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Neuroprotective and anti-inflammatory effects of eicosane on glutamate and NMDA-induced retinal ganglion cell injury

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 638-645页

作者： Zhen-Kai Wu Huan-Yu Li you-lin Zhu Meng-Qin Xiong Jing-Xiang Zhong Department of Ophthalmology the First Affiliated Hospital of Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Changde Hospital Xiangya School of MedicineCentral South University(the First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina

AIM:To investigate the protective effects,antioxidant potential,and anti-inflammatory mechanisms of eicosane on glutamate-induced cell damage and on N-methyl-Daspartate(NMDA)-induced retinal ganglion cell(RGC)injury in a mouse model of ***:The protective effects of eicosane on the rat R28 retinal precursor cell line were assessed using cell counting kit-8 assays and Hoechst-propidium iodide *** reactive oxygen species(ROS)production was measured using the fluorescent probe 2'-7'-dichlorofluorescin diacetate and flow *** protective role of eicosane on NMDA-induced RGC injury in a mouse glaucoma model was determined by immunostaining of frozen sections of *** effects of eicosane on the metabolome of the retina in mice with NMDA-induced RGC damage were evaluated by liquid chromatographymass spectroscopy(LC-MS)and untargeted metabolomics ***:Eicosane treatment significantly attenuated glutamate-induced damage to R28 cells in *** also protected RGCs against NMDA-induced injury in a mouse glaucoma *** metabolomics analyses showed that eicosane increased multiple metabolites,including L-arginine and L-carnitine,in the ***:Eicosane has protective effects,antioxidant potential,and anti-inflammatory properties in an in vitro model of glutamate-induced cell damage and in an in vivo model of NMDA-induced RGC injury in mouse glaucoma through modulation of L-arginine and/or L-carnitine metabolism.

关键词： glaucoma metabolites eicosane

Colon perforation with severe peritonitis caused by erotic toy insertion and treated using vacuum-assisted closure:A case report

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World Journal of Clinical Cases 2024年第18期12卷 3548-3554页

作者： Cheng-you lin Ta-Wei Pu Department of Surgery Division of Colon and Rectal SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Surgery Taichung Armed Force General HospitalTaichung 411Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan branchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Colorectal foreign bodies are commonly encountered during *** are frequently observed in men 20 to 90 years of age and have bimodal age *** management is necessary for cases of rectal ***,surgical site infections are the most common complications after colorectal *** SUMMARY We discuss a case of rectal perforation in a patient who presented to our hospital 2 d after its *** perforation occurred as a result of the patient inserting a sex toy in his *** peritonitis was attributable to delayed *** Vacuum-assisted closure was performed to treat the wound,which healed well after *** complications were noted.

关键词： Colorectal surgery Foreign bodies Intestinal perforation Surgical site infection Wound closure techniques Case report

人文经济赋能新质生产力:内在逻辑与实践路径

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苏州大学学报（哲学社会科学版） 2024年第5期45卷 1-9页

作者：张佑林南方科技大学全球城市文明典范研究院广东深圳518055

人文经济学讲求以人为本、以文化为灵魂,以文化创新引领新质生产力协同发展。人文经济主要是从推动新质生产力主体的形成、动力机制的启动、发展载体的形成、动力源泉的生成以及营商环境的培育等诸多方面,通过建立一整套完整、协调、高... 详细信息

人文经济学讲求以人为本、以文化为灵魂,以文化创新引领新质生产力协同发展。人文经济主要是从推动新质生产力主体的形成、动力机制的启动、发展载体的形成、动力源泉的生成以及营商环境的培育等诸多方面,通过建立一整套完整、协调、高效的运行机制,引领我国战略性新兴产业与未来产业萌发兴起,赋能新质生产力高效发展,由此构建人文经济创新引领新质生产力发展的内生逻辑。人文经济在实践层面主要是围绕文化创新、科技创新、企业家创新、文化创意、教育创新、制度创新等六大路径赋能新质生产力高效发展,最终达成文化创新引领新时代中国经济高质量发展目标的实现。

关键词：人文经济新质生产力高质量发展赋能科技创新

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喷水推进船舶骑浪横甩薄弱性衡准校核方法

船舶力学 2024年第8期28卷 1133-1140页

作者：封培元蔡佑林范佘明喷水推进技术重点实验室上海201100 上海市船舶工程重点实验室上海200011 中国船舶及海洋工程设计研究院上海200011

当前国际海事组织(IMO)二代稳性规范中骑浪/横甩稳性失效模式的第二层薄弱性衡准校核方法仅适用于采用常规螺旋桨推进方式的船舶。然而,采用喷水推进方式的船舶同样属于该稳性失效模式的敏感船型,因此有必要建立此类船舶的规范校核方法... 详细信息

当前国际海事组织(IMO)二代稳性规范中骑浪/横甩稳性失效模式的第二层薄弱性衡准校核方法仅适用于采用常规螺旋桨推进方式的船舶。然而,采用喷水推进方式的船舶同样属于该稳性失效模式的敏感船型,因此有必要建立此类船舶的规范校核方法。本研究通过类比螺旋桨推力模型,建立喷水推进系统的力学模型,在不改变当前骑浪/横甩第二层薄弱性衡准校核理论方法和框架的前提下,通过最少的流程变动实现适用于喷水推进船舶的第二层薄弱性衡准校核,并基于实泵数据和样船算例证明所提出方法的有效性。基于研究成果形成专门针对喷水推进船舶的规范校核方法,突破当前规范在船舶推进方式方面的局限性,不但使规范变得更为完备,而且能为喷水推进船舶的稳性安全评估提供有利的技术支撑。

关键词：二代稳性骑浪/横甩喷水推进薄弱性衡准校核流程

Time-resolved ultra-small-angle X-ray scattering beamline(BL10U1)at SSRF

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Nuclear Science and Techniques 2024年第2期35卷 6-19页

作者： Wen-Qiang Hua Chun-Ming Yang Ping Zhou Feng Tian Jin-you lin Yu-Zhu Wang Xiao-Yun Li Xia-Ran Miao Chun-Xia Hong Qiu-Shi Huang Xin-Tong Zhao Yong-Feng Men Jie Wang Xing-Yu Gao Xiu-Hong Li Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Key Laboratory of Advanced Micro Structural Materials MOEInstitute of Precision Optical EngineeringSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

The construction of a new beamline,BL10U1,was completed at the Shanghai synchrotron radiation facility in *** multipurpose beamline was designed to provide X-ray scattering techniques such as ultra-small-angle X-ray scattering(USAXS),small-angle X-ray scattering(SAXS),wide-angle X-ray scattering,and microfocus SAXS(μSAXS)for a broad user *** realize fast time-resolved USAXS experiments,the beamline adopted an in-vacuum undulator with a total length of 1.6 m as the photon *** in-house cryogenic-cooled double multilayer monochromator was installed to deliver a photon flux of approximately 10^(13) photons/s at a photon energy of 10 *** three-year successful operation of this beamline demonstrated that the monochromator operated smoothly,as ***10U1 has three end stations in succession:USAXS end station,μSAXS end station,and end station for industrial *** minimum scattering vector q~0.0042 nm^(-1) at 10 keV can be achieved at the USAXS end station equipped with a 28 m-long and 1.8 m-diameter vacuum flight *** theμSAXS end station,a beam spot of less than 10×8μm was achieved for micro-SAXS *** contrast,in situ experimental instruments up to 5 m high and 8 m wide can be mounted at the industrial application end station,which offers industrial scientists the opportunity to use their large industrial ***10U1 opens up a new capability to investigate phenomena such as non-equilibrium and dynamic processes of materials with a wide length scale from angstroms to micrometers with millisecond time *** this paper,we also report beamline design considerations and commissioning results.

关键词： Synchrotron radiation Ultra-small-angle X-ray scattering Micro small-angle X-ray scattering USAXS Time resolved μSAXS

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论何休日月时例中的详与略

聊城大学学报（社会科学版） 2024年第2期 116-128页

作者：赵友林聊城大学文学院山东聊城252059

《公羊》学者何休从详与略的角度对《春秋》的日月时例作了大量的阐发。何休基于二元对立的思维,对日、月、时这三个要素作两两对待,即日、月相对,日为详,月为略;月、时相对,月为详,时为略。何休从日月时的详略轻重出发,阐发蕴含其中的... 详细信息

《公羊》学者何休从详与略的角度对《春秋》的日月时例作了大量的阐发。何休基于二元对立的思维,对日、月、时这三个要素作两两对待,即日、月相对,日为详,月为略;月、时相对,月为详,时为略。何休从日月时的详略轻重出发,阐发蕴含其中的褒贬大义,但何休并没有采取二元对立的思维来阐明褒贬,即并不是详书日月以示褒,略书就意味着贬;其实有很多情况,日月时的详略表明的是褒、贬程度的浅深。也正因为日月时的详略在意义的阐发上具有程度上的深浅轻重等的变化关系,因此能很好地与其三世进化说相结合,从而具有王道进化的意义。而随着三世的演进,王道的逐渐实现,日月时的详略轻重的差异渐趋消弥,从而完成了它的王道进化的使命。

关键词：何休日月时例详略

近代福建非金融机构私票发行史——兼论私票属性与作用

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福建江夏学院学报 2024年第3期14卷 29-40页

作者：张林友福建江夏学院图书馆福建福州350108

近代中国通货体系中私票居于边缘地位,却长期维系着乡村社会的货币金融关系。私票发行主体的多元化格局影响其流通范围、职能作用甚至基本性质。地域性是私票的基本属性之一。福建在清末已普遍流通私票,商号等非金融机构钱票的兴起到20... 详细信息

近代中国通货体系中私票居于边缘地位,却长期维系着乡村社会的货币金融关系。私票发行主体的多元化格局影响其流通范围、职能作用甚至基本性质。地域性是私票的基本属性之一。福建在清末已普遍流通私票,商号等非金融机构钱票的兴起到20世纪20年代末达到鼎盛,以闽西北、闽东等地为多,福州、闽南因特殊的市场状况而少有商号钱票。20世纪30年代中期,非金融机构私票发行的组织化程度有所提高。福建省银行设立后,私票发行收缩,抗战爆发后有所恢复,解放战争末期短暂重兴。总体而言,福建非金融机构私票虽仅具有部分货币职能,且一再被政府取缔,但因其特殊的属性与作用,始终具有一定的生命力。

关键词：福建非金融机构私票

考虑数据共享和平台赋能的智能制造生态合作策略演化

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软科学 2024年第7期38卷 135-144页

作者：邢青松陈佑琳邓富民重庆交通大学经济与管理学院重庆400074 四川大学商学院成都610065

在揭示智能制造平台和制造企业生态合作机理的基础上,构建考虑数据共享和平台赋能的博奔模型,对影响双方生态合作演化稳定性的因素进行分析,并通过MATLAB数值仿真,进一步探讨不同关键因素对双方行为演化结果的影响。结果表明:(1)不同组... 详细信息

在揭示智能制造平台和制造企业生态合作机理的基础上,构建考虑数据共享和平台赋能的博奔模型,对影响双方生态合作演化稳定性的因素进行分析,并通过MATLAB数值仿真,进一步探讨不同关键因素对双方行为演化结果的影响。结果表明:(1)不同组合的初始意愿会影响双方最后的策略选择,对有意愿进行生态合作的制造企业,智能制造平台应主动发出合作信号;(2)平台赋能成本和数据共享成本增加会对生态合作起到抑制作用;(3)随着数据价值转化系数、数据保护力度等的增大,双方选择生态合作策略的速度将加快;(4)降低数字化转型的风险成本,合理设置收益分配机制能够对生态合作演化形成正向激励。

关键词：数据共享平台赋能智能制造生态合作

A Generic Dynamic Load Model Framework

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Journal of Modern Power Systems and Clean Energy 2022年第2期10卷 399-406页

作者： you lin Jianhui Wang the Department of Electrical and Computer Engineering Southern Methodist UniversityDallasUSA

Formulating accurate dynamic load models is critical for power system analysis,control,and *** this paper,a generic dynamic load model is *** dynamic power response of the load is directly approximated as the superposition of various mathematical functions that produce a dynamic *** physical principles of the dynamic process are reflected in the mathematical functions utilized in the proposed ***,different stages of the dynamic process are detected based on the continuity of derivatives of the ***,a complete set of mathematical functions that produce the dynamic responses in electric devices are ***,a parsimonious set of mathematical functions is selected at each stage by performing feature selection using nonlinear principal component *** proposed model is further formulated based on the parsimonious set of mathematical functions at each ***,the parameters of the proposed model corresponding to different system events are *** on the formulated model,its possible application in event detection is further *** proposed model is easy to implement given limited data *** tests on different system event data are performed to validate the effectiveness of the proposed *** results show that the proposed model has excellent accuracy and robustness for different system events.

关键词： Approximation dynamic process generic framework load model physical principle.