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24th International Papillomavirus Conference and Clinical Workshop

作者： Sebastien Teissier youcef benkhalifa Christian Desaintes Francoise Thierry Institute of Medical Biology A-StarSingapore Institute of Medical Biology A-StarSingapore SCKCEN Belgium Institute of Medical Biology A-StarSingapore

＜正＞In cervical carcinoma ceils,the E6 and E7 proteins from oncogenic human papillomaviruses are continuously expressed and induce cell transformation through their interactions with the p53 and pRB pathways,respectively.A critical event on the path to malignant transformation is the loss of expression of the E2 repressor of E6 and E7 transcription due to the integration into the host genome of the viral *** microarravs,we have shown that reintroduction of a functional E2 in the HeLa cervical

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Role of CXCL12-dependent Signalling Pathways In Human Papillomavirus （HPV） Pathogenesis:Insight Into The Chronic And Malignant Hpv Infections In Whim Syndrome

Role of CXCL12-dependent Signalling Pathways In Human Papill...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Ken Yc Chow youcef benkhalifa Bastien Teissier Bernard Lagane Fran-oise Thierry Fran-oise Bachelerie Inserm U-819 Laboratoire De Pathogenie Virale MoleculaireInstitut PasteurParisFrance Institute Of Medical Biology Singapore Institute Of Medical Biology Singapore Inserm U-819 Laboratoire De Pathogenie Virale MoleculaireInstitut PasteurParisFrance Institute Of Medical Biology Singapore Inserm U-819 Laboratoire De Pathogenie Virale MoleculaireInstitut PasteurParisFrance

＜正＞Profuse skin and malignant anogenital warts associated with chronic human Papillomavirus（HPV）infection is a major clinical symptom of a rare inherited immuno-hematological disorder called WHIM *** responsiveness of the G-protein coupled chemokine receptor-CXCR4-to its ligand（SDF-1/CXCL12）,as previously characterized in patient cells,likely accounts for the clinical manifestations of the ***,HPVs that we identified in WHIM patients-derived condy-

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Oxidative stress in male infertility and therapeutic approach: A mini-review

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Asian pacific Journal of Reproduction 2023年第6期12卷 249-255页

作者： Marwa Lahimer Henda Mustapha Véronique Bach Hafida Khorsi-Cauet Moncef benkhalifa Mounir Ajina Habib Ben Ali Service of Reproductive Medicine University Hospital Farhat HachedSousseTunisia Exercise Physiology and Physiopathology:from Integrated to Molecular“Biology Medicine and Health”(Code:LR19ES09)SousseTunisia Péritox(UMR_I 01) UPJV/INERISUPJVCURSChemin de Thil 80025 AmiensFrance ART and Reproductive Biology Laboratory University Hospital and School of MedicinePicardie University Jules VerneCHU Sud80054AmiensFrance Laboratory Histology Embryology Faculty of Medicine SousseUniversity of SousseSousseTunisia

Growing evidence suggests that oxidative stress is a major cause of male *** are highly sensitive cells due to the vulnerability of their membrane fatty acids and the diminished antioxidant *** oxygen species(ROS)impact multiple signaling pathways involved in mitochondrial dysfunction,hormonal unbalance and semen quality *** origin of ROS is diverse,including generated normal cellular metabolism,environmental exposure,advanced paternal age and *** has indicated that antioxidant supplementation can improve oxidative stress and reduce the risk of chronic ***,it is widely known that antioxidant supplementation can enhance sperm quality and increase the pregnancy rate in couples undergoing fertility *** current study highlights the deleterious effect of ROS and its impact on semen *** addition,it contributes to the development of a clinical approach for the use of antioxidants in the management of male infertility.

关键词： Oxidative stress Reactive oxygen species Mitochondria Antioxidant supplementation Spermatozoa

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既往卵母细胞单精子显微注射(ICSI)不良结局和有限的第2次有丝分裂中期卵细胞的患者应用激光辅助的ICSI

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 42-43页

作者： Demirol A. benkhalifa M. Sari T. Gurgan T. 张旸 Women's Health Infertility and IVF Center Ankara Turkey Dr.

In this study, laser-assisted intracytoplasmic sperm injection (ICSI) improved the fertilization rate and the embryo quality in patients with a history of poor ICSI outcome and with limited metaphase II oocytes. This ... 详细信息

关键词：显微注射 ICSI 卵母细胞有丝分裂中期受精率操作过程

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