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Advancements in hemostatic strategies for managing upper gastrointestinal bleeding: A comprehensive review

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World Journal of Gastroenterology 2024年第15期30卷 2087-2090页

作者： Ah young Lee joo young Cho Division of Gastroenterology Department of Internal MedicineCha Gangnam Medical CenterCha University College of MedicineSeoul 06135Korea

Upper gastrointestinal(GI)hemorrhage presents a substantial clinical *** management typically involves resuscitation and endoscopy within 24 h,although the benefit of very early endoscopy(<12 h)for high-risk patients is *** goals include stopping acute bleeding,preventing rebleeding,and using a multimodal approach encompassing endoscopic,pharmacological,angiographic,and surgical *** agents such as vasopressin,prostaglandins,and proton pump inhibitors are effective,but the increase in antithrombotic use has increased GI bleeding *** hemostasis,particularly for nonvariceal bleeding,employs techniques such as electrocoagu-lation and heater probes,with concerns over tissue injury from monopolar *** methods such as Hemospray and Endoclot show promise in creating mechanical tamponades but have ***,the first-line therapy includes thermal probes and hemoclips,with over-the-scope clips emerging for larger ulcer *** gold probe,combining bipolar electrocoagulation and injection,offers targeted coagulation but has faced device-related *** advancements involve combining techniques and improving endoscopic imaging,with studies exploring combined approaches showing *** research is crucial for developing standardized and effective hemorrhage management strategies.

关键词： Upper gastrointestinal bleeding Hemostasis Endoscopy Probe Spray Clip

Clinical diagnostic advances in intestinal anastomotic techniques:Hand suturing,stapling,and compression devices

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1231-1234页

作者： Ah young Lee joo young Cho Division of Gastroenterology Department of Internal MedicineCha Gangnam Medical CenterCha University College of MedicineSeoul 06135South Korea

The development of intestinal anastomosis techniques,including hand suturing,stapling,and compression anastomoses,has been a significant advancement in surgical *** methods aim to prevent leakage and minimize tissue fibrosis,which can lead to stricture *** healing process involves various phases:hemostasis and inflammation,proliferation,and *** staplers and sutures can cause inflammation and fibrosis due to the release of profibrotic *** anastomosis devices,including those made of nickel-titanium alloy,offer a minimally invasive option for various surgical challenges and have shown safety and ***,despite advancements,anastomotic techniques are evaluated based on leakage risk,with complications being a primary *** devices like Magnamosis use magnetic rings for compression anastomosis,demonstrating greater strength and patency compared to *** technology is also being explored for other medical *** there are promising results,particularly in animal models,the realworld application in humans is limited,and further research is needed to assess their safety and practicality.

关键词： Anastomoses Diagnostic advances,Anastomotic techniques Technique Intestine

Cryptogenic organizing pneumonia associated with pregnancy:A case report

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World Journal of Clinical Cases 2022年第6期10卷 1946-1951页

作者： young joo Lee young Sun Kim Department of Obstetrics and Gynecology Kyung Hee University Medical CenterSeoul 02447South Korea

BACKGROUND Cryptogenic organizing pneumonia(COP),formerly known as bronchiolitis obliterans organizing pneumonia,is an extremely rare disease in *** this case,we report on COP diagnosed in recurrent pneumonia that does not respond to antibiotics in pregnant *** SUMMARY A 35-year-old woman with no prior lung disease presented with concerns of chest pain with cough,sputum,dyspnea,and mild fever at 11 wk’*** was diagnosed with community-acquired pneumonia and treated with antibiotics;her symptoms improved *** weeks after discharge,she was readmitted with aggravated *** computed tomography demonstrated multifocal patchy airspace consolidation and ground-glass opacities at the basal segments of the right lower lobe,at the lateral basal segment of the lower lobe,and at the lingular segment of the left upper *** lavage revealed an increased lymphocyte count and a decreased CD4/CD8 ***(0.5 mg/kg/d)was administered for 10 d after the second *** improved after 3 d of steroid treatment and other symptoms improved on the 5th day of steroid ***-delivery transbronchial lung biopsy further revealed the presence of granulation tissue with fibroblasts in smallbronchiole *** This case suggests that it is important to differentiate COP from atypical pneumonia in the deteriorated condition despite antibiotic treatment.

关键词： Antibiotics Bronchiolitis obliterans organizing pneumonia Corticosteroid Cryptogenic organizing pneumonia Pregnancy Case report

Sigmoid-sigmoid colon fistula caused by diverticulitis

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Chinese Medical Journal 2022年第4期135卷 491-492页

作者： Jeonghun Lee young joo Lee youngsun Kim Department of Internal Medicine Ye HospitalAnyangRepublic of Korea Department of Obstetrics and Gynecology Kyung Hee University HospitalKyung Hee University College of MedicineSeoulRepublic of Korea

To the Editor:Diverticular disease is common worldwide and the incidence of this disease increases with *** diverticulitis is serious and includes abscess,fistula,obstruction,and ***,surgical treatment is recommended to the patients with symptomatic *** these,colocolic fistula caused by diverticulitis is rare findings and especially,sigmoid-sigmoid fistula is an extremely rare *** present report describes a case of sigmoid-sigmoid colon fistula caused by *** results of this case may help physicians to recognize that multidisciplinary management and surgery are needed for the treatment of complicated diverticulitis with fistula.

关键词： fistula colon obstruction

Primary rectal mucosa-associated lymphoid tissue lymphoma treated with only endoscopic submucosal dissection:A case report

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World Journal of Clinical Cases 2023年第14期11卷 3362-3368页

作者： Wan-Sik Lee Myung-Giun Noh young-Eun joo Department of Internal Medicine Chonnam National University Medical SchoolHwasun-eup 58128South Korea Department of Pathology Chonnam National University Medical SchoolHwasun-eup 58128South Korea

BACKGROUND Mucosa-associated lymphoid tissue(MALT)lymphoma is a distinct subtype of non-Hodgkin B cell lymphoma that mostly involves the gastrointestinal *** stomach is the most commonly affected site whereas colorectal involvement occurs very *** its rarity,the management and clinical outcome of colorectal MALT lymphoma are not well established *** SUMMARY From the superficial capillary bed in the lower *** ultrasonography showed homogenous hypoechoic lesions in the deep mucosal *** submucosal dissection(ESD)was done for accurate histologic diagnosis and treatment and both the rectal lesions were completely removed en bloc and subsequently diagnosed as primary rectal MALT ***,we report a case of primary rectal MALT lymphoma in a 68-year-old woman that was treated by only ESD,and the 12-month follow-up revealed no tumour *** These results of our case and previous reports suggest that endoscopic resection alone may be a feasible and safe treatment for primary colorectal MALT lymphoma and allows organ preservation.

关键词： Rectum Mucosa-associated lymphoid tissue lymphoma Endoscopic submucosal dissection

Usefulness of the acromioclavicular joint cross-sectional area as a diagnostic image parameter of acromioclavicular osteoarthritis

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World Journal of Clinical Cases 2022年第7期10卷 2087-2094页

作者： young joo Jee Youn Moon Jung Youn Han Yun-Sic Bang Keum Nae Kang young Su Lim young-SoonChoi young-Uk Kim Department of Anesthesiology and Pain Medicine CHA Ilsan Medical CenterSchool of MedicineCHA UniversityIlsanGyeonggi-do 10414South Korea Department of Anesthesiology and Pain Medicine Seoul National University Hospital College of MedicineSeoul 03080South Korea Department of Anesthesiology and Pain Medicine CHA Bundang Medical CenterSchool of MedicineSeongnamGyeonggi-do 13496South Korea Department of Anesthesiology and Pain Medicine National Police HospitalSeoul 05715South Korea Department of Anesthesiology and Pain Medicine Catholic Kwandong UniversityCollege of MedicineInternational St.Mary’s HospitalIncheon 22711South Korea

BACKGROUND Acromioclavicular joint(ACJ)space narrowing has been considered to be an important diagnostic image parameter of ACJ osteoarthritis(ACJO).However,the morphology of the ACJ space is irregular because of osteophyte formation,subchondral irregularity,capsular distention,sclerosis,and ***,we created the ACJ cross-sectional area(ACJCSA)as a new diagnostic image parameter to assess the irregular morphologic changes of the *** To hypothesize that the ACJCSA is a new diagnostic image parameter for *** ACJ samples were obtained from 35 patients with ACJO and 30 healthy individuals who underwent shoulder magnetic resonance(S-MR)imaging that revealed no evidence of *** coronal,T2-weighted,fat-suppressed SMR images were acquired at the ACJ level from the two *** measured the ACJCSA and the ACJ space width(ACJSW)at the ACJ on the S-MR images using our imaging analysis *** ACJCSA was measured as the cross-sectional area of the *** ACJSW was measured as the narrowest point between the acromion and the *** The average ACJCSA was 39.88±10.60 mm;in the normal group and 18.80±5.13 mm;in the ACJO *** mean ACJSW was 3.51±0.58 mm in the normal group and 2.02±0.48 mm in the ACJO *** individuals had significantly lower ACJCSA and ACJSW than the healthy *** operating characteristic curve analyses demonstrated that the most suitable ACJCSA cutoff score was 26.14 mm^(2),with 91.4%sensitivity and 90.0%*** The optimal ACJSW cutoff score was 2.37 mm,with 88.6%sensitivity and 96.7%*** though both the ACJCSA and ACJSW were significantly associated with ACJO,the ACJCSA was a more sensitive diagnostic image parameter.

关键词： Acromioclavicular joint Osteoarthritis Cross-sectional area Diagnosis

Stable carbon and nitrogen isotopic composition of gas hydrate-bearing sediment from Hydrate Ridge,Cascadia Margin

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Science China Earth Sciences 2006年第8期49卷 872-880页

作者： young-joo Lee Petroleum and Marine Resources Research Division Korea Institute of Geoscience and Mineral Resources Daejon 305-350South Korea

54 sediments were sampled at 5 sites, 1244, 1245, 1246, 1250 and 1251 from ODP Leg 204, Hydrate Ridge, Cascadia Margin. The stable carbon and nitrogen isotopic composition, δ C of 13 organic matter and δ N, have been used to characterize the depositional variation of sediments with 15 gas hydrate bearing. Values of δ C of bulk organic matter range between ?22.37‰ and ?24.72‰ 13 PDB, with a mean value of ?23.54±1.17‰ PDB; δ N of the same sedimentary samples range from 15 3.30‰ to 5.68‰, with a mean value of 4.49±1.19‰; Values of C/N ratio range from 4.53 to 9.26, with a mean value of 6.90±2.37. The occurrence of gas hydrate changed the diagenetic evolution trend of the carbon and nitrogen in organic matter. The δ N and C/N ratio depletion suggest that the nitrogen 15 fixation related with the bacteria/archaea maybe occurred in the sediments near the hydrate. The stable carbon and nitrogen isotopic composition could be used to evaluate the depositional environ- ment in the study area.

关键词： gas hydrate, carbon isotopes, nitrogen isotopes, C/N ratio, nitrogen fixation.

Pseudomembranous conjunctivitis in a patient with DRESS syndrome

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 309-311页

作者： young joo Lee youngsub Eom Seo Yeon Park Jung Jin Shin young Choi Jong Suk Song Hyo Myung Kim Department of Ophthalmology Korea University Ansan HospitalGyeonggi-do 15535Republic of Korea Department of Ophthalmology Korea University College of MedicineSeoul 02841Republic of Korea Department of Ophthalmology Emory University School of MedicineAtlantaGA 30322USA BGN Jamsil Lotte Tower Eye Clinic Seoul 05551Republic of Korea Department of Dermatology Korea University Ansan HospitalGyeonggi-do 15355Republic of Korea Shin’s Eye Clinic Chungcheongnam-do 31513Republic of Korea

Dear Editor,Drug rash with eosinophilia and systemic symptoms(DRESS)syndrome is a drug reaction featuring high fever,eosinophilia,skin rashes,and multi-organ involvement that may be *** manifestations,including cicatrizing conjunctivitis,corneal infiltration,and anterior uveitis,are rarely reported[1-6]but may cause serious complications if ***,it is important to diagnose DRESS syndrome in patients with ocular features promptly with appropriate *** article reports a case diagnosed with DRESS syndrome associated with pseudomembranous conjunctivitis secondary to carfilzomib.

关键词： membranous conjunctivitis involvement

Selective apoptotic effect of Zelkova serrata twig extract on mouth epidermoid carcinoma through p53 activation

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International Journal of Oral Science 2012年第2期4卷 78-84页

作者： Hoe-Jin Kang young-joo Jang Laboratory of Cell Cycle and Signal Transduction World Class University Research Department of Nanobiomedical Science and Institute of Tissue Regeneration EngineeringDankook UniversityCheonanKorea

Apoptosis or programmed cell death plays an essential role in chemotherapy-induced tumor cell killing, and inducers of apoptosis are commonly used in cancer therapy. Treatment with Zelkova serrata extracts was performed in human gingival fibroblast （HGF）, mouth epidermoid carcinoma cell （KB）, lower gingival squamous cancer cell （YD38） and tongue mucoepidermoid carcinoma cells （YD15）. We observed that extract prepared from Zelkova serrata twig selectively inhibited proliferation of various oral cancer cells, but not normal gingival fibroblasts, in a dose-dependent manner. Caspase-8-mediated apoptosis was induced by treatment with the extract only in mouth epidermoid carcinoma and not in other types of cancer cells, including lower gingival squamous cell carcinoma. The selective apoptotic effect of Zelkova serrata twig extract in mouth epidermoid carcinoma was dependent on normal p53 status. Apoptosis was not remarkably induced by treatment with the extract in either lower gingival squamous or tongue mucoepidermoid carcinoma cells, both of which contain abnormalities of p53. Upon treatment with Zelkova serrata twig extract, mouth epidermoid carcinoma cells accumulated in S phase by activation of p21. These data indicate that Zelkova serrata twig extract exerted a cancer type-specific, p53-dependent apoptotic effect and disturbed the cell cycle, which suggests that herbal medicine could be a treatment for specific types of cancers.

关键词： anticancer apoptosis oral carcinomas p53 Zelkova serrata