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A case of cerebral venous sinus thrombosis associated with Crohn’s disease:dilemma in management

Gastroenterology Report 2016年第2期4卷 154-157,I0003页

作者： younghoon kwon Ryan J Koene Yeilim Cho St.Joseph’s Hospital HealthEast Care SystemSaint PaulMinnesotaUSA Department of Medicine University of MinnesotaMinneapolisMinnesotaUSA

Inflammatory bowel disease(IBD)is known to increase the risk of venous *** venous sinus thrombosis(CVST)is a rare but important complication of *** diagnosis,particularly in younger patients,requires a high level of suspicion in order to prevent potentially devastating complications such as hemorrhage or venous *** paper presents a 44-year-old Caucasian woman with a previous history of Crohn’s disease and deep venous *** resonance imaging confirmed the diagnosis of *** therapeutic anticoagulation with warfarin was difficult,due to presumed pharmacological interaction between warfarin and *** should have a high index of suspicion for CVST when a patient with Crohn’s disease presents with acute headache,and be aware of challenges related to medical management.

关键词： cerebral venous sinus thrombosis Crohn’s disease anticoagulation mercaptopurine warfarin

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High risk for obstructive sleep apnea and risk of hypertension in military personnel: The CHIEF sleep study

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World Journal of Clinical Cases 2023年第30期11卷 7309-7317页

作者： Wei-Nung Liu Ko-Huan Lin Kun-Zhe Tsai Chen-Chih Chu Yun-Chen Chang younghoon kwon Gen-Min Lin Department of Medicine Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Department of Psychiatry Hualien Tzu Chi HospitalHualien City 970TaiwanChina Department of Stomatology of Periodontology Mackay Memorial HospitalTaipei 104TaiwanChina School of Nursing and Graduate Institute of Nursing China Medical UniversityTaichung 406TaiwanChina Department of Medicine University of WashingtonSeattle98104-2499United States Department of Medicine Hualien Armed Forces General HospitalHualien City 970TaiwanChina

BACKGROUND Epidemiological studies have revealed an association between obstructive sleep apnea(OSA)and hypertension in the general population,while the association in military personnel was rarely *** To examine the association between high risk for OSA and hypertension by phenotypes in military young *** A total of 746 military personnel,aged 27.9 years,were included in the cardiorespiratory fitness and health in armed forces(CHIEF)-sleep study in Taiwan in *** medications were not used by the *** risk for OSA was assessed using the Berlin *** was defined using the 7th Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure(JNC 7)and the 2017 American College of Cardiology(ACC)/American Heart Association(AHA)*** cutoff levels of systolic and diastolic blood pressure(SBP and DBP)for the 2017 ACC/AHA-and JNC 7-based guidelines were 130/140 mmHg and 80/90 mmHg,*** phenotypes included isolated systolic and diastolic hypertension(ISH,high SBP only and IDH,high DBP only)and combined hypertension(both high SBP and DBP).Multivariable logistic regression analysis with adjustment for demographics,lifestyle and metabolic *** The prevalence of high risk for OSA,JNC 7-based hypertension and 2017 ACC/AHA-based hypertension were 8.0%,5.2%and 22.0%,*** with a high risk for OSA had a higher probability of JNC 7-based overall and combined hypertension(odds ratios(ORs))and 95%confidence intervals:2.82(1.07-7.42)and 7.54(1.10-51.54),although the probabilities of ISH and IDH were unaffected by a high risk for OSA(ORs:1.96 and 2.35,respectively,both P>0.05).In contrast,no associations for any hypertension phenotypes were found according to the 2017 ACC/AHA *** A high risk for OSA was associated with severe hypertension and combined hypertension among Asian military young adults.

关键词： Asian young adults Berlin questionnaire Hypertension phenotypes Military Sleep apnea

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Vitisin B inhibits influenza A virus replication by multi-targeting neuraminidase and virusinduced oxidative stress

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Acta Pharmaceutica Sinica B 2023年第1期13卷 174-191页

作者： Eun-Bin kwon Wei Li Young Soo Kim Buyun Kim Hwan-Suck Chung younghoon Go Hyun-Jeong Ko Jae-Hyoung Song Young Ho Kim Chun Whan Choi Jang-Gi Choi Korean Medicine(KM)Application Center Korea Institute of Oriental MedicineDaegu 41062Republic of Korea College of Pharmacy Chungnam National UniversityDaejeon 34134Republic of Korea Natural Product Research Team BiocenterGyeonggido Business and Science AcceleratorGyeonggi-Do 16229Republic of Korea Laboratory of Microbiology and Immunology College of PharmacyKangwon National UniversityChuncheon 24341Republic of Korea

The development of drug-resistant influenza and new pathogenic virus strains underscores the need for antiviral ***,neuraminidase(NA)inhibitors are commonly used antiviral drugs approved by the US Food and Drug Administration(FDA)for the prevention and treatment of ***,we show that vitisin B(VB)inhibits NA activity and suppresses H1N1 viral replication in MDCK and A549 *** oxygen species(ROS),which frequently occur during viral infection,increase virus replication by activating the NF-κB signaling pathway,downmodulating glucose-6-phosphate dehydrogenase(G6PD)expression,and decreasing the expression of nuclear factor erythroid2-related factor 2(Nrf2)antioxidant response *** decreased virus-induced ROS generation by increasing G6PD expression and Nrf2 activity,and inhibiting NF-κB translocation to the nucleus through IKK *** addition,VB reduced body weight loss,increased survival,decreased viral replication and the inflammatory response in the lungs of influenza A virus(IAV)-infected *** together,our results indicate that VB is a promising therapeutic candidate against IAV infection,complements existing drug limitations targeting viral *** modulated the intracellular ROS by G6PD,Nrf2 antioxidant response pathway,and NF-κB signaling *** results demonstrate the feasibility of a multi-targeting drug strategy,providing new approaches for drug discovery against IAV infection.

关键词： Influenza Vitisin B Vitis vinifera L. Neuraminidase Reactive oxygen species NF-κB Multi-targeting Nrf2 G6PD

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Analysis of Uncontrollable Variables to the Performance of Predefined Tasks

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Journal of Software Engineering and Applications 2012年第12期5卷 140-143页

作者： Eunghyun Lee Jinwoo Lee Jungwan Hong younghoon Ko Yongjin kwon Sang C. Park Jonghoon Lee Miseon Yi Agency for Defense Development South Korea Department of Industrial Engineering Ajou University Suwon South Korea

The aim of this research was to investigate the impacts of changing environmental factors on pilots by implementing the effective flight procedure that we found from the previous research. During the experiments, camcorders were used to monitor and analyze the tasks and physical exhaustion of the pilot. NASA-TLX was also used to collect the data of the workload. Through this experiment, we were able to approach the experiment from a different angle regarding the optimal assigned work of the pilot, unlike the previous studies. Also, we were able to find out the impacts of environmental factors on the pilot’s workload.

关键词： Helicopter mission Task performance time task workload Armed Helicopter

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