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Efficacy and safety of percutaneous transhepatic biliary radiofrequency ablation in patients with malignant obstructive jaundice

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World Journal of Clinical Cases 2024年第17期12卷 2983-2988页

作者： Ying Xing Zheng-Rong liu you-guo li Hong-Yi Zhang Department of General Surgery Tiantan HospitalBeijing 100170China

BACKGROUND Percutaneous transhepatic cholangiodrainage(PTCD)and endoscopic retrograde cholangiopancreatography/endoscopic nasobiliary drainage are the most common clinical procedures for jaundice control in patients with unresectable malignant obstructive jaundice,yet the safety and effect of endobiliary radiofrequency ablation(EB-RFA)combined PTCD is rarely reported,in this article,we report our experience of EB-RFA combined PTCD in such *** To retrospectively study the efficacy and safety of EB-RFA combined PTCD in patients with unresectable malignant obstructive *** Patients with unresectable malignant obstructive jaundice treated with EB-RFA under PTCD were selected,the bile ducts of the right posterior lobe was selected as the target bile ducts in all *** general conditions of all patients,preoperative tumour markers,total bilirubin(TBIL),direct bilirubin(DBIL),albumin(ALB),alkaline phosphatase(ALP),and glutamyl transferase(GGT)before and on the 7th day after the procedure,as well as perioperative complications,stent patency time and patient survival were *** All patients successfully completed the operation,TBIL and DBIL decreased significantly in all patients at the 7th postoperative day(P=0.009 and 0.006,respectively);the values of ALB,ALP and GGT also decreased compared with the preoperative period,but the difference was not statistically *** biliary bleeding occurred in 2 patients,which was improved after transfusion of blood and other conservative treatments,pancreatitis appeared in 1 patient after the operation,no serious complication and death happened after *** for 3 patients with loss of visits,the stent patency rate of the remaining 14 patients was 100%71%and 29%at the 1^(st),3^(rd),and 6^(th)postoperative months respectively,with a median survival of 4 *** EB-RFA under PTCD in patients with unresectable malignant obstructive jaundice has a satisfactory therapeu

关键词： Biliary tract tumour Malignant obstructive jaundice Percutaneous transhepatic cholangiodrainage Endoluminal radiofrequency ablation Biliary radiofrequency ablation

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Analysis of long-term outcome of modified gastric bypass for type 2 diabetes mellitus in Chinese patients

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World Journal of Clinical Cases 2024年第25期12卷 5697-5705页

作者： Ying Xing Ri-Xing Bai you-guo li Jun Xu Zhi-Qiang Zhong Ming Yan Wen-Mao Yan Department of General Surgery Beijing Tiantan HospitalBeijing 100170China

BACKGROUND Bariatric and metabolic surgery have been routinely performed following the rapid increase in obesity and metabolic diseases *** all evolving procedures,Roux-en-Y gastric bypass(RYGB)is considered the gold standard for surgical treatment of patients with type 2 diabetes mellitus(T2DM)and *** was introduced in China nearly 20 years ago,but the number of RYGB surgeries only accounts for 3.1%of the total number of weight loss and metabolic surgeries in China,it’s effect on Chinese people still needs further *** To investigate the effect and safety of a modified gastric bypass performed in Chinese patients with *** Patients with obesity and T2DM who underwent modified gastric bypass,with>5-year follow-up data,were *** All 37 patients underwent uneventful laparoscopic surgery,no patient was switched to laparotomy during the surgery,and no severe complications were *** weight and body mass index of the patients reduced from 84.6±17.3(60.0–140.0)kg and 30.9±5.0(24.7–46.2)kg/m2 to 67.1±12.2(24.7–46.2)kg and 24.6±3.9(17.7–36.5)kg/m2,respectively,and fasting plasma glucose and glycated hemoglobin decreased from 7.4±3.4 mmol/L and 8.2%±1.7%preoperatively to 6.5±1.3 mmol/L and 6.5%±0.9%5-years postoperatively,*** 29.7%(11/37)of the patients used hypoglycemic drugs 5-years postoperatively,and the complete remission rate of T2DM was 29.7%(11/37).Triglyceride level reduced significantly but high-density lipoprotein increased significantly(both P<0.05)compared with those during the preoperative *** and renal function improved significantly postoperatively,and binary logistic regression analysis revealed that the patients’preoperative history of T2DM and fasting C-peptide were significant prognostic factors influencing complete T2DM remission after RYGB(P=0.006 and 0.012,respectively).CONCLUSION The modified gastric bypass is a safe and feasible procedure for Chinese patients with obesity an

关键词： Laparoscopic Roux-en-Y gastric bypass Chinese patients Metabolic surgery Bariatric surgery Type 2 diabetes mellitus

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ANALYSIS OF EDL EFFECTS ON THE FLOW AND FLOW STABIliTY IN MICROCHANNELS

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Journal of Hydrodynamics 2010年第5期22卷 725-731页

作者： you Xue-yi guo li-xiang School of Environmental Science and Engineering Tianjin University 300072 Tianjin China

The effects of the Electrical Double Layer （EDL） on the liquid mean flow and the flow stability in microchannels are investigated by solving the Poisson-Boltzmann equation. The models of the traditional streaming Electrical Current Balance （ECB） and the newly introduced streaming Electrical Current Density Balance （ECDB） are applied to determine the electrical streaming current. The numerical results show that the electrical streaming current backflow in the ECB model near the wall can be removed by using the ECDB model, which is suitable to study the effects of the EDL on the mean flow and the flow stability in microchannels. The flow is found more unstable if the ECDB model is applied.

关键词： electrical double layer Poisson-Boltzmann equation electrical streaming current balance flow stability microchan

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Chromones from an ascomycete,Chaetomium aureus

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Chinese Chemical Letters 2010年第10期21卷 1203-1205页

作者： li Mei li Qiang Zou guo you li Scientific Research Center Chengdu Medical College Chengdu 610083 China Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China

A novel chromone, named chaetoaurin （1）, along with six known chromone derivatives （2-7）, was isolated from the ethyl acetate extract of a solid-state fermented culture of Chaetomium aureus. Their structures were ... 详细信息

关键词： Chaetomium aureus Chaetomiaceae Chromone Chaetoaurin

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Secondary metabolites from fungus Alternaria sp. CIB 108

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Chinese Chemical Letters 2011年第10期22卷 1226-1228页

作者： Qian Feng Chen Min Zhou Tao Yang Xiao Zhen Chen Chun Wang guo lin Zhang guo you li Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China School of Pharmaceutical Sciences Southwest University Chongqing 400715 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

A new compound,3-butyryl-6-[rel-（1S,2S）-1,2-dihydroxypropyl]-4-hydroxy-2H-pyran-2-one（1）,was isolated from the solid fermented rice culture of Alternaria *** 108,along with three known ones,deoxyradicinin（2）,3-epiradicinol（3）,and 3- epideoxyradicinol（4）.Their structures were elucidated on the basis of spectroscopic *** single crystal X-ray diffraction was applied to further clarify the structure of ***,compounds 1-4 possessed no cytotoxicity against several cell lines（HeLa, HepG2,and Ros） and showed no antibacterial activity at 40μmol/L.

关键词： Altemaria Fermentation Pyrone

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Latest assessment methods for mitochondrial homeostasis in cognitive diseases

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Neural Regeneration Research 2024年第4期19卷 754-768页

作者： Wei you Yue li Kaixi liu Xinning Mi Yitong li Xiangyang guo Zhengqian li Department of Anesthesiology Peking University Third Hospital Peking University Third Clinical Medical College Beijing Center of Quality Control and Improvement on Clinical Anesthesia Anesthesia and Perioperative Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

Mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,subcellular distribution,and overall health through mitochondrial *** the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,mild cognitive impairment,and postoperative cognitive *** review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences,from the perspectives of energy metabolism,oxidative stress,calcium homeostasis,and mitochondrial dynamics(including fission-fusion,transport,and mitophagy).

关键词： cognitive disorders mitochondrial dysfunction mitochondrial energy metabolism mitochondrial dynamics mitochondrial transport mitophagy mitochondrial biogenesis oxidative stress calcium homeostasis

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Application of side-to-side anastomosis of the lesser curvature of stomach and jejunum in gastric bypass

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World Journal of Gastroenterology 2016年第37期22卷 8398-8405页

作者： Ri-Xing Bai Wen-Mao Yan you-guo li Jun Xu Zhi-Qiang Zhong Ming Yan Department of General Surgery Beijing Tian Tan Hospital Capital Medical University

AIM To evaluate the feasibility of side-to-side anastomosis of the lesser curvature of stomach and jejunum in laparoscopic Roux-en-Y gastric bypass(LRYGB).METHODS Seventy-seven patients received side-to-side anastomosis of the lesser curvature of stomach and jejunum by utilization of linear stapler in LRYGB from April 2012 to July 2015 were retrospectively *** All patients were successfully completed laparoscopic gastric bypass with the side-to-side anastomosis of the lesser curvature of stomach and jejunum. No patient was switched to laparotomy during operation. No early complications including gastrointestinal anastomotic bleeding, fistula, obstruction, deep vein thrombosis, incision infections, intra-abdominal hernia complications were found. One patient complicated with stricture of gastrojejunal anastomosis(1.3%) and six patients complicated with incomplete intestinal obstruction(7.8%). BMI and Hb A1 c determined at 3, 6, 12, 24 mo during follow up period were significantly reduced compared with preoperative baselines respectively. The percentage of patients who maintain HbA 1c(%) lity procedure. It is effective to lighten the body weight of patients and improve type 2 diabetes and related complications.

关键词： Laparoscopic Roux-en-Y gastric bypass Gastric bypass Gastrojejunostomy Metabolic surgery Bariatric surgery Type 2 diabetes mellitus

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Rethinking attribute localization for zero-shot learning

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Science China(Information Sciences) 2024年第7期67卷 184-196页

作者： Shuhuang CHEN Shiming CHEN guo-Sen XIE Xiangbo SHU Xinge you Xuelong li School of Electronic Information and Communication Huazhong University of Science and Technology School of Computer Science and Engineering Nanjing University of Science and Technology School of Artificial Intelligence Optics and Electronics Northwestern Polytechnical University

Recent advancements in attribute localization have showcased its potential in discovering the intrinsic semantic knowledge for visual feature representations, thereby facilitating significant visual-semantic interactions essential for zero-shot learning(ZSL). However, the majority of existing attribute localization methods heavily rely on classification constraints, resulting in accurate localization of only a few attributes while neglecting the rest important attributes associated with other classes. This limitation hinders the discovery of the intrinsic semantic relationships between attributes and visual features across all *** address this problem, we propose a novel attribute localization refinement(ALR) module designed to enhance the model's ability to accurately localize all attributes. Essentially, we enhance weak discriminant attributes by grouping them and introduce weighted attribute regression to standardize the mapping values of semantic attributes. This module can be flexibly combined with existing attribute localization *** experiments show that when combined with the ALR module, the localization errors in existing methods are corrected, and state-of-the-art classification performance is achieved.

关键词： zero-shot learning attention mechanism attribute localization image classification

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Neoantigen cancer vaccines:a new star on the horizon

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Cancer Biology & Medicine 2024年第4期21卷 274-311页

作者： Xiaoling li Jian you liping Hong Weijiang liu Peng guo Xishan Hao Cell Biotechnology Laboratory Tianjin Cancer Hospital Airport HospitalTianjin 300308China National Clinical Research Center for Cancer Tianjin 300060China Haihe Laboratory of Synthetic Biology Tianjin 300090China Department of Thoracic Oncology Tianjin Cancer Hospital Airport HospitalTianjin 300308China Department of Thoracic Oncology Surgery Tianjin Medical University Cancer Institute&HospitalTianjin 300060China Tianjin Medical University Cancer Institute&Hospital Tianjin 300060China

Immunotherapy represents a promising strategy for cancer treatment that utilizes immune cells or drugs to activate the patient's own immune system and eliminate cancer *** of the most exciting advances within this field is the targeting of neoantigens,which are peptides derived from non-synonymous somatic mutations that are found exclusively within cancer cells and absent in normal *** neoantigen-based therapeutic vaccines have not received approval for standard cancer treatment,early clinical trials have yielded encouraging outcomes as standalone monotherapy or when combined with checkpoint *** made in high-throughput sequencing and bioinformatics have greatly facilitated the precise and efficient identification of ***,personalized neoantigen-based vaccines tailored to each patient have been developed that are capable of eliciting a robust and long-lasting immune response which effectively eliminates tumors and prevents *** review provides a concise overview consolidating the latest clinical advances in neoantigen-based therapeutic vaccines,and also discusses challenges and future perspectives for this innovative approach,particularly emphasizing the potential of neoantigen-based therapeutic vaccines to enhance clinical efficacy against advanced solid tumors.

关键词： Immunotherapy neoantigen cancer vaccine solid tumors high-throughput sequencing bioinformatics PDOs AI HLA TCR

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Biphenyls from aerial parts of Ribes takare

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Chinese Chemical Letters 2014年第1期25卷 127-130页

作者： Xiao-Zhen Chen Sheng-Ming Lu guo-you li Wei Jiao Tian-Fang Huang Tao Yang Dong-Mei Fang Chengdu Institute of Biology Chinese Academy of Sciences

Three new biphenyls, 4,7,8-trimethoxy-2,3-methylenedioxydibenzofuran （1）, 7-hydroxy-4,8- dimethoxy-2,3-methylenedioxydibenzofuran （2）, and 3＇,5-dimethoxy-3,4-methylenedioxybiphenyl （3）, along with eighteen known compounds （4-21） were isolated from the aerial part of Ribes takare D. Don. Their structures were elucidated on the basis of spectroscopic data. Compound I and compound 2 showed mild α-glucosidase inhibitory activity.

关键词： Biphenyl Ribes takare D. Don α-Glycosidase Inhibitory activity

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