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Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism

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World Journal of Gastroenterology 2022年第43期28卷 6131-6156页

作者： Zi-Li Ai Xian Zhang Wei Ge you-bao zhong Hai-Yan Wang Zheng-Yun Zuo Duan-Yong Liu Department of Postgraduate Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Department of Proctology Affiliated Hospital of Jiangxi University of Chinese MedicineNanchang 330006Jiangxi ProvinceChina Laboratory Animal Research Center for Science and Technology Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Formula-Pattern Research Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina

BACKGROUND Studies have shown that a high-fat diet(HFD) can alter gut microbiota(GM)homeostasis and participate in lipid metabolism disorders associated with ***, regulating the construction of GM with the balance of lipid metabolism has become essential for treating obesity. Salvia miltiorrhiza extract(Sal), a common traditional Chinese medicine, has been proven effective against atherosclerosis, hyperlipidemia, obesity, and other dyslipidemia-related *** To investigate the anti-obesity effects of Sal in rats with HFD-induced obesity, and explore the underlying mechanism by focusing on GM and lipid *** Obesity was induced in rats with an HFD for 7 wk, and Sal(0.675 g/1.35 g/2.70g/kg/d) was administered to treat obese rats for 8 wk. The therapeutic effect was evaluated by body weight, body fat index, waistline, and serum lipid level. Lipid factors(cAMP, PKA, and HSL) in liver and fat homogenates were analyzed by ELISA. The effect of Sal on GM and lipid metabolism was assessed by 16S rRNAbased microbiota analysis and untargeted lipidomic analysis(LC-MS/MS),*** Sal treatment markedly reduced weight, body fat index, serum triglycerides(TG), total cholesterol(TC), low-density lipoprotein, glucose, free fatty acid, hepatic lipid accumulation, and adipocyte vacuolation, and increased serum high-density lipoprotein(HDL-C) in rats with HFD-induced obesity. These effects were associated with increased concentrations of lipid factors such as c AMP, PKA, and HSL in the liver and adipose tissues, enhanced gut integrity, and improved lipid metabolism. GM analysis revealed that Sal could reverse HFD-induced dysbacteriosis by promoting the abundance of Actinobacteriota and Proteobacteria, and decreasing the growth of Firmicutes and Desulfobacterita. Furthermore, LC-MS/MS analysis indicated that Sal decreased TGs(TG18:2/18:2/20:4, TG16:0/18:2/22:6), DGs(DG14:0/22:6, DG22:6/22:6), CL(18:2/18:1/18:1/20:0), and increased ceramides

关键词： Salvia miltiorrhiza extract Obesity Gut microbiota Lipid metabolism High fat diet

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Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance

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World Journal of Gastroenterology 2023年第36期29卷 5226-5239页

作者： Lin-Xin Zheng Kai-En Guo Jia-Qi Huang Miao-Hua Liu Bai-Ling Deng Duan-Yong Liu Bu-Gao Zhou Wen Zhou you-bao zhong Hai-Mei Zhao Department of Postgraduate Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina College of Traditional Chinese Medicine Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Formula-Pattern Research Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Nanchang Medical College Nanchang 330052Jiangxi ProvinceChina Laboratory Animal Research Center for Science and Technology Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina

BACKGROUND Restoration of immune homeostasis by targeting the balance between memory T helper(mTh)cells and memory follicular T helper(mTfh)cells is a potential therapeutic strategy against ulcerative colitis(UC).Because of its anti-inflammatory and immunomodulatory properties,curcumin(Cur)is a promising drug for UC ***,fewer studies have demonstrated whether Cur can modulate the mTh/mTfh subset balance in mice with *** To explore the potential mechanism underlying Cur-mediated alleviation of colitis induced by dextran sulfate sodium(DSS)in mice by regulating the mTh and mTfh immune *** Balb/c mice were administered 3%and 2%DSS to establish the UC model and treated with Cur(200 mg/kg/d)by gavage on days *** the 18th d,all mice were anesthetized and euthanized,and the colonic length,colonic weight,and colonic weight index were *** changes in the mouse colon were observed through hematoxylin-eosin *** of Th/mTh and Tfh/mTfh cell subsets in the spleen were detected through flow *** blotting was performed to detect SOCS-1,SOCS-3,STAT3,p-STAT3,JAK1,p-JAK1,and NF-κB p65 protein expression levels in colon *** Cur effectively mitigates DSS-induced colitis,facilitates the restoration of mouse weight and colonic length,and diminishes the colonic weight and colonic weight ***,it hinders ulcer development and inflammatory cell infiltration in the colonic mucous *** the percentage of Th1,mTh1,Th7,mTh7,Th17,mTh17,Tfh1,mTfh1,Tfh7,mTfh7,Tfh17,and mTfh17 cells decreased after Cur treatment of the mice for 7 d,and the frequency of mTh10,Th10,mTfh10,and Tfh10 cells in the mouse spleen *** studies revealed that Cur administration prominently decreased the SOCS-1,SOCS-3,STAT3,p-STAT3,JAK1,p-JAK1,and NF-κB p65 protein expression levels in the colon *** Cur regulated the mTh/mTfh cell homeostasis to reduce DSS-induced colonic pat

关键词： Curcumin Ulcerative colitis Memory T helper Memory follicular T helper JAK1/STAT3/SOCS

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Curcumin alleviates experimental colitis via a potential mechanism involving memory B cells and Bcl-6-Syk-BLNK signaling

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World Journal of Gastroenterology 2022年第40期28卷 5865-5880页

作者： Si-Yi Wei Tian-Tian Wu Jia-Qi Huang Zeng-Ping Kang Meng-Xue Wang you-bao zhong Wei Ge Bu-Gao Zhou Hai-Mei Zhao Hai-Yan Wang Duan-Yong Liu Department of Postgraduate Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Laboratory Animal Research Center for Science and Technology Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Affiliated Hospital Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina Formula-Pattern Research Center Jiangxi University of Chinese MedicineNanchang 330004Jiangxi ProvinceChina

BACKGROUND Immune dysfunction is the crucial cause in the pathogenesis of inflammatory bowel disease(IBD),which is mainly related to lymphocytes(T or B cells,including memory B cells),mast cells,activated neutrophils,and *** the precursor of B cells,the activation of memory B cells can trigger and differentiate B cells to produce a giant variety of inducible B cells and tolerant B cells,whose dysfunction can easily lead to autoimmune diseases,including *** To investigate whether or not curcumin(Cur)can alleviate experimental colitis by regulating memory B cells and Bcl-6-Syk-BLNK *** Colitis was induced in mice with a dextran sulphate sodium(DSS)solution in drinking *** mice were given Cur(100 mg/kg/d)orally for 14 consecutive *** colonic weight,colonic length,intestinal weight index,occult blood scores,and histological scores of mice were examined to evaluate the curative *** levels of memory B cells in peripheral blood of mice were measured by flow cytometry,and IL-1β,IL-6,IL-10,IL-7A,and TNF-αexpression in colonic tissue homogenates were analyzed by enzyme-linked immunosorbent *** blot was used to measure the expression of Bcl-6,BLNK,Syk,and other signaling pathway related *** After Cur treatment for 14 d,the body weight,colonic weight,colonic length,colonic weight index,and colonic pathological injury of mice with colitis were *** secretion of IL-1β,IL-6,TNF-α,and IL-7A was statistically decreased,while the IL-35 and IL-10 levels were considerably *** of memory B cell subsets in colitis mice was confirmed by a remarkable reduction in the expression of IgM,IgG,IgA,FCRL5,CD103,FasL,PD-1,CD38,and CXCR3 on the surface of CD19^(+)CD27^(+)B cells,while the number of CD19^(+)CD27^(+)IL-10^(+)and CD19^(+)CD27^(+)Tim-3^(+)B cells increased *** addition,Cur significantly inhibited the protein levels of Syk,p-Syk,Bcl-6,and CIN85,and increased BLNK and p-BLNK

关键词： Curcumin Experimental colitis Memory B cell Bcl-6 BLNK

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Metal-organic frameworks with dinuclear metal centers for synergistically boosting CO2 photoreduction

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Science China Chemistry 2025年第1期68卷 201-208页

作者： Hui-Feng Wang Wen-Jie Shi Yu-Xin Yang bao-Xia Dong Tong-Bu Lu Di-Chang zhong School of Chemistry and Chemical Engineering Yangzhou University Institute for New Energy Materials and Low Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology

Dinuclear metal synergistic catalysis （DMSC） has been proved powerful in boosting CO2reduction,while this has not been achieved in heterogeneous catalysts with long-range order *** this study,we,by introduction of metal catalytic centers into an indium-based metal-organic framework （MOF）,obtained a series of isostructural In-MOFs,including three MOFs with mononuclear metal catalytic center （M-In）,three MOFs with dinuclear homometallic catalytic centers （MM-In）,and three MOFs with dinuclear heterometallic catalytic centers (MM’-In,M/M’=Co（II）,Ni（II）,Zn（II）).It was found that all these MOFs can serve as catalysts for photochemical CO2reduction to *** with M-In,the catalytic activities of MM-In were obviously enhanced,and that of MM’-In was further significantly *** example,the CO yield of Co Zn-In reaches a record value of 12,700μmol g-1h-1,which is 4.0,8.1,9.4,and 18.6-fold higher than that of Co Co-In,Zn Zn-In,Co-In,and Zn-In,***,the catalytic activities of Co Ni-In and Ni Zn-In also show different fold increase than those of corresponding dinuclear homometallic and mononuclear metallic *** results of control experiments and theoretical calculation reveal that the higher catalytic activities of MM-In over M-In can be ascribed to the DMSC effect,and the higher catalytic activity of MM’-In over MM-In can be ascribed to the strengthened DMSC *** work reveals the relationship between DMSC effect and bimetal centers in CO2reduction,which provides new insights into the DMSC and paves a new way to design highly active catalysts for photochemical CO2reduction.

关键词： metal-organic frameworks dinuclear metal centers synergistic catalysis CO2 reduction photocatalysis

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网络远程勘验的法律定位与规制

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电脑与信息技术 2024年第2期32卷 103-107页

作者：赵长江游中宝重庆邮电大学重庆400060

网络远程勘验是信息化时代催生的新型电子数据取证手段。网络远程勘验已经在内涵、性质和功能上突破了传统勘验制度的规定,在实践中呈现出强制性侦查措施属性。但相关立法对网络远程勘验的规定粗疏,存在与网络在线提取之间的顺位矛盾,... 详细信息

网络远程勘验是信息化时代催生的新型电子数据取证手段。网络远程勘验已经在内涵、性质和功能上突破了传统勘验制度的规定,在实践中呈现出强制性侦查措施属性。但相关立法对网络远程勘验的规定粗疏,存在与网络在线提取之间的顺位矛盾,且未对其落实审批程序、缺乏相应的监督和救济程序,导致侦查机关在实践中易产生侵权情形。因此有必要贯彻网络远程勘验审批程序、理清与网络在线提取之间的顺位问题、落实检察机关的监督机制、拓宽被勘验人员的救济途径等,促进网络远程勘验规则体系的有序构建。

关键词：网络远程勘验强制侦查侦查措施体系

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吸能防冲锚杆索-围岩耦合振动特征与防冲机理

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煤炭学报 2016年第11期41卷 2734-2742页

作者：王爱文潘一山赵宝友李忠华李国臻代连朋辽宁工程技术大学力学与工程学院辽宁阜新123000 辽宁工程技术大学冲击地压研究院辽宁阜新123000 辽宁大学辽宁沈阳110036 辽宁工程技术大学辽宁阜新123000

为提高冲击危险巷道防冲支护的有效性,研发了由内置六角管衬里的吸能套筒、端部设有摩擦圆柱的螺纹钢锚杆、钢绞线锚索与锚杆尾部吸能装置组成的吸能锚杆索。将吸能锚杆索中吸能套筒的作用简化为设置在锚杆底部并联的弹簧与阻尼器,建立... 详细信息

为提高冲击危险巷道防冲支护的有效性,研发了由内置六角管衬里的吸能套筒、端部设有摩擦圆柱的螺纹钢锚杆、钢绞线锚索与锚杆尾部吸能装置组成的吸能锚杆索。将吸能锚杆索中吸能套筒的作用简化为设置在锚杆底部并联的弹簧与阻尼器,建立了吸能锚杆索-围岩在冲击载荷作用下的三维轴对称力学模型。对黏性阻尼围岩中吸能锚杆索与围岩耦合振动时锚杆顶部动力响应进行了解析研究,获得了锚杆顶部的位移阻抗函数的解析表达。结果表明:在相同频率的冲击载荷作用下,锚杆顶部位移振荡幅值随着围岩黏性阻尼、围岩强度、锚固长度以及锚杆底部阻尼的增加而衰减。采用吸能锚杆索支护时,吸能套筒能够吸收一部分作用在锚杆锚固岩体上的冲击能;后注浆全长锚固增强了支护系统抵抗纵向变形的能力;尾部吸能装置能够削减冲击波的发射拉伸作用;支护系统在冲击载荷作用下的稳定性得到显著提高。在此基础上,初步阐述了吸能锚杆索支护系统的"缓冲-抗震-消波"吸能防冲机理。

关键词：冲击危险巷道吸能锚杆索耦合振动动力学模型防冲机理

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Ballistic penetration damages of hybrid plain-woven laminates with carbon,Kevlar and UHMWPE fibers in different stacking sequences

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Defence Technology（防务技术） 2023年第8期26卷 23-38页

作者： Zhi-yong Li you-song Xue bao-zhong Sun Bo-hong Gu Shanghai Frontier Science Research Center for Modern Textiles College of TextilesDonghua UniversityShanghai201620China

Hybrid composite materials combine different fibers in preform and take advantages of different mechanical behaviors for improving ballistic impact damage *** we report ballistic impact damages of plain-woven laminates with different hybrids and stacking *** kinds of hybrid laminates,i.e.,carbon/Kevlar,carbon/ultra-high molecular weight polyethylene(UHMWPE),and UHMWPE/Kevlar,had been prepared and tested in ballistic penetration with fragment simulating projectiles(FSP).The residual velocities of the projectiles and impact damage morphologies of the laminates have been obtained to show impact energy absorptions for the different hybrid schemes.A microstructural model of the hybrid laminates had also been established to show impact damage mechanisms with finite element analysis(FEA).We found that the UHMWPE/Kevlar hybrid laminates with Kevlar layers as the front face have the highest energy absorption capacity,followed by the carbon/Kevlar hybrid laminates with carbon layers as the front *** main damage modes are fiber breakages,matrix crack and interlayer *** ballistic damage evolutions from the FEA results show that the major damage is shear failure for front layers,while tension failure for the back *** expect that the ballistic impact performance could be improved from the different hybrid schemes.

关键词： Hybrid laminates Ballistic impact damages Energy absorption Finite element analysis(FEA)

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Thermal-flow-electric coupling performance analysis of a liquid-immersed battery thermal management system

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Science China Technological Sciences 2025年第1期 157-176页

作者： Qiang GAO Jun TIAN Chujin bao Yangfan zhong Chengbin ZHANG Yongping CHEN School of Energy and Environment Southeast University Battery Testing Center China North Vehicle Research Institute Zhejiang Immertech Co. Ltd. Alibaba Cloud Computing Co. Ltd.

Ensuring the safety and performance of lithium-ion batteries(LIBs) is a significant challenge for electric *** tackle this issue, an innovative liquid-immersed battery thermal management system(LIBTMS) using bionic baffles with fish-like perforations is developed. The thermal-flow-electric coupling characteristics of LIBTMSs with different baffle structures(no baffle, conventional baffle, baffle with circular perforations and baffle with fish-like perforations) are systematically investigated using experimental and numerical methods. The results indicate that the forced flow scheme exhibits better thermal management performance and voltage equalization than static flow. Moreover, the LIB temperatures and voltage deviations of different LIBTMSs increase quickly with increasing discharge rates. More importantly, the innovative LIBTMS exhibits the best thermoelectric performance due to its excellent thermoelectric equilibrium behavior caused by high electrical and temperature consistency, as well as the best overall performance involving the balance between the pressure loss and heat transfer capacity of the system. Compared with other structures, the innovative LIBTMS using baffles with fish-like perforations exhibits a maximum reduction of 10.1%, 15.2%, 25.8% and 9.0% in LIB maximum temperature, maximum temperature difference, system pressure drop and voltage deviation, respectively, under the same operating ***, for the LIBTMS using baffles with fish-like perforations, the bottom inlet and top outlet configuration and coolant precooling are suggested to enhance cooling performance.

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A CAD System for Tube Drawing Based on Finite Element Simulation of Drawing Process

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Journal of Iron and Steel Research International 2001年第1期8卷 27-33页

作者： HAN bao-yun JIN Ming WU you-cai zhong Qian-xia Central Iron & Steel Research Institute

Acicular Ferrite (AF) is beneficial in welds because it provides a tough and strong microstructure. Therefore, much works have been done in the study of the effect of alloying elements and welding conditions aimed at obtaining more AF in the weld metal. However, the knowledge about the nature of AF is limited due to the lack of kinetics researches. In this paper, the kinetic curves of AF transformation in an X65 weld metal were established by means of welding thermal simulation test. The results showed that AF transformation is a typical diffusion process of nucleation and growth with incubation period. AF transformation in weld metal obeys the relationship described by JMA Equation. The effect of welding heat input was also studied.

关键词： weld metal acicular ferrite kinetics pipe steel

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Recent progress in high temperature permanent magnetic materials

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Rare Metals 2013年第5期32卷 431-440页

作者： Cheng-bao Jiang Shi-zhong An School of Materials Science and Engineering Beihang University

Permanent magnetic materials capable of operating at high temperature up to 500℃ have wide potential applications in fields such as aeronautics, space, and electronic cars. SmCo alloys are candidates for high temperature applications, since they have large magnetocrystalline anisotropy field （6-30 T）, high Curie temperature （720-920℃）, and large energy product （〉200 kJ.m-3） at room temperature. However, the highest service temperature of commercial 2：17 type SmCo magnets is only 300℃, and many efforts have been devoted to develop novel high temperature permanent magnets. This review focuses on the development of three kinds of SmCo based magnets： 2：17 type SmCo magnets, nanocrystalline SmCo magnets, and nanocomposite SmCo magnets. The oxidation protection, including alloying and surface modification, of high temperature permanent magnets is discussed as well.

关键词： Magnetic materials Sm-Co alloys Permanent magnets High temperature

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