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Reciprocal inhibition of expression between RAV1 and BES1 modulates plant growth and development in Arabidopsis

Journal of Integrative Plant Biology 2023年第5期65卷 1226-1240页

作者： Dami Yang Hyun-young shin Hyun Kyung Kang Yun Shang So young Park Dong-hoon Jeong Kyoung Hee Nam Department of Biological Sciences Sookmyung Women's UniversitySeoul 04310Republic of Korea Research Institute for Women's HealthSookmyung Women's UniversitySeoul 04310Republic of Korea Department of Life Science and Multidisciplinary Genome Institute Hallym UniversityChuncheon 24252Republic of Korea Present Address:Peking University Institute of Advanced Agricultural ScienceWeifang 261325China

RAV1(Related to ABI3/VP1)is a plant-specific B3 and AP2 domain-containing transcription factor that acts as a negative regulator of growth in many plant *** expression of RAV1 is downregulated by brassinosteroids(BRs);large-scale transcriptome analyses have shown that the expression of RAV1 was previously targeted by BRI1-EMS-SUPPRESOR1(BES1)and BRASSINAZOLE-RESISTANT1(BZR1),which are critical transcription factors for the BR-signaling *** RAV1-overexpressing transgenic plants,we showed that RAV1 overexpression reduced the BR signaling capacity,resulting in the downregulation of BR biosynthetic genes and BES1 ***,we demonstrated that BES1,not BZR1,is directly bound to the RAV1 promoter and repressed RAV1 expression,and vice versa;RAV1 is also bound to the BES1 promoter and repressed BES1 *** mutual inhibition was specific to RAV1 and BES1 because RAV1 exhibited binding activity to the BZR1 promoter but did not repress BZR1 *** observed that constitutively activated BR signaling phenotypes in bes1-D were attenuated by the repression of endogenous BES1 expression in transgenic bes1-D plants overexpressing ***-sequencing analysis of RAV1-overexpressing transgenic plants and bes1-D mutant plants revealed differentially expressed genes by RAV1 and BES1 and genes that were oppositely co-regulated by RAV1 and ***1 and BES1 regulated different transcriptomes but co-regulated a specific set of genes responsible for the balance between growth and *** results suggested that the mutual inhibitory transcriptional activities of RAV1 and BES1 provide fine regulatory mechanisms for plant growth and development.

关键词： BES1 growth modulation RAV1 transcriptional regulation

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Efficacy and safety of a patient-positioning device(EZ-FIX)for endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2015年第19期21卷 5995-6000页

作者： Seungho Lee Joung-ho Han Hee Seung Lee Ki Bae Kim In-kwang Lee Eun-Jong Cha young Duck shin Namgyu Park Seon Mee Park Department of Internal Medicine College of Medicine Chungbuk National University Department of Biomedical Engineering Chungbuk National University College of Medicine Department of Anesthesiology Chungbuk National University College of Medicine

AIM: To assess the efficacy and safety of a patientpositioning device(EZ-FIX) for endoscopic retrograde cholangiopancreatography(ERCP).METhoDS: A total of 105 patients were randomized to the EZ-FIX(n = 53) or non-EZ-FIX(n = 52) group in this prospective study. Midazolam and propofol,titrated to provide an adequate level of sedation during therapeutic ERCP, were administered by trained registered nurses under endoscopist *** outcome measures were the total dose of propofol and sedative-related complications, including hypoxia and hypotension. Secondary outcome measures were recovery time and sedation satisfaction of the endoscopist, nurses, and ***: There was no significant difference in the rate of hypoxia, but there was a statistical trend(EX-FIX group; n = 4, 7.55%, control group; n = 6, 11.53%,P = 0.06). The mean total dose of propofol was lower in the EZ-FIX group than in the non-EZ-FIX group(89.43 ± 49.8 mg vs 112.4 ± 53.8 mg, P = 0.025).In addition, the EZ-FIX group had a shorter mean recovery time(11.23 ± 4.61 mg vs 14.96 ± 5.12 mg, P< 0.001). Sedation satisfaction of the endoscopist and nurses was higher in the *** group than in the nonEZ-FIX group. Technical success rates of the procedure were 96.23% and 96.15%, respectively(P = 0.856).Procedure-related complications did not differ by group(11.32% vs 13.46%, respectively, P = 0.735).CONCLUSION: Using EZ-FIX reduced the total dose of propofol and the recovery time, and increased the satisfaction of the endoscopist and nurses.

关键词： EZ-FIX Patient-positioning device Propofol Sedation Endoscopic retrograde cholangiopancreaRandomizedtography

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Clinical significance of the leptin and leptin receptor expressions in prostate tissues

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Asian Journal of Andrology 2008年第6期10卷 923-928页

作者： Jung hoon Kim shin young Lee Soon Chul Myung young Sun Kim Tae-Hyoung Kim Mi Kyung Kim Departments of Urology College of Medicine Chung-Ang University Seoul 140-757 Korea Departments of Pathology College of Medicine Chung-Ang University Seoul 140-757 Korea

Aim： To evaluate the expression of leptin and leptin receptor in benign prostatic hyperplasia （BPH） and prostate cancer （PCa）, and to investigate whether they are associated with the development and progression of PCa. Methods： hnmunohistochemical staining was performed to examine the expression of leptin and leptin receptor in BPH and PCa. PCa was divided into three groups： localized PCa, locally advanced PCa and metastatic PCa. The positive staining was identified and the percentage of the positive staining was graded. We also assessed the relationship between both the Gleason score and body mass index （BMI） and PCa. Results： The percentage of the leptin expression in PCa was significantly higher than that in BPH （P 〈 0.01）. For the PCa group, the expressed levels of leptin showed a considerable correlation with localized PCa and metastatic PCa （P 〈 0.05）. Leptin receptor, however, did not reveal a definite difference between BPH and PCa. The expression of leptin indicated a significant difference between well-differentiated PCa （Gleason score ≤6） and poorly differentiated PCa （Gleason score 8-10）（P 〈 0.05）. The relation between the leptin expression level in PCa and the BMI was not remarkable （P = 0.447）. Conclusion： Our results suggest that leptin might have a promoting effect on the carcinogenesis and progression of PCa.

关键词： leptin leptin receptor prostatic neoplasms

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Effect of preoperative biliary drainage on surgical results after pancreaticoduodenectomy in patients with distal common bile duct cancer:Focused on the rate of decrease in serum bilirubin

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World Journal of Gastroenterology 2008年第7期14卷 1102-1107页

作者： Yun Mee Choi Eung-ho Cho Keon-young Lee Seung-Ik Ahn Sun Keun Choi Sei Joong Kim Yoon Seok Hur young Up Cho Kee-Chun hong Seok-Hwan shin Kyung Rae Kim Ze-hong Woo Department of Surgery College of MedicineInha UniversityIncheonKorea

AIM: To examine if the rate of decrease in serum bilirubin after preoperative biliary drainagecan be used as a predicting factor for surgical complications and postoperative recovery after pancreaticoduodenectomy in patients with distal common bile duct ***: A retrospective study was performed in 49 consecutive patients who underwent pancrea-ticoduodenectomy for distal common bile duct cancer. Potential risk factors were compared between the complicated and uncomplicated groups. Also, the rates of decrease in serum bilirubin were compared pre- and postoperatively. RESULTS: Preoperative biliary drainage (PBD) was performed in 40 patients (81.6%). Postoperative morbidity and mortality rates were 46.9% (23/49) and 6.1% (3/49), respectively. The presence or absence of PBD was not different between the complicated and uncomplicated groups. In patients with PBD, neither the absolute level nor the rate of decrease in serum bilirubin was significantly different. Patients with rapid decrease preoperatively showed faster decrease during the first postoperative week (5.5 ± 4.4 μmol/L vs -1.7 ± 9.9 μmol/L, P = 0.004).CONCLUSION: PBD does not affect the surgical outcome of pancreaticoduodenectomy in patients with distal common bile duct cancer. There is a certain group of patients with a compromised hepatic excretory function, which is represented by the slow rate of decrease in serum bilirubin after PBD.

关键词： Distal bile duct cancer Drainage Bilirubin Rate

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Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1(G93A)mice and SOD1(G17S and G86S)ALS patients

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Translational Neurodegeneration 2020年第3期9卷 323-343页

作者： Ki Yoon Kim Yu Ri Kim Kyung Won Choi Mijung Lee Somyung Lee Wooseok Im Je-young shin Jin young Kim Yoon ho hong Manho Kim Jong-ll Kim Jung-Joon Sung Department of Neurology Seoul National University Hospital 28 yongon-DongChongno-guSeoul 110-744Republic of Korea Division of Mass Spectrometry Research Korea Basic Science InstituteDaejunRepublic of Korea Department of Neurology Seoul National University Seoul Metropolitan Government Boramae Medical G enterSeoulRepublic of Korea Department of Biochemistry and Molecular Biology Seoul National University College of MedicineSeoulRepublic of Korea

Background:MicroRNAs(miRNAs)are endogenous non-coding RNAS that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative *** miRNAs play an important role in amyotrophic lateral sclerosis(ALS);however,the pathogenic mechanisms of deregulated miRNAS are still ***:We aimed to assess the dysfunction of RNAS or miRNAs in fALS(SOD1 mutations).We compared the RNA-seq of subcellular fractions in NSC-34 WT(hSOD1)and MT(hSOD1(G93A))cells to find altered RNAs or *** identified that Hif1a and Mef2c were upregulated,and Mctp1 and Rarb were downregulated in the cytoplasm of NSC-34 MT ***:SOD1 mutations decreased the level of *** Hif1a which is the target for miR-18b increased Mef2c expression as a transcription ***2c upregulated miR-206 as a transcription *** of Mctp1 and Rarb,which are targets of miR-206,induced intracellular Ca^2+ levels and reduced cell differentiation,*** miR-18b-5p pathway was also observed in G93A Tg mice,fALS(G86S)patient,and iPSC-derived motor neurons from fALS(G17S)***:Our data indicate that SOD1 mutation decreases miR-18b-5p,which sequentially regulates Hif1a,Mef2c,miR-206,Mctp1 and Rarb in fALS-linked SOD1 *** results provide new insights into the downregulation of miR-18b-5p-dependent pathogenic mechanisms of ALS.

关键词： miRNAs Hif1a Mef2c Mctp1 Rarb

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Pseudoaneurysm of gastroduodenal artery following radical gastrectomy for gastric carcinoma patients

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World Journal of Gastroenterology 2003年第12期9卷 2878-2879页

作者： Dong YiKim Jae KyoonJoo SeongYeobRyu young JinKim shin KonKim Yong-Yeon Jung Division of Gatroenterologic Surgery Department of SurgeryChonnam National University Medical SchoolGwangjuKorea Department of Radiology Chonnam National University Medical SchoolGwangjuKorea

We report a rare case of postoperative pseudoaneurysm of the gastroduodenal artery following radical *** trauma to the gastroduodenal artery during regional lymphadenectomy was considered as the cause of the postoperative pseudoaneurysm. The pseudoaneurysm was successfully managed by ligating the bleeding vessel. We should consider the possibility of pseudoaneurysm formation in a patient with gastrointestinal bleeding in the postoperative period following radical gastrectomy with regional lymph node and perivascular lymphatic dissection.

关键词： Aged Aneurysm, False Duodenum Fatal Outcome Gastrectomy Humans Male Mesenteric Artery, Superior Stomach Stomach Neoplasms Time Factors

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The hidden switches undertying RORα-mediated circuits that critically regulate uncontrolled cell proliferation

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Journal of Molecular Cell Biology 2014年第4期8卷 338-348页

作者： Dongkwan shin Ik Soo Kim Ji Min Lee Sung-young shin Jong-hoon Lee Sung Hee Baek Kwang-Hyun Cho Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Republic of Korea Department of Biological Sciences Creative Research Initiative Center for Chromatin Dynamics Seoul National University Seou1151-742 Republic of Korea

Prostaglandin E2 （PGE2） is known to have a key role in the development of colorectal cancer, but previous experiments showed its contrasting （i.e. tumor-promoting or tu mor-suppressive） roles depending on experimental conditions. To elucidate the mechanisms underlying such contrasting roles of PG E2 in tumorigenesis, we investigated all the previous experiments and found a new signal transduction pathway mediated by retinoic acid receptor-related orphan receptor （ROR）α, in which PGE2/PKCα-dependent phosphorylation of RORα attenuates Wnt target gene expression in colon cancer ceils. From mathematical simulations combined with biochemical experimentation, we revealed that RORα induces a biphasic response of Wnt target genes to PGE2 stimulation through a regulatory switch formed by an incoherent feedforward loop, which provides a mechanistic explanation on the contrasting roles of PGE2 observed in previous experiments. More interestingly, we found that RORα constitutes another regulatory switch formed by coupled positive and negative feedback loops, which regulates the hysteretic response of Wnt signaling and eventually converts a proliferative cellular state into an anti-proliferative state in a very delicate way. Our results indicate that RORα is the key regulator at the center of these hidden switches that critically regulate cancer celt proliferation and thereby being a promising anti-cancer therapeutic target.

关键词： colorectal cancer Wnt signaling RORα mathematical modeling biphasic response hysteresis systems biology

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Retrieval of the Single Scattering Albedo of Asian Dust Mixed with Pollutants Using Lidar Observations

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Advances in Atmospheric Sciences 2014年第6期31卷 1417-1426页

作者： Sungkyun shin young Min NOH Kwonho LEE Hanlim LEE Detlef MLLER Y.J.KIM Kwanchul KIM Dongho shin School of Environmental Science and Engineering Gwangju Institute of Science and TechnologyKorea Department of Geoinformatics Engineering Kyungil UniversityKorea Department of Spatial Information Engineering Pukyong National UniversityKorea Science System and Applications Inc. NASA Langley Research CenterUSA University of Hertfordshire United Kingdom

The vertical distribution of single scattering albedos （SSAs） of Asian dust mixed with pollutants was derived using the multi-wavelength Raman lidar observation system at Gwangju （35.10°N,126.53°E）.Vertical profiles of both backscatter and extinction coefficients for dust and non-dust aerosols were extracted from a mixed Asian dust plume using the depolarization ratio from lidar *** profiles of backscatter and extinction coefficients of non-dust particles were input into an inversion algorithm to retrieve the SSAs of non-dust *** aerosol layers at different heights had different light-absorbing *** SSAs of non-dust particles at each height varied with aerosol type,which was either urban/industrial pollutants from China transported over long distances at high altitude,or regional/local pollutants from the Korean *** advantage of independent profiles of SSAs of non-dust particles,vertical profiles of SSAs of Asian dust mixed with pollutants were estimated for the first time,with a new approach suggested in this study using an empirical determination of the SSA of pure *** SSAs of the Asian dust-pollutants mixture within the planetary boundary layer （PBL） were in the range 0.88-0.91,while the values above the PBL were in the range 0.76-0.87,with a very low mean value of 0.76 ± *** total mixed dust plume SSAs in each aerosol layer were integrated over height for comparison with results from the Aerosol Robotics Network （AERONET） *** of SSA retrieved from lidar observations of 0.92 ± 0.01 were in good agreement with the results from AERONET measurements.

关键词： lidar Asian dust depolarization ratio microphysical properties single scattering albedo

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Sex-based differences in histology,staging,and prognosis among 2983 gastric cancer surgery patients

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World Journal of Gastroenterology 2022年第9期28卷 933-947页

作者： Yonghoon Choi Nayoung Kim Ki Wook Kim Hyeong ho Jo Jaehyung Park Hyuk Yoon Cheol Min shin young Soo Park Dong ho Lee Hyeon Jeong Oh Hye Seung Lee young Suk Park Sang-hoon Ahn Yun-Suhk Suh Do Joong Park Hyung-ho Kim Ji-Won Kim Jin Won Kim Keun-Wook Lee Won Chang Ji hoonPark Yoon Jin Lee Kyoung ho Lee young hoon Kim Department ofInternal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Nayoung Department of Internal Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Radiology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Radiology Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer(GC).AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for *** A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang hospital between 2003 and 2017 were *** clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were *** Among the 2983 patients, 2005(67.2%) and 978(32.8%) were males and females, *** average age of the female group(59.36 years) was significantly younger than that of the male group(61.66 years;P younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male *** of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with *** overall survival rate was significantly higher in females(P however, this difference disappeared for GC-specific survival(P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer(stage Ⅲ or above) in females(P = 0.045).The risk factors for GC-related mortality were older age, upper location of GC, and diffuse-or mixed-type *** terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in *** Sex-based differences in GC were

关键词： Gastric cancer Histology Prognosis Sex difference Survival

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Clinicopathologic characteristics of gastric carcinoma in elderly patients: A comparison with young patients

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World Journal of Gastroenterology 2005年第1期11卷 22-26页

作者： Dong-Yi Kim Jae-Kyoon Joo Seong-Yeob Ryu young-Kyu Park young-Jin Kim shin-Kon Kim Division of Gastroenterologic Surgery

AIM:To examine the clinicopathologic features of elderly patients with gastric carcinoma and to investigate the relationship between prognosis and ***: We reviewed the hospital records of 2 014patients with gastric carcinoma retrospectively to compare the clinicopathologic findings in elderly (age ＞70 years) and young (age ＜36 years) patients during the period from 1986 to 2000 in a tertiary referral center in Gwangju, Korea. Overall survival was the main outcome ***: Of the 2 014 patients, 194 (9.6%) were in the elderly group and 137 (6.8%) were in the young *** elderly and young patients had similar distributions with respect to depth of invasion, nodal involvement, hepatic metastasis, peritoneal dissemination, tumor stage at the initial diagnosis, and type of surgery. Synchronous multiple carcinomas were found in 14/194 (7.2%) of the elderly group and 4/137 (2.9%) of the young group (P＜0.05). Using the Borrmann classification, type Ⅳ was more frequent in the young patients than in the elderly patients (P＜0.05).Significantly more elderly patients had a well or moderately differentiated histology, and more young patients had a poorly differentiated histology and signet ring cell carcinoma (P＜0.001). The 5-year survival rates of elderly and young patients did not differ statistically (52.8% vs 46.5%,P = 0.5290). Multivariate analysis showed that the histologic type, nodal involvement and operative curability were significant prognostic factors, and age itself was not an independent prognostic factor of survival for elderly gastric carcinoma ***: Elderly patients with gastric carcinoma do not have a worse prognosis than young patients. The important prognostic factor is whether the patients undergo a curative resection.

关键词： Gastric carcinomas Prognosis Age Surgery

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