者： ROGHAYEH GHORBANI mahmoud GHARBAVI ALI SHARAFI ELHAM RISMANI HAMED REZAEEJAM YOUSEF MORTAZAVI BEHROOZ JOHARI Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Department of Pharmaceutical Biotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Molecular Medicine Department Biotechnology Research CenterPasteur Institute of IranPasteur AvenueTehranIran Department of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer *** decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics *** were loaded on the synthesized Se@BSA@Chi-MTX *** physicochemical characteristics of nanostructures were determined by FTIR,DLS,UV-vis,TEM,EDX,in vitro release,and hemolysis ***,the cytotoxicity properties of them with and without X-irradiation were investigated by uptake,MTT,cell cycle,apoptosis,and scratch assays on the LNCaP cell *** results of DLS and TEM showed negative charge(−9 mV)and nanometer size(40 nm)for Se@BSA@Chi-DEC-MTX NPs,*** results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of *** results of hemolysis showed the hemocompatibility of this nanoparticle in concentrations less than 6 mg/*** ODNs release from the nanostructures showed a pH-dependent manner,and the release rate was 15%higher in acidic *** targeted Se@BSA@Chi-labeled ODN-MTX NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific membrane antigen(PSMA).The significant synergistic effects of nanostructure(containing MTX drug)treatment along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/M phase),and migration inhibition(up to 90%)compared to the *** results suggested that the Se@BSA@Chi-DEC-MTX NPs can potentially suppress the cell growth of LNCaP *** nanostructure system can be a promising approach for targeted drug delivery and chemoradiotherapy in prostate cancer treatment.

关键词： Chemoradiotherapy Combination therapy Decoy oligodeoxynucleotides Myc transcription factor Selenium nanoparticle Prostate cancer

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Editorial special issue:Friendly nutritional strategies for sustainable aquaculture

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Aquaculture and Fisheries 2024年第1期9卷 1-2页

作者： mahmoud A.O.Dawood Zulhisyam Abdul Kari Animal Production Department Faculty of AgricultureKafrelsheikh UniversityKafr El-Sheikh33516Egypt The Center for Applied Research on the Environment and Sustainability The American University in Cairo11835CairoEgypt Department of Agricultural Sciences Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli Campus17600JeliKelantanMalaysia Advanced Livestock and Aquaculture Research Group Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli Campus17600JeliKelantanMalaysia

The aquaculture sector provides the primary protein source for the global population while generating income and revenue(FAO,2020).Apart from that,aquaculturists are responsible for developing and maintaining sustaina... 详细信息

关键词： Aquafeed industry Alternative remedy Functional supplements Feeding strategies Sustainability

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Trauma to the solid abdominal organs:The missed dark box of colonoscopy

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World Journal of Gastroenterology 2024年第7期30卷 624-630页

作者： Mohamed H Emara Usama Mazid Yasmine A Elshaer mahmoud A Elkerdawy Dilaver Farooq Malik Aya M Mahros Department of Hepatology Gastroenterologyand Infectious DiseasesKafrelsheikh UniversityKafr-Elshikh 33516Egypt Department of Medicine Alyousif HospitalAlkhobar 31952Saudi Arabia

Colonoscopy is an integral part of the lower bowel care and is generally considered a potentially safe diagnostic and therapeutic procedure performed as a daycare outpatient *** is associated with different complications that are not limited to adverse events related to the bowel preparation solutions used,the sedatives used,but to the procedure related as well including bleeding and *** to the extra-luminal abdominal organs during colonoscopy are uncommon,however,serious complications related to the procedure have been reported infrequently in the *** threatening injuries to the spleen,liver,pancreas,mesentery,and urinary bladder have been reported as early as in *** injuries should not be overlooked by clinicians and *** increasing abdominal pain,abdominal distension,and hemodynamic instability in absence of rectal bleeding should raise the possibility of severe organ *** and hepatic injury following colonoscopy are usually serious and may be life *** conservative management may help,yet they usually need interventional radiology or surgical *** pancreatitis following colonoscopy is usually mild and is mostly managed *** mechanism of abdominal organ injuries during colonoscopy is not fully understood,however many risk factors have been identified,which can be classified as-organ related,procedure related,and local abdominal *** colonoscopy and prior intra-abdominal adhesions are probably the most relevant risk factors for these *** lateral position,avoidance of looping and excessive force during the procedure would probably reduce the risk of such injuries.

关键词： Colonoscopy Pancreatitis Trauma Complications Adhesions

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Does local vaginal estrogen after tension-free transobturator vaginal tape reduce overactive bladder symptoms in postmenopausal women? A prospective randomized, controlled study

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Asian Journal of Urology 2024年第1期11卷 86-92页

作者： Samer mahmoud Morsy Dalia Farouk Sara Hassan Ahmed Yehia Abdelaziz Hussein Aly Hussein Urology Department Kasr Al Ainy HospitalCairo UniversityCairoEgypt Obstetrics and Gynecology Department Kasr Al Ainy HospitalCairo UniversityCairoEgypt

Objective:We aimed to evaluate the efficacy of topical estrogen after transvaginal tension-free vaginal tape-obturator(TVT-O)in the treatment of de novo overactive bladder symptoms that appear after ***:This is a prospective randomized controlled study performed in the Urology and Gynecology Departments,Kasr Al Ainy Hospital,Cairo University,Cairo,*** hundred and ten postmenopausal females presenting during the period between January 2017 and November 2020 with stress urinary incontinence were included in the *** were divided into two groups,105 patients in Group A(treatment group)and 105 patients in Group B(control group).Patients in Group A underwent transvaginal TVT-O followed by local vaginal estrogen treatment for 6 months,while patients in Group B underwent transvaginal TVT-O *** study included any postmenopausal female with urodynamic stress urinary *** patients had to fulfill a 3-day bladder diary,overactive bladder symptoms score,urine analysis,urodynamic study,and post-voiding residual urine measurement by abdominal ultrasound preoperatively and at 3-month and 6-month ***:At 6-month follow-up,daytime frequency was reduced to 8%in Group A(increased to 21%in Group B)with a statistically significant difference between both groups(p=0.009).At 6-month follow-up,nocturia was 8%in Group A(11%in Group B)with no statistically significant difference between both groups(p=0.469).There was a statistically significant difference between both groups as regards to urinary urgency at 6-month follow-up(p=0.024).There was a statistically significant difference in postoperative wound healing events as regards to cure,hyperemia,gapping,and wound infection 1 week after intervention between both groups(p=0.008).No local or systemic side-effects were reported from local estrogen ***:Local vaginal estrogen treatment given to postmenopausal patients after midurethral sling procedures can reduce the symptoms o

关键词： Stressurinary incontinence Estrogen Midurethral sling Overactive bladder symptom

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Insulin therapy in type 2 diabetes: Insights into clinical efficacy, patient-reported outcomes, and adherence challenges

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World Journal of Diabetes 2024年第5期15卷 828-852页

作者： mahmoud Emad-Eldin Gehan F Balata Eman A Elshorbagy Mona S Hamed Mohamed S Attia Department of Pharmacy Practice Faculty of PharmacyZagazig UniversityZagazig HFQM+872Al-Sharqia GovernorateEgypt Department of Pharmacy Practice Faculty of PharmacyHeliopolis UniversityCairo 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt Department of Internal Medicine Faculty of MedicineZagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt Department of Community at Faculty of Medicine Zagazig UniversityZagazig 44519Al-Sharqia GovernorateEgypt

Insulin therapy plays a crucial role in the management of type 2 diabetes as the disease *** the past century,insulin formulations have undergone significant modifications and bioengineering,resulting in a diverse range of available insulin *** products show distinct pharmacokinetic and pharmacodynamic ***,various insulin regimens have em-erged for the management of type 2 diabetes,including premixed formulations and combinations of basal and bolus *** utilization of different insulin regimens yields disparate clinical outcomes,adverse events,and,notably,patient-reported outcomes(PROs).PROs provide valuable insights from the patient’s perspective,serving as a valuable mine of information for enhancing healthcare and informing clinical *** to insulin therapy,a critical patient-reported outcome,significantly affects clinical outcomes and is influenced by multiple *** review provides insights into the clinical effectiveness of various insulin preparations,PROs,and factors impacting insulin therapy adherence,with the aim of enhancing healthcare practices and informing clinical decisions for individuals with type 2 diabetes.

关键词： Adherence Diabetes Insulin Patient-reported outcomes Pharmacokinetic Pharmacodynamic

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Effects of friction stir processing and nano-hydroxyapatite on the microstructure,hardness,degradation rate and in-vitro bioactivity of WE43 alloy for biomedical applications

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Journal of Magnesium and Alloys 2024年第1期12卷 209-224页

作者： Bo Wu Farazila Yusof Fuguo Li Huan Miao A.R.Bushroa Mohd Ridha Bin Muhamad Irfan Anjum Badruddin mahmoud Z.Ibrahim Department of Mechanical Engineering Faculty of EngineeringUniversiti MalayaKuala Lumpur 50603Malaysia Centre of Advanced Manufacturing and Material Processing(AMMP Centre) Universiti MalayaKuala Lumpur 50603Malaysia Center of Foundation studies in Science Universiti MalayaKuala Lumpur 50603Malaysia State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Mechanical Engineering Department College of EngineeringKing Khalid UniversityAbha 61421Saudi Arabia Design and Production Engineering Faculty of EngineeringAin Shams UniversityCairo 11517Egypt

Nowadays,magnesium alloys are emerging in biomedical implants for their similar properties to natural ***,the rapid degradation of magnesium alloys in biological media hinders successful *** of microstructure,as well as reinforcement particles can significantly improve the degradation *** this work,multi-pass friction stir processing(FSP)was proposed to synthesize WE43/nano-hydroxyapatite(n HA)surface composite,the microstructure,reinforced particle distribution,micro-hardness,corrosion behavior and in-vitro bioactivity were *** subsequent FSP passes of WE43 alloy and WE43/n HA composite refined the grain size which was reduced by 94.29%and 95.92%(2.63 and 1.88μm,respectively)compared to base metal after three *** resulted in increasing the microhardness by 120%(90.86 HV0.1)and 135%(105.59 HV0.1)for the WE43 and WE43-n HA,*** is found that increasing FSP passes improved the uniform distribution of n HA particles within the composite matrix which led to improved corrosion resistance and less degradation *** corrosion rate of the FSPed WE43/n HA composite after three passes was reduced by 38.2%(4.13 mm/year)and the degradation rate was reduced by 69.7%(2.87 mm/y).This is attributed to secondary phase(Mg24Y5and Mg41Nd5)particle fragmentation and redistribution,as well as a homogeneous distribution of n ***,the growing Ca-P and Mg(OH)2layer formed on the surface represented a protective layer that reduced the degradation *** wettability test revealed a relatively hydrophilic surface with water contact angle of 49.1±2.2°compared to 71.2±2.1°for base ***,biomineralization test showed that apatite layer grew after immersion 7d in simulated body fluid with atomic ratio of Ca/P 1.60 approaching the stoichiometric ratio(1.67)indicating superior bioactivity of FSPed WE43/n HA composite after three *** results raise that the grain refinement by FSP and introduction of n HA partic

关键词： Friction stir processing Magnesium-based composite Nano-hydroxyapatite Corrosion behavior In-vitro bioactivity

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A Model for a Dual Universe

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 52-66页

作者： Tharwat mahmoud El-Sherbini Physics Department Faculty of Science Cairo University Cairo Egypt

A model for a dual universe is proposed, based on the assumption that simultaneously with our universe an anti-matter counterpart was initiated immediately following the Big Bang. At the heart of the model is a primordial anti-particle that differentiates itself from its counterpart, a previously hypothesized S-particle responsible for the formation of our own universe, through its course of rotation. The angular rotation of the anti-particle, in accordance with space-time rotation, together with the counter rotation of the S-particle, resulted in a time difference in the formation processes of both universes and consequently led to a large distance between the spatial locations occupied by our universe and its dual counterpart in the same space-time continuum. The existence of this anti-matter universe might solve the present mystery of matter anti-matter asymmetry and thus explain why hardly any free anti-matter can be observed in our universe. Moreover, the model implicates the possibility of the presence of a repulsive gravitational force exerted by the clusters of anti-particles in the anti-matter universe upon our universe. The repulsive gravitational force from the clusters of antiparticles in the dual universe as a whole upon our universe is completely different from the electrostatic repulsive force between similarly charged particles. It is also different from that due to possible gravitational or anti-gravitational interaction between individual matter and antimatter or particle and its antiparticle that might violate the CPT invariance, the theory of general relativity or the law of energy conservation. It is rather, a kind of negative gravity that affects our universe as a whole, due to the opposite course of rotation of the dual anti-universe relative to ours. The effect of this opposite rotation of the dual universe can cause anti-gravitational waves that penetrate our universe interacting with the space-time mesh around the galaxies in our universe a

关键词： Cosmology Antimatter High Energy Astrophysics Particle Physics

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Performance Comparison of Hyper-V and KVM for Cryptographic Tasks in Cloud Computing

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Computers, Materials & Continua 2024年第2期78卷 2023-2045页

作者： Nader Abdel Karim Osama A.Khashan Waleed K.Abdulraheem Moutaz Alazab Hasan Kanaker mahmoud E.Farfoura Mohammad Alshinwan Department of Intelligent Systems Faculty of Artificial IntelligenceAl-Balqa Applied UniversityAl-Salt1705Jordan Research and Innovation Centers Rabdan AcademyP.O.Box 114646Abu DhabiUnited Arab Emirates Department of Information Systems and Networks TheWorld Islamic Sciences and Education UniversityAmman11947Jordan Department of Cyber Security Isra UniversityAmman1162Jordan Faculty of Science and Information Technology Al-Zaytoonah University of JordanAmman11733Jordan Middle East University Research Unit Middle East UniversityAmman11831Jordan

As the extensive use of cloud computing raises questions about the security of any personal data stored there,cryptography is being used more frequently as a security tool to protect data confidentiality and privacy in the cloud environment.A hypervisor is a virtualization software used in cloud hosting to divide and allocate resources on various pieces of *** choice of hypervisor can significantly impact the performance of cryptographic operations in the cloud *** important issue that must be carefully examined is that no hypervisor is completely superior in terms of performance;Each hypervisor should be examined to meet specific *** main objective of this study is to provide accurate results to compare the performance of Hyper-V and Kernel-based Virtual Machine(KVM)while implementing different cryptographic algorithms to guide cloud service providers and end users in choosing the most suitable hypervisor for their cryptographic *** study evaluated the efficiency of two hypervisors,Hyper-V and KVM,in implementing six cryptographic algorithms:Rivest,Shamir,Adleman(RSA),Advanced Encryption Standard(AES),Triple Data Encryption Standard(TripleDES),Carlisle Adams and Stafford Tavares(CAST-128),BLOWFISH,and *** study’s findings show that KVM outperforms Hyper-V,with 12.2%less Central Processing Unit(CPU)use and 12.95%less time overall for encryption and decryption operations with various file *** study’s findings emphasize how crucial it is to pick a hypervisor that is appropriate for cryptographic needs in a cloud environment,which could assist both cloud service providers and end *** research may focus more on how various hypervisors perform while handling cryptographic workloads.

关键词： Cloud computing performance virtualization hypervisors Hyper-V KVM cryptographic algorithm

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Novel Sustainable Cellulose Acetate Based Biosensor for Glucose Detection

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Journal of Renewable Materials 2024年第2期12卷 369-380页

作者： M.F.Elkady E.M.El-Sayed mahmoud Samy Omneya A.Koriem H.Shokry Hassan Chemical and Petrochemical Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Fabrication Technology Research Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt Department of Public Works Engineering Faculty of EngineeringMansoura UniversityMansoura35516Egypt Environmental Engineering Department Egypt-Japan University of Science and TechnologyNew Borg El-ArabAlexandriaEgypt Electronic Materials Research Department Advanced Technology and NewMaterials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)New Borg El-ArabAlexandria21934Egypt

In this study,green zinc oxide(ZnO)/polypyrrole(Ppy)/cellulose acetate(CA)film has been synthesized via solvent *** film was used as supporting material for glucose oxidase(GOx)to sensitize a glucose *** nanoparticles have been prepared via the green route using olive leaves extract as a ***/Ppy nanocomposite has been synthesized by a simple in-situ chemical oxidative polymerization of pyrrole(Py)monomer using ferric chloride(FeCl3)as an oxidizing *** produced materials and the composite films were characterized using X-ray diffraction analysis(XRD),scanning electron microscope(SEM),Fourier transform infrared(FTIR)and thermogravimetric analysis(TGA).Glucose oxidase was successfully immobilized on the surface of the prepared film and then ZnO/Ppy/CA/GOx composite was sputtered with platinum electrode for the current determination at different initial concentrations of *** measurements proved the suitability and the high sensitivity of the constructed biosensor for the detection of glucose levels in different *** performance of the prepared biosensor has been assessed by measuring and comparing glucose concentrations up to 800 *** results affirmed the reliability of the developed biosensor towards real samples which suggests the wide-scale application of the proposed biosensor.

关键词： Biosensors composite films glucose polypyrrole green ZnO cellulose acetate

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未热解厚热障涂层的隔热能力和黏接强度

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Transactions of Nonferrous Metals Society of China 2024年第4期34卷 1226-1236页

作者： Mohammad IZADINIA Reza SOLTANI mahmoud HEYDARZADEH SOHI Javad MOSTAGHIMI School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehranIran Centre for Advanced Coating Technologies Department of Mechanical and Industrial EngineeringUniversity of TorontoTorontoOntarioCanada

对比研究使用未热解粉末制备的厚热障涂层(UPTTBC)和传统TBC、厚TBC(TTBC)及密集垂直裂纹(DVC)TTBC 4种涂层的隔热能力和黏接强度。采用降温法测试涂层的隔热能力;根据ASTM C633标准,采用拉拔试验检测涂层的黏接强度。结果显示,UPTTBC和... 详细信息

对比研究使用未热解粉末制备的厚热障涂层(UPTTBC)和传统TBC、厚TBC(TTBC)及密集垂直裂纹(DVC)TTBC 4种涂层的隔热能力和黏接强度。采用降温法测试涂层的隔热能力;根据ASTM C633标准,采用拉拔试验检测涂层的黏接强度。结果显示,UPTTBC和DVC TTBC的黏接强度分别比TTBC高35%和25%。这可能是由于UPTTBC结构中存在亚微米尺度的未熔化区域,起到了阻止裂纹扩展的作用。此外,隔热测试的结果表明,DVCTTBC涂层的隔热能力最差,为0.28℃/μm,而UPTTBC涂层的隔热能力最强,为0.40℃/μm。由于UPTTBCs显微组织中存在亚微米区域,使涂层展现出优越的隔热能力。相反,DVCTTBC因其致密的结构,具有最低的隔热能力。

关键词：厚热障涂层密集垂直裂纹热障涂层未热解粉末黏接强度隔热能力

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