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Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction

World Journal of Gastroenterology 2015年第9期21卷 2614-2621页

作者： Hyun joo Shin eun young Chang Hye Sun Lee Jung Hwa Hong Gyuri Park Hyun Gi Kim Myung-joon Kim Mi-Jung Lee Department of Radiology and Research Institute of Radiological Science Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Department of Pediatric Surgery Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Biostatistics Collaboration Unit Yonsei University College of MedicineSeoul 120-752South Korea Department of Laboratory Animal Resources Avison Bio Medical Research CenterYonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal ***:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction *** performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were *** CEUS,signal intensity of liver parenchyma with a time-intensity curve was *** parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to *** grades of liver fibrosis were assessed according to the Metavir score system immediately after *** estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical *** perfusion parameters were measured on the last day and the difference between day 0 and the last day were ***:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two *** the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis ***:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter.

关键词： Ultrasonography Contrast enhanced ultrasound Liver

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High-temperature Oxidation Behavior of Zircaloy-4 and Zirlo in Steam Ambient

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Journal of Materials Science & Technology 2010年第9期26卷 827-832页

作者： Hyung Hoon Kim Jun Ho Kim Jin young Moon Ho Seong Lee Jeong joo Kim young Suck Chai School of Materials Science and Engineering Kyungpook National University School of Mechanical Engineering Yeungnam University214-1 Dae-dongGyeongsan-si

The oxidation characteristics for Zircaloy-4 and Zirlo in the temperature range of 700-1200°C under steam supply condition were investigated by using a modified thermo-gravimetric *** specimens were oxidized for 3600 s at each temperature and then quenched in a *** oxidation rate constants were measured from the weight gains to evaluate the oxidation behavior in Zircaloy-4 and *** weight gain rates of Zirlo were lower than those of Zircaloy-4,leading to the low rate *** different oxidation behaviors between both cladding materials were considered to be due to the difference in their chemical compositions.

关键词： Zircaloy-4 Zirlo Oxidation

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Colorectal cancer mortality in Hong Kong of China,Japan,South Korea,and Singapore

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World Journal of Gastroenterology 2013年第7期19卷 979-983页

作者： Aesun Shin Kyu-Won Jung young-joo Won Cancer Registration and Statistics Branch National Cancer Control InstituteNational Cancer CenterGoyang-si 410-769South Korea Molecular Epidemiology Branch Division of Cancer Epidemiology and PreventionNational Cancer Center Research InstituteGoyang-si 410-769South Korea

To clarify the trend in colorectal cancer mortality in Asian *** analyzed the colorectal cancer mortality in four Asian countries using the World Health Organization mortality database and the Korea National Statistics Office *** annual age-standardized rates and truncated rated for the three age groups(30-49,50-69 and ≥ 70 years) for Hong Kong of China(1969-2009),Japan(1955-2009),South Korea(1985-2006),and Singapore(1966-2009) were estimated.A joinpoint regression model was used to detect significant trends in mortality *** cancer mortality in men started to decrease in 1992 in Japan followed by Singapore and Hong Kong of China in *** mortality rates in women stared to decrease in 1980 in Singapore,followed by Hong Kong of China and Japan in *** all countries and both genders,except for women in Singapore,the decrease in mortality began in the younger age *** colorectal cancer mortality in the four studied Asian countries has started to decrease,and the decrease occurred first in the younger age groups.

关键词： Colorectal cancer Mortality Joinpoint regression Trends Early detection of cancer Mass screening

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Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

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World Journal of Gastroenterology 2018年第34期24卷 3849-3860页

作者： Jae Yoon Jeong young Seo Cho joo Hyun Sohn Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medicine Department of Radiology Hanyang University Guri Hospital Hanyang University College of Medicine

Liver biopsy is the gold standard for evaluating the degree of liver fibrosis in patients with chronic liver disease. However, due to the many limitations of liver biopsy, there has been much interest in the use of noninvasive techniques for this purpose. Among these techniques real-time two-dimensional shear wave elastography(2D-SWE) has the advantage of measuring tissue elasticity with the guidance of B-mode images. Recently, many studies have been conducted on the application of 2D-SWE in patients with various liver diseases, and their validity has been confirmed. Here, we briefly discuss the role of 2D-SWE in patients with chronic liver diseases, particularly aspects of the examination techniques and clinical applications.

关键词： Shear wave elastography Liver disease Liver fibrosis Portal hypertension Hepatocelluar carcinoma

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Adaptive Model Predictive Control for Yaw System of Variable-speed Wind Turbines

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Journal of Modern Power Systems and Clean Energy 2021年第1期9卷 219-224页

作者： Dongran Song Qing Chang Songyue Zheng Sheng Yang Jian Yang young Hoon joo the School of Automation Central South Universityand Hunan Provincial Key Laboratory of Power Electronics Equipment and GridChangsha 410083China the School of Energy Science and Engineering Central South UniversityChangsha 410083China the School of IT Information and Control Engineering Kunsan National UniversityKunsan 54150Korea

Due to varying characteristics of the wind condition, the performance of the wind turbines can be optimized by adapting the parameters of the control system. In this letter, an adaptive technique is proposed for the novel model predictive control(MPC) for the yaw system of the wind turbines. The control horizon is adapted to the one with the best predictive performance among multiple control horizons. The adaptive MPC is demonstrated by simulations using real wind data, and its performance is compared with the baseline MPC at fixed control horizon. Results show that the adaptive MPC provides better comprehensive performance than the baseline ones at different preview time of wind directions. Therefore, the proposed adaptive technique is potentially useful for the wind turbines in the future.

关键词： Wind turbine yaw system wind direction adaptive model predictive control

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Effect of robot-assisted gait training on the biomechanical properties of burn scars:a single-blind,randomized controlled trial

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Burns & Trauma 2022年第1期10卷 191-199页

作者： Yoon Soo Cho So young joo Cheong Hoon Seo Department of Rehabilitation Medicine Hangang Sacred Heart HospitalCollege of MedicineHallym UniversitySeoul 07247Republic of Korea

Background:Robot-assisted gait training(RAGT)is more effective in the range of motion(ROM)and isometric strength in patients with burns than conventional ***,concerns have been raised about whether RAGT might negatively affect the scars of patients with ***,we investigated the effects of RAGT-induced mechanical load on the biomechanical properties of burn ***:This was a single-blind,randomized clinical trial conducted on inpatients admitted to the Department of Rehabilitation Medicine between September 2020 and August *** was conducted for 30 min per day,five days a week for 12 weeks and the control group received conventional gait training for 12 *** pre-training ROM of lower extremity joints was evaluated and the levels of melanin,erythema,trans-epidermal water loss,scar distensibility and elasticity were assessed before training and at 4 and 12 weeks after ***,19 patients in the gait assistance robot(GAR)group and 20 patients in the control group completed the 12-week trial and all ***:There were no significant differences in the epidemiologic characteristics,pre-training ROM of joints and pre-training biomechanical properties of the burn scar between the groups(p>0.05 for all).None of the patients experienced skin abrasion around the burn scar where the fastening belts were applied or musculoskeletal or cardiovascular adverse events during the *** thickness significantly increased in both groups(p=0.037 and p=0.019)and scar distensibility significantly decreased in the control group(p=0.011)during the *** was significantly decreased in the GAR group during the training(p=0.038).The GAR and control groups showed significant difference in the change in the values of hysteresis between pre-training and 12 weeks after training(p=0.441 and p=0.049).Conclusions:RAGT significantly decreased hysteresis in hypertrophic burn scars and did not cause a significant decrease

关键词： Robot-assisted gait training Burn Scar biomechanical properties Hysteresis Burn rehabilitation

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An Efficient and Spam-Robust Proximity Measure Between Communication Entities

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Journal of Computer Science & Technology 2013年第2期28卷 394-400页

作者： joo Hyuk Jeon Jihwan Song Jeong eun Kwon Yoon joon Lee Man Ho Park Myoung Ho Kim Department of Computer Science Korea Advanced Institute of Science and Technology Biz Solution Team SK Telecom Information Technology R&D Center Mobile Communication Convergence Research Team Electronics and Telecommunications Research Institute

Electronic communication service providers are obliged to retain communication data for a certain amount of time by their local laws. The retained communication data or the communication logs are used in various applications such as crime detection, viral marketing, analytical study, and so on. Many of these applications rely on effective techniques for analyzing communication logs. In this paper, we focus on measuring the proximity between two communication entities, which is a fundamental and important step toward further analysis of communication logs, and propose a new proximity measure called ESP （Efficient and Spam-Robust Proximity measure）. Our proposed measure considers only the （graph- theoretically） shortest paths between two entities and gives small values to those between spam-like entities and others. Thus, it is not only computationally efficient but also spam-robust. By conducting several experiments on real and synthetic datasets, we show that our proposed proximity measure is more accurate, computationally efficient and spam-robust than the existing measures in most cases.

关键词： proximity closeness spam electronic communication

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Enhancement of photoresponsive electrical characteristics of multilayer MoS2 transistors using rubrene patches

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Nano Research 2015年第3期8卷 790-800页

作者： eun Hei Cho Won Geun Song Cheol joon Park Jeongyong Kim Sunkook Kim Jinsoo joo Department of Physics Korea University Seou1136-713 R. O. Korea Department of Electronics and Radio Engineering Institute for Laser Engineering Kyung Hee University Yongin Gyeonggi-do 446-70 I R. O. Korea Center for Integrated Nanostructure Physics (CINAP) Institute for Basic Science (IBS) Department of Energy Science Sungkyunkwan University Suwon 440-746 R. O. Korea

Multilayer MoS2 is a promising active material for sensing, energy harvesting, and optoelectronic devices owing to its intriguing tunable electronic band structure. However, its optoelectronic applications have been limited due to its indirect band gap nature. In this study, we fabricated a new type of phototransistor using multilayer MoS2 crystal hybridized with p-type organic semiconducting rubrene patches. Owing to the outstanding photophysical properties of rubrene, the device characteristics such as charge mobility and photoresponsivity were considerably enhanced to an extent depending on the thickness of the rubrene patches. The enhanced photoresponsive conductance was analyzed in terms of the charge results of the nanoscale laser confocal time-resolved PL measurements. transfer doping effect, validated by the microscope photoluminescence （PL） and

关键词： MoS2 rubrene transistor photoresponsivity charge transfer

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Celecoxib attenuates 5-fluorouracil-induced apoptosis in HCT-15 and HT-29 human colon cancer cells

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World Journal of Gastroenterology 2007年第13期13卷 1947-1952页

作者： Yun Jeong Lim Jong Chul Rhee young Mee Bae Wan joo Chun Department of Internal Medicine Dongguk University International Hospital Dongguk University College of Medicine Goyang Korea Division of Gastroenterology Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea Department of Parasitology Seoul National University College of Medicine Seoul Korea Department of Pharmacology Kangwon National University College of Medicine Chuncheon Korea

AIM： To investigate the combined chemotherapeutic effects of celecoxib when used with 5-FU in vitro. METHODS： Two human colon cancer cell lines （HCT-15 and HT-29） were treated with 5-FU and celecoxib, alone and in combination. The effects of each drug were evaluated using the MTT （3-（4, 5-dimethylthiazol-2-yl）-2, 5-diphenyltetrazolium bromide） assay, flow cytometry, and western blotting. RESULTS： 5-FU and celecoxib showed a dosedependent cytotoxic effect. When treated with 10-3 mol/L 5-FU （IC50） and celecoxib with its concentration ranging from 10.8 mol/L to 10.4 mol/L of celecoxib, cells showed reduced cytotoxic effect than 5-FU （10.3 mol/L） alone. Flow cytometry showed that celecoxib attenuated 5-FU induced accumulation of cells at subG1 phase. Western blot analyses for caspase-3 and poly （ADP-ribose） polymerase （PARP） cleavage showed that celecoxib attenuated 5-FU induced apoptosis. Western blot analyses for cell cycle molecules showed that G2/M arrest might be possible cause of 5-FU induced apoptosis and celecoxib attenuated 5-FU induced apoptosis via blocking of cell cycle progression to the G2/M phase, causing an accumulation of cells at the GI/S phase. CONCLUSION： We found that celecoxib attenuated cytotoxic effect of 5-FU. Celecoxib might act via inhibition of cell cycle progression, thus preventing apoptosis induced by 5-FU.

关键词： Antagonism Celecoxib Colorectal neoplasms Fluorouracil

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Flow characteristics of aluminum coated boron steel in hot press forming

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中国有色金属学会会刊：英文版 2009年第4期19卷 913-916页

作者： Jeong-Hwan JANG Jae-Ho LEE Bye ong-Don joo young-Hoon MOON School of Mechanical Engineering Pusan National University

The flow characteristics of aluminum coated boron steel in hot press forming were ***,the effects of aluminum coated layer on press forming were analyzed during deep *** results show that aluminum coated boron steel exhibits a high sensitivity on temperature and strain *** coating layer appears in surface flaking in a temperature range of 700-800 ℃,but smooth surface is formed above 900 ℃.

关键词：热压成型流动特性铝涂层硼钢表面剥落温度范围冲压成形高灵敏度

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