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Hemodynamic Profiling Using a Cardiac Index–Systemic Vascular Resistance Plot in Patients with Fontan Circulation

Congenital Heart Disease 2023年第4期18卷 431-445页

作者： Yuki Kawasaki Takeshi sasaki Daisuke Kobayashi Division of Pediatric Cardiology Osaka City General Hospital Pediatric Medical CenterOsaka5340021Japan Division of Cardiology St.Louis Children’s HospitalDepartment of PediatricsWashington University in St.LouisSt.LouisMO 63130USA

Background: Elevated Fontan pressure (FP) alone cannot fully predict clinical outcomes. We hypothesized thathemodynamic profiling using a cardiac index (CI)-systemic vascular resistance (SVR) plot could characterize clinicalfeatures and predict the prognosis of post-Fontan patients. Methods: We included post-Fontan patients whounderwent cardiac catheterization at age < 10 years. Patients were classified into four categories: A, CI ≥ 3, SVRindex (SVRI) ≥ 20;B, CI < 3, SVRI ≥ 20;C, CI ≥ 3, SVRI < 20;and D, CI < 3, SVRI < 20. The primary outcome wasfreedom from the combined endpoint: new onset of protein-losing enteropathy or plastic bronchitis, heart transplant,and death. Clinical and hemodynamic variables and freedom from the endpoint were compared betweenthe hemodynamic categories and outcome predictors were evaluated. Results: Eighty-three patients wereincluded. Median follow-up was 5.3 years. Category A/B/C/D consisted of 4/15/53/11 patients, respectively. Allthe patients in category A were New York Heart Association I/II and had a significantly lower pulmonary vascularresistance index (PVRI). Patients in category C had lower pulmonary/systemic blood flow. Patients in category Dhad a higher PVRI and had the poorest freedom from the endpoint (44% at 5 years). Elevated FP and category Dwere outcome predictors. Conclusions: CI-SVR plots was a novel adjunctive method for Fontan hemodynamicprofiling.

关键词： Cardiac index systemic vascular resistance perfusion pressure hemodynamic category fontan circulation prognosis

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Regulating migration of esophageal stents-management using a Sengstaken-Blakemore tube:A case report and review of literature

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World Journal of Gastroenterology 2018年第28期24卷 3192-3197页

作者： Hisaho Sato Kaoru Ishida Shusaku sasaki Masahiro Kojika Shigeatsu Endo Yoshihiro Inoue Akira sasaki Department of Critical Care Medicine Iwate Medical UniversitySchool of MedicineMoriokaIwate 020-0023Japan Department of Surgery Iwate Medical UniversitySchool of MedicineMoriokaIwate 020-0023Japan Morioka Yuai Hospital MoriokaIwate 020-0834Japan

Stent migration, which causes issues in stent therapy for esophageal perforations, can counteract the therapeutic effects and lead to complications. Therefore, techniques to regulate stent migration are important and lead to effective stent therapy. Here, in these cases, we placed a removable fully covered self-expandable metallic stent(FSEMS) in a 52-year-old man with suture failure after surgery to treat Boerhaave syndrome, and in a 53-yearold man with a perforation in the lower esophagus due to acute esophageal necrosis. At the same time, we nasally inserted a Sengstaken-Blakemore tube(SBT), passing it through the stent lumen. By inflating a gastric balloon, the lower end of the stent was supported. When the stent migration was confirmed, the gastric balloon was lifted slightly toward the oral side to correct the stent migration. In this manner, the therapy was completed for these two patients. Using a FSEMS and SBT is a therapeutic method for correcting stent migration and regulating the complete migration of the stent into the stomach without the patient undergoing endoscopic rearrangement of the stent. It was effective for positioning a stent crossing the esophagogastric junction.

关键词： Self-expandable metallic stents Esophageal perforation Boerhaave syndrome Endoscopy Enteral nutrition

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Activation of hypoxia-inducible factor 1 attenuates periapical inflammation and bone loss

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International Journal of Oral Science 2018年第2期10卷 92-101页

作者： Kimito Hirai Hisako Furusho Kiichi Hirota Hajime sasaki Department of Cariology Restorative Sciences & Endodontics University of Michigan School of Dentistry Department of Immunology and Infectious Diseases The Forsyth Institute Department of Oral and Maxillofacial Pathobiology Hiroshima University Department of Human Stress Response Science Institute of Biomedical Science Kansai Medical University

Hypoxia（low oxygen level） is an important feature during infections and affects the host defence mechanisms. The host has evolved specific responses to address hypoxia, which are strongly dependent on the activation of hypoxia-inducible factor 1（HIF-1）.Hypoxia interferes degradation of HIF-1 alpha subunit（HIF-1α）, leading to stabilisation of HIF-1α, heterodimerization with HIF-1 beta subunit（HIF-1β） and subsequent activation of HIF-1 pathway. Apical periodontitis（periapical lesion） is a consequence of endodontic infection and ultimately results in destruction of tooth-supporting tissue, including alveolar bone. Thus far, the role of HIF-1 in periapical lesions has not been systematically examined. In the present study, we determined the role of HIF-1 in a wellcharacterised mouse periapical lesion model using two HIF-1α-activating strategies, dimethyloxalylglycine（DMOG） and adenovirusinduced constitutively active HIF-1α（CA-HIF1 A）. Both DMOG and CA-HIF1 A attenuated periapical inflammation and tissue destruction. The attenuation in vivo was associated with downregulation of nuclear factor-κappa B（NF-κB） and osteoclastic gene expressions. These two agents also suppressed NF-κB activation and subsequent production of proinflammatory cytokines by macrophages. Furthermore, activation of HIF-1α by DMOG specifically suppressed lipopolysaccharide-stimulated macrophage differentiation into M1 cells, increasing the ratio of M2 macrophages against M1 cells. Taken together, our data indicated that activation of HIF-1 plays a protective role in the development of apical periodontitis via downregulation of NF-κB, proinflammatory cytokines, M1 macrophages and osteoclastogenesis.

关键词： CA Activation hypoxia-inducible factor attenuates periapical inflammation bone loss HIF

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Design of efficient Pt-based electrocatalysts through characterization by X-ray absorption spectroscopy

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Frontiers in Energy 2017年第3期11卷 236-244页

作者： Nebojsa S. MARINKOVIC Kotaro sasaki Radoslav R. ADZIC Synchrotron Catalysis Consortium and Columbia University NY 10027 USA Brookhaven National Laboratory Upton NY 11973 USA

A method is described to determine the internal structure of electrocatalyst nanoparticles by in situ X-ray absorption spectroscopy （XAS）. The nondestructive spec- troscopic technique typically utilizing synchrotron radiation as the source measures changes in the X-ray absorption coefficient as a function of energy. The bulk technique has found its use for materials characterization in all scientific areas, including nanomaterials. The analysis of the internal structure of nanoparticles reveals intera- tomic distances and coordination numbers for each element, and their values and mutual relations indicate whether the elements form a homogeneous or hetero- geneous mixture. The core-shell heterogeneous structure in which certain elements are predominantly located in the core, and others form the encapsulating shell is of particular importance in catalysis and electrocatalysis because it may reduce the amount of precious metals in nanoparticles by replacing the atoms in the core of nanoparticles with more abundant and cheaper alternatives. The examples of nanoparticle structures designed in the laboratory and the approach to model efficient catalysts through systematic analysis of XAS data in electrochemical systems consisting of two and three metals are also demonstrated.

关键词： X-ray absorption spectroscopy EXAFS XANES nanocatalysts core shell

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Influence of Separated Vortex on Aerodynamic Noise of an Airfoil Blade

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Journal of Thermal Science 2010年第1期19卷 60-66页

作者： Soichi sasaki Hajime Takamatsu Masao Tsujino Haruhiro Tsubota Hidechito Hayashi Faculty of Engineering Nagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Graduate School of Science and Technology Nagasaki University1-14 Bunkyo-machiNagasaki 852-8521Japan Research Division Komatsu Ltd.1200MandaHiratsuka-shiKanagawa 254-8567Japan

In order to clarify the mechanism by which aerodynamic noise is generated from separated flow around an airfoil blade,the relation between the attack angle and the aerodynamic noise of the blade was analyzed using a wind tunnel experiment and a CFD *** the case of rear surface separation,the separated vortex which has a large-scale structure in the direction of the blade chord is transformed into a structure that concentrates at the trailing edge with an increase in the attack *** aerodynamic noise level then becomes small according to the vortex scale in the blade *** the flow is separated at the leading edge,a separated vortex of low pressure is formed at the vicinity of the trailing *** pressure fluctuations on the blade surface at the vicinity of the trailing edge become large due to the vortex in the *** is considered that the aerodynamic noise level increases when the flow is separated at the leading edge because the separated vortex is causing the fluctuations due to wake vortex shedding.

关键词： Vortex Aerodynamic Noise Shear Flow Separation Airfoil

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Monitoring dynamics of defects and single Fe atoms in N-functionalized few-layer graphene by in situ temperature programmed scanning transmission electron microscopy

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Journal of Energy Chemistry 2022年第1期31卷 520-530,I0014页

作者： Rosa Arrigo Takeo sasaki June Callison Diego Gianolio Manfred Erwin Schuster School of Science Engineering and EnvironmentUniversity of SalfordManchester M54WTUK Diamond Light Source Harwell Science and Innovation CampusDidcot 0X1/ODEUK JEOL UK Ltd.JEOL House 1-2 Silver CourtWatchmeadWelwyn Garden CityHerts AL71LTUK Department of Chemistry University College London20 Gordon StreetLondon WC1H OAJUK UK Catalysis Hub Research Complex at Harwell(RCaH)Rutherford Appleton LaboratoryHarwell Oxon 0X11 OFAUK Johnson Matthey Technology Centre Reading RG49NH.UK

In this study,we aim to contribute an understanding of the pathway of formation of Fe species during top-down synthesis of dispersed Fe on N-functionalized few layer graphene,widely used in *** use X-ray absorption spectroscopy to determine the electronic structure and coordination geometry of the Fe species and in situ high angle annular dark field scanning transmission electron microscopy combined with atomic resolved electron energy loss spectroscopy to localize these,identify their chemical configuration and monitor their dynamics during thermal *** show the high mobility of peripheral Fe atoms,first diffusing rapidly at the trims of the graphene layers and at temperatures as high as 573 K,diffusing from the edge planes towards in-plane locations of the graphene layers forming three-,four-coordinated metal sites and more complexes polynuclear Fe *** process occurs via bond C-C breaking which partially reduces the extension of the graphene ***,the vast majority of Fe is segregated as a metal *** dynamic interconversion depends on the structural details of the surrounding graphitic environment in which these are formed as well as the Fe loading.N species appear stabilizing isolated and polynuclear Fe species even at temperatures as high as 873 *** significance of our results lies on the fact that single Fe atoms in graphene are highly mobile and therefore a structural description of the electroactive sites as such is insufficient and more complex species might be more relevant,especially in the case of multielectron transfer *** we provide the experimental evidence of the formation of these polynuclear Fe-N sites and their structural characteristics.

关键词： HAADF-STEM Single Fe atom sites N-doped Few-layer graphene Dinuclear Fe species

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Principle and basic techniques in urinary tract surgery

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畜牧与兽医 2012年第S2期44卷 1-3页

作者： Nobuo sasaki Nippon Institute for Biological Science The University of Tokyo

Among the disease of the urinary tract in dogs and cats,the most common diseases requiring surgery are urinary bladder and *** this article,the principles of diagnosis,strategy of treatments and basic techniques for these diseases are discussed.1 Urinary bladder In dogs,most common bladder diseases are cystitis,cystic calculi,cystic trauma due to car accident and bladder *** patients often show abnormal urination such as incontinence,pollakiuria and *** urine or he-

关键词： bladder urinary cystitis incontinence requiring urethral trauma suture radiography ureter

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Laser Trimming for Adjustment of Grating Offset in Phase-Shifted Fiber Grating Coupler for All-Optical Switching Application

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光学学报 2003年第S1期23卷 231-232页

作者： Hirohisa Yokota Yutaka sasaki Department of Systems Engineering Faculty of Engineering Ibaraki University 4-12-1 Nakanarusawa Hitachi Ibaraki 316-8511 JapanDepartment of Systems Engineering Faculty of Engineering Ibaraki University 4-12-1 Nakanarusawa Hitachi Ibaraki 316-8511 Japan

We theoretically investigated laser trimming to adjust grating offset in phase-shifted fiber grating coupler (FGC) for all-optical switching application. It was clarified that the trimming made the extinction ratio hi... 详细信息

关键词： for as et in Laser Trimming for Adjustment of Grating Offset in Phase-Shifted Fiber Grating Coupler for All-Optical Switching Application of

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Clinical features of acute esophageal mucosal lesions and reflux esophagitis Los Angeles classification grade D: A retrospective study

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World Journal of Gastrointestinal Surgery 2023年第3期15卷 408-419页

作者： Chikamasa Ichita Akiko sasaki Sayuri Shimizu Department of Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533KanagawaJapan Department of Health Data Science Yokohama City UniversityYokohama 236–0027KanagawaJapan

BACKGROUND Acute esophageal mucosal lesions(AEMLs)are an underrecognized and largely unexplored *** findings are similar,and a higher percentage of AEML could be misdiagnosed as reflux esophagitis Los Angeles classification grade D(RE-D).These diseases could have different pathologies and require different *** To compare AEML and RE-D to confirm that the two diseases are different from each other and to clarify the clinical features of *** We selected emergency endoscopic cases of upper gastrointestinal bleeding with circumferential esophageal mucosal injury and classified them into AEML and RE-D groups according to the mucosal injury’s shape on the oral *** examined patient background,blood sampling data,comorbidities at onset,endoscopic characteristics,and outcomes in each *** Among the emergency cases,the AEML and RE-D groups had 105(3.1%)and 48(1.4%)cases,*** variables exhibited significantly different results,indicating that these two diseases are *** clinical features of AEML consisted of more comorbidities[risk ratio(RR):3.10;95%confidence interval(CI):1.68–5.71;P<0.001]and less endoscopic hemostasis compared with RE-D(RR:0.25;95%CI:0.10–0.63;P<0.001).Mortality during hospitalization was higher in the AEML group(RR:3.43;95%CI:0.82–14.40;P=0.094),and stenosis developed only in the AEML *** AEML and RE-D were clearly distinct diseases with different clinical *** may be more common than assumed,and the potential for its presence should be taken into account in cases of upper gastrointestinal bleeding with comorbidities.

关键词： Acute esophageal mucosal lesion Comorbidities Esophageal reflux Black esophagus Acute necrotizing esophagitis

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Retinoblastoma tumor suppressor functions shared by stem cell and cancer cell strategies

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World Journal of Stem Cells 2016年第4期8卷 170-184页

作者： Susumu Kohno Shunsuke Kitajima Nobunari sasaki Chiaki Takahashi Division of Oncology and Molecular Biology Cancer Research InstituteKanazawa University Department of Medical Oncology Dana-Farber Cancer Institute Department of Pharmacy Graduate School of MedicineKeio University

Carcinogenic transformation of somatic cells resembles nuclear reprogramming toward the generation of pluripotent stem *** events share eternal escape from cellular senescence,continuous self-renewal in limited but certain population of cells,and refractoriness to terminal differentiation while maintaining the potential to differentiate into cells of one or multiple *** represented by several oncogenes those appeared to be first keys to pluripotency,carcinogenesis and nuclear reprogramming seem to share a number of core *** retinoblastoma tumor suppressor product retinoblastoma(RB)seems to be critically involved in both events in highly complicated ***,disentangling such complicated interactions has enabled us to better understand how stem cell strategies are shared by cancer *** review covers recent findings on RB functions related to stem cells and stem cell-like behaviors of cancer cells.

关键词： Stem cells Cancer Retinoblastoma Cancer stem cells

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