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Pattern of instent neointimal formation compared to native atherosclerosis in the coronary bifurcation lesions： volumetric intravascular ultrasound analysis

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Chinese Medical Journal 2013年第18期126卷 3505-3510页

作者： XU Jian-qiang young Bin Song Joo-Yong Hahn Seung-Hyuk Choi Jin-Ho Choi LU Cheng-zhi Sang hoon Lee Kyung Pyo Hong Jeung Euy Park Hyeon-Cheol Gwon Division of Cardiology Department of Medicine Samsung MedicalCenter Sungkyunkwan University School of Medicine Seoul Korea Cardiovascular CenterTianjin First Central Hospital Tianjin 300192 China

Background No clinical study has systematically analyzed and compared circumferential neointimal and plaque distribution of stent neointimal proliferation and in native atherosclerotic plaques. This study aimed to investigate and compare the pattern of instent neointimal formation and native atherosclerosis in the coronary bifurcation lesions by volumetric analysis using systematic intravascular ultrasound （IVUS）. Methods We examined bifurcation lesions in native coronary artery （plaque group, n=102） and stented bifurcations at 9-month follow-up （neointima group, n=51） using volumetric IVUS analysis of both the main vessel （MV） and side branch （SB）. Three 5-mm segments were analyzed; the proximal MV （MVp）, distal MV （MVd） and SB ostium （SBo）. For each segment, volumetric analysis was performed in each of four quadrants （divided according to the branch takeoff and the geometric center of the lumen）; carinal, epicardial, abcarinal, and myocardial. The eccentricity index was defined as the ratio of the abcarinal plaque （or neointimal） volume to the carinal plaque （or neointimal） volume. Results The plaque distribution differed significantly between the four quadrants, with the largest in the abcarinal quadrant, followed by the myocardial, epicardial, and carinal quadrants. The distribution of neointima was similar in the MV, but the four quadrants in the SB did not differ significantly. The eccentricity indices of both the MVd （P 〈0.001） and SBo （P=-0.001） were significantly higher for the plaque group than the neointima group. Conclusions The distribution of neointimal proliferation seems to have a similar pattern to that of atherosclerotic plaque in native coronary arteries. Darticularlv in the main vessel, but the trend is less prominent.

关键词： atherosclerosis bifurcations plaque distribution neointimal distribution intravascular ultrasound

Phase separations in graded-indium content InGaN/GaN multiple quantum wells and its function to high quantum efficiency

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Journal of Semiconductors 2012年第5期33卷 13-16页

作者：郭洪英孙元平 Yong-hoon Cho Eun-Kyung Suh Hai-Joon Lee Rak-Jun Choi Yoon-Bong Hahn Institute of Science and Technology for Opto-Electronic Information Yantai University Department of Physics Korea Advanced Institute of Science and Technology School of Semiconductor and Chemical Engineering Semiconductor Physics Research CenterChonbuk National University School of Chemical Engineering Chonbuk National University

Phase separations have been studied for graded-indium content In_xGa_（1-x）N/GaN multiple quantum wells（MQWs） with different indium contents by means of photoluminescence（PL）,cathodeluminescence（CL） and time-resolved PL（TRPL） *** the main emission peaks,all samples show another 2 peaks at the high and low energy parts of the main peaks in PL when excited at 10 *** images show a clear contrast for 3 samples,which indicates an increasing phase separation with increasing indium *** spectra at 15 K of the main emissions show an increasing delay of rising time with indium content,which means a carrier transferring from low indium content structures to high indium content structures.

关键词： carrier transfer phase separation graded-indium content multiple quantum wells

The Effects of Adhesion Layer on Electrical Characteristics Performance in Bottomcontact Organic Thin Film Transistors

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The Effects of Adhesion Layer on Electrical Characteristics ...

Low grade chondrosarcoma of the nasal septum

2007亚洲显示国际会议

作者： Gun Woo Hyung Jun Ho Kim Seo Ji Hyun Seo Ji hoon Park II Houng young Kwan Kim Department of Materials Science and Engineering Hongik University Seoul 121-791Korea Center for Organic Materials and Information DevicesHongik UniversitySeoul 121-791Korea Department of Electronic Engineering Hongik University Seoul 121-791Korea Center for Organic Materials and Information DevicesHongik UniversitySeoul 121 -791Korea Department of Information Display Hongik University Seoul 121-791Korea Center for Organic Materials and Information DevicesHongik UniversitySeoul 121-791Korea

We demonstrated that organic thin-film-transistors(OTFTs)can be fabricated by using organic gate insulators using a vapor deposition polymerization(VDP)*** basic material properties of organic thin-film fabricated by VDP method were investigated and organic thin film was adopted as adhesion layer to investigate electrical ***- film-transistors based on organic semiconductor(OTFTs)have received considerable attention because of their potential application in a variety of industries,since the performance of silicon TFTs can be replaced by *** the high-per- formance OTFTs,it is reported that the grown crystalline characteristics of pentacene are critically correlated with the sur- face energy for the *** this study,instead of polyimide which was well known gate insulators,6FDA-ODA was used as a polymeric adhesion layer deposited on inorganic gate insulator such as silicon nitride(SiN),which was formed by vapor deposition polymerization(VDP)instead of spin-coating *** have investigated the effect of the adhesion layer on the interfacial characteristics between Pentacene and *** hence,the The electrical characteristics of OTFTs using 6FDA-ODA as an adhesion layer could be compared and ***,bottom-contact structure adop- ting organic thin film fabricated by VDP method was investigated.

关键词： Organic Thin-film Transistor(OTFT) Vapor Deposition Polymerization(VDP) Adhesion Layer

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World Journal of Clinical Cases 2013年第1期1卷 64-66页

作者： Dong hoon Lee Se Hee Jung Tae Mi Yoon Joon Kyoo Lee young Eun Joo Sang Chul Lim Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea Department of Radiology Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea Department of Research Institute of Medical Sciences Chonnam National University Medical School and Hwasun Hospital Hwasun Jeonnam 519-809 South Korea

Chondrosarcoma of the nasal septum is extremely rare. In some cases, it may be diff icult to preoperatively differentiate low grade chondrosarcoma from benign cartilaginous tumors such as chondroma. We report a case of low grade chondrosarcoma of the nasal septum with characteristic radiologic f indings. Characteristic radiologic f indings such as calcif ications on computed tomography scan and a ring-and-arc pattern on enhanced T1 weighted image were useful in the preoperative diagnosis of low grade chondrosarcoma of the septum. Awareness of radiologic f indings of low grade chondrosarcoma can help to make an accurate diagnosis and perform appropriate excision, leading to successful local control.

关键词： Chondrosarcoma Nasal septum Endoscopic surgical procedure Computed tomography Radiology

Macrophage PD-L1 strikes back: PD-1/PD-L1 interaction drives macrophages toward regulatory subsets

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Advances in Bioscience and Biotechnology 2013年第8期4卷 19-29页

作者： Yun-Jung Lee young-Hye moon Kyeong Eun Hyung Jong-Sun Yoo Mi Ji Lee Ik Hee Lee Byung Sung Go Kwang Woo Hwang Laboratory of Host Defense Modulation College of Pharmacy Chung-Ang University Seoul Korea

Activated macrophages have been simply de?ned as cells that secrete in?ammatory mediators and kill intracellular pathogens until few years ago. Recent studies have proposed a new classification system to separate activated macrophages based on their functional phenotypes: host defense, wound healing, and immune regulation. Regulatory macrophages can arise following innate or adaptive immune responses and hinder macrophage-mediated host defense and inflammatory functions by inhibiting the production of pro-inflammatory mediators. In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host defense activity, which consists of the production of pro-inflammatory cytokine IL-6 and the exhibition of increased IL-10, SPHK1 and LIGHT gene levels in early phases of LPS stimulation. This differentiation seems to occur through excessive activation of TLR4 downstream MAPK signaling pathways. Regulatory macrophages induced from PD-1/PD-L1 interaction decrease inflammatory mediators and produce anti-inflammatory cytokines, so this macrophage subset has been under considerable attention as a possible immune regulation mechanism. Understanding and modulating regulatory macrophages may lead to new approches to treat or prevent auto-immune diseases such as type I diabetes, rheumatic syndrome and hypersensitivity-related diseases, which are concerned with the overproduction of inflammatory cytokines in macroages.

关键词： Regulatory Macrophage PD-1 PD-L1

Randomized controlled trial to evaluate the efficacy and safety of fexuprazan compared with esomeprazole in erosive esophagitis

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World Journal of Gastroenterology 2022年第44期28卷 6294-6309页

作者： Kang Nyeong Lee Oh young Lee hoon Jai Chun Jin Il Kim Sung Kook Kim Sang Woo Lee Kyung Sik Park Kook Lae Lee Suck Chei Choi Jae-young Jang Gwang Ha Kim In-kyung Sung Moo In Park Joong Goo Kwon Nayoung Kim Jae Jun Kim Soo Teik Lee Hyun Soo Kim Ki Bae Kim Yong Chan Lee Myung-Gyu Choi Joon Seong Lee Hwoon-Yong Jung Kwang Jae Lee Jie-Hyun Kim Hyunsoo Chung Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Korea University Anam HospitalSeoul 02841South Korea Department of Internal Medicine The Catholic University of KoreaYeouido ST.Mary’s HospitalSeoul 07260South Korea Department of Internal Medicine Kyungpook National University HospitalDaegu 41944South Korea Department of Internal Medicine Korea University Ansan HospitalAnsan-si 15355South Korea Department of Internal Medicine Keimyung University Dongsan HospitalDaegu 42601South Korea Department of Internal Medicine Seoul Metropolitan Government Seoul National University Boramae Medical CenterSeoul 07061South Korea Department of Internal Medicine Wonkwang University HospitalIksan 54538South Korea Department of Internal Medicine KyungHee University Medical CenterSeoul 02447South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 47241South Korea Department of Internal Medicine KKonkuk University Medical CenterSeoul 05030South Korea Department of Internal Medicine Kosin University Gaspel HospitalBusan 49267South Korea Department of Internal Medicine Daegu Catholic University Medical CenterDaegu 42471South Korea Department of Internal Medicine Seoul National University Bundang HospitalSeongnam-si 13620Gyeonggi-doSouth Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chonbuk National University HospitalJeonju-si 54907South Korea Department of Internal Medicine Chonnam National University HospitalGwangju 61469South Korea Department of Internal medicine Chungbuk National University School of MedicineCheong Ju 28644South Korea Department of Internal Medicine Severance HospitalSeoul 03722South Korea Department of Internal Medicine The Catholic University of KoreaSeoul ST.Mary’s HospitalSeoul 06591South Korea Digestive Disease Center Soon

BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal ***’s suppression of gastric acid was maintained in healthy individuals for 24 h in a dose-dependent *** To compare fexuprazan to esomeprazole and establish its efficacy and safety in patients with erosive esophagitis(EE).METHODS Korean adult patients with endoscopically confirmed EE were randomized 1:1 to receive fexuprazan 40 mg or esomeprazole 40 mg once daily for eight *** primary endpoint was the proportion of patients with healed EE confirmed by endoscopy at week *** secondary endpoints included the healing rate of EE at week 4,symptom response,and quality of life *** profiles and serum gastrin levels were compared between the *** Of the 263 randomized,218 completed the study per protocol(fexuprazan 40 mg,n=107;esomeprazole 40 mg,n=111).Fexuprazan was non-inferior to esomeprazole regarding the healing rate at week 8[99.1%(106/107)vs 99.1%(110/111)].There were no between-group differences in the EE healing rate at week 4[90.3%(93/103)vs 88.5%(92/104)],symptom responses,and quality of life ***,serum gastrin levels at weeks 4 and 8 and drug-related side effects did not significantly differ between the *** Fexuprazan 40 mg is non-inferior to esomeprazole 40 mg in EE healing at week *** suggest that fexuprazan is an alternative promising treatment option to PPIs for patients with EE.

关键词： Gastroesophageal reflux Esophagitis Proton pump inhibitors Heartburn Quality of life

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腕关节三角纤维软骨复合体损伤的关节镜治疗

中国矫形外科杂志 2003年第24期11卷 1687-1689页

作者： young-lae moon Sung-jae.Kim 玄文虎韩国光州广域市朝鲜大学附属医院矫形外科韩国汉城延世大学

目的 :对外伤性腕关节三角纤维软骨复合体 (TFCC)损伤关节镜治疗后疗效评价。方法 :选有急慢性外伤史的 13例 14侧腕关节三角纤维软骨复合体损伤病例 ,年龄 2 1～ 45岁 ,平均 2 8.3岁。经关节造影、物理检查及MRI检查有异常者施行关节... 详细信息

目的 :对外伤性腕关节三角纤维软骨复合体 (TFCC)损伤关节镜治疗后疗效评价。方法 :选有急慢性外伤史的 13例 14侧腕关节三角纤维软骨复合体损伤病例 ,年龄 2 1～ 45岁 ,平均 2 8.3岁。经关节造影、物理检查及MRI检查有异常者施行关节镜检查 ,其中 8例TFCC中心性撕裂在关节镜下行游离边缘切除术 ,5例 6侧TFCC边缘部撕裂施行缝合修复术 ,术后平均随访 2 8个月。利用Green -O’Brien功能评定方法。结果 :优 9例 ,良 3例 ,可 2例。其中 12例疗效良好以上者恢复原来工作。结论 :对腕关节三角纤维软骨复合体损伤关节镜治疗是明确诊断及术后可以得到良好疗效并早期康复的一种有效术式。

关键词：三角纤维软骨复合体 TFCC 腕关节镜边缘切除术治疗临床资料

A New Factorized Backprojection Algorithm for Stripmap Synthetic Aperture Radar

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Positioning 2013年第1期4卷 42-56页

作者： Kyra moon David G. Long Microwave Earth Remote Sensing Laboratory Brigham Young University Provo USA

Factorized backprojection is a processing algorithm for reconstructing images from data collected by synthetic aperture radar (SAR) systems. Factorized backprojection requires less computation than conventional time-domain backprojection with minimal loss in accuracy for straight-line motion. However, its implementation is not as straightforward as direct backprojection. This paper provides a new, easily parallelizable formulation of factorized backprojection designed for stripmap SAR data that includes a method of implementing an azimuth window as part of the factorized backprojection algorithm. We compare the performance of windowed factorized backprojection to direct backprojection for simulated and actual SAR data.

关键词： Backprojection Windows Synthetic Aperture Radar (SAR)

Clinical significance and risk factors of postembolization fever in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第2期19卷 284-289页

作者： Chung Hwan Jun Ho Seok Ki hoon Ki Lee Kang Jin Park Seon young Park Sung Bum Cho Chang Hwan Park young Eun Joo Hyun Soo Kim Sung Kyu Choi Jong Sun Rew Division of Gastroenterology Department of Internal MedicineChonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate tumor response and survival in patients with postembolization fever(PEF) and to determine the risk factors for ***:Four hundred forty-three hepatocellular carcinoma(HCC) patients who underwent the first session of transcatheter arterial chemoembolization(TACE) between January 2005 and December 2009 were analyzed *** was defined as a body temperature greater than 38.0 ℃ that developed within 3 d of TACE without evidence of *** tumor progression-free interval was defined as the interval from the first TACE to the second TACE based on mRECIST *** staging was based on the American Joint Committee on Cancer tumor,node,metastases(TNM) classification of malignant *** patients were admitted before their 1 st TACE treatment,and blood samples were obtained from all patients before and after *** variables and host-related variables were compared between two groups:patients with PEF vs patients without ***,variables related to 20-mo mortality and tumor progression-free survival were ***:The study population comprised 370(85.4%) men and 73(14.6%) women with a mean age of 62.29 ± 10.35 years.A total of 1836 TACE sessions were conducted in 443 patients,and each patient received between 1 and 27(mean:4.14 ± 3.57) TACE *** mean follow-up duration was 22.23 ± 19.6 mo(range:0-81 mo).PEF developed in 117 patients(26.41%) at the time of the first TACE *** was not associated with 20-mo survival(P = 0.524) or computed tomography(CT) response(P = 0.413) in a univariate analysis.A univariate analysis further indicated that diffuse-type HCC(P = 0.021),large tumor size(≥ 5 cm)(P = 0.046),lipiodol dose(≥ 7 mL,P = 0.001),poor blood glucose control(P = 0.034),alanine aminotransferase(ALT) value after TACE(P = 0.004) and C-reactive protein(CRP) value after TACE(P = 0.036) served as possible risk factors correlated with *** ALT value after TACE(P = 0.02

关键词： Chemoembolization Therapeutic Fever Carcinoma Hepatocellular Prognosis Progression-free survival