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医药导报 2022年第1期41卷 99-102页

作者：吴加东王爱飞徐又佳孙焕建南京医科大学盐城临床医学院骨科盐城224005 江苏医药职业学院临床学院(盐城市第三医院)骨科盐城224005 苏州大学附属第二医院骨科苏州215200

哺乳动物雷帕霉素靶蛋白(mTOR)能感受外界各种信号(如缺氧、应激、营养素等),调节机体代谢(包括细胞的生长、存活等),影响生物功能。该文综述了mTOR抑制药雷帕霉素在癌症、代谢、寿命等方面的药理作用,为其临床应用提供参考。

关键词：雷帕霉素哺乳动物雷帕霉素靶蛋白药理作用

铁调素对小鼠单核细胞RAW264.7膜铁转运蛋白1(FPN1)表达的影响

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中国骨质疏松杂志 2014年第12期20卷 1383-1386,1406页

作者：赵国阳狄东华王波张鹏徐又佳江苏大学附属医院骨一科江苏镇江212001 苏州大学附属第二医院骨科江苏苏州215004

目的观察铁调素对小鼠单核细胞RAW264.7膜铁转运蛋白1(FPN1)的表达,探讨铁调素对RAW264.7细胞作用的可能通路和机制。方法将不同浓度的铁调素加入含有核因子κB受体活化因子配体(RANKL)的RAW264.7细胞培养基,24h后用免疫荧光和Western-b... 详细信息

目的观察铁调素对小鼠单核细胞RAW264.7膜铁转运蛋白1(FPN1)的表达,探讨铁调素对RAW264.7细胞作用的可能通路和机制。方法将不同浓度的铁调素加入含有核因子κB受体活化因子配体(RANKL)的RAW264.7细胞培养基,24h后用免疫荧光和Western-blot方法测定FPN1的表达,共聚焦显微镜(CLSM)测定细胞内铁离子的浓度。结果 RAW264.7细胞膜上存在FPN1受体的阳性表达;在本实验铁调素浓度干预范围内,FPN1的表达随着铁调素浓度的增加呈浓度依赖性降低(P<0.05),同时细胞内铁离子的含量随着铁调素浓度的增加呈浓度依赖性增加(P<0.05)。结论小鼠单核细胞RAW264.7是铁调素作用的靶细胞,铁调素可通过降解其细胞膜上的FPN1增加细胞内的铁离子。

关键词：铁调素 RAW264.7细胞膜铁转运蛋白1

Bio-inspired inorganic-protein coating on Mg-based biomaterials for bioengineering applications

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Science China Materials 2024年第5期67卷 1678-1680页

作者： xuwen Peng Haolan xu Department of Chemistry Engineering Tsinghua UniversityBeijing100084China Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaT6G 1H9Canada Future Industries Institute UniSA STEMUniversity of South AustraliaMawson Lakes CampusAdelaideSouth Australia5095Australia

Developing smart and advanced functional materials inspired by the unparalleled complexity and efficiency of biological tissues has received much attention across various *** alloys,particularly pure magnesium,have emerged as notable candidates in orthopedics and dentistry due to their exceptional biocompatibility,degradability,and ability to promote bone regeneration[1].However,the highly reactive chemical nature of magnesium and its rapid degradation upon exposure to water.

关键词： coating alloys magnesium

Highly Strong,Tough,and Cryogenically Adaptive Hydrogel Ionic Conductors via Coordination Interactions

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Research 2024年第3期2024卷 703-713页

作者： Zhuomin Wang Siheng Wang Lei Zhang He Liu xu xu Institute of Chemical Industry of Forestry Products Key Laboratory of Biomass Energy and MaterialJiangsu ProvinceKey Laboratory of Chemical Engineering of Forest ProductsNational Forestry and Grassland AdministrationNational Engineering Research Center of Low-Carbon Processing and Utilization of Forest BiomassJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesChinese Academy of ForestryNanjing 210042China College of Chemical Engineering Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest ResourcesNanjing Forestry UniversityNanjing 210037China.

Despite the promise of high flexibility and conformability of hydrogel ionic conductors,existing polymeric conductive hydrogels have long suffered from compromises in mechanical,electrical,and cryoadaptive properties due to monotonous functional improvement strategies,leading to lingering ***,we propose an all-in-one strategy for the preparation of poly(acrylic acid)/cellulose(PAA/Cel)hydrogel ionic conductors in a facile yet effective manner combining acrylic acid and salt-dissolved cellulose,in which abundant zinc ions simultaneously form strong coordination interactions with the two polymers,while free solute salts contribute to ionic conductivity and bind water molecules to prevent ***,the developed PAA/Cel hydrogel simultaneously achieved excellent mechanical,conductive,and cryogenically adaptive properties,with performances of 42.5 MPa for compressive strength,1.6 MPa for tensile strength,896.9%for stretchability,9.2 MJ m^(−3)for toughness,59.5 kJ m^(−2)for fracture energy,and 13.9 and 6.2 mS cm^(−1)for ionic conductivity at 25 and−70°C,*** by these features,the resultant hydrogel ionic conductor is further demonstrated to be assembled as a self-powered electronic skin(e-skin)with high signal-to-noise ratio for use in monitoring movement and physiological signals regardless of cold temperatures,with hinting that could go beyond high-performance hydrogel ionic conductors.

关键词： Highly freezing salts

前交叉韧带重建中股骨侧纽扣钢板和界面钉固定方法的手术特点及疗效分析

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中华医学杂志 2015年第45期95卷 3673-3677页

作者：华俊刘栋沈光思徐炜周海斌谢宗刚李涧董启榕徐又佳苏州大学附属第二医院骨科 215004

目的比较前交叉韧带重建中股骨侧运用纽扣钢板和界面钉固定方法的手术特点的疗效。方法回顾分析2008年6月至2011年12月苏州大学附属第二医院骨科收治膝关节前交叉韧带损伤行重建手术的患者共97例，男54例，女43例；平均年龄27．5（18～5... 详细信息

目的比较前交叉韧带重建中股骨侧运用纽扣钢板和界面钉固定方法的手术特点的疗效。方法回顾分析2008年6月至2011年12月苏州大学附属第二医院骨科收治膝关节前交叉韧带损伤行重建手术的患者共97例，男54例，女43例；平均年龄27．5（18～53）岁。损伤原因：重物砸伤44例，运动损伤31例，车祸伤16例，摔伤6例，术前MRI检查均提示前交叉韧带连续信号中断，受伤至手术时间平均13．1（6—20）d，根据患者自愿原则分为两组，其中52例患者股骨侧应用界面钉固定，45例患者应用纽扣钢板固定，手术均在关节镜下完成，所有患者术后4周开始扶拐负重训练，术后6—8周开始弃拐行走，术后8周恢复日常活动。比较术后1、2年及4年的疗效。结果所有患者均获54．6（48—60）个月随访；两组患者股骨侧无术后不适感，负重训练、正常行走无特殊异常；无术后感染、韧带自发断裂、韧带松动等并发症；Lyshdm膝关节评分[界面钉组（56．1±7．9）分比（93．1±6．1）分，纽扣钢板组（55．3±8．5）分比（93．2±5．7）分]、国际膝关节评分委员会（IKDC）膝关节功能主观评分[界面钉组（49．7±5．9）分比（91．7±5．0）分，纽扣钢板组（50．2±6．3）分比（91．0±6．1）分]、KT．1000膝关节测量仪检查[界面钉组（9．2±1．8）分比（2．1±1．4）分，纽扣钢板组（9．5±1．7）分比（2．1±1．5）分]较术前均有明显提高，差异有统计学意义（P〈0．01）；两种固定方法之间差异无统计学意义[（93．1±6．1）分比（93．2±5．7）分，P〉0．05]。结论在交叉韧带重建中，股骨侧应用界面钉和纽扣钢板固定均能达到理想疗效，两种固定方法近、中期疗效无显著差异，长期疗效尚需进一步随访。

关键词：前交叉韧带关节镜检查内固定器纽扣钢板界面钉

Design of Robust Var Reserve Contract for Enhancing Reactive Power Ancillary Service Market Efficiency

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 767-771页

作者： Yunyang Zou Yan xu School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In a deregulated Var market, market power issue is more serious than in an energy market since reactive power cannot be transmitted over long distances. This letter designs a multi-timescale Var market framework, where market power that may arise in the hourly-ahead Var support service market due to system configuration deficiency and market structure flaws can be eliminated by day-ahead contract-based Var reserve service market. Settlement of day-ahead Var reserve contract is formulated as a two-stage robust optimization (TSRO) model considering worst case of uncertainty realization and potential market power that may arise in hourly-ahead market. TSRO with integer recourses is then solved by a new column and constraint generation algorithm. Results show a robust Var reserve contract can fully eliminate market power, and prevent suppliers from manipulating market prices.

关键词： Market efficiency market power reactive power ancillary service two-stage robust optimization Var reserve

Challenges and prospects for room temperature solid-state sodiumsulfur batteries

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Nano Research 2024年第3期17卷 1402-1426页

作者： Yashuang Qiu Jing xu Research Center of Grid Energy Storage and Battery Application School of Electrical and Information EngineeringZhengzhou UniversityZhengzhou 450001China

Room temperature sodium-sulfur(Na-S)batteries,known for their high energy density and low cost,are one of the most promising next-generation energy storage ***,the polysulfide shuttling and uncontrollable Na dendrite growth as well as safety issues caused by the use of organic liquid electrolytes in Na-S cells,have severely hindered their ***-state electrolytes instead of liquid electrolytes are considered to be the most direct and effective solution to solve the above ***,its practical application is still greatly challenged due to the poor interfacial compatibility between the all-solid-state electrolytes and the anode/cathode,ionic conductivity,and the shuttle effect caused by the presence of liquid phase in the quasi-solid-state *** paper presents a comprehensive review of solid-state Na-S batteries from the perspective of regulating interfacial compatibility and improving ionic conductivity as well as suppressing polysulfide *** to different components,solid-state electrolytes were divided into five categories:solid inorganic electrolytes,solid polymer electrolytes,polymer/inorganic solid hybrid electrolytes,gel polymer electrolytes,and liquid–solid inorganic hybrid ***,the prospect of developing high performance solid-state electrolytes to improve the cycling stability of room temperature Na-S cells is envisaged.

关键词： sodium-sulfur batteries solid-state electrolytes ionic conductivity polysulfide shuttling interfacial compatibility

川崎病接受首次静脉使用免疫球蛋白标准剂量后病情反应情况与治疗前实验室指标相关性的Meta分析

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中国循证医学杂志 2018年第4期18卷 347-353页

作者：刘卓勋温晓莹郑燕霞许尤佳杨京华广州中医药大学第二附属医院/广东省中医院儿科

目的系统评价川崎病（KD）患者接受首次静脉使用免疫球蛋白（IVIG）标准剂量后病情反应情况与治疗前实验室指标的相关性。方法计算机检索PubMed、EMbase、The Cochrane Library、CBM、CNKI、VIP和WanFang Data，搜集KD接受首次静脉使用I... 详细信息

目的系统评价川崎病（KD）患者接受首次静脉使用免疫球蛋白（IVIG）标准剂量后病情反应情况与治疗前实验室指标的相关性。方法计算机检索PubMed、EMbase、The Cochrane Library、CBM、CNKI、VIP和WanFang Data，搜集KD接受首次静脉使用IVIG标准剂量后病情反应情况与治疗前实验室指标相关性的病例．对照研究，检索时限均为建库至2017年12月31日。由2位评价者独立筛选文献、提取资料并评价纳入研究的偏倚风险后，采用RevMan5．3软件进行Meta分析。结果共纳入30个研究。Meta分析结果显示，IVIG无反应型KD患者的Hb水平[SMD=-0．21，95％CI（-0．32，-0．09），P〈0．001]、ALB水平[SMD=-0．68，95％CI（-0．90，-0．47），P〈0．001]、血钠浓度[SMD=-0．64，95％CI（-1．01，-0．27），P〈0．001]均低于有反应组；而ALT水平[SMD=0．74，95％CI（0．36，1．13），P〈0．001]、AST水平[SMD=0．61，95％CI（0．24，0．99），P=0．001]和CRP水平[SMD=0．63，95％CI（0．38，0．87），P〈0．001]均高于有反应组。结论现有证据表明，IVIG无反应型KD可能与低Hb、低ALB、低血钠和高CRP、高ALT、高AST有关。受纳人研究质量和数量的限制，上述结论尚需开展更多高质量研究进一步验证。

关键词： IVIG 川崎病无反应型病例-对照研究系统评价 Meta分析

Hydrologic Response to Future Climate Change in the Dulong-Irra-waddy River Basin Based on Coupled Model Intercomparison Project 6

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Chinese Geographical Science 2024年第2期34卷 294-310页

作者： xu Ziyue MA Kai YUAN xu HE Daming Institute of International Rivers and Eco-security Yunnan UniversityKunming 650500China Yunnan Key Laboratory of International Rivers and Transboundary Eco-security Kunming 650500China

Within the context of the Belt and Road Initiative(BRI)and the China-Myanmar Economic Corridor(CMEC),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among China,India and Myanmar,plays a significant role as both a valuable hydro-power resource and an essential ecological ***,the water resources and security exhibit a high degree of vulnerabil-ity to climate change *** research evaluates climate impacts on the hydrology of the Dulong-Irrawaddy River Basin(DIRB)by using a physical-based hydrologic *** crafted future climate scenarios using the three latest global climate models(GCMs)from Coupled Model Intercomparison Project 6(CMIP6)under two shared socioeconomic pathways(SSP2-4.5 and SSP5-8.5)for the near(2025-2049),mid(2050-2074),and far future(2075-2099).The regional model using MIKE SHE based on historical hydrologic processes was developed to further project future streamflow,demonstrating reliable performance in streamflow simulations with a val-idation Nash-Sutcliffe Efficiency(NSE)of *** showed that climate change projections showed increases in the annual precip-itation and potential evapotranspiration(PET),with precipitation increasing by 11.3%and 26.1%,and PET increasing by 3.2%and 4.9%,respectively,by the end of the century under SSP2-4.5 and *** changes are projected to result in increased annual streamflow at all stations,notably at the basin’s outlet(Pyay station)compared to the baseline period(with an increase of 16.1%and 37.0%at the end of the 21st century under SSP2-4.5 and SSP5-8.5,respectively).Seasonal analysis for Pyay station forecasts an in-crease in dry-season streamflow by 31.3%-48.9%and 22.5%-76.3%under SSP2-4.5 and SSP5-8.5,respectively,and an increase in wet-season streamflow by 5.8%-12.6%and 2.8%-33.3%,***,the magnitude and frequency of flood events are pre-dicted to escalate,potentially impacting hydropower production and food security *** res

关键词： climate change hydrologic response Coupled Model Intercomparison Project 6(CMIP6) MIKE SHE(Système Hydrologique Europeén) Dulong-Irrawaddy River Basin

Output feedback stabilization of stochastic high-order planar nonlinear systems with stochastic inverse dynamics and output-constraint

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Science China(Information Sciences) 2024年第3期67卷 182-196页

作者： Ruiming XIE Shengyuan xu Nanjing University of Science and Technology School of Automation

In this paper, we solve the output feedback control problem of stochastic high-order planar nonlinear systems with output constraint and stochastic integral input-to-state stability(SiISS) inverse dynamics. By employing a key coordinate transformation, a stochastic nonlinear system with output constraint and SiISS inverse dynamics is converted into an unconstrained system. By skillfully constructing an observer and adopting SiISS small-gain conditions, we develop a new output feedback control design and analysis method, and prove that all the closed-system signals are bounded almost surely, the output constraint is not violated almost surely, and the equilibrium point of the closed-loop system is stochastically asymptotically stable.

关键词： stochastic high-order planar nonlinear system output constraint stochastic inverse dynamics output feedback stabilization stochastic integral input-to-state stability (SiISS)