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平行叠落地铁区间施工地表沉降特征研究

市政技术 2024年第1期42卷 147-153,224页

作者：王祐菁刘飞北京建筑大学土木与交通工程学院北京100044

北京某在建地铁区间暗挖段工程北侧为单跨双层拱顶直墙断面,采用PBA法施工;南侧为双洞叠落标准断面,上层采用CRD法施工,下层采用台阶法施工。因此,利用有限元软件进行数值模拟分析,研究了“先小后大”+“先下后上”、“先小后大”+“先... 详细信息

北京某在建地铁区间暗挖段工程北侧为单跨双层拱顶直墙断面,采用PBA法施工;南侧为双洞叠落标准断面,上层采用CRD法施工,下层采用台阶法施工。因此,利用有限元软件进行数值模拟分析,研究了“先小后大”+“先下后上”、“先小后大”+“先上后下”、“先大后小”+“先下后上”以及“先大后小”+“先上后下”4种不同施工顺序下,地铁区间施工对纵向地表沉降与横向地表沉降的影响。研究结果表明:在该工程中,采用“先大后小”+“先下后上”的施工顺序引起的地表沉降值最小。该研究成果可为同类型工程地表变形控制提供参考。

关键词：地铁区间平行叠落工序数值模拟地表沉降多工法

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Progress　in　Acupuncture　Studies　Abroad

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中国针灸 1995年第S2期15卷 248-249页

作者： wang youjing(Institute of Acupuncture and Moxibustion,China Academy of TCM)

ＰｒｏｇｒｅｓｓｉｎＡｃｕｐｕｎｃｔｕｒｅＳｔｕｄｉｅｓＡｂｒｏａｄ￥ＷａｎｇＹｏｕｊｉｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＡｃｕｐｕｎｃｔｕｒｅａｎｄＭｏｘｉｂｕｓｔｉｏｎ，ＣｈｉｎａＡｃａｄｅｍｙｏｆＴＣＭ）Ｉｎｔｈｉｓ... 详细信息

ＰｒｏｇｒｅｓｓｉｎＡｃｕｐｕｎｃｔｕｒｅＳｔｕｄｉｅｓＡｂｒｏａｄ￥ＷａｎｇＹｏｕｊｉｎｇ（ＩｎｓｔｉｔｕｔｅｏｆＡｃｕｐｕｎｃｔｕｒｅａｎｄＭｏｘｉｂｕｓｔｉｏｎ，ＣｈｉｎａＡｃａｄｅｍｙｏｆＴＣＭ）Ｉｎｔｈｉｓｐａｐｅｒ，ｆｏｒｅｉｇｎＰｒｏｇ...

关键词： Acupuncture Abroad Progress Studies in

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A bystander cell-based GM-CSF secreting vaccine synergized with a low dose of cyclophosphamide presents therapeutic immune responses against murine hepatocellular carcinoma

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Cellular & Molecular Immunology 2013年第4期10卷 349-359页

作者： Chen Chen Jiajie Hou Zhe Lin Ming Yao Runqiu Jiang youjing wang Yun Gao Qing Shao Lei Deng Yun Chen Beicheng Sun Liver Transplantation Center The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Microbiology and Immunology Nanjing Medical University Nanjing China Department of Ophthalmology The First Affiliated Hospital of Nanjing Medical University Nanjing China

Granulocyte-macrophage colony-stimulating factor （GM-CSF） secreting cellular tumor vaccines contribute to the induction of potent antitumor immune responses in murine models and patients suffering from cancers. Hepatocellular carcinoma （HCC） is one of the most frequent and malignant cancers in China. We describe, for the first time, a GM-CSF releasing vaccine strategy that represents a step toward combating this type of cancer. In this study, a bystander cell-based GM-CSF secreting vaccine against murine HCC, Hepa 1-6/B78H 1-GM-CSF, was co-administered with a low dose of cyclophosphamide （CY）. After challenging with tumor and vaccination, immunological assays demonstrated that the cellular antitumor immune responses were efficiently activated and that tumor development was significantly retarded, which was dependent on synergy with CY. The promising outcome of the anti-HCC vaccine in the murine model demonstrates the feasibility of a future clinical application for this treatment in HCC patients.

关键词： cellular immunotherapy GM-CSF GVAX hepatocellular carcinoma T regulatory cells

Dose-Response Meta-Analysis on Risk of Diabetes in Relation to Red and Processed Meat Consumption—Asian Populations,2006−2021

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China CDC weekly 2023年第45期5卷 1012-1016,I0003-I0009页

作者： Hancheng Yu Jijuan Zhang Jinchi Xie Xianli Li youjing wang Yijia Yang Fengshuang Zhou Meichen Liu Zhe Zhang Zhilei Shan Gang Liu An Pan Department of Epidemiology and Biostatistics Ministry of Education Key Laboratory of Environment and Health and State Key Laboratory of Environmental Health(incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan CityHubei ProvinceChina

Summary What is already known about this topic?Red and processed meat consumption has been positively related to an increased risk of diabetes in Western ***,the results remain inconclusive within Asian *** is added by this report?This dose-response meta-analysis of prospective cohort studies conducted in East Asian populations reveals a positive relation between the consumption of processed meat and increased risk of ***,a Ushaped association was identified between the consumption of unprocessed red meat and the risk of *** are the implications for public health practice?This research presents substantive evidence advocating for the reduction of processed and unprocessed red meat consumption as a viable strategy for mitigating the risk of diabetes in East Asian populations.

关键词： viable diabetes Diabetes

Integrated metabolomic and transcriptome analyses reveal the regulatory mechanisms of partridge tea phenolics-rich extracts on type 2 diabetes mice

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Food Science and Human Wellness 2024年

作者： Ruyan Fan Songjie Li youjing Wei Yingxin Liu Lu wang School of Food Science and Engineering， Hainan University Key Laboratory of Food Nutrition and Functional Food of Hainan Province， Hainan University

Partridge tea (Mallotus fortians Muell-Arg)， an important and widely consumed substitute tea in Hainan， possessed multi-biological activities. This study investigated the composition and content of phenolics-rich extracts purified from partridge tea， and then explored the effect of partridge tea polyphenol extract (PTE) on glucose and lipid metabolism disorders in type 2 diabetes mellitus (T2DM) mice. The results showed that the dominant components in PTE included rutin (152.78 ± 2.93) mg/g， 3-chlorogenic acid (85.81 ± 3.48) mg/g， caffeic acid (63.78 ± 1.86) mg/g， catechin (12.10 ± 1.41) mg/g， gallic acid (5.24 ± 0.12) mg/g， kaempferitrin， ellagic acid， ferulic acid， caffeic acid methylester， and geraniin. After 6 weeks of PTE intervention， glucose tolerance， insulin resistance， and pancreatic β-cell function in T2DM mice have significantly improved. This improvement was corroborated by an increase in glucagon-like peptide-1 (GLP-1); homeostasis model assessment of β-cell function (HOMA-β)， glycogen， insulin protein expression， and reduction of insulin， glycosylated serum protein (GSP)， homeostasis model assessment-insulin resistance index (HOMA-IR)， glucagon protein expression. The supplementation of PTE also seems to alleviate the inflammatory response， as evidenced by a decrease in endotoxin and inflammatory cytokine levels. Hyperglycemia-induced mitochondrial damage is alleviated by PTE intervention. Hematoxylin-eosin staining (H & E staining) and lipid profile analysis indicate that PTE intervention can help regulate lipid metabolism disorders. In addition， the integration of metabolomics and transcriptomic analysis indicates that PTE intervention could regulate glycolipid metabolism pathways related to T2DM， including insulin， AMPK， bile acid metabolism and glutathione metabolism signaling pathways. More importantly， the validation results from reverse transcription-polymerase chain reaction (RT-PCR) confirmed that the expressions of Scd1， Fasn， Hmgcr， and Slc

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Blockade of IL-1 or IL-17A prevent hepatic ischemia/reperfusion injury

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Blockade of IL-1 or IL-17A prevent hepatic ischemia/reperfus...

2013中国器官移植大会

作者： Zhongming Tan Runqiu Jiang Xuehao wang youjing wang Ling Lu Beicheng Sun The key laboratory of living donor liver transplantation ministry of health and Liver Transplantation CenterThe First Affiliated Hospital of Nanjing Medical University

Background&Aims Hypoxic liver ischemia-reperfusion(I/R)injury is a common complication following hepatic surgery or trauma leading to neutrophilic inflammation and hepatic ***-1 and IL-17A are the common inflammatory cytokines upregulated in many diseases,but their nature and interual relationship in liver I/R injury are remain elusive. Methods In this study,by using the genetic and neutralizing tool,we demonstrate that IL-1 and IL-17A comprised a positive feedback loop in liver I/R injury induced by 70%partial liver I/R model. Results We report that in the absence of IL-1R1 signaling neutrophil recruitment and hepatic damage are reduced along with diminished hepatic IL-17 *** we asked whether IL-17 is involved and found that I/R induced inflammation,IL-1β, KC expression and hepatic damage are drastically diminished in IL-17RA deficient ***,neutralization of either IL-1 or IL—

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用n表示第n个素数

南京航空航天大学学报 1999年第4期31卷 434-435页

作者：王友菁蒋华松南京林业大学基础部南京210037

给出一个用ｎ表示第ｎ个素数的公式ｐ１＝２ｐｎ＝３＋ ∑∞ｋ＝１１＋ｎ－１２－ ∑ｋｉ＝１ｓｉｎ（２ｉ）２ｉ＋１πｓｉｎ π２ｉ＋１ｎ－１２－ ∑ｋｉ＝１ｓｉｎ（２ｉ）２ｉ＋１πｓｉｎ π２ｉ ... 详细信息

给出一个用ｎ表示第ｎ个素数的公式ｐ１＝２ｐｎ＝３＋ ∑∞ｋ＝１１＋ｎ－１２－ ∑ｋｉ＝１ｓｉｎ（２ｉ）２ｉ＋１πｓｉｎ π２ｉ＋１ｎ－１２－ ∑ｋｉ＝１ｓｉｎ（２ｉ）２ｉ＋１πｓｉｎ π２ｉ＋１　　（ｎ＝２，３，４，…）

关键词：素数 Wilson定理第n个素数

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深水碳酸盐岩沉积体系与储层发育控制因素--以中东H油田白垩系Khasib组为例

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海相油气地质 2022年第1期27卷 1-10页

作者：张杰乔占峰王友净王鼐吕洲中国石油杭州地质研究院中国石油集团碳酸盐岩储层重点实验室中国石油勘探开发研究院

深水碳酸盐岩是有利的油气储集岩,中东地区上白垩统Khasib组缓坡型深水碳酸盐岩是重要的产油层系。伊拉克H油田Khasib组储层非均质性较强,储层发育特征及控制因素、油气分布规律不清,制约了选区评价及勘探部署。在区域地质调研的基础上... 详细信息

深水碳酸盐岩是有利的油气储集岩,中东地区上白垩统Khasib组缓坡型深水碳酸盐岩是重要的产油层系。伊拉克H油田Khasib组储层非均质性较强,储层发育特征及控制因素、油气分布规律不清,制约了选区评价及勘探部署。在区域地质调研的基础上,基于岩心、薄片和测井资料,对H油田Khasib组岩相、沉积微相和沉积模式、储层发育控制因素进行了研究,取得了以下认识:①研究区发育生物碎屑颗粒灰岩、生物碎屑泥粒灰岩、含生物碎屑粒泥灰岩、泥晶灰岩和灰质泥岩5种岩石类型;②研究区中缓坡相海侵体系域发育3类碳酸盐岩沉积微相(生物碎屑滩、滩翼、缓坡灰泥)和1类碳酸盐岩重力流沉积;③Khasib组KA1-2小层和KB段储层的生物扰动较发育,渗透率与骨屑颗粒含量呈正相关,储层主要受沉积微相、生物扰动和准同生溶蚀作用控制。明确了研究区6个小层的沉积微相演化规律,建立了伊拉克地区从西到东的滨岸—内缓坡—中缓坡—外缓坡的缓坡型碳酸盐沉积模式,研究成果对于深水碳酸盐岩储层分布预测具有借鉴和参考意义。

关键词：深水碳酸盐岩中缓坡沉积微相沉积模式 Khasib组中东

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竞争性放射分析法在针刺原理研究中的应用

针刺研究 1985年第2期10卷 157-160页

作者：王友京中医研究院针灸研究所

放射免疫测定法是六十年代初开始发展起来的一项新的超微量分析技术,它是利用免疫学上抗体和抗元之间相互反应的高度特异性和放射性同位素检测技术高度的灵敏性相结合而形成的一门新兴学科。放射受体分析的原理与放射免疫分析相似,只不... 详细信息

放射免疫测定法是六十年代初开始发展起来的一项新的超微量分析技术,它是利用免疫学上抗体和抗元之间相互反应的高度特异性和放射性同位素检测技术高度的灵敏性相结合而形成的一门新兴学科。放射受体分析的原理与放射免疫分析相似,只不过是用组织受体代替抗体,作为结合试剂而已,实际上它也是竞争性蛋白结合分析法的一种,所不同的是它以受体蛋白作为特异性结合剂。目前,常将放射免疫法、竞争性蛋白结

关键词：针刺镇痛电针治疗激素放射受体分析放射化学分析血浆皮质醇放射免疫分析法原理研究皮质酮 MLF 结合分析法