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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung lee Seung Baek Hong Ji Hyun Ahn young Mok Park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

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Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga Hee Kim Yeong Chan lee Tae Jun Kim Sung Noh Hong Dong Kyung Chang young-Ho Kim Dong-Hoon Yang Chang Mo Moon Kyunga Kim Hyun Gun Kim Eun-Ran Kim Division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea Biomedical Statistics Center Samsung Medical CenterSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy

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Characteristics analysis and library development for piezoelectric transformer to drive a ballast for a 35 W class fluorescent lamp using PSPICE modeling

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Journal of Central South University 2016年第1期23卷 169-180页

作者： KIM young-choon Division of Mechanical and Automotive Engineering College of Engineering Kongju National University

PSPICE model driven by an electric equivalent circuit of a piezoelectric circuit is presented. In order to confirm this model to be effective, an independent model of cold cathode fluorescent lamp(CCFL) driving circuit is used to conduct simulations, leading to a precise modeling. A library is configured through modeling and its accuracy is verified through simulations for widely used and representative lamps such as CCFL, fluorescent lamps, HID lamps, and electrodeless fluorescent lamps. On the basis of experiments, a lamp simulation is also performed using PSPICE, which allows us to take advantage of the lamp library easily. Also, PSPICE model driven by an electric equivalent circuit of a piezoelectric transformer is presented. In order to confirm this model to be effective, an independent model of CCFL driving circuit is used to conduct simulations, leading to a precise modeling. In addition, a new type of electronic ballast is proposed, which allows 35 W-class(T5-class) fluorescent lamp to work. This system is built by a rectifier which has improved power factor and half-bridge series resonant inverter. Also, with size of 27.5 mm high, 27.5 mm wide and 2.5 mm thick, the produced piezoelectric transformer has a high step-up ratio, through which it is possible for the electric ballast circuit to be lighter, smaller and more efficient. After the produced ballast is used to drive the fluorescent lamp for 25 min, it yields 0.95 in power factor correction, 86% in efficiency, 35.07 W in output voltage and 20.5 °C in temperature increase while meeting the characteristics of the 35 W-class fluorescent lamp.

关键词： PSPICE 35 W-class cold cathode fluorescent lamp (CCFL) fluorescent lamp library

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Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

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Journal of Integrative Medicine 2024年第5期 600-613页

作者： Mijung Yeom Sora Ahn Dae-Hyun Hahm Sun-young Jang Se Hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-young Oh In-Seon lee Kyuseok Kim Soon-Kyeong Kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee University Department of Physiology School of MedicineKyung Hee University BioNanocomposite Research Center Kyung Hee University Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee University College of Korean Medicine Kyung Hee University Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee University Division of Applied Life Science (BK21) Gyeongsang National University Department of Anatomy & Information Sciences College of Korean MedicineKyung Hee University

Objective: Atopic dermatitis(AD) is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome. Acupuncture has been proven to be effective in reducing AD symptoms without serious adverse events, but its underlying mechanism is not completely understood. The purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut ***: AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11) acupoints. AD-like symptoms were assessed by lesion scores,scratching behavior, and histopathological changes; intestinal barrier function was measured by fecal output, serum lipopolysaccharide levels, histopathological changes, and mRNA expression of markers involved in intestinal permeability and inflammation. Gut microbiota was profiled using 16S rRNA gene sequencing from fecal ***: Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening, and also significantly altered gut microbiota structure as revealed by β-diversity indices and analysis of similarities. These beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated mice. Interestingly, AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability, atrophy of the mucosal structure(reduced villus height and crypt depth), decreased expression of tight junctions and mucus synthesis genes, and increased expression of inflammatory mediators in the ileum. Acupuncture attenuated these abnormalities, which was gut ***: Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier, providing new perspective for non-phar

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Lightweight design of 45000r/min spindle using full factorial design and extreme vertices design methods

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Journal of Central South University 2011年第1期18卷 153-158页

作者： PARK Seong-jin lee choon-man HWANG young-kug Department of Mechanical Design and Manufacturing Engineering Changwon National University

Factors for determining the spindle size are the shaft diameter, positions of bearing and motor, and entire length of the spindle. Then, it is important to find the assembling of the optimal design variables, which satisfy the stiffimss and rotational speed required to the spindle. A general full factorial design method was used to verify some factors that affect the natural frequency of a spindle. It is verified that the shorter shaft length and bearing span length represent the higher natural frequency, and there are some effects according to the change in the levels of factors. The detailed spindle dimension is determined by applying an EVD method, which can define the optimal bearing position through considering the limiting condition. Based on the estimated regression model, the optimal spindle size and bearing distance that can improve the primary natural frequency are obtained, and the influence of design factors on the natural frequency is also analyzed.

关键词： high-speed spindle extreme vertices design natural frequency lightweight design full factorial design

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Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-Micro Letters 2024年第12期 476-522页

作者： Jung Hwan Park Srinivas Pattipaka Geon-Tae Hwang Minok Park Yu Mi Woo young Bin Kim Han Eol lee Chang Kyu Jeong Tiandong Zhang Yuho Min Kwi-Il Park Keon Jae lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering) Kumoh National Institute of Technology Department of Materials Science and Engineering Pukyong National University Energy Technologies Area Lawrence Berkeley National Laboratory Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST) Division of Advanced Materials Engineering Jeonbuk National University School of Electrical and Electronic Engineering Harbin University of Science and Technology Key Laboratory of Engineering Dielectrics and Its Application Ministry of Education Harbin University of Science and Technology Department of Materials Science and Metallurgical Engineering Kyungpook National University School of Materials Science and Engineering Yeungnam University

This review provides a comprehensive overview of the progress in light-material interactions(LMIs), focusing on lasers and flash lights for energy conversion and storage applications. We discuss intricate LMI parameters such as light sources, interaction time, and fluence to elucidate their importance in material processing. In addition, this study covers various light-induced photothermal and photochemical processes ranging from melting, crystallization, and ablation to doping and synthesis, which are essential for developing energy materials and devices. Finally, we present extensive energy conversion and storage applications demonstrated by LMI technologies, including energy harvesters, sensors, capacitors, and batteries. Despite the several challenges associated with LMIs, such as complex mechanisms, and high-degrees of freedom, we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

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NC code generation for laser assisted turn-mill of various type of clovers and square section members

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Journal of Central South University 2012年第11期19卷 3064-3068页

作者： CHOI Jun-young lee choon-man Department of Mechanical Design & Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea

Laser assisted turning （LAT） is one of the advanced machining technologies, which uses laser power to heat the surface of a workpiece before the material is removed. It has several advantages of low manufacturing costs, high productivity and high qualities to machine difficult-to-cut materials such as silicon nitride, muUite, zirconia and Ni. A large part of studies on LAT have been focused on a round bar. With increasing demands for high quality products and high performance engineering system, the researches on LAT for clover and square section members are necessary. But, these workpieces are impossible to be machined on conventional CNC lathe and to generate NC code with current CAM softwares. As a basic research for combining LAT with a tilting index table type 5-axis machining center, i.e. laser assisted turn-mill, a new method is suggested to generate NC code that can process various types of clover and square section members through development of C＋＋ program.

关键词： laser assisted turning (LAT) NC code clover section turn-mill square section turn-mill

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Enhancement of Performance by Blade Optimization in Two-Stage Ring Blower

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Journal of Thermal Science 2010年第5期19卷 383-389页

作者： choon-Man Jang Gi-young Han Plant Research Division Korea Institute of Construction Technology dh-m co. ltd.626-5Bulmo-dongSeo-guIncheon404-270Korea

This paper describes the shape optimization of an impeller used for two-stage high pressure ring *** shape variables,which are used to define an impeller shape,are introduced to increase the blower *** pressure of a blower is selected as an object function,and the blade optimization is performed by a response surface ***-dimensional Navier-Stokes equations are introduced to analyze the internal flow of the blower and to find the value of object function for the training *** good agreement between experimental measurements and numerical simulation is obtained in the present *** the shape optimization,it is found that a hub height is effective to increase pressure in the ring *** pressure rise for the optimal two-stage ring blower is successfully increased up to 1.86% compared with that of reference at the design flow *** recirculation flow having low velocity is formed in both sides of the impeller outlet by different flow direction of the inlet and outlet of the *** flow field inside the ring blower is also analyzed and discussed.

关键词： Ring blower Blower performance Numerical simulation Blade optimization Response surface method

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Estimation of deformed laser heat sources and thermal analysis on laser assisted turning of square member

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Journal of Central South University 2012年第2期19卷 402-407页

作者： KIM Jae-hyun KIM Kwang-sun CHOI Jun-young lee choon-man Department of Mechanical Design and Manufacturing Engineering Changwon National University

Laser assisted machining （LAM） has difficulties in estimating temperature after applying a LAM process due to its very small heat input area, large energy and movement. In particular, in the case of laser assisted turning （LAT） process, it is more difficult to estimate the temperature after preheating because it has a shape of ellipse when a laser heat source is rotated. A prediction method and thermal analysis method for heat source shapes were proposed as a square shaped member was preheated. The temperature distribution was calculated according to the rotation of the member. Compared with the results of the former study, the maximum temperature of the calculation results, 1 407.1 ℃, is 8.5 ℃ higher than that of the square member, which is 1 398.6 ℃. In a LAT process for a square member, the maximum temperature is 1 850.8 ℃. It is recognized that a laser power control process is required because square members show a maximum temperature that exceeds a melting temperature at around a vertex of the member according to the rotation.

关键词： laser assisted machining laser assisted turning laser preheating laser power control

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Molecular Docking Studies on Streptomycin Antileishmanial Activity

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Open Journal of Physical Chemistry 2024年第2期14卷 36-48页

作者： Todd A. young Matthew George Jr. Ayele Gugssa William M. Southerland Yayin Fang Clarence M. lee Department of Biology Howard University Washington DC United States Department of Biochemistry and Molecular Biology Howard University Washington DC United States

Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study reported here is to investigate if Streptomycin, an aminoglycoside, and Amphotericin B, the second-line treatment drug, exhibit antileishmanial activity through a similar mechanism. By using MOE (Molecular Operating Environment), we performed molecular docking studies on these drugs binding to a range of targets including ribosome targets in Leishmania and H. sapiens. Our study shows that the two drugs do not bind to the same pockets in Leishmania targets but to the same pockets in the human ribosome, with some differences in interactions. Moreover, our 2D maps indicated that Amphotericin B binds to the A-site in the human cytoplasmic ribosome, whereas streptomycin does not.

关键词： Leishmaniasis Streptomycin Amphotericin B Molecular Docking Aminoglycosides Antileishmanial

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