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Chinese Journal of Cancer Research 2011年第2期23卷 129-133页

作者： you-quan Li An-hui shi Fu-hai Li Rong Yu Guang-ying Zhu Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Radiation Oncology Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing 100142 China

Objective： To evaluate the maximum tolerated dose （MTD） of docetaxel （DCT） and cisplatin （DDP） concurrently with three dimensional （3D） conformal radiotherapy or IMRT for patients with locally advanced non-small cell lung cancer （stage IIIa and IIIb） after 2–4 cycles of induction chemotherapy. Methods： Fourteen patients with histological/cytological proven stage III non–small-cell lung cancer were eligible. 3D or IMRT radiotherapy （60-70Gy in 30-35 fractions, 6-7weeks, 2 Gy/fraction） was delivered concurrently with cisplatin and docetaxel, 2 cycles during concurrent chemoradiotherapy （CCRT）. The level I dosage was composed of 56 mg/m2 DCT, on day 1 and 28mg/m2 DDP, on day 1 and day 2. The level II was composed of 60 mg/m2 DCT, on day 1 and 30 mg/ m2 DDP, on day 1 and day 2. The level III was composed of 64 mg/m2 DCT, on day 1 and 32 mg/ m2 DDP, on day 1 and day 2. Results： Fourteen patients were allocated and finished concurrent chemoradiotherapy. The dose-limiting neutropenia was at the dose Level III （64 mg/m2） and occurred in 2 of 5 patients. No dose limiting non-hematologic or hematologic toxicity occurred in the other patients. Conclusions： Patients with locally advanced non-small cell lung cancer may tolerate 60mg/m2 docetaxel and 60mg/m2 cisplatin for 2 cycles during concurrent radiotherapy after 2-3 cycles of induction chemotherapy.

关键词： Non–small-cell lung cancer Concurrent chemoradiotherapy Cisplatin docetaxel Toxicity

Optimized strategy of rotational atherectomy of underexpanded coronary stents in patients with acute coronary syndrome

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World Journal of Emergency Medicine 2021年第3期12卷 198-201页

作者： Kun Cui you-quan shi Yuan-zheng Zhang Zheng-gong Li Chang-ling Li Department of Cardiology Chongqing General HospitalChongqing 400013China Department of Cardiology the Third People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830000China Department of Cardiology the First People’s Hospital of TianshuiTianshui 741000China Department of Cardiology the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BACKGROUND:Stent under-expansion is a main cause of acute coronary syndrome(ACS),which can lead to serious clinical *** rotational atherectomy of underexpanded coronary stents(academically called stent ablation,SA)by intravascular ultrasound(IVUS)may provide more visual reference in the *** aim to analyze the procedural and long-term outcomes of the optimized strategy of SA in patients with ACS and to provide real-world data on this ***:A total of 11 patients with ACS who underwent SA between April 2017 and January 2019 were *** follow-ups were obtained either by telephone call or by scheduled *** end-points included periprocedural and postprocedural myocardial infarction,stent thrombosis,target lesion revascularization,and major adverse cardiac ***:The mean age of patients was 69.6±6.5 years,and five(45.5%)patients were *** cases presented with unstable angina and were admitted with *** patients required at least two burrs during the intervention and the size of the burr was selected based on the data of minimum lumen diameter(MLD),and the fi rst and the second burr/stent MLD ratios were 0.93(0.88-0.99)and 1.09(1.02-1.14),*** patients were treated with drug-eluting stents and two were treated with drug-coated *** were no complications including no fl ow,perforation,or burr entrapment during the *** in-hospital deaths or major adverse cardiac events were documented during the follow-up *** our study,less contrast agent and a lower dose of radiation were used during the ***:SA guided by IVUS can reduce the risk of complications,assess the results of surgery,inform the selection of stent size,and decrease the required dose of radiation and contrast.

关键词： Acute coronary syndrome Intravascular ultrasound Rotational atherectomy Underexpanded stent

Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng Chu quan shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling shi quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Amperometric Glucose Sensor Based on Batch CuO-Modified Screen-Printed Silver-Carbon Electrodes

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 35-41页

作者： XIA Haiyan HUANG Yin YANG Hua WANG Xintian shi Jianping LIU Lixia FU Yacheng quan Changyun LI Suyuan Cofoe Medical Technology Company Limited Changsha 410000China Institute of New Energy Hexi UniversityZhangye 734000China Chemistry and Chemical Engineering Central South UniversityChangsha 410000China

CuO nanoparticles were successfully synthesized via a two-jet electrospun method,and then screen-printed on silver-carbon electrodes,forming CuO-modified Ag-C(CuO/Ag-C)disposable strip *** natural environment condition for glucose detection,the obtained CuO/Ag-C electrodes show a high sensitivity of 540 nA·mM^(-1)·cm^(-2),and a low limit of detection(0.68 mM)in a wide linear response range of 0.68 mM and 3 mM(signal/noise=3),*** addition,the CuO/Ag-C electrodes also exhibit excellent anti-interference,air stability and *** a result,the fabrication of CuO nanoparticles via an electrospun process and the technique of screen-printed electrodes are of great significance for glucose detection.

关键词： electrochemical sensor CuO nanoparticles glucose detection screen-printing technique

发酵法制备沙棘籽粕总黄酮的初步纯化及抗衰老活性评价

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日用化学工业 2019年第10期49卷 661-667页

作者：由士权王昌涛张佳婵李萌赵丹安全北京工商大学植物资源研究开发北京市重点实验室北京100048 北京工商大学北京食品营养与人类健康高精尖创新中心北京100048 云南白药集团健康产品有限公司云南昆明650500

研究大孔吸附树脂纯化沙棘籽粕发酵提取液的工艺条件以及抗衰老活性。对3种大孔吸附树脂分离纯化的效果进行了比较,考察了X-5大孔树脂分离的较佳工艺条件,并通过MTT法评价了提取物对细胞生长的影响,采用DPPH法、提取物对细胞内活性氧和M... 详细信息

研究大孔吸附树脂纯化沙棘籽粕发酵提取液的工艺条件以及抗衰老活性。对3种大孔吸附树脂分离纯化的效果进行了比较,考察了X-5大孔树脂分离的较佳工艺条件,并通过MTT法评价了提取物对细胞生长的影响,采用DPPH法、提取物对细胞内活性氧和MMP-1活性的抑制、促进胶原蛋白合成来评价提取物的抗衰老活性。结果表明,较佳工艺条件为:吸附时间2h,吸附温度15℃,洗脱剂体积分数60%,洗脱时间2.5h,洗脱温度45℃。在此条件下吸附量可达2.33 mg/g,解析率可达94.75%;MTT实验表明对成纤维细胞基本无毒副作用;对DPPH自由基清除率达到50%时的质量浓度(IC50)为1.06 mg/L,活性氧水平显著下降,MMP-1活性降低,胶原蛋白含量有所提高。沙棘籽粕发酵液有较好的抗衰老活性。

关键词：化妆品添加剂沙棘籽粕黄酮发酵抗衰老

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： quan shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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基于区块链的车联网跨域数据安全传输系统设计

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现代电子技术 2025年第1期48卷 71-79页

作者：陈晨王斓凯施佺南通大学信息化中心江苏南通226019 南通大学交通与土木工程学院江苏南通226019

为有效应对车联网系统在数据传输过程中的安全问题,提出一种基于区块链的车联网跨域数据安全传输系统。该系统将车联网安全数据传输过程划分为注册、安全通信与数据共享三个关键环节。在注册阶段,车辆和路边单元需要通过可信机构完成注... 详细信息

为有效应对车联网系统在数据传输过程中的安全问题,提出一种基于区块链的车联网跨域数据安全传输系统。该系统将车联网安全数据传输过程划分为注册、安全通信与数据共享三个关键环节。在注册阶段,车辆和路边单元需要通过可信机构完成注册,以确保其的身份合法性;在通信阶段,为了减少路边单元与车辆频繁认证,设计了跨域认证的方法,保障数据传输的可靠性和完整性,并引入假名来保护用户隐私;在共享阶段,文中设计了基于多线程遍历共享广播森林的事务广播算法,利用广度优先搜索思想建立广播森林,并使用多线程遍历进行数据事务广播传输。实验仿真结果显示,文中方案的签名计算成本减少70%,验证计算成本减少41%;其次,在ER模型下,相比使用Gossip协议进行事务数据传输,该方案中交通数据事务总时间降低了93%;在BA模型下降低了87%。

关键词：区块链车联网身份认证密钥协商广播森林数据安全传输系统

Low-temperature heat capacities and standard molar enthalpy of formation of N-methylnorephedrine C11H17NO（s）

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Chinese Physics B 2008年第9期17卷 2859-2866页

作者： Di you-Ying Wang Da-Qi shi quan Tan Zhi-Cheng College of Chemistry and Chemical Engineering Liaocheng University Liaocheng 252059 China Thermochemistry Laboratory Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

This paper reports that low-temperature heat capacities of N-methylnorephedrine C11H17NO（s） have been measured by a precision automated adiabatic calorimeter over the temperature range from T=78K to T=400K. A solid to liquid phase transition of the compound was found in the heat capacity curve in the temperature range of T=342-364 K. The peak temperature, molar enthalpy and entropy of fusion of the substance were determined. The experimental values of the molar heat capacities in the temperature regions of T=78-342 K and T=364-400 K were fitted to two poly- nomial equations of heat capacities with the reduced temperatures by least squares method. The smoothed molar heat capacities and thermodynamic functions of N-methylnorephedrine C11H17NO（s） relative to the standard refer- ence temperature 298.15 K were calculated based on the fitted polynomials and tabulated with an interval of 5 K. The constant-volume energy of combustion of the compound at T=298.15 K was measured by means of an isoperibol precision oxygen-bomb combustion calorimeter. The standard molar enthalpy of combustion of the sample was calculated. The standard molar enthalpy of formation of the compound was determined from the combustion enthalpy and other auxiliary thermodynamic data through a Hess thermochemical cycle.

关键词： N-methylnorephedrine C11H17NO(s) heat capacity constant-volume energy of combus-tion standard molar enthalpy of formation

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A method to determine the shell layout scheme for equipment battlefield damage tests under artillery fire

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Defence Technology（防务技术） 2021年第2期17卷 682-691页

作者： Cai Chen quan shi Zhi-feng you Hong-yu Ge Fang Zhang Equipment Command and Management Department Army Engineering UniversityShijiazhuang050003China Baicheng Ordnance Test Center of China Baicheng137001China No.32178 Troops of PLA Beijing100012China

In this paper,a new method for determining the shell layout scheme is proposed,which can make the equipment damage data by the battlefield damage test resemble as close as possible the actual combat *** method is based on the analysis of the impact point distribution and effective damage area of *** order to obtain the position of the impact points,an impact point distribution model under artillery fire was ***,in order to obtain the effective damage area of equipment,the concepts of generalized damage area and task-based equipment functional damage probability were demonstrated,and the corresponding calculation model was *** case analysis,the shell layout scheme was effectively obtained,verifying the correctness of the proposed method.

关键词： Battlefield damage test Projectile impact point Effective damage area Functional damage