检索结果-南通市图书馆

Discovery of highly immunogenic spleen-resident FCGR3^(+)CD103^(+)cDC1s differentiated by IL-33-primed ST2^(+)basophils

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第7期20卷 820-834页

作者： Myeong-Ho Kang JungHyub Hong Jinjoo Lee Min-Suk Cha Sangho Lee Hye-young Kim Sang-Jun Ha Yong Taik Lim Yong-Soo bae Department of Biological Sciences Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea Center for Immune Research on Non-Lymphoid Organs Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyounggi-do 16419Republic of Korea Laboratory of Mucosal Immunology Department of Biomedical SciencesSeoul National University College of Medicine103 Daehak-roJongno-guSeoul 03080Republic of Korea Institute of Allergy and Clinical Immunology Seoul National University Medical Research CenterSeoulRepublic of Korea Department of Biochemistry College of Life Science and BiotechnologyYonsei UniversitySeoul 03722Republic of Korea Department of Nano Engineering and School of Chemical Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-siGyeonggi-do 16419Republic of Korea.

Recombinant interleukin-33(IL-33)inhibits tumor growth,but the detailed immunological mechanism is still ***-33-mediated tumor suppression did not occur in Batf3^(−/−)mice,indicating that conventional type 1 dendritic cells(cDC1s)play a key role in IL-33-mediated antitumor immunity.A population of CD103^(+)cDC1s,which were barely detectable in the spleens of normal mice,increased significantly in the spleens of IL-33-treated *** newly emerged splenic CD103^(+)cDC1s were distinct from conventional splenic cDC1s based on their spleen residency,robust effector T-cell priming ability,and surface expression of *** and DC precursors did not express Suppressor of Tumorigenicity 2(ST2).However,recombinant IL-33 induced spleen-resident FCGR3^(+)CD103^(+)cDC1s,which were found to be differentiated from DC precursors by bystander ST2+immune *** immune cell fractionation and depletion assays,we found that IL-33-primed ST2^(+)basophils play a crucial role in the development of FCGR3^(+)CD103^(+)cDC1s by secreting IL-33-driven extrinsic *** GM-CSF also induced the population of CD103^(+)cDC1s,but the population neither expressed FCGR3 nor induced any discernable antitumor *** population of FCGR3^(+)CD103^(+)cDC1s was also generated in vitro culture of Flt3L-mediated bone marrow-derived DCs(FL-BMDCs)when IL-33 was added in a pre-DC stage of ***-BMDCs generated in the presence of IL-33(FL-33-DCs)offered more potent tumor immunotherapy than control Flt3L-BMDCs(FL-DCs).Human monocyte-derived DCs were also more immunogenic when exposed to IL-33-induced *** findings suggest that recombinant IL-33 or an IL-33-mediated DC vaccine could be an attractive protocol for better tumor immunotherapy.

关键词： Recombinant interleukin-33(IL-33) Highly immunogenic Spleen residency FCGR3^(+)CD103^(+)cDC1s ST2^(+)basophils Antitumor immunity

Synthesis of a Rod-rod Diblock Copolymer, Poly (3-hexylthiophene)-block-poly(furfuryl isocyanate), through the Anionic Polymerization with an Oxyanionic Macroinitiator

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2019年第9期37卷 866-874页

作者： Chang-Geun Chae Joonkeun Min In-gyu Bak Jae-Suk Lee School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST)

A rod-rod diblock copolymer (diBCP), poly(3-hexylthiophene)-block-poly(furfuryl isocyanate)(P3HT-b-PFIC), was synthesized through the anionic polymerization with an oxyanionic macroinitiator of P3HT. The properties of the diBCP (molecular weight, dispersity, composition, thermal stability, UV-visible absorption, and thin film morphology) were determined by various analytical methods. P3HT-b-PFIC was blended with C60 in a toluene solution to prepare a thin film of binary electron donor/acceptor system. Such blending enabled partial conjugation of the two components by the Diels-Alder reaction between furan and C60 at 60℃ for 3 h;the mixture was then spin-cast as a thin film, and annealed at 250℃ for 24 h. Tapping-mode atomic force microscopy (AFM) revealed that P3HT and C60 domains had nanoscale interfaces without a large phase segregation. This result indicated that the microphase separation of C60-functionalized P3HT-b-PFIC preserved even at high temperature provided free C60 molecules with channels to diffuse on the sides of P3HT domain, thus preventing the macroscopic crystallization of free C60 through the interfacial stabilization.

关键词： Rod-rod diblock copolymer Poly(3-hexylthiophene)-block-poly(furfuryl isocyanate) C60 Diels-Alder reaction Nanoscale interfaces

Effect of friction on the contact stress of a coated polymer gear

在线全文

学校读者我要写书评

暂无评论

Friction 2020年第6期8卷 1169-1177页

作者： Su-Min bae Kuk-Jin SEO Dae-Eun KIM Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea

Polymer gears are used extensively in various ***,durability issues have been emerging because of friction at gear tooth contact *** extend the lifetime of polymer gears,a low-frictional coating has been considered as a possible *** this study,a finite element simulation method was performed to investigate the contact stress between a pair of coated polymer *** simulation included various friction coefficients(COFs)for studying the effects of friction during the *** results revealed that the friction causes the contact stress to shift over the roll angle,which is attributed to the direction of the sliding friction based on a free-body *** also investigated the effects of coating and found that a thin coating has little effect on the bulk deformation behavior of the ***,the stress distribution in the coating at the pitch point was investigated as the COF *** zero friction,three notable stress regions were observed:1)the center of the surface,2)the end of the contact,and 3)the overall contact *** COF was increased in the micro-slip region of the contact interface,both tensile and compressive stresses in the coating *** study provides significant aid to engineers for understanding the stress response of the coating applied to polymer gears to achieve an optimal design.

关键词： coating contact stress finite element method(FEM) friction polymer gear

Injury of the Papez circuit in a patient with traumatic spinal cord injury and concomitant mild traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第1期13卷 161-162页

作者： Sung Ho Jang Hyeok gyu Kwon Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Department of Physical Therapy College of Health Sciences Catholic University of Pusan

Little is known about brain injury in concomitant mild traumatic brain injury （TBI） following traumatic spinal cord injury （TSCI）. In this study, we reported on a male patient with memory impairment who showed inj... 详细信息

关键词： TBI

Endoscopic submucosal dissection of a large colonic lipoma:Report of two cases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第10期21卷 3127-3131页

作者： Jae Min Lee Jeong Ho Kim Myungsung Kim Jun Hyoung Kim young bae Lee Jae Hyuk Lee Che Wan Lim Department of Internal Medicine Myongji Hospital

A colonic lipoma is a very rare benign tumor that is usually asymptomatic and is found incidentally by *** with a large colonic lipoma may present with symptoms such as abdominal pain,bleeding,and colonic obstruction or *** report two patients with large colonic lipomas and *** endoscopic submucosal dissection(ESD) was performed to remove the lipomas instead of conventional surgical bowel *** complications were observed during or after the *** tumors were resected en bloc,and the patients were discharged 2 d after ESD with a regular *** results indicate that ESD can be applied as safe and effective treatment for a large colonic lipoma.

关键词： Colon lipoma Endoscopic submucosal dissection

Characteristics of surface and subsurface of formed thread parts by axial-infeed thread rolling process

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2023年第3期36卷 471-481页

作者： Shuowen ZHANG Dawei ZHANG Shengdun ZHAO Fei JIANG Myoung-gyu LEE Xi’an Key Laboratory of Intelligent Equipment and Control School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China Department of Materials Science and Engineering Seoul National University08826 SeoulRepublic of Korea

The thread rolling process has been widely applied to manufacture high-performance thread *** this process,the evolutions of surface and subsurface are frequently introduced,which affect the working performance of manufactured *** this study,an axial-infeed thread rolling process(ATRP)is employed,and the macro-meso surface characteristics under different lubrications and operating conditions are ***,the distributions of microstructure and hardness on the subsurface of formed tooth are analyzed in detail,along with the study of stress state and yield strength *** is found that the MoS_(2)grease is more effective in reducing the surface roughness and defects than the lubrication oil and water-base graphite during the ATRP *** rolling speed improves the quality of surface morphology and can reduce the surface *** the subsurface of bottom and flank,intensive shear stress occurs in a narrow region,resulting in the elongation and refinement of the grains and increasing the low angle grain boundary *** on the grain size and plastic strain,the yield strength is *** maximum yield strength and hardness on the bottom of formed tooth are improved by 41.2% and 39.4%,respectively.

关键词： ATRP Lubrication Surface characteristics Microstructure distribution Hardness improvement Grain size

Recent progress in quasi-two-dimensional and quantum dot perovskite light-emitting diodes harnessing the diverse effects of ligands:A review

在线全文

学校读者我要写书评

暂无评论

Nano Research 2022年第7期15卷 6449-6465页

作者： Yurim bae Jun Ryu Saemon Yoon Dong-Won Kang School of Energy Systems Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Smart City Chung-Ang UniversitySeoul 06974Republic of Korea

Halide perovskites have been extensively studied for use as light-emitting diodes(LEDs)in next-generation displays due to their beneficial characteristics,including their high color purity and wide color *** perovskites can be categorized into four representative structures:three-dimensional(3D)bulk,two-dimensional(2D),quasi-two-dimensional(quasi-2D),and quantum dot(QD).Recently,excellent advances in the performance of perovskite LEDs(PeLEDs),especially those with quasi-2D and QD architectures,have been demonstrated with the incorporation of organic chain *** can both modify the structure of PeLEDs,such as forming multi-quantum wells in quasi-2D PeLEDs and essential passivation layers in QD PeLEDs,and also enhance their optical *** appropriate use of ligands in PeLEDs can thus lead to greater luminescence,current efficiency,power efficiency,and external quantum *** this review,the principal roles of ligands in quasi-2D and QD PeLEDs are systematically ***,current limitations and future perspectives are discussed in detail.

关键词： perovskites light emitting diode ligands quasi-two-dimensional(quasi-2D) quantum dot

Gait Optimization of a Quadruped Robot Using Evolutionary Computation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bionic Engineering 2021年第2期18卷 306-318页

作者： Jihoon Kim Dang Xuan Ba Hoyeon Yeom Joonbum bae Mechanical Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919South Korea Automatic Control HoChiMinh City University of Technology and Education(HCMUTE)HoChiMinh City 71307Vietnam

Evolutionary Computation(EC)has strengths in terms of computation for gait ***,conventional evolutionary algorithms use typical gait parameters such as step length and swing height,which limit the trajectory deformation for optimization of the foot ***,the quantitative index of fitness convergence is *** this paper,we perform gait optimization of a quadruped robot using foot placement perturbation based on *** proposed algorithm has an atypical solution search range,which is generated by independent manipulation of each placement that forms the foot trajectory.A convergence index is also introduced to prevent premature cessation of *** conventional algorithm and the proposed algorithm are applied to a quadruped robot;walking performances are then compared by gait *** the two algorithms exhibit similar computation rates,the proposed algorithm shows better fitness and a wider search *** evolutionary tendency of the walking trajectory is analyzed using the optimized results,and the findings provide insight into reliable leg trajectory design.

关键词： bionic robot evolutionary computation genetic algorithm gait optimization parameter perturbation convergence index

Novel Time-dependent Multi-omics Integration in Sepsis-associated Liver Dysfunction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1101-1116页

作者： Ann-Yae Na Hyojin Lee Eun Ki Min Sanjita Paudel So young Choi HyunChae Sim Kwang-Hyeon Liu Ki-Tae Kim Jong-Sup bae Sangkyu Lee Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 41566Republic of Korea Department of Environmental Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of PharmacyKyungpook National UniversityDaegu 41566Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

The recently developed technologies that allow the analysis of each single omics have provided an unbiased insight into ongoing disease ***,it remains challenging to specify the study design for the subsequent integration strategies that can associate sepsis pathophysiology and clinical ***,we conducted a time-dependent multi-omics integration(TDMI)in a sepsis-associated liver dysfunction(SALD)*** successfully deduced the relation of the Toll-like receptor 4(TLR4)pathway with *** TLR4 is a critical factor in sepsis progression,it is not specified in single-omics analyses but only in the TDMI *** finding indicates that the TDMI-based approach is more advantageous than single-omics analyses in terms of exploring the underlying pathophysiological mechanism of ***,TDMI-based approach can be an ideal paradigm for insightful biological interpretations of multi-omics datasets that will potentially reveal novel insights into basic biology,health,and diseases,thus allowing the identification of promising candidates for therapeutic strategies.

关键词： Multi-omics Omics technology Sepsis-associated liver dysfunction Single omics Time-dependent integration