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Diagnostic accuracy of administrative database for bile duct cancer by ICD-10 code in a tertiary institute in Korea

Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 575-580页

作者： young-Jae Hwang Seon Mee Park soomin Ahn Jongchan Lee young soo Park nayoung Kim Department of Internal Medicine Seoul National University Bundang HospitalSeongnamKorea Department of Internal Medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongjuKorea Department of Pathology Seoul National University Bundang HospitalSeoungnamKorea Department of Internal Medicine and Institute of Liver Research Seoul National University College of MedicineSeoulKorea Tumor Microenvironment Global Core Research Center Seoul National UniversitySeoulKorea

Background:Administrative database provides valuable information for large cohort studies,especially when tissue diagnosis is rather difficult such as the diagnosis for bile duct cancer(BDC).The aim of this study was to evaluate the diagnostic accuracy of administrative database for BDC by International Classification of Diseases(ICD)-10 codes in a tertiary ***:BDC and control groups were collected from 2003 to 2016 at Seoul national University Bundang *** of BDC were identified in the national Health Insurance Service(NHIS)database by ICD 10-code supported by V *** control group was selected from cases without ICD-10 codes for BDC.A definite or possible diagnosis was defined according to pathologic *** records,images,and pathology reports were analyzed to evaluate ICD-10 codes for ***,specificity,positive predictive value,and negative predictive value for BDC were analyzed according to diagnostic criteria and cancer ***:A total of 1707 patients with BDC and 1707 controls were *** those with BDC,1320(77.3%)were diagnosed by definite ***(99.4%)of them had *** of definite diagnosis was the highest for ampulla of Vater(88.9%),followed by that for extrahepatic(84.9%)and intrahepatic(68.3%)*** positive cases commonly had hepatocellular *** overall diagnosis of BDC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.94%,98.33%,98.30%,and 99.94%,*** accuracies were similar regardless of diagnostic criteria or tumor ***:Administrative database for BDC collected according to ICD-10 code with V code shows good accuracy.

关键词： national Health Insurance Service Bile duct cancer ICD-10

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The Role of Relative Spinal Motion during Feline Galloping for Speed Performance

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Journal of Bionic Engineering 2014年第4期11卷 517-528页

作者： young Kook Kim Jongwon Park Byungho Yoon Kyung-soo Kim soohyun Kim Robotics Program Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea

Felines use their spinal column to increase their running speed at rapid locomotion performance. However, its motion profile behavior during fast gait locomotion has little attention. The goal of this study is to examine the relative spinal motion profile during two different galloping gait speeds. To understand this dynamic behavior trend, a dynamic motion of the feline animal （Felis catus domestica） was measured and analyzed by motion capture devices. Based on the experiments at two different galloping gaits, we observed a significant increase in speed （from 3.2 m.s-1 to 4.33 m.s-1） during the relative motion profile synchronization between the spinal （range： 118.86~ to 168.00~） and pelvic segments （range： 46.35~ to 91.13~） during the hindlimb stance phase （time interval： 0.495 s to 0.600 s）. Based on this discovery, the relative angular speed profile was applied to understand the possibility that the role of the relative motion match during high speed locomotion generates bigger ground reaction force.

关键词： feline galloping galloping gait pattern relative spinal motion speed performance phase match

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Stud welding for fixation of cryogenic insulation of membrane tanks in LNG ship building

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中国有色金属学会会刊：英文版 2009年第B09期19卷 271-275页

作者： Jeong-soo LEE young-soo RYU nam-In KIM Bong-Joon KIM Yoo-Kyung KIM Myung-Hyun KIM Hanjin Heavy Industries & Construction Co. Ltd Department of naval Architecture and Ocean Engineering Pusan National University

The support plates including all of the inner hulls such as E grade steel, weld seams and SUS304L were considered to establish the optimal stud welding condition in LNG ship building. The stainless steel plate was especially applied to the bracket on the liquid dome. The polished and etched surfaces of the welded stud and support plate were examined if the bead was properly formed. With the micrographic examination, the fusion boundary of metal weld zone formed by stud welding was analyzed to optimize the welding parameters. And also the analysis of the unacceptable welding faults such as cold and hot weld were performed. The mechanical tests such as tensile tests and bending tests were carried out to reveal any abnormal variation in the relationship of process parameters and the strength.

关键词：螺柱焊接 LNG船绝缘膜优化工艺参数低温坦克不锈钢板最佳条件

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Formation and Characterization of Plasma Sprayed Photocatalytic TiO2- ZnO nano- Compounded Coatings

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Journal of Rare Earths 2004年第z2期22卷 162-166页

作者： Lee soo Wohn Aum Ho Sung Hur Bo young Chen Huang Division of Materials and Chemical Engineering Sun Moon UniversityAsanChungnam 336708Korea Division of Mechanical and Control EngineeringSun Moon UniversityAsanChungnam 336708Korea Division of Materials EngineeringGyeong Sang National UniversityChinju 660701Korea Division of Materials and Chemical EngineeringSun Moon UniversityAsanChungnam 336708Korea

Two kinds of TiO2-ZnO nano-compounded powders aggregated by spray-drying process and evaporation method were used to deposit photocatalytic coatings by atmospheric plasma spraying technique. The phase compositions, morphologies of the agglomerated TiO2-ZnO powders and the as-sprayed coating were characterized using X-ray diffraction (XRD) and field emission scanning electron microscope (FESEM) respectively. Furthermore, roughness measurements were carried out on their surfaces of the plasma sprayed TiO2-ZnO nano-comPounded coatings. Compared with the TiO2ZnO nano-compounded coating deposited from the spray-dried powder, it was found that the TiO2-ZnO nano-compounded coating deposited from the evaporated powder possesses higher anatase phase. It is ascribed to the existing of partially melted or non-melted microstructure in the TiO2-ZnO coating deposited from the evaporated powder. The partially-meltedor non-melted microstructure was retained from the starting agglomerated powder. This microstructure is beneficial to improve the photocatalytic properties of plasma sprayed TiO2-ZnO nano-compounded coatings.

关键词： plasma spraying spray-drying evaporation characterization TiO2-ZnO rare earths

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Chemical composition and antioxidant capacity of the aqueous extract of Phellodendron amurense

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Journal of Forestry Research 2018年第4期29卷 1033-1040页

作者： natarajan Velmurugan Duraisamy Kalpana Jae young Cho Yang soo Lee Department of Forestry College of Agriculture and Life Sciences Chonbuk National University Jeonju 54896 Republic of Korea Branch Laboratory-Itanagar CSIR-North East Institute of Science and Technology Naharlagun Arunachal Pradesh 791 110 India Department of Agricultural Chemistry Chonbuk National University Jeonju 54896 Republic of Korea

The aqueous extract of Phellodendron amurense Rupr. （Amur Cork Tree） provides a rich source of antioxidants and chemical compounds, and can be used for food and wood preservative materials. In this study, we characterized the chemical composition of this extract by GC and GC/MS. The antioxidant capacity was evaluated using a variety of antioxidant assays （superoxide radical, hydroxyl radical, nitric oxide radical, and DPPH radical scavenging activity）. Additionally, total polyphenolic content was determined. Phenolic acids and acetone derivatives were major compounds of the extract capable of scavenging the DPPH free radical and reducing ferric ions. DPPH and ferric ion reduction results were strongly correlated with total phenolic content of the extract which also exhibited strong nitric oxide, hydroxyl radical scavenging and superoxide anion radical scavenging activities.

关键词： Phellodendron amurense Aqueous extract Chemical characterization Antioxidant activity

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ASpediaFI:Functional Interaction Analysis of Alternative Splicing Events

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 466-482页

作者： Kyubin Lee Doyeong Yu Daejin Hyung soo young Cho Charny Park Bioinformatics Branch Research InstituteNational Cancer CenterGoyang 10408Republic of Korea

Alternative splicing(AS)regulates biological processes governing phenotypes and *** AS(DAS)gene test methods have been developed to investigate important exonic expression from high-throughput ***,the DAS events extracted using statistical tests are insufficient to delineate relevant biological *** this study,we developed a novel application,Alternative Splicing Encyclopedia:Functional Interaction(ASpediaFI),to systemically identify DAS events and co-regulated genes and *** establishes a heterogeneous interaction network of genes and their feature nodes(i.e.,AS events and pathways)connected by coexpression or pathway gene set ***,ASpediaFI explores the interaction network using the random walk with restart algorithm and interrogates the proximity from a query gene ***,ASpediaFI extracts significant AS events,genes,and *** evaluate the performance of our method,we simulated Rna sequencing(Rna-seq)datasets to consider various conditions of sequencing depth and sample *** performance was compared with that of other ***,we analyzed three public datasets of cancer patients or cell lines to evaluate how well ASpediaFI detects biologically relevant *** exhibits strong performance in both simulated and public *** integrative approach reveals that DAS events that recognize a global co-expression network and relevant pathways determine the functional importance of spliced genes in the *** is publicly available at https://***/packages/ASpediaFI.

关键词： Alternative splicing Rna-seq Heterogeneous interaction network Random walk with restart Gene set enrichment analysis

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我国高校心理健康教育政策发展历程与主题演进分析

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黑龙江高教研究 2024年第10期42卷 128-136页

作者：肖娜阳剑兰南华大学湖南衡阳421001

以1987—2023年国家层面颁布的高校心理健康教育政策文本为研究对象,综合政策效力量化模型和LDA主题模型分别对我国高校心理健康教育政策的演进历程、主题识别及强度演化情况进行分析。研究结果表明:我国高校心理健康教育政策演进历程... 详细信息

以1987—2023年国家层面颁布的高校心理健康教育政策文本为研究对象,综合政策效力量化模型和LDA主题模型分别对我国高校心理健康教育政策的演进历程、主题识别及强度演化情况进行分析。研究结果表明:我国高校心理健康教育政策演进历程分为萌芽扎根期、成长探索期、深化发展期等三个阶段,政策体系经历了从无到有的发展过程;政策主题涵盖“思想健康与品德教育”“心理健康知识与技能教学”“青年人才择业心理疏导与服务”“心理咨询服务与队伍建设”“心理健康教育环境与体系构建”“心理卫生工作保健与服务”等六个方面,各主题强度随着政策演进阶段的发展而趋于平衡,政府愈加重视高校心理健康教育工作建设并统筹兼顾其各方面发展。

关键词：高校心理健康教育政策演进主题挖掘 LDA主题模型政策效力量化模型

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Nusinersen for spinal muscular atrophy types Ⅱ and Ⅲ:a retrospective single-center study in South Korea

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World Journal of Pediatrics 2023年第5期19卷 450-459页

作者： Hui Jin Shin Ji-Hoon na Hyunjoo Lee young-Mock Lee Department of Pediatrics Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-RoGangnam-GuSeoul135-720Korea

Background This study investigated the efficacy and safety of nusinersen,an antisense oligonucleotide,in patients with spinal muscular atrophy(SMA)types II(OMIM:253,550)or III(OMIM:253,400),including those with severe scoliosis or requiring respiratory support via mechanical *** Data from 40 patients with genetically confirmed SMA who were treated with nusinersen at our institute from March 2019 to April 2022 were retrospectively *** these,30 patients with an age of onsetnal Motor Scale-Expanded(HFMSE)*** The mean age of symptom onset was 1.2 *** patients were diagnosed with SMA type II(27/30,90%).Nusinersen was administered via computed tomography-guided or direct intrathecal injection in 87%(26/30)and 13%(4/30)of the patients,*** the 6-,14-,22-,and 26-month follow-ups,72%,71%,88%,and 86%of patients showed motor improvement,respectively,with mean changes in HFMSE scores of 2.10,2.88,4.21,and 5.29,*** analysis showed that the use of noninvasive ventilation was associated with poorer outcomes of motor *** Patients with SMA type II or III who received nusinersen treatment showed significant improvement in motor function.A longer treatment duration led to a higher number of patients with improved motor *** significant side effects of nusinersen were *** with SMA,even those with severe scoliosis or on respiratory support,can be safely treated using nusinersen.

关键词： Hammersmith Functional Motor Scale Expanded Motor function Nusinersen South Korea Spinal muscular atrophy

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中国式现代化理论在高职思政课教学中的价值与实践路径研究

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成才之路 2024年第21期 109-111页

作者：王娜娜济源职业技术学院河南济源459000

党的二十大报告首次系统阐述了“中国式现代化”,作为人类文明发展的新形态,该理论是高职院校将立德树人根本任务贯彻于思政课的关键所在,能够助推青年群体将走中国特色社会主义道路作为己任,将中华民族复兴之梦作为自身发展追求。“中... 详细信息

党的二十大报告首次系统阐述了“中国式现代化”,作为人类文明发展的新形态,该理论是高职院校将立德树人根本任务贯彻于思政课的关键所在,能够助推青年群体将走中国特色社会主义道路作为己任,将中华民族复兴之梦作为自身发展追求。“中国式现代化”内容丰富,既紧扣党的二十大精神,又与高职思政课教学紧密联系。深刻把握“中国式现代化”理论与思政课教学内在契合性有效开展,是用中国化时代化的马克思主义对正处于“拔节孕穗期”青少年的启智润心、激扬斗志,落实立德树人根本任务的必由之路。

关键词：中国式现代化理论思政课思想政治教育立德树人高职教育

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Comparison between sodium iodate and lipid peroxide murine models of age-related macular degeneration for drug evaluation-a narrative review

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Annals of Eye Science 2022年第1期7卷 86-105页

作者： soo-young Kim Haohua Qian Department of Pharmaceutics Department of BiologyVirginia Commonwealth UniversityRichmondVAUSA Center for nanomedicine Wilmer Eye InstituteDepartment of OphthalmologyJohns Hopkins University of MedicineBaltimoreMDUSA Visual Function Core National Eye InstituteNational Institutes of HealthBethesdaMDUSA

Objective:In this review,non-transgenic models of age-related macular degeneration(AMD)are discussed,with focuses on murine retinal degeneration induced by sodium iodate and lipid peroxide(HpODE)as preclinical study ***:AMD is the most common cause of vision loss in a world with an increasingly aging *** major phenotypes of early and intermediate AMD are increased drusen and autofluorescence,Müller glia activation,infiltrated subretinal microglia and inward moving retinal pigment epithelium(RPE)*** AMD may progress to advanced AMD,characterized by geography atrophy and/or choroidal neovascularization(CNV).Various transgenic and non-transgenic animal models related to retinal degeneration have been generated to investigate AMD pathogenesis and pathobiology,and have been widely used as potential therapeutic evaluation ***:Two retinal degeneration murine models induced by sodium iodate and HpODE are *** pathological features and procedures of these two models are *** addition,practical protocol and material preparation and assessment methods are ***:Retina degeneration induced by sodium iodate and HpODE in mouse eye resembles many clinical aspects of human AMD and complimentary to the existent other animal ***,standardization of procedure and assessment protocols is needed for preclinical *** studies of HpODE on different routes,doses and species will be valuable for the future extensive *** many merits of murine studies,differences between murine and human should be always considered.

关键词： Retina degeneration retinal pigment epithelium(RPE) photoreceptor microglia

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