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Retrospective analysis of extra-gastrointestinal stromal tumors

World Journal of Gastroenterology 2015年第6期21卷 1845-1850页

作者： Jun Ho Yi Byeong-Bae Park Jung Hun Kang In Gyu Hwang Dong Bok Shin Sun Jin Sym Hee Kyung Ahn Soon Il Lee Do Hyoung Lim Keon Woo Park young-woong won Sung Hee Lim Se Hoon Park Division of Hematology-Oncology Department of Internal Medicine Hanyang University Seoul Hospital Division of Hematology-Oncology Department of Internal Medicine Gyeongsang National University School of Medicine Division of Hematology-Oncology Department of Internal Medicine Chung-Ang University Hospital ChungAng University College of Medicine Division of Hematology-Oncology Department of Internal MedicineGachon University Gil Hospital Department of Hematology-Oncology Dankook University School of Medicine Division of Hematology and Oncology Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine Division of HematologyOncology Department of Medicine Sungkyunkwan University Samsung Medical Center Cancer hospital

AIM:To investigate the clinicopathologic features of patients with extra-gastrointestinal stromal tumors(EGISTs)in South ***:A total of 51 patients with an EGIST were *** clinicopathologic features,including sex,age,location,tumor size,histology,mitotic rate,immunohistochemical features,genetic status and survival data,were ***:The median age was 55 years(range:29-80years),and male:female ratio was 1:*** most common site was in the mesentery(n=15)followed by the retroperitoneum(n=13)and omentum(n=8).The median tumor size was 9.0 cm(range:2.6-30.0cm)and the median mitotic rate was 5.0/50HPF.(1/50-185/50).KIT was analyzed in 16,which revealed 10cases with wild-type KIT and 6 cases with an exon *** 51 patients,31 patients had undergone surgery,and 10 had unresectable disease and had taken palliative imatinib,which resulted in 22.7 mo of progression-free *** the patients who had undergone surgery,18 did not take adjuvant imatinib,and 8 of these were categorized as"high risk"according to the risk ***,the relapse-free survival was not different(P=0.157)between two ***:Because the biologic behaviors of GISTs differ according to the location of the tumor,a more stratified strategy is required for managing EGISTs including incorporation of molecular features.

关键词： Gastrointestinal stromal tumor Survival Imatinib R

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Effect of an extraction solvent on the antioxidant quality of Pinus densiflora needle extract

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Journal of Pharmaceutical Analysis 2019年第3期9卷 193-200页

作者： Thamizhiniyan Venkatesan young-woong Choi young-Kyoon Kim Department of Forest Products and Biotechnology College of Science and TechnologyKookmin University

Pinus densiflora needle extract (PDNE) is widely reported to have many pharmacological activities including antioxidant potential. However, the solvent system used for extraction greatly affects its antioxidant quality. Hence, in the present study, we investigated the effect of a different ratio (vol/vol) of ethanol to water (0-100%) in the extraction of PDNE with potent antioxidant capacity. The chemical assays, 2,2-diphenyl-1 picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), were conducted to assess the antioxidant potential of PDNE. Subsequently, the cytoprotective effect of PDNE was determined using tert-butyl hydroperoxide (TBHP)-challenged HepG2 cellular model. The needle extracts from 40% ethanol (PDNE-40) showed greater radical scavenging activity followed by 60%, 20%, 80%, 0% and 100% ethanol extracts. EC50 value of the most active extract, PDNE-40, was 8.56 ± 0.51 μg/mL, relative to 1.34 ± 0.28 μg/mL of the standard trolox (for ABTS radical), and 75.96 ± 11.60 μg/mL, relative to 4.83 ± 0.26 μg/mL of the standard trolox (for DPPH radical). Either PDNE-20 or PDNE-40 pretreatment remarkably decreased the levels of reactive oxygen species (ROS), lipid peroxides and protein carbonyls in TBHP-challenged HepG2 cells. In addition, both PDNE-20 and PDNE-40 significantly reversed the decreased ratio of reduced (GSH) to oxidized (GSSG) glutathione. Moreover, these two extracts showed a significant inhibitory effect on TBHP-induced nuclear damage and loss of cell viability. In summary, the inclusion of 40% ethanol in water for extraction of Pinus densiflora needle greatly increases the antioxidant quality of the extract.

关键词： Pinus densiflora needle extract Oxidative stress Cytoprotective Natural antioxidant

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Room-temperature synthesis of ZrSnO4 nanoparticles for electron transport layer in efficient planar hetrojunction perovskite solar cells

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Journal of Materials Science & Technology 2020年第7期42卷 38-45页

作者： young Wook Noh In Su Jin Sang Hyun Park Jae woong Jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea

The interface engineering plays a key role in controlled optoelectronic properties of perovskite photovoltaic devices,and thus the electron transport layer(ETL)material with tailored optoelectronic properties remains a challenge for achieving high photovoltaic performance of planar perovskite solar cells(PSCs).Here,the fine and crystalline zirconium stanate(ZrSnO4)nanoparticles(NPs)was synthesized at low temperature,and its optoelectronic properties are systematically *** from the favorable electronic structure of ZrSnO4 NPs for applications in ETL,efficient electron transport and extraction with suppre s sed charge recombination are achieved at the interface of perovskite *** a result,the optimized ZrSnO4 NPs synthesized at room-temperature deliver the optimized power conversion efficiency up to 16.76%with acceptable *** work opens up a new class of ternary metal oxide for the use in ETL of the planar PSCs and should pave the way toward designing new interfacial materials for practical optoelectronic devices.

关键词： ZrSnO4 Electron transport layer Nanoparticles Perovskite solar cells

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Effect of Deformation Temperature on Microstructure and Mechanical Properties of AZ31 Mg Alloy Processed by Differential-Speed Rolling

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Journal of Materials Science & Technology 2015年第5期31卷 498-503页

作者： Mosab Kaseem Bong Kwon Chung Hae woong Yang Kotiba Hamad young Gun Ko School of Materials Science and Engineering Yeungnam University

A differential-speed rolling(DSR) was applied to AZ31 magnesium alloy sample at different rolling temperatures of 473,523,573,and 623 K with 1-pass and 2-pass *** microstructural evolution and mechanical properties of the deformed samples were *** rolling temperature was found to be an important parameter affecting the microstructural *** DSR at 473 K,the microstructure was more homogeneous than that obtained after deformation by equal-speed rolling(ESR).The fully recrystallized microstructures were generated after DSR at 573 and 623 *** to mechanical properties,the yield strength(YS) and ultimate tensile strength(UTS) decreased monotonously with increasing rolling *** contrast,the elongation of the DSR-deformed samples was improved as the rolling temperature *** strain hardening exponent(n) calculated by Hollomon equation increased with increasing the rolling temperature,which would explain an increase in the uniform elongation.

关键词： Differential-speed rolling Magnesium alloy Mechani

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Plastic anisotropy calculation of severely-deformed Al-Mg-Si alloy considering texture changes in electron backscatter diffraction

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Journal of Materials Science & Technology 2019年第7期35卷 1439-1443页

作者： I Putu Widiantara Hae woong Yang Min Jun Kim young Gun Ko Plasticity Control & Mechanical Modeling Lab. School of Materials Science & Engineering Yeungnam University

The investigation studied the plastic anisotropy of the severely-deformed Al-Mg-Si alloy by considering texture *** sample deformed via asymmetrical rolling under cross-shear condition was annealed at 598 K where recrystallization was in *** is found upon annealing that the intensity of Cube({001})was comparable to those of plane-strain components while the intensities of shear components remained constant despite their instabilities in the recrystallization *** annealing,the average Lankford value(r)of the present sample was close to a unity whereas the in-plane anisotropy(△r)decreased,resulting in nearly isotropic characteristics of Al-Mg-Si alloy.

关键词： Al-Mg-Si alloy Anisotropy Recrystallization Microstructures

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Sperm hyaluronidase is critical to mammals'fertilization for its ability to disperse cumulus-oocyte complex layer

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Asian Journal of Andrology 2022年第4期24卷 411-415页

作者： Dong-won Seol Sang Hoon Joo young-Hyun Kim Bong-Seok Song Bo-woong Sim Sun-Uk Kim Soojin Park Gabbine Wee Ekyune Kim Laboratory Animal Center Daegu-Gyeongbuk Medical Innovation Foundation(DGMIF)Daegu 41061Korea College of Pharmacy Catholic University of DaeguGyeongbuk 38430Korea National Primate Research Center(NPCR) Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyChungcheongbuk-do 28116Korea Department of Biochemistry and Molecular Biology Melvin and Bren Simon Comprehensive Cancer CenterIndiana University School of MedicineIndianapolisIN 46202USA

Glycosylphosphatidylinositol-anchored sperm hyaluronidases have long been believed to assist in sperm penetration through the cumulus-oocyte complex(COC);however,their role in mammalian fertilization remains ***,we have shown that hyaluronidase 5(Hyal5)/Hyal7 double-knockout(dKO)mice produce significantly fewer offspring than their wild-type(WT)counterparts because of defective COC *** infertility is mainly caused by a low sperm *** can be further exacerbated by the deficiency of sperm hyaluronidase,which disperses the cumulus cells of the outer layer of the *** the current study,we evaluated the effects of a low count of Hyal-deficient sperm and conditions of ovulated oocytes on the fertilization rate using a mouse *** results demonstrated that a low sperm count further decreases the in vitro fertilization(IVF)rate of Hyal-deficient dKO *** addition,the dKO spermatozoa resulted in a fertilization rate of 12.5%upon fertilizing COCs with a thick cumulus layer,whereas the IVF rate was comparable to that of WT spermatozoa when oocytes with a thin or no cumulus layer were ***,we proved that the IVF rate of dKO spermatozoa could be recovered by adding rat spermatozoa as a source of sperm *** results suggest that a deficiency of proteins involved in fertilization,such as sperm hyal,has a vital role in fertilization.

关键词： HYAL5 HYAL7 cumulus-oocyte complex fertilization infertility sperm hyaluronidase

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Improving the electrochemical stability of AZ31 Mg alloy in a 3.5wt.%NaCl solution via the surface functionalization of plasma electrolytic oxidation coating

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Journal of Magnesium and Alloys 2022年第5期10卷 1311-1325页

作者： Mosab Kaseem Tehseen Zehra Burak Dikici Ali Dafali Hae woong Yang young Gun Ko Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Metallurgical and Materials Engineering Ataturk UniversityErzurum 25240Turkey Faculty of Sciences Oujda Department of ChemistryMohamed the First UniversityOujdaMorocco Pohang Institute of Metal Industry Advancement Pohang 37666Republic of Korea Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea

The unique interactions between hexadecanoic acid(HA)and albumin(ALB)molecules on the surface of the porous layer of AZ31 Mg alloy were exploited to fabricate a novel hybrid composite film with excellent electrochemical stability in a 3.5 wt.%Na Cl ***,the inorganic layer(IL)obtained by plasma electrolytic oxidation of AZ31 Mg alloy in an alkaline-phosphate-WO_(3)electrolyte was soaked in an organic solution composed of ALB and HA for 10 and 24 h at 60℃.Although albumin and HA may coexist on the same surface of IL,the higher reactivity of ALB molecules would prevent the formation of a thick layer of *** donor-acceptor complexes formed due to the unique interactions between ALB and/or HA and IL surface would reduce the area exposed to the corrosive species which in turn would efficiently protect the substrate from *** porous structure of the IL would provide preferable sites for the physical and chemical locking triggered by charge-transfer phenomena,leading to the inhomogeneous nucleation and crystal growth of a flowery flakes-like organic *** calculations were performed to reveal the primary bonding modes between the ALB,HA,and IL and to assess the mechanistic insights into the formation of such novel hybrid composites.

关键词： Hybrid composite Coordination bond Albumin Fatty acid Porous layer Corrosion Theoretical approach

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An advanced segmentation using area and boundary tracing technique in extraction of lungs region

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Journal of Central South University 2014年第10期21卷 3811-3820页

作者： Kiran THAPALIYA Sang-woong LEE Jae-young PYU Heon JEONG Goo-Rak Kwon Department of Information and Communication Engineering Chosun University School of Computer Engineering Chosun University Deparment of Fire Administration Chodang University

A new method is presented for the segmentation of pulmonary parenchyma. The proposed method is based on the area calculation of different objects in the image. The main purpose of the proposed algorithm is the segment of the lungs images from the computer tomography(CT) images. The original image is binarized using the bit-plane slicing technique and among the different images the best binarized image is chosen. After binarization, the labeling is done and the area of each label is calculated from which the next level of binarized image is obtained. Then, the boundary tracing algorithm is applied to get another level of binarized image. The proposed method is able to extract lung region from the original images. The experimental results show the significance of the proposed method.

关键词： bit-plane slicing technique connected component labeling area tracing boundary tracing

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A case of unsuspected trans-orbital-cranial penetrating injury by a wooden chopstick in a one-year-old infant

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 523-526页

作者： Yeon woong Chung Soon young Lee Tae Yoon La Department of Ophthalmology St.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSeoul 16247Korea

Dear Editor,Transorbital penetrating injury is one emergency faced by ophthalmologists during primary care that requires special attention because it can lead to serious ophthalmic and neurological *** all head injuries, intracranial penetrating injuries occur at a low rate of 0.4%[1], and transorbital-cranial penetrating injuries are even more rare, but do occur more frequently in young children than in adults[2-3].

关键词： injuries infant orbital

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Double guidewire technique vs transpancreatic precut sphincterotomy in difficult biliary cannulation

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World Journal of Gastroenterology 2013年第1期19卷 108-114页

作者： young Wook Yoo Sang-Woo Cha woong Cheul Lee Sae Hee Kim Anna Kim young Deok Cho Department of Internal Medicine Gastroenterology and Hepatobiliary CenterCheongju St.Mary's HospitalCheongju 360-568South Korea Department of Internal Medicine Soonchunhyang University College of MedicineInstitute for Digestive ResearchDigestive Disease CenterSoonchunhyang University HospitalSeoul 140-743South Korea Division of Gastroenterology Department of Internal MedicineEulji University College of MedicineEulji University HospitalDaejeon 302-799South Korea

AIM:To compare the outcomes between doubleguidewire technique(DGT) and transpancreatic precut sphincterotomy(TPS) in patients with difficult biliary ***:This was a prospective,randomized study conducted in single tertiary referral hospital in *** January 2005 and September 2010.A total of 71 patients,who bile duct cannulation was not possible and selective pancreatic duct cannulation was achieved,were randomized into DGT(n = 34) and TPS(n = 37) *** or TPS was done for selective biliary *** measured the technical success rates of biliary cannulation,median cannulation time,and procedure related ***:The distribution of patients after randomization was balanced,and both groups were comparable in baseline characteristics,except the higher percentage of endoscopic nasobiliary drainage in the DGT group(55.9% vs 13.5%,P < 0.001).Successful cannulation rate and mean cannulation times in DGT and TPS groups were 91.2% vs 91.9% and 14.1 ± 13.2 min vs 15.4 ± 17.9 min,P = 0.732,*** was no significant difference between the two *** overall incidence of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis was 38.2% vs 10.8%,P < 0.011 in the DGT group and the TPS group;post-procedure pancreatitis was significantly higher in the DGT *** the overall incidence of post-ERCP hyperamylasemia was no significant difference between the two groups;DGT group vs TPS group:14.7% vs 16.2%,P < ***:When free bile duct cannulation was difficult and selective pancreatic duct cannulation was achieved,DGT and TPS facilitated biliary cannulation and showed similar success ***,post-procedure pancreatitis was significantly higher in the DGT group.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Duoble guidewire technique Transpancrestic precut sphincterotomy

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