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HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer

World Journal of Gastroenterology 2016年第41期22卷 9141-9153页

作者： Yiseul Choi young san ko Jinju Park youngsun Choi younghoon Kim Jung-Soo Pyo Bo Gun Jang Douk Ho Hwang Woo Ho Kim Byung Lan Lee Department of Tumor Biology Cancer Research Institute Seoul National Universit College of Medicine Department of Anatomy Seoul National University College of Medicine Department of Pathology Seoul National University College of Medicine Department of Pathology Eulji University Hospital Eulji University College of Medicine Department of Pathology Jeju National University Hospital Ischemic/Hypoxic Disease Institute Medical Research Center Seoul National University College of Medicine

AIM To investigated the relationships between HER2, c-Jun N-terminal kinase(JNK) and protein kinase B(AKT) with respect to metastatic potential of HER2-positive gastric cancer(GC) *** Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively. Transwell assay, Western blot, semi-quantitative reverse transcriptionpolymerase chain reaction and immunofluorescence staining were used in cell culture experiments. RESULTS In GC specimens, HER2, JNK, and AKT activations were positively correlated with each other. In vitro analysis revealed a positive regulatory feedback loop between HER2 and JNK in GC cell lines and the role of JNK as a downstream effector of AKT in the HER2/AKT signaling pathway. JNK inhibition suppressed migratory capacity through reversing EMT and dual inhibition of JNK and AKT induced a more profound effect on cancer cell *** HER2, JNK and AKT in human GC specimens are positively associated with each other. JNK and AKT, downstream effectors of HER2, co-operatively contribute to the metastatic potential of HER2-positive GC cells. Thus, targeting of these two molecules in combination with HER2 downregulation may be a good approach to combat HER2-positive GC.

关键词： Gastric cancer HER2 c-Jun N-terminal kinase Protein kinase B Metastatic potential

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Advanced prediction of organic–metal interactions through DFT study and electrochemical displacement approach

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Journal of Magnesium and Alloys 2023年第1期11卷 301-316页

作者： Abdelkarim Chaouiki Wail Al Zoubi young Gun ko Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541South Korea

Heterocyclic compounds are the promising biological compounds as nature-friendly for the corrosion protection of metallic *** this work,three heterocyclic compounds such as 1-azanaphthalene-8-ol(8-AN),2-methylquinoline-8-ol(8-MQ),and 8-quinolinol-5-sulfonic acid(8-QSA)were used as green compounds,and their anti-corrosion performance for AZ31 Mg in saline water was discussed on the basis of impedance interpretation and surface *** found that the electrochemical performance was improved in the order of 8-AN>8-MQ>8-QSA,demonstrating the electron donor effect of N-heterocycles to form coordination complexes on the magnesium *** the electrochemical performance,the protective layer constructed at the optimal concentration reinforces the barrier against aggressive environments,with potential inhibition efficiency of 87.4%,99.0%,and 99.9%for 8-QSA,8-MQ,and 8-AN,*** chemical parameters and electron density distribution for free organic species in the absence and presence of Mg^(2+)cation were evaluated using density functional theory(DFT).Upon the formation of coordination complexes between organic compound and Mg^(2+),energy gap underwent change about ΔE=5.7 eV in the 8-AN/Mg^(2+)***,the adsorption of heterocyclic compounds on Mg surface reveals the formation of strong covalent bonds with Mg atoms,which further confirmed by the electron density difference and projected density of states *** on theoretical calculations,three inhibitors can adsorb on the metal surface in both parallel and perpendicular orientations via C,O and N *** the parallel configuration,the C-Mg,N-Mg and O-Mg bond distances are between 2.11 and 2.25˚A,whereas the distances in the case of perpendicular adsorption are between 2.20 and 2.40˚A(covalent bonds via O and N atoms).The results indicated that parallel configurations are energetically more stable,in which the adsorption energies are-4.48 eV(8-AN),-4.28 eV(8-MQ)and-3.82 e

关键词： Organic layer Heterocyclic compounds Electrochemical behavior DFT modeling

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Nucleation and growth behavior of coating film on Mg–Al–Zn alloy with different surface topographies via plasma electrolytic oxidation

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Journal of Magnesium and Alloys 2022年第8期10卷 2185-2192页

作者： Nisa Nashrah Sung Hun Baek young Gun ko Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea

This work was made to investigate how nucleation and growth behavior of the coating film were affected by surface topographies of Mg–Al–Zn alloy substrate during the initial stage of plasma electrolytic oxidation(PEO).To satisfy this end,a single substrate was prepared by mechanical treatment exhibiting rough and smooth regions with an equal area on the *** rough region with prominent hills and grooves induced the breakdown of passive film,which was indicated by an early appearance of plasma discharge on the rough region since nucleation of coating film occurred preferentially around the ***,the coating film grown on the grooves was somewhat thicker and more porous than the film grown on the hills and smooth *** was due to the fact that the growth of the coating film was found to be localized in the presence of rough region,which was in line with the discharge ***,the nucleation and growth behavior during the initial stage of PEO will be discussed schematically on the basis of microstructural interpretation.

关键词： Mg alloy Surface roughness Plasma electrolytic oxidation Coating film

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Fabrication of branch-like Aph@LDH-MgO material through organic-inorganic hybrid conjugation for excellent anti-corrosion performance

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Journal of Magnesium and Alloys 2023年第7期11卷 2469-2485页

作者： Maryam Chafiq Abdelkarim Chaouiki Rachid Salghi young Gun ko Materials Electrochemistry Laboratory School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea Laboratory of Applied Chemistry and Environment ENSAUniversity Ibn ZohrPO Box 1136Agadir80000Morocco

Layered double hydroxides(LDH)frameworks have shown significant enhancement in stability and reusability,and their tailorable architecture brings new insight into the development of the next generation of hybrid materials,which attracted considerable attention in many fields over the *** of the factors contributing to the widespread applicability of layered double hydroxides is their adaptable composition,which can accommodate a wide spectrum of potential anionic *** exceptional property makes the LDH system simple to adjust for various ***,most LDH systems are synthesized in situ in an autoclave at high temperatures and pressures that severely restrict the industrial use of such coating *** this study,LDH was directly synthesized on a magnesium alloy that had undergone plasma electrolytic oxidation(PEO)treatment in the presence of ethylenediaminetetraacetic acid,thereby avoiding the use of hydrothermal autoclave *** LDH system was compared with a hybrid architecture consisting of organic-inorganic *** organic layer was fabricated on top of the LDH film using 4-Aminophenol(Aph)compound,resulting in a smart hierarchical structure that can provide a robust Aph@LDH film with excellent anti-corrosion *** the molecular level,the conjugation characteristics and adsorption mechanism of Aph molecule were studied using two levels of theory as ***,Localized orbit locator(LOL)-πisosurface,electrostatic potential(ESP)distribution,and average local ionization energy(ALIE)on the molecular surface were used to highlight localization region,reveal the favorable electrophilic and nucleophilic attacks,and clearly explore the type of interactions that occurred around interesting ***,first-principles based on density functional theory(DFT)was applied to study the hybrid mechanism of Aph on LDH system and elucidate their mutual *** experimental and computational analyses suggest t

关键词： Magnesium alloy Surface modification LDH Organic-inorganic hybrid materials Inter-/intra-molecular interactions

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Cutting force signal pattern recognition using hybrid neural network in end milling

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中国有色金属学会会刊：英文版 2009年第B9期19卷 209-214页

作者： Song-Tae SEONG ko-Tae JO young-Moon LEE Research and Development Department Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Yeongnam University School of Mechanical Engineering Kyungpo ok National University

Under certain cutting conditions in end milling, the signs of cutting forces change from positive to negative during a revolution of the tool. The change of force direction causes the cutting dynamics to be unstable which results in chatter vibration. Therefore, cutting force signal monitoring and classification are needed to determine the optimal cutting conditions and to improve the efficiency of cut. Artificial neural networks are powerful tools for solving highly complex and nonlinear problems. It can be divided into supervised and unsupervised learning machines based on the availability of a teacher. Hybrid neural network was introduced with both of functions of multilayer perceptron (MLP) trained with the back-propagation algorithm for monitoring and detecting abnormal state, and self organizing feature map (SOFM) for treating huge datum such as image processing and pattern recognition, for predicting and classifying cutting force signal patterns simultaneously. The validity of the results is verified with cutting experiments and simulation tests.

关键词：切削力信号混合神经网络模式识别铣床人工神经网络切削条件信号监测监督学习

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Magnetic resonance spectroscopy in Leigh-MELAS overlap syndrome

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World Journal of Pediatrics 2019年第3期15卷 306-308页

作者： Ara ko young-Mock Lee Department of Pediatrics Pusan National University Children’S HospitalPusan National University School of MedicineYangsanKorea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsanRepublic of Korea Department of Pediatrics Gangnam Severance HospitalYonsei University College of Medicine201 1 Eonju—roGangnam—guSeoul 06273South Korea

A 4-year-old boy presented with insidious psychomotor regression at the age of 12 *** MRI revealed symmetric lesions in the bilateral basal ganglia (Fig.1a),whereas brain magnetic resonance spectroscopy (MRS) revealed no abnormalities (***).Muscle biopsy revealed ragged red fibers,megaconia,and mitochondrial respiratory chain complex I *** investigation confirmed the ND3 mitochondrial mutation 10191T>*** was diagnosed with Leigh *** years later,he experienced *** revealed new focal diffusion-restricted lesions in multiple cortices (Fig.2a),and MRS revealed an inverted doublet lactate peak (Fig.2b).He was finally diagnosed with Leigh-MELAS overlap syndrome.

关键词： Magnetic resonance spectroscopy Leigh-MELAS overlap syndrome

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Comprehensive Analysis of Caching Performance under Probabilistic Traffic Patterns for Content Centric Networking

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China Communications 2016年第3期13卷 127-136页

作者： Dabin Kim young-Bae ko Sung-Hwa Lim Department of Computer Engineering Graduate School of Ajou University Department of Multimedia Namseoul University

The phenomenon of data explosion represents a severe challenge for the upcoming big data ***,the current Internet architecture is insufficient for dealing with a huge amount of traffic owing to an increase in redundant content transmission and the end-point-based communication ***-centric networking(ICN)is a paradigm for the future Internet that can be utilized to resolve the data explosion *** this paper,we focus on content-centric networking(CCN),one of the key candidate ICN *** has been studied in various network environments with the aim of relieving network and server burden,especially in name-based forwarding and in-network caching *** paper studies the effect of several caching strategies in the CCN domain from the perspective of network and server ***,we comprehensively analyze the in-network caching performance of CCN under several popular cache replication methods(i.e.,cache placement).We evaluate the performance with respect to wellknown Internet traffic patterns that follow certain probabilistic distributions,such as the Zipf/Mandelbrot–Zipf distributions,and *** the experiments,we developed an OPNET-based CCN simulator with a realistic Internet-like topology.

关键词： content-centric networking probabilistic Internet traffic patterns caching performance analysis OPNET

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Tuning the reactivity of TiO_(2)layer with uniform distribution of Sub-5 nm Fe_(2)O_(3)particles via in situ voltage-assisted oxidation for robust catalytic reduction

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Nano Materials Science 2024年第2期6卷 223-234页

作者： Nisa Nashrah Abdelkarim Chaouiki Wail Al Zoubi young Gun ko Integrated Materials Chemistry Laboratory School of Materials Science and EngineeringYeungnam UniversityGyeongsan38541Republic of Korea

The trade-off between efficiency and stability has limited the application of TiO_(2)as a catalyst due to its poor surface ***,we present a modification of a TiO_(2)layer with highly stable Sub-5 nm Fe_(2)O_(3)nanoparticles(NP)by modulating its structure-surface reactivity relationship to attain efficiency-stability balance via a voltage-assisted oxidation *** situ simultaneous oxidation of the Ti substrate and Fe precursor using high-energy plasma driven by high voltage resulted in uniform distribution of Fe_(2)O_(3)NP embedded within porous TiO_(2)*** surface characterizations with density functional theory demonstrated an improved electronic transition in TiO_(2)due to the presence of surface defects from reactive oxygen species and possible charge transfer from Ti to Fe;it also unexpectedly increased the active site in the TiO_(2)layer due to uncoordinated electrons in Sub-5 nm Fe_(2)O_(3)NP/TiO_(2)catalyst,thereby enhancing the adsorption of chemical functional groups on the *** unique embedded structure exhibited remarkable improvement in reducing 4-nitrophenol to 4-aminophenol,achieving approximately 99%efficiency in 20 min without stability decay after 20 consecutive cycles,outperforming previously reported TiO_(2)-based *** finding proposes a modified-electrochemical strategy enabling facile construction of TiO_(2)with nanoscale oxides extandable to other metal oxide systems.

关键词： Titanium dioxide Oxide nanoparticle Electrochemical oxidation Surface reactivity Efficiency Stability

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Electrochemical response of MgO/Co_(3)O_(4) oxide layers produced by plasma electrolytic oxidation and post treatment using cobalt nitrate

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Journal of Magnesium and Alloys 2023年第3期11卷 1057-1073页

作者： Mosab Kaseem Tehseen Zehra Tassawar Hussain young Gun ko Arash Fattah-alhosseini Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Materials Electrochemistry Group School of Materials Science and EngineeringYeungnam UniversityGyeongsan 38541Republic of Korea Department of Materials Engineering Bu-Ali Sina UniversityHamedan 65178-38695Iran

This work looked into the influence of the sealing treatment on the structural feature and electrochemical response of AZ31 Mg alloy coated via plasma electrolytic oxidation(PEO).Here,the inorganic layers produced by PEO in an alkaline-phosphate electrolyte were subsequently immersed for different periods in cold(60°C)and hot(100°C)aqueous solutions containing either 1 or 3 gr of cobalt nitrate hexahydrate in the presence of hydrogen peroxide as an *** results showed that the sealing treatments in the hot solutions could trigger the hydration reactions of PEO coating which would largely assist the surface incorporation of Co_(3)O_(4)into the *** contrast,the sealing in cold solutions led to less compact coatings,which was attributed to the fact the hydration reactions would be restricted at 60°C.A nearly fully sealed coating with a porosity of~0.5%was successfully formed on the sample immersed in the hot solution containing 1 gr of cobalt nitrate ***,the electrochemical stability of this fully sealed coating was superior to the other samples as it had the lowest corrosion current density(4.71×10^(-10)A·cm^(-2))and the highest outer layer resistance(3.81×10^(7)Ω·cm^(2)).The composite coatings developed in this study are ideal for applications requiring high electrochemical stability.

关键词： AZ31 Mg alloy Plasma electrolytic oxidation Co_(3)O_(4) Hydration Corrosion

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