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Bispectral index monitoring as an adjunct to nurse-administered combined sedation during endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2012年第43期18卷 6284-6289页

作者： Se young Jang Hyun Gu Park Min Kyu jung Chang Min Cho Soo young Park Seong Woo Jeon Won young Tak young Oh Kweon Sung Kook Kim young hoon Jeon Department of Internal Medicine Kyungpook National University School of Medicine Daegu 700-721 South Korea Department of Anesthesiology and Pain Medicine Kyungpook National University School of Dentistry Daegu 700-721 South Korea

AIM:To determine whether bispectral index (BIS) monitoring is useful for propofol administration for deep sedation during endoscopic retrograde cholangiopancreatography (ERCP). METHODS:Fifty-nine consecutive patients with a variety of reasons for ERCP who underwent the procedure at least twice between 1 July 2010 and 30 November 2010. This was a randomized cross-over study, in which each patient underwent ERCP twice, once with BIS monitoring and once with control monitoring. Whether BIS monitoring was done during the first or second ERCP procedure was random. Patients were intermittently administered a mixed regimen including midazolam, pethidine, and propofol by trained nurses. The nurse used a routine practice to monitor sedation using the Modified Observer's Assessment of Alertness/Sedation (MOAA/S) scale or the BIS monitoring. The total amount of midazolam and propofol used and serious side effects were compared between the BIS and control groups. RESULTS:The mean total propofol dose administered was 53.1 ± 32.2 mg in the BIS group and 54.9 ± 30.8 mg in the control group (P = 0.673). The individual propofol dose received per minute during the ERCP procedure was 2.90 ± 1.83 mg/min in the BIS group and 3.44 ± 2.04 mg in the control group (P = 0.103). The median value of the MOAA/S score during the maintenance phase of sedation was comparable for the two groups. The mean BIS values throughout the procedure (from insertion to removal of the endoscope) were 76.5 ± 8.7 for all 59 patients in using the BIS monitor. No significant differences in the frequency of < 80% oxygen saturation, hypotension (< 80 mmHg), or bradycardia (< 50 beats/min) were observed between the two study groups. Four cases of poor cooperation occurred, in which the procedure should be stopped to add the propofol dose. After adding the propofol, the procedure could be conducted successfully (one case in the BIS group, three cases in the control group). The endoscopist rated patient sedation as exc

关键词： Conscious sedation Bispectral index monitors Pancreatic neoplasm Endoscopic retrograde cholangiopancreatography

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Evaluation of non-ampullary duodenal polyps: Comparison of non-neoplastic and neoplastic lesions

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World Journal of Gastroenterology 2010年第43期16卷 5474-5480页

作者： Sung hoon jung Woo Chul Chung Eun jung Kim Seol Hye Kim Chang Nyol Paik Bo In Lee young Seok Cho Kang-Moon Lee Department of Internal Medicine College of Medicine The Catholic University of Korea

AIM: To evaluate duodenal polyps, divided into nonneoplastic and neoplastic lesions. In addition, the clinical characteristics of duodenal hyperplastic polyps are determined. METHODS: We analyzed medical records of 50 114 consecutive patients submitted to for first diagnostic esophago-gastroduodenoscopy between January 2004 and December 2009. We excluded lesions on the ampulla of Vater and submucosal tumors. We studied 510 cases that were diagnosed endoscopically with duodenal polyps and enrolled a total of 221 cases that had undergone tissue biopsy. We analyzed the differences between non-neoplastic and neoplastic lesions, and determined the clinical features of duodenal hyperplastic polyps. RESULTS: Non-neoplastic lesions were found in 196 patients and neoplastic lesions in 25 patients. On uni-variate analysis, there were significant differences in shape, location, and size. Polyps more than 10 mm in diameter or polyps in the second portion had independent risk factors for being neoplastic lesions, as identified by multivariate analysis. In 23 cases of hyperplastic polyps (79.3%), they were accompanied by gastroduodenal pathology, which was possibly associated with Helicobacter pylori . CONCLUSION: Polyps of more than 10 mm or polyps in the second portion of the duodenum should be evaluated by histological examination.

关键词： Duodenum Polyp Helicobacter pylori

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Immunotherapy for pancreatic cancer

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World Journal of Clinical Cases 2021年第13期9卷 2969-2982页

作者： Jai hoon Yoon Ye-Ji jung Sung-hoon Moon Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Department of Internal Medicine Hallym UniversityAnyang 14068South Korea Department of Internal Medicine University of Hallym College of MedicineHallym University Sacred Heart HospitalAnyang 14068South Korea

Pancreatic cancer, a highly lethal cancer, has the lowest 5-year survival rate forseveral reasons, including its tendency for the late diagnosis, a lack of serologicmarkers for screening, aggressive local invasion, its early metastaticdissemination, and its resistance to chemotherapy/radiotherapy. Pancreaticcancer evades immunologic elimination by a variety of mechanisms, includinginduction of an immunosuppressive microenvironment. Cancer-associatedfibroblasts interact with inhibitory immune cells, such as tumor-associatedmacrophages and regulatory T cells, to form an inflammatory shell-like desmoplasticstroma around tumor cells. Immunotherapy has the potential to mobilizethe immune system to eliminate cancer cells. Nevertheless, althoughimmunotherapy has shown brilliant results across a wide range of malignancies,only anti-programmed cell death 1 antibodies have been approved for use inpatients with pancreatic cancer who test positive for microsatellite instability ormismatch repair deficiency. Some patients treated with immunotherapy whoshow progression based on conventional response criteria may prove to have adurable response later. Continuation of immune-based treatment beyond diseaseprogression can be chosen if the patient is clinically stable. Immunotherapeuticapproaches for pancreatic cancer treatment deserve further exploration, given theplethora of combination trials with other immunotherapeutic agents, targetedtherapy, stroma-modulating agents, chemotherapy, and multi-way combinationtherapies.

关键词： Pancreatic adenocarcinoma Pancreatic cancer Immunotherapy Immune checkpoint inhibitor

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Low degree GW invariants of surfaces Ⅱ

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Science China Mathematics 2011年第8期54卷 1679-1706页

作者： KIEM young-hoon LI Jun Department of Mathematics and Research Institute of Mathematics Seoul National UniversitySeoul 151-747Korea Department of Mathematics Stanford UniversityStanfordUSA

We prove a conjectural formula of Maulik-Pandharipande on the degree one and two GW invariants of a surface with a smooth canonical *** use the method of degeneration and the localized GW invariants introduced by the ... 详细信息

关键词： Gromov-Witten invariant cosection degeneration formula localized virtual cycle

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Molecular and prognostic heterogeneity of microsatellite-unstable colorectal cancer

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World Journal of Gastroenterology 2014年第15期20卷 4230-4243页

作者： jung Ho Kim Gyeong hoon Kang Department of Pathology SMG-SNU Boramae Medical CenterSeoul 156-707South Korea Department of Pathology Seoul National University College of MedicineSeoul 110-799South Korea Laboratory of Epigenetics Cancer Research InstituteSeoul National University College of MedicineSeoul 110-799South Korea

Colorectal cancers (CRCs) with a high level of microsatellite instability (MSI-H) are clinicopathologically distinct tumors characterized by predominance in females, proximal colonic localization, poor differentiation, mucinous histology, tumor-infiltrating lymphocytes, a Crohn’s-like lymphoid reaction and a favorable prognosis. In terms of their molecular features, MSI-H CRCs are heterogeneous tumors associated with various genetic and epigenetic alterations, including DNA mismatch repair deficiency, target microsatellite mutations, BRAF mutations, a CpG island methylator phenotype-high (CIMP-H) status, and a low level of genomic hypomethylation. The molecular heterogeneity of MSI-H CRCs also depends on ethnic differences; for example, in Eastern Asian countries, relatively low frequencies of CIMP-H and BRAF mutations have been observed in MSI-H CRCs compared to Western countries. Although the prognostic features of MSI-H CRCs include a favorable survival of patients and low benefit of adjuvant chemotherapy, there may be prognostic differences based on the molecular heterogeneity of MSI-H CRCs. Here, we have reviewed and discussed the molecular and prognostic features of MSI-H CRCs, as well as several putative prognostic or predictive molecular markers, including HSP110 expression, beta2-microglobulin mutations, myosin 1a expression, CDX2/CK20 expression, SMAD4 expression, CIMP status and LINE-1 methylation levels.

关键词： Colorectal cancer Microsatellite instability DNA mismatch repair DNA methylation CpG islands Prognosis Adjuvant chemotherapy

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Induction of vascular endothelial growth factor receptor expression in human umbilical vein endothelial cells after repeated bevacizumab treatment in vitro

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1064-1068页

作者： Ji Eun Lee Jin young Kim Jae Ho jung Dong hoon Shin Sung Who Park Department of Ophthalmology School of MedicinePusan National University Medical Research Institute Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Pathology School of MedicinePusan National University

AIM： To investigate the mechanism underlying the loss of responsiveness to anti-vascular endothelial growth factor（VEGF） treatment after repeated injections for choroidal neovascularization, VEGF and VEGF receptor（VEGFR） expressions were evaluated following repeated bevacizumab treatments in hypoxic human umbilical vein endothelial cells（HUVECs） in ***： HUVECs were incubated under hypoxic conditions in two media of different bevacizumab concentrations（1.0 or 2.5 mg/m L） for 17 h, and then in a new medium without bevacizumab for 7h. This procedure was repeated twice more. A culture with an identical volume of excipients served as the control. Cytotoxicity and cell proliferation were assessed using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide and Ki-67 assays, respectively. Levels of VEGF and VEGFR were assessed using enzyme-linked immunosorbent assay and Western blot ***： Cytotoxic effects were not reported for either bevacizumab concentration. Cell proliferation was not reduced after anti-VEGF treatments. VEGF level after single treatment was significantly higher than that of the control and after repeated treatments. Phosphorylated VEGFR-2 expression increased significantly after singleand repeated bevacizumab treatments compared with the control. The 1.0 mg/m L bevacizumab induced significantly higher expressions of VEGFR-2 than the 2.5 mg/m L in single and repeated treatment ***： Bevacizumab treatment of HUVECs elevated VEGFR expression in both single and repeated treatments, indicating a mechanism for the reduced efficacy of anti-VEGF therapy in ocular neovascular disorders.

关键词： vascular endothelial growth factor vascular endothelial growth factor receptor choroidal neovascularization bevacizumab repeated treatments

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Dual-priming oligonucleotide-based multiplex PCR using tissue samples in rapid urease test in the detection of Helicobacter pylori infection

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World Journal of Gastroenterology 2014年第21期20卷 6547-6553页

作者： Woo Chul Chung Sung hoon jung jung Hwan Oh Tae Ho Kim Dae young Cheung Byung Wook Kim Sung Soo Kim Jin Il Kim Eun young Sin Department of Internal Medicine the Catholic University of KoreaSeoul 130-709South Korea The Research Institute of St. Vincent Hospital the Catholic University of KoreaSuwon 442-723South Korea

AIM: To investigate whether tissue samples processed by the rapid urease test (RUT) kit are suitable for dual-priming oligonucleotide-based multiplex polymerase chain reaction (DPO-PCR) to detect Helicobacter pylori (... 详细信息

关键词： Helicobacter pylori Diagnosis Dual-priming oligonucleotide-based multiplex polymerase chain reaction

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Use of ^(137)Cs and ^(210)Pb_(ex) fallout radionuclides for spatial soil erosion and redistribution assessment on steeply sloping agricultural highlands

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Journal of Mountain Science 2021年第11期18卷 2888-2899页

作者： jung-Hwan YOON young-Nam KIM Kye-hoon KIM M.B.KIRKHAM Hyuck Soo KIM Jae E.YANG Kangwon Institute of Inclusive Technology Kangwon National UniversityChuncheon 24341Republic of Korea Department of Biological Environment Kangwon National UniversityChuncheon 24341Republic of Korea Institute of Agriculture and Life Science Gyeongsang National UniversityJinju 52828Republic of Korea Department of Environmental Horticulture University of SeoulSeoul 02504Republic of Korea Department of Agronomy Kansas State UniversityManhattanKS 66506-0110USA

The steeply sloping agricultural highlands in Korea have severe soil *** of both soil erosion and sedimentation in these highlands is necessary to make plans for soil-conservation measures,but it is not feasible using existing soil-erosion *** study measured the site-specific concentrations of ^(137)Cs and ^(210)Pb_(ex) on both a highland slope(33%slope)and a reference site(undisturbed flat area)to estimate soil erosion and *** use of the fallout radionuclide(FRN)method was evaluated to see if it is a suitable method for characterizing soil *** were compared with those obtained with the Universal Soil Loss Equation(USLE),which is an empirical model that estimates annual soil *** average concentrations of ^(137)Cs and ^(210)Pb_(ex) at the reference site were 11.57±0.24 Bq kg^(-1) and 59.74±4.2 Bq kg^(-1),*** of ^(137)Cs and ^(210)Pb_(ex) in the experimental slope were 16.4%and 10.8%,respectively,of those at the reference *** inventories were lower at the upper point of the slope than those at the basal point of the *** of ^(137)Cs and ^(210)Pb_(ex) were significantly correlated with available phosphorus,organic matter,CEC,and exchangeable *** of soil redistribution rate using ^(137)Cs and ^(210)Pb_(ex) showed site-specific variations at different points along the slope,and respective ranges were^(-1)7.46~-207.51 and 1.55~-581.38 Mgha^(-1) yr^(-1),which indicated that more erosion was assessed by ^(210)Pb_(ex) than by ^(137)*** analysis showed that soil erosion occurred along the entire slope,except for the bottom point of the slope where 1.55 Mgha^(-1) yr^(-1) of sediment *** USLE provided a single value of the average annual soil loss in the entire slope,which was either 166 or 398 Mgha^(-1) yr^(-1),depending on the soil erodibility factor(soil series factor and calculated factor from soil sample analysis)used in t

关键词： Soil erosion Steep highland Fallout radionuclide ^(137)Cs ^(210)Pb_(ex) USLE

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Structural,Sintering and Electrical Properties of Cr-doped La_(0.6)Sr_(0.4)Cr_xFe_(1-x)O_(3-δ)(x=0.10,0.20) Oxides

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Journal of Materials Science & Technology 2012年第7期28卷 654-660页

作者： LinlinZhu Jong Pyo Kim Sou Hwan Son jung hoon Park State Key SLaboratory of Catalysis.Dalian Institute of Chemical Physics Chinese~Academy of Sciences Dalian 116023 China Greenhouse Gas Research Center Climate Change Technology Research Division Korea Institute of Energy ResearchDaejeon 305-343 Korea College of Chemistry and Materials Science Liaoning University of Petroleum and Chemical Technology Fushun113001 China

The perovskite Cr-doped La0.6Sr0.4CrxFe1-xO3-δ （x=0.10, 0.20） oxides were synthesized via the citrate gel method. The perovskite forming of the Lao.6Sr0.4CrxFel-xO3-δ （x=0.10, 0.20） oxides were studied by ther- mogravimetric analysis （TG）, differential scanning calorimetry （DSC）, and X-ray diffraction （XRD）. Structural and chemical stability under H2-containing helium atmospheres of Lao.6Sro.4CrxFel-xO3-δ （x=0.10, 0.20） were investigated by TG and XRD. The sintering microstructures of the perovskite Lao.6Sr0.4Cr2Fel-xO3-δ （x--0.10, 0.20） ceramics were investigated by scanning electron microscopy （SEM）, and the electrical conduc- tivities of both oxide ceramics were also measured up to 900℃. The results demonstrated that the chemical stability of the Co-free ***.4CrxFe1-xO3-δ （x=0.10, 0.20） oxides was significantly improved compared to the Co-containing Lao.6Sr0.4C00.2Fe0.8O3-δ and Ba0.5Sr0.5Co0.8Fe0.2O3-δ oxides. The incorporation of Cr cations in the B-site of the pervoskite oxides resulted in the improved structural and chemical stability of the as-synthesized Lao.6Sr0.4CrxFe1-xO3-δ （x=0.10, 0.20） oxides.

关键词： Perovskite Crystal structure Sintering Electrical conductivity

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Nontarget screening using passive air and water sampling with a level Ⅱ fugacity model to identify unregulated environmental contaminants

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Journal of Environmental Sciences 2017年第12期29卷 84-91页

作者： In-young Chung Yu-Mi Park Hyun-Jeoung Lee Hyuk Kim Dong-hoon Kim Il-Gyu Kim Sang-Min Kim young-Sun Do Kwang-Seol Seok jung-Hwan Kwon Chemical Research Division Environmental Health Research Department National Institute of Environmental ResearchIncheon Division of Environmental Science and Ecological Engineering Korea University

It is thought that there are many unregulated anthropogenic chemicals in the *** risk assessment of chemicals, it is essential to estimate the predicted environmental concentrations. As an effort of identifying residual organic contaminants in air and water in Korea, nontarget screening using two-dimensional gas chromatography time-of-flight mass spectrometry（GC × GC-TOFMS） was conducted at 10 sites using polyurethane foam passive air sampler and at 6 sites using polydimethyl siloxane（PDMS） passive water sampler in three different seasons in 2014. More than 600 chemical peaks were identified satisfying the identification criteria in air and water samples, respectively, providing a list for further investigation. Chemical substances with reported national emission rates in2014（n = 149） were also screened for potential existence in the environment using a level Ⅱ fugacity model. Most of chemical substances classified as not detectable were not identified with detection frequency greater than 20% by nontarget screening, indicating that a simple equilibrium model has a strong potential to be used to exclude chemicals that are not likely to remain in the environment after emissions from targeted monitoring.

关键词： Nontarget screening GC × GC-TOFMS Passive sampling Pollutant release and transfer register(PRTR) Fugacity model

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