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Novel berberine derivatives as adjuvants in the battle against Acinetobacter baumannii: A promising strategy for combating multi-drug resistance

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Chinese Chemical Letters 2024年第10期35卷 334-340页

作者： Liping Zhao Xixi Guo Zhimeng Zhang Xi Lu Qingxuan Zeng Tianyun Fan Xintong Zhang Fenbei Chen Mengyi Xu min Yuan Zhenjun Li Jiandong Jiang jing Pang Xuefu you Yanxiang Wang Danqing Song Beijing Key Laboratory of Antimicrobial Agents Institute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory for Infectious Diseases Prevention and Control Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

The development of resistance against most of the available antibiotics has made Acinetobacter baumannii(***)a pathogen of high *** this study,thirty novel berberine derivatives are rationally designed,synthesized,and evaluated for their synergistic antibacterial activities against *** them,compound 2d shows the most potent synergetic effect to aztreonam against ***,including carbapenem-resistant and extended-spectrumβ-lactamases-producing ***,synergistic effects were observed for the combinations of 2d and different antibacterial used in clinical practices,indicating its potent broad-spectrum antibiotic-sensitizing effects against *** combination of 2d and aztreonam significantly improves the survival rates of *** larvae compared with aztreonam treatment *** studies indicate that 2d inhibits the drug efflux and iron acquisition of the bacteria by targeting the AdeB transporter protein,thus achieving a synergistic antimicrobial efficacy with different antibacterial ***,berberine derivatives represent a new family of antimicrobial adjuvants against ***,with the advantage of dual-function antibacterial effect,and are worthy of further investigation.

关键词： Acinetobacter baumannii Berberine derivatives Rational design Synergistic effect Eflux Ironacquisition

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空调压缩机噪声声品质主客观评价及其相关性研究

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流体机械 2007年第11期35卷 1-4,53页

作者：尤晋闽陈天宁和丽梅西安交通大学陕西西安710049 长安大学陕西西安710064

通过对某生产厂家的空调压缩机进行现场噪声测试,采用评分法对噪声声品质偏好性指标进行主观评价,并计算出A声级、响度和尖锐度值作为声品质的客观评价指标。对主客观评价结果进行相关性分析及线性回归分析,提出了声品质主观偏好性值的... 详细信息

通过对某生产厂家的空调压缩机进行现场噪声测试,采用评分法对噪声声品质偏好性指标进行主观评价,并计算出A声级、响度和尖锐度值作为声品质的客观评价指标。对主客观评价结果进行相关性分析及线性回归分析,提出了声品质主观偏好性值的预估模型。研究结果表明,压缩机噪声声品质主要受A声级、响度和尖锐度的共同影响。

关键词：声品质压缩机偏好性 A声级响度尖锐度

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Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： ZHOU Li WANG Guo-rong WAN min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental *** control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control ***,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each *** direction interference observers are designed to track the timevarying boundary *** this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead *** addition,the stability of the closed-loop system is proven by Lyapunov stability *** the system states are bounded,and the vibration offset of the riser converges to a small area of the initial ***,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

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Particle effects on the hydrodynamics in slurry bubble column reactors:A review from multiscale mechanisms Author links open overlay panel

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Particuology 2024年第8期91卷 176-189页

作者： min An jingqi Gao Tiankuo Wang Xiangnan Li National Supercomputing Center in Zhengzhou Zhengzhou UniversityZhengzhou450001China School of Chemical Engineering and New Energy Xiamen University MalaysiaSepangSelangor43900Malaysia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang453007China

Particles can appear as catalyst,reactant or product in various gas-liquid-solid three-phase production *** bubble column reactors(SBCRs),as a kind of three-phase reactors,are preferred for phase contacting and ***,literature studies concerning the effects of particles on the hydrodynamics of SBCRs are manifold and inconsistent in ***,the multiscale interactions between particles,turbulent eddies and bubbles determine the reactor *** review focuses on revealing the particle effects in SBCRs from the perspective of multiscale *** hydrodynamic changes due to particle effects in literature are *** parameters,including the Stokes number,the solid-to-liquid density ratio,the ratio of particle and liquid characteristic lengths,the contact angle and the particle volume fraction are adopted to evaluate the characteristics of gas-liquid-solid *** relationships between particle influencing mechanisms and these parameters are analyzed and *** experimental results are explained by different ranges of these dimensionless ***,particle effects at the mesoscale and microscale,such as the influence on the bubble dynamics and the pivoting effect on the turbulence energy spectrum,are ***,progress in modeling the SBCRs with consideration of particles effects using the Euler method are *** review aims to improve the overall understanding of the complex hydrodynamics in the SBCRs.

关键词： Slurry bubble column reactors Particle effects Turbulence characteristics Bubble dynamics CFD

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Weighted Forwarding in Graph Convolution Networks for Recommendation Information Systems

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Computers, Materials & Continua 2024年第2期78卷 1897-1914页

作者： Sang-min Lee Namgi Kim Department of Computer Science Kyonggi UniversitySuwonKorea

Recommendation Information Systems(RIS)are pivotal in helping users in swiftly locating desired content from the vast amount of information available on the *** Convolution Network(GCN)algorithms have been employed to implement the RIS ***,the GCN algorithm faces limitations in terms of performance enhancement owing to the due to the embedding value-vanishing problem that occurs during the learning *** address this issue,we propose a Weighted Forwarding method using the GCN(WF-GCN)*** proposed method involves multiplying the embedding results with different weights for each hop layer during graph *** applying the WF-GCN algorithm,which adjusts weights for each hop layer before forwarding to the next,nodes with many neighbors achieve higher embedding *** approach facilitates the learning of more hop layers within the GCN *** efficacy of the WF-GCN was demonstrated through its application to various *** the MovieLens dataset,the implementation of WF-GCN in LightGCN resulted in significant performance improvements,with recall and NDCG increasing by up to+163.64%and+132.04%,***,in the *** dataset,LightGCN using WF-GCN enhanced with WF-GCN showed substantial improvements,with the recall and NDCG metrics rising by up to+174.40%and+169.95%,***,the application of WF-GCN to Self-supervised Graph Learning(SGL)and Simple Graph Contrastive Learning(SimGCL)also demonstrated notable enhancements in both recall and NDCG across these datasets.

关键词： Deep learning graph neural network graph convolution network graph convolution network model learning method recommender information systems

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An Approximation Algorithm Based on Seeding Algorithm for Fuzzy k-Means Problem with Penalties

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Journal of the Operations Research Society of China 2024年第2期12卷 387-409页

作者： Wen-Zhao Liu min Li School of Mathematics and Statistics Shandong Normal UniversityJinan 250014ShandongChina

As a classic NP-hard problem in machine learning and computational geometry,the k-means problem aims to partition the given dataset into k clusters according to the minimal squared Euclidean *** from k-means problem and most of its variants,fuzzy k-means problem belongs to the soft clustering problem,where each given data point has relationship to every center *** to fuzzy k-means problem,fuzzy k-means problem with penalties allows that some data points need not be clustered instead of being paid *** this paper,we propose an O(αk In k)-approximation algorithm based on seeding algorithm for fuzzy k-means problem with penalties,whereαinvolves the ratio of the maximal penalty value to the minimal ***,we implement numerical experiments to show the effectiveness of our algorithm.

关键词： Approximation algorithm Seeding algorithm Fuzzy k-means problem with penalties

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Different concentrations of hyaluronic acid eye drops for dry eye syndrome: a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1110-1119页

作者： Xiao-Wei Ouyang Sheng Fang Yun-min Yi Shi-Peng Zou Qi-Yu Hu Zi-Xuan Huang Qing-Xia Li jin-Yan Luo Department of Ophthalmology Nanchang Hongdu Hospital of Traditional Chinese MedicineNanchang 330000Jiangxi ProvinceChina Department of Ophthalmology Jiangxi Hospital of Integrated Traditional Chinese and Western MedicineNanchang 330000Jiangxi ProvinceChina Department of Cataract Nanchang University Affiliated Eye HospitalNanchang 330000Jiangxi ProvinceChina Department of Neuro-ophthalmology Nanchang University Affiliated Eye HospitalNanchang 330000Jiangxi ProvinceChina

AIM:To compare high or low concentration of hyaluronic acid eye drops(HY)for dry eye syndromes(DES).METHODS:Randomized controlled trials(RCTs)comparing various concentrations of HY were searched in PubMed,Embase,Web of Science,Cochrane,SinoMed,CNKI,Wanfang Database,CQVIP,and Chinese journals databases between inception and July *** standardized mean differences(SMD)or weighted mean difference(WMD)with 95%confidence intervals(CI)from RCTs evaluating Schirmer’s I test(SIT),corneal fluorescein staining score(CFS),tear breakup time(TBUT),DES score(DESS),and Ocular Surface Disease Index(OSDI)were *** analysis,Egger’s test and Meta-regression analysis were performed for all ***:We conducted a Meta-analysis of 10 RCTs that met the inclusion criteria,involving 1796 ***-concentrations group significantly improved the outcome of CFS according to random effects modelling(SMD,-3.37;95%CI,-5.25 to-1.48;P=0.0005).The rest of the results were not statistically significant,including indicators such as SIT,TBUT,DESS and ***:For dry eyes with positive corneal staining,a high concentration of HY is recommended,whereas in other cases,a high concentration of HY does not offer a more pronounced advantage over a low concentration of HY in the treatment of dry eyes.

关键词： dry eye hyaluronic acid concentration Meta-analysis

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Genomic analysis of Nypa fruticans elucidates its intertidal adaptations and early palm evolution

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Journal of Integrative Plant Biology 2024年第4期66卷 824-843页

作者： Weihong Wu Xiao Feng Nan Wang Shao Shao min Liu Fa Si Linhao Chen Chuanfeng jin Shaohua Xu Zixiao Guo Cairong Zhong Suhua Shi Ziwen He State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Greater Bay Area Institute of Precision Medicine School of Life SciencesFudan UniversityGuangzhou 511462China Hainan Academy of Forestry(Hainan Academy of Mangrove) Haikou 571100China

Nypa fruticans(Wurmb),a mangrove palm species with origins dating back to the Late Cretaceous period,is a unique species for investigating long-term adaptation strategies to intertidal environments and the early evolution of ***,we present a chromosome-level genome sequence and assembly for *** integrated the genomes of *** and other palm family members for a comparative genomic analysis,which confirmed that the common ancestor of all palms experienced a whole-genome duplication event around 89 million years ago,shaping the distinctive characteristics observed in this *** also inferred a low mutation rate for the *** genome,which underwent strong purifying selection and evolved slowly,thus contributing to its stability over a long evolutionary ***,ancient duplicates were preferentially retained,with critical genes having experienced positive selection,enhancing waterlogging tolerance in ***,we discovered that the pseudogenization of Early Methionine-labelled 1(EM1)and EM6 in *** underly its crypto-vivipary characteristics,reflecting its intertidal *** study provides valuable genomic insights into the evolutionary history,genome stability,and adaptive evolution of the mangrove *** results also shed light on the long-term adaptation of this species and contribute to our understanding of the evolutionary dynamics in the palm family.

关键词： crypto-vivipary genome stability long-term adaptation mangrove Nypa fruticans palm

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One-pot synthesis of a giant twisted double-layer chiral macrocycle via [4+8] imine condensation and its X-ray structure

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Chinese Chemical Letters 2024年第10期35卷 241-243页

作者： Yu Pang min Wang Ning-Hua Yang min Xue Yong Yang School of Science Department of PhysicsKey Laboratory of Optical Field Manipulation of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China School of Chemistry and Chemical Engineering Key Laboratory of Surface&Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou310018China

Trifluoroacetic acid(TFA)catalyzed condensation reaction between tetraaminooxacalix[4]arene and N-alkylcarbazole-3,6-dicarbaldehyde in CH_(2)Cl2afforded a single product in 87%–89%***-defined yet undissolvable1H NMR spectra suggested formation of robust and discrete structures in solution.X-ray single crystal analysis further revealed a giant twisted double-layer chiral macrocycle in the solid state,which was formed from[4+8]condensation of the two reactants via 16 imine *** calculations discovered that only the[4+8]twisted product is thermodynamically favorable,which accounts for its highly selective and efficient formation out of a library of many other combinations.

关键词： One-pot synthesis Oxacalixarene Dynamic covalent chemistry Chiral macrocycle X-ray single crystal

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Physiological and pathological functions of circular RNAs in the nervous system

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Neural Regeneration Research 2024年第2期19卷 342-349页

作者： min Zhou Shi Li Chuan Huang School of Life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

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