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Tocotrienol isoforms:The molecular mechanisms underlying their effects in cancer therapy and their implementation in clinical trials

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Journal of Integrative Medicine 2024年第1期22卷 1-11页

作者： Maria younes Ghady Loubnane Christopher Sleiman Sandra Rizk Department of Natural Sciences Lebanese American UniversityByblosLebanon

Tocotrienols are found in a variety of natural sources,like rice bran,annatto seeds and palm oil,and have been shown to have several health-promoting properties,particularly against chronic diseases such as *** incidence of cancer is rapidly increasing around the world,not only a result of continued aging and population growth,but also due to the adoption of aspects of the Western lifestyle,such as high-fat diets and low-physical *** literature provides strong evidence that tocotrienols are able to inhibit the growth of various cancers,including breast,lung,ovarian,prostate,liver,brain,colon,myeloma and pancreatic *** findings,along with the reported safety profile of tocotrienols in healthy human volunteers,encourage further research into these compounds’potential use in cancer prevention and *** current review provided detailed information about the molecular mechanisms of action of different tocotrienol isoforms in various cancer models and evaluated the potential therapeutic effects of different vitamin E analogues on important cancer hallmarks,such as cellular proliferation,apoptosis,angiogenesis and ***/PubMed and Scopus databases were used to identify recently published articles that investigated the anticancer effects of vitamin E derivatives in various types of cancer in vitro and in vivo along with clinical evidence of adjuvant chemopreventive *** an overview of pre-clinical studies,we describe several completed and ongoing clinical trials that are paving the way for the successful implementation of tocotrienols in cancer chemotherapy.

关键词： Vitamin E Tocotrienols Cancer Molecular mechanism Clinical trials

Phase Transfer Catalysis of Henry and Darzens Reactions

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International Journal of Organic Chemistry 2011年第3期1卷 119-124页

作者： Layla Mhamdi Hafedh Bohli younes moussaoui Ridha ben Salem 不详

We describe in this work the influence of the addition of phase transfer catalyst in heterogeneous medium liquid/liquid on the output of the reactions of Darzens and Henry. It proves that the reaction of Darzens is favoured in the presence of low base such as K2CO3 and Et3N. Phase transfer catalysis is an efficient activation method in Darzens and Henry reactions. Thus, the Ethylene Diammonium Diacetate (EDD) has a comparable catalytic activity has that of quaternary ammonium salts in the reaction of Darzens.

关键词： Darzens Henry Phase Transfer Catalysis Mechanism

Integrated hazard assessment of rockfall incidents in the Cap Aokas Cliff Region

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Journal of Mountain Science 2024年第6期21卷 1916-1929页

作者： Zohra LADJEL Farid ZAHRI Riheb HADJI younes HAMED Karim ZIGHMI Kaddour BENMARCE Department of Earth Sciences Institute of Architecture and Earth SciencesFerhat Abbas UniversitySetif 19137Algeria Unit of Emerging Materials Research Ferhat Abbes UniversitySétif 19137Algeria Laboratory of Applied Research in Engineering Geology GeotechnicsWater Sciencesand EnvironmentFerhat Abbas UniversitySetif 19137Algeria International Association of Water Resources in the Southern Mediterranean Basin Gafsa 2112Tunisia Department of Earth Sciences Faculty of SciencesUniversity of GafsaGafsa 2112Tunisia

Rock fall accidents in mountainous cliff areas have significant consequences for human life and *** study aimed to evaluate the rockfall hazard in the Cap Aokas cliff region located along the northeast coast of Algeria by identifying the key factors contributing to rockfall *** employed a combination of kinematic analysis,Matterocking method,and 3D trajectory simulations to determine zones that are susceptible to rockfall *** using a probabilistic and structural approach in conjunction with photogrammetry,we identified the controlling *** kinematic analysis revealed the presence of five discontinuity families,which indicated both plane and wedge failure *** 3D trajectory simulations demonstrated that the falling blocks followed the stream *** then validated the susceptibility maps generated from the analysis using aerial photos and historical rockfall *** findings of this study enhance our understanding of rockfall phenomena and provide valuable insights for the development of effective strategies to mitigate rockfall hazards.

关键词： Trajectory simulations Probabilistic analysis Structural approach Rockfall hazard Cap Aokas cliff

Phase Transfer Catalysis Improved Synthesis of 3,4-Dihydropyrimidinones

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International Journal of Organic Chemistry 2013年第3期3卷 96-100页

作者： Hela Slimi Khemais Said younes moussaoui Ridha Ben Salem Physical Organic Chemistry Laboratory(UR11ES74) Science Faculty of SfaxSfax UniversitySfaxTunisia Science Faculty of Gafsa Gafsa UniversityGafsaTunisia

Various 3,4-dihydropyrimidinones can be prepared via Biginelli reaction in aqueous media by using quaternary ammonium salts of different alkyl groups (C4 and C8) and anions (Cl-?and Br-) as catalysts. The use of quaternary ammonium salts along with longer alkyl chains increases the yield of the Biginelli reaction;however, bromide ammonium salts are less active than the chloride ones.

关键词： Multicomponent Reaction Biginelli Reaction 3,4-Dihydropyrimidinones Phase-Transfer Catalysis Quaternary Ammonium Salts

Broken Rules,Broken Lives

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Beijing Review 2024年第36期67卷 26-27页

作者： younes Abouyoub Governance and State-Building Section United Nations Economic Social Commission for Western Asia(UN-ESCWA)

As we observe the 75th anniversary of the adoption of the 1949 Geneva Conventions(hereinafter referred to as the Conventions),which are deemed the most essential treaties in international humanitarian law as they provide a widely accepted and comprehensive framework for protecting individuals during armed conflicts,their relevance is underscored by the ongoing challenges in ensuring the protection of civilians,prisoners of war and the wounded.

关键词： anniversary wound law

Overall Assessment of Heat Transfer for a Rarefied Flow in a Microchannel with Obstacles Using Lattice Boltzmann Method

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工程与科学中的计算机建模(英文) 2024年第1期138卷 273-299页

作者： Siham Hammid Khatir Naima Omolayo M.Ikumapayi Cheikh Kezrane Abdelkrim Liazid Jihad Asad Mokdad Hayawi Rahman Farhan Lafta Rashid Naseer Ali Hussien younes Menni Laboratory of Development in Mechanics and Materials(LDMM) Zian Achour UniversityDjelfaPB 3117Algeria Department of Technology University Center Salhi Ahmed Naama(Ctr.Univ.Naama)P.O.Box 66Naama45000Algeria Department of Mechanical and Mechatronics Engineering Afe Babalola University Ado Ekiti360101Nigeria Departement of Physics Faculty of ScienceAbou Bekr Belkaid UniversityTlemcen13000Algeria Department of Physics Faculty of Applied SciencesPalestine Technical University-KadoorieTulkarmPalestine Aeronautical Technical Engineering Al-Farahidi UniversityBaghdad10011Iraq Mechanical Engineering Department University of KerbalaKarbala56001Iraq Information and Communication Technology Research Group Scientific Research CenterAl-Ayen UniversityThi-QarIraq National University of Science and Technology Dhi QarIraq

The objective of this investigation is to assess the effect of obstacles on numerical heat transfer and fluid flow momentum in a rectangular microchannel(MC).Two distinct configurations were studied:one without obstacles and the other with alternating obstacles placed on the upper and lower *** research utilized the thermal lattice Boltzmann method(LBM),which solves the energy and momentum equations of fluids with the BGK approximation,implemented in a Python coding *** jump and slip velocity conditions were utilized in the simulation for the MC and extended to all obstacle *** study aims to analyze the rarefaction effect,with Knudsen numbers(Kn)of 0.012,0.02,and *** outcomes indicate that rarefaction has a significant impact on the velocity and temperature *** presence of nine obstacles led to slower fluid movement inside the microchannel MC,resulting in faster cooling at the *** MCs with obstacles,the rarefaction effect plays a crucial role in decreasing the Nusselt number(Nu)and skin friction coefficient(Cf).Furthermore,the study demonstrated that the obstacles played a crucial role in boosting fluid flow and heat transfer in the *** findings suggest that the examined configurations could have potential applications as cooling technologies in micro-electro-mechanical systems and microdevice applications.

关键词： Microfluid rarefied flow LBM microchannel Knudsen number numerical simulation

Metasurfaces for next-generation wireless communication systems

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National Science Review 2023年第8期10卷 17-19页

作者： younes Ra'di Nikita Nefedkin Petar Popovski Andrea Alù Department of Electrical Engineering and Computer Science Syracuse University Photonics Initiative Advanced Science Research Center City University of New York Department of Electronic Systems Aalborg University Physics Program Graduate Center City University of New York

The pace of development in the world of 5G communication systems has proven to be much more demanding than previous generations, with 5G-Advanced seemingly around the corner [1]. Extensive research is already underway to structure the next generation of wireless systems(i.e. 6G), which may potentially enable an unprecedented level of human–machine interaction [2].

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A systematic review of occupational exposure to respirable coal mine dust(RCMD)in the *** industry

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International Journal of Coal Science & Technology 2023年第2期10卷 32-44页

作者： younes Shekarian Elham Rahimi Mohammad Rezaee Pedram Roghanchi John and Willie Leone Family Department of Energy and Mineral Engineering Earth and Mineral Sciences(EMS)Energy InstituteThe Pennsylvania State UniversityUniversity ParkUSA Department of Mineral Engineering New Mexico Institute of Mining and TechnologySocorroNMUSA

Cumulative inhalation of respirable coal mine dust(RCMD)can lead to severe lung diseases,including coal worker's pneu-moconiosis(CWP),silicosis,mixed dust pneumoconiosis,dust-related diffuse fibrosis(DDF),and progressive massive fibrosis(PMF).Statistics from the number of reported cases showed a significant decrease in the progression of respiratory diseases in the ***,an unexpected increase in the number of CWP cases was reported in the late *** date,there has been no comprehensive systematic review to assess all contributing factors to the resurgence of CWP *** study aims to investigate the effects of various mining parameters on the prevalence of CWP in coal mines.A systematic review using the preferred reporting items for systematic reviews and meta-analysis(PRISMA)method was conducted to investigate the health effects of RCMD exposure and identify the factors that may contribute to the recent resurgence of CWP *** systematic review yielded a total of 401 papers,which were added to the *** total number of 148 and 208 papers were excluded from the database in the process of screening and eligibility,***,18 papers were considered for data selection and full-text *** review revealed that factors including geographic location,mine size,mining operation type,coal-seam thickness,coal rank,changes in mining practices,technology advancement,and engi-neering dust control practices are contributing to the recent resurgence of CWP among coal ***,the evidence for root causes is limited owing to the methodological constraints of the studies;therefore,further detailed studies are needed.

关键词： Respirable coal mine dust Systematic review Coal worker's pneumoconiosis Respiratory diseases Exposure limit Occupational exposure

Efficient method for wind velocity estimation and power-extraction maximization using a fourth-order Luenberger observer in a wind-energy-conversion system

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Clean Energy 2022年第6期6卷 797-809页

作者： younes Azelhak Damien Voyer Hicham Medromi Laboratory of Research in Engineering(LRI) System Architecture Team(EAS)Hassan II University—ENSEM Casablanca 8118 Morocco EIGSI La Rochelle 17000 France 3Laboratory of Research in Engineering(LRI)System Architecture Team(EAS)Hassan II University—ENSEM Casablanca 8118Morocco

This paper proposes an advanced method for estimating numerous parameters in a wind-energy-conversion system with high precision,especially in a transient state,including the rotation speed and mechanical torque of the turbine as well as wind *** suggested approach is designed into two ***,a fourth-order Luenberger observer is proposed to take into account the significant fluctuations of the mechanical torque that can be caused by wind *** observer provides an accurate estimate of speed and mechanical torque in all weather conditions and especially when the wind is *** the same time,the wind velocity is calculated using the Luenberger observer outputs and a model of the mechanical power generated by the ***,these estimated parameters are exploited as input in a maximum-power-point tracking(MPPT)algorithm using the tip-speed ratio(TSR)to improve the sensorless strategy *** results were performed using MATLAB®/Simulink®for both wind gust and real wind *** have verified that for wind gusts with jumps ranging from 3 to 7 m/s,the new observer manages to better follow the rotation speed and the torque of the turbine compared to a usual *** addition,we demonstrated that by applying the proposed estimator in the improved TSR-MPPT strategy,it is possible to extract 3.3%more energy compared to traditional approaches.

关键词： wind velocity estimation mechanical parameters estimation MPPT algorithm wind-energy-conversion system