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校园众包物流方案设计——以新疆农业大学为例

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物流工程与管理 2019年第2期41卷 87-88页

作者：尹三平新疆农业大学新疆维吾尔自治区乌鲁木齐830091

随着电子商务和互联网经济的蓬勃发展,网络购物变得越来越便利,逐渐成为人们主要的购物方式,在年轻人中尤为明显。而以年轻人为主体的高校,其网络购物更是发展快速,由此带来高校快递业务量的增长所导致高校快递的配送问题逐渐凸显出来... 详细信息

随着电子商务和互联网经济的蓬勃发展,网络购物变得越来越便利,逐渐成为人们主要的购物方式,在年轻人中尤为明显。而以年轻人为主体的高校,其网络购物更是发展快速,由此带来高校快递业务量的增长所导致高校快递的配送问题逐渐凸显出来。文中主要运用了调查法、文献资料法和重心法,通过对高校快递、众包物流现状的调研,结合新疆农业大学的实际情况,将众包物流引入校园,对其关键技术、物流模式、流程和结构进行设计,为新疆农业大学设计一个以APP+众包为核心的高校快递众包模式,提高学校物流配送的速度和灵活性,造福广大师生。

关键词：网络购物高校快递众包物流

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猪瘟病毒E2基因DNA疫苗的试验研究

河南农业大学学报 2007年第5期41卷 541-544页

作者：王三虎李祥瑞南京农业大学动物医学院

用构建的E2-pcDNA4.0 DNA疫苗对Balb/c小鼠、家兔和仔猪进行免疫,经3次肌肉接种,间隔15 d免疫后,测定抗体水平.结果表明,构建的DNA疫苗能诱导小鼠产生中和性抗体,免疫家兔最少可抵抗10个最小感染剂量(M ID)的猪瘟兔化弱毒苗的攻击.攻毒... 详细信息

用构建的E2-pcDNA4.0 DNA疫苗对Balb/c小鼠、家兔和仔猪进行免疫,经3次肌肉接种,间隔15 d免疫后,测定抗体水平.结果表明,构建的DNA疫苗能诱导小鼠产生中和性抗体,免疫家兔最少可抵抗10个最小感染剂量(M ID)的猪瘟兔化弱毒苗的攻击.攻毒试验结果表明,E2-pcDNA4.0 DNA疫苗可抵抗致死剂量的CSFV石门株强毒的攻击.

关键词：猪瘟 E2基因 DNA疫苗

空间重构与自我呈现逻辑变化:青年短视频传播伦理失范动因探析

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未来传播 2024年第1期31卷 60-66页

作者：刘峰严三九上海大学新闻传播学院上海200072

随着短视频平台在青年群体中的普及,短视频使用中出现了诸多传媒伦理失范问题,如侵犯隐私、内容低俗化、网络暴力等。基于青年群体短视频空间的角度,发现青年短视频用户在使用中打破了物理空间与媒体空间的界限,自我呈现的逻辑发生了改... 详细信息

随着短视频平台在青年群体中的普及,短视频使用中出现了诸多传媒伦理失范问题,如侵犯隐私、内容低俗化、网络暴力等。基于青年群体短视频空间的角度,发现青年短视频用户在使用中打破了物理空间与媒体空间的界限,自我呈现的逻辑发生了改变,同时未意识到“前区”“后区”的重构,为短视频伦理失范问题的产生提供了可能性。

关键词：青年短视频传播伦理空间

Major Limb Amputations: Etiological and Clinical Profile in a Hospital in Sub-Saharan Africa

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Open Journal of Orthopedics 2021年第2期11卷 40-46页

作者： S. Diao A. N. Kassé J. D. Diouf J. C. sané B. Thiam M. B. Diallo M. H. Sy Department of Orthopedics and Trauma Surgery General Hospital Idrissa Pouye Dakar Sénégal

Introduction: During the 19th and 20th centuries, the Wars were the cause of many amputations among military and civilians. Despite the absence of armed conflict in our country, we notice a high frequency of major amputations in our activity. Objective: The aim of this work was to study the causes of major amputations observed in our practice in order to develop preventive measures. Materials and Method: This was a descriptive retrospective study over a 6-year period, from January 1, 2008 to December 31, 2014. The following parameters were studied: epidemiological aspects (age according to WHO age groups and gender of patients), type of amputation, level of amputation and causes. Results: Two hundred and fifty-two patients were included. The distribution of amputations by cause and age group showed two distinct entities: The forms of the young subject where there was a predominance of tumour and traumatic causes;and the forms of the elderly person caused by vascular infections and conditions. Infections were the main cause of amputation in both sexes. Conclusion: The causes of major limb amputations vary according to age and limb: tumor and trauma in young people and for the upper limb, infectious and vascular in the elderly and for the lower limb.

关键词： Diabetes Disarticulation Infections Limb Major Amputation Tumors

Deficiency of mitochondrial aldehyde dehydrogenase increases type 2 diabetes risk in males via autophagy dysregulation

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Chinese Medical Journal 2021年第18期134卷 2246-2248页

作者： Xiang-Wei Liu Lin Jiang Peng Wang Xiao-Lei Sun Xin Ma Hong Zhu Zhen Dong Cheng Shen san-Li Qian Bing-Yu Li Zhen-Sheng Xu Ai-Jun Sun Jun-Bo Ge Shanghai Institute of Cardiovascular Diseases Zhongshan HospitalFudan UniversityShanghai 200032China Xiangya Hospital Central South UniversityChangshaHunan 410008China Huashan Hospital Fudan UniversityShanghai 200040China Institute of Biomedical Science Fudan UniversityShanghai 200032China

Metrics To the editor:The diabetes epidemic has increasingly become a major public health concern *** 2014,there were 102.9 million diabetic adults in China,representing 24.4%of the world's diabetic population,even though China only comprised 18.7%of the global population at the time.[1]Furthermore,the estimated overall prevalence of diabetes and prediabetes was 10.9%and 35.7%,respectively,indicating China as one of the countries with the highest prevalence of diabetes in the world.[2]Although factors,including sedentary lifestyles and energy-dense diets,drive the diabetes epidemic,genetic architecture may also contribute to the susceptibility of an individual's response to environmental *** dehydrogenase(ALDH)2 is a key enzyme that eliminates toxic aldehydes by catalyzing their oxidation to non-reactive *** evidence has suggested that individuals with ALDH2 deficiency have an increased risk of cardiovascular and metabolic diseases,in addition to alcohol intolerance,nitroglycerin tolerance,and carcinoma.[3]Notably,a unique ALDH2 loss-of-function allele,ALDH2∗2,is found in approximately 50%of the East Asian and 8%of the global *** has been reported that this ALDH2 mutation is associated with a higher prevalence of diabetes in coronary artery disease(CAD)patients,accompanied with increased C-reactive protein(CRP)levels.[4]ALDH2 mutation is also related to various diabetes risk factors,but the direct correlation remains ***,we have explored the potential pathogenicity and mechanisms of ALDH2 deficiency in the development of type 2 diabetes in both laboratory and clinical settings.

关键词： diabetes prevalence eliminate

Bidirectional modulation of HIF-2 activity through allosteric ligands

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中国药理学与毒理学杂志 2019年第10期 767-768页

作者： WU Da-lei SU Xiao-yu LU Jing-ping LI Sheng Becky HOOD Stefan VASILE Nalini POTLURI DIAO Xiao-tong young-chang KIM Sepideh KHORAsanIZADEH Fraydoon RASTINEJAD State Key Laboratory of Microbial Technology Shandong University sanford Burnham Prebys Medical Discovery Institute 3. Department of Medicine University of California San Diego 4. Argonne National Laboratory 5. Nuffield Department of Medicine University of Oxford

OBJECTIVE Hypoxia-inducible factor-2(HIF-2) is a heterodimeric transcription factor formed through dimerization between an oxygen-sensitive subunit HIF-2α subunit and its obligate partner subunit *** HIF-2 activity drives some cancers, while reduced activity causes anemia in chronic kidney disease. Therefore, modulation of HIF-2 activity via direct-binding ligands could provide many new therapeutic benefits. METHODS We explored HIF-2α chemical ligands using combined crystallographic, biophysical, and cell-based functional studies. RESULTS We found chemically unrelated antagonists to employ the same mechanism of *** binding displaced residue M252 from inside the HIF-2α PAS-B pocket toward the ARNT subunit to weaken heterodimerization. We also identified first-in-class HIF-2α agonists and found they significantly displaced pocket residue Y281. Its dramatic side-chain movement increases heterodimerization stability and transcriptional *** Our findings show that despite binding to the same HIF-2α PAS-B pocket, ligands can manifest as inhibitors versus activators by mobilizing different pocket residues to al osterical y alter HIF-2α-ARNT heterodimerization.

关键词： hypoxia-inducible factor agonist antagonist allosteric effects

棉花恢复系中含有26S rRNA序列的GH18Rorf392基因克隆

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棉花学报 2008年第5期20卷 323-329页

作者：吴巧雯宋洋张锐王远郭三堆中国农业科学院生物技术研究所

以Y18R×P30A杂交F1代自交材料播种后根据雄蕊形态学判断其育性,然后分别提取可育和不育材料现蕾3 ～5 d的幼蕾总RNA。通过抑制差减杂交的方法获得来自棉花恢复系的EST序列之后,以该EST序列设计引物再做5'和3'RACE,从而获得其全长cDNA... 详细信息

以Y18R×P30A杂交F1代自交材料播种后根据雄蕊形态学判断其育性,然后分别提取可育和不育材料现蕾3 ～5 d的幼蕾总RNA。通过抑制差减杂交的方法获得来自棉花恢复系的EST序列之后,以该EST序列设计引物再做5'和3'RACE,从而获得其全长cDNA序列。由于该基因来源于陆地棉(Gossypium hirsutum)恢复系Y18R,并且编码392个氨基酸的蛋白质,因此,将其命名为GH18Rorf392。该基因的5'端是一个全新的序列,3'端含有26S rRNA序列。该基因可能对研究棉花育性相关功能有帮助。

关键词：棉花恢复系抑制差减杂交细胞质雄性不育育性恢复

Proposal of new expanded selection criteria using total tumor size and ^(18)F-fluorodeoxyglucose- positron emission tomography/computed tomography for living donor liver transplantation in patients with hepatocellular carcinoma:The National Cancer Center K

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World Journal of Transplantation 2016年第2期6卷 411-422页

作者： Seung Duk Lee Bora Lee Seong Hoon Kim Jungnam Joo Seok-Ki Kim young-Kyu Kim sang-Jae Park Center for Liver Cancer Research Institute and HospitalNational Cancer Center Biometric Research Branch Research Institute and HospitalNational Cancer Center Department of Nuclear Medicine Research Institute and HospitalNational Cancer Center Department of Surgery College of MedicineJeju National University

AIM: To expand the living donor liver transplantation(LT) pool of eligible patients with hepatocellular carcinoma(HCC) using new morphological and biological ***: Patients with HCC who underwent living donor LT(LDLT) from March 2005 to May 2013 at the National Cancer Center korea(NCCK) were enrolled. We performed the 18F-fluorodeoxyglucose positron emission tomography/computed tomography(PET/CT)before LDLT. Overall and disease-free survival analysis was done in patients to evaluate the usefulness of new NCCK criteria using PET/CT and total tumor size(10 cm).RESULTS: We enrolled a total of 280 patients who pathologically confirmed to have HCC and performed the PET/CT before transplantation. Among them, 164(58.6%) patients fulfilled the NCCK criteria and 132 patients(47.1%) met the Milan criteria. Five-year overall and disease-free survival rates for patients who fulfilled the NCCK criteria showed 85.2% and 84.0%, respectively, and were significantly higher than those beyond the NCCK criteria(60.2% and 44.4%, respectively; P san Francisco(UCSF) criteria using the receiver operating characteristics curves revealed the similar area under the curve value criteria(NCCK vs Milan, P = 0.484; NCCK vs UCSF, P = 0.189 at 5-years).CONCLUSION: The NCCK criteria using hybrid concept of both morphological and biological parameters showed an excellent agreement between preoperative imaging and pathological results, and favorable survival outcomes. These new criteria might select the optimal patients with HCC waiting LDLT and expand the selection pool.

关键词： Hepatocellular carcinoma Living donor Liver transplantation Selection criteria

一种基于CCD图像传感器的杨氏弹性模量测量方法

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红外 2006年第7期27卷 35-38页

作者：黎三华刘灿中南大学物理科学与技术学院长沙410083

测量杨氏弹性模量是大学物理实验的一个重要实验,也是材料力学中衡量固体材料抗形变能力的重要物理量,还是选定机械构件材料的依据之一和工程技术中常用的参数.杨氏弹性模量通常用镜尺法进行测量,此方法的系统误差较大,根据近千份实验... 详细信息

测量杨氏弹性模量是大学物理实验的一个重要实验,也是材料力学中衡量固体材料抗形变能力的重要物理量,还是选定机械构件材料的依据之一和工程技术中常用的参数.杨氏弹性模量通常用镜尺法进行测量,此方法的系统误差较大,根据近千份实验报告统计,其相对误差达5%。本文介绍一种新的杨氏弹性模量测量方法。该方法利用激光束照射光杠杆镜面,用高灵敏度的线型固态CCD图像传感器自动接受激光光束偏转方位来取代传统的依靠人眼从望远镜读数中获取数据的方法,实现了过程自动化,从而消除了测量过程中所产生的人为因素的影响。该方法实验测量杨氏弹性模量的相对误差为0.88%,大大提高了测量精度。这一技术可直接运用于有关材料的杨氏模量测量,并将传统的物理实验改进成了一个有意义的集设计、研究、综合于一体的实验。

关键词：光杠杆杨氏弹性模量光电图像传感器CCD(电荷耦合器件)