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The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Metaanalysis

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1128-1137页

作者： Xiao-Yan Wang Hong-Wei Deng Jian Yang Xue-Mei Zhu Feng-Ling Xiang Jing Tu Ming-Xue huang Yun Wang Jin-Hua Gan Wei-Hua Yang School of Nursing Southwest Medical UniversityLuzhou 646600Sichuan ProvinceChina Shenzhen Eye Institute Shenzhen Eye HospitalJinan UniversityShenzhen 518040Guangdong ProvinceChina Luzhou Traditional Chinese Medicine Hospital Luzhou 646000Sichuan ProvinceChina The Affiliated Hospital of Southwest Medical University Luzhou 646099Sichuan ProvinceChina

AIM:To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of ***:A systematic search was conducted across the Cochrane Library,PubMed,Web of Science,EMBASE,CNKI,CBM,VIP,and Wanfang database,encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17,*** extraction and quality assessment were performed,and a network Meta-analysis was executed using Stata version 14.0 *** were visually represented through ***:Fourteen papers comprising 2475 cases were included;five different concentrations of atropine solution were *** network Meta-analysis,along with the surface under the cumulative ranking curve(SUCRA),showed that 1%atropine(100%)>0.05%atropine(74.9%)>0.025%atropine(51.6%)>0.02%atropine(47.9%)>0.01%atropine(25.6%)>control in refraction change and 1%atropine(98.7%)>0.05%atropine(70.4%)>0.02%atropine(61.4%)>0.025%atropine(42%)>0.01%atropine(27.4%)>control in axial length(AL)***:In Chinese children and teenagers,the five various concentrations of atropine can reduce the progression of *** the network Meta-analysis showed that 1%atropine is the best one for controlling refraction and AL change,there is a high incidence of adverse effects with the use of 1%***,we suggest that 0.05%atropine is optimal for Chinese children to slow myopia progression.

关键词： atropine China children and adolescents myopia network Meta-analysis

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Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting Yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao Min huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte count<3.5×10^(9)/L over two *** Of 148 patients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

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天然虾青素的稳定性及稳态化技术研究进展

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食品工业科技 2024年第5期45卷 367-376页

作者：黄慧玲高静广东药科大学食品科学学院广东中山528458

虾青素是自然界中最强的抗氧化物质,同时兼有抗炎、抗肿瘤、调节免疫力等生理功能,在食品、药品和化妆品领域都有广泛的应用。但是,天然虾青素不稳定,在提取和储存及加工过程中容易降解。因此,提高虾青素的稳定性是当前该领域的研究热... 详细信息

虾青素是自然界中最强的抗氧化物质,同时兼有抗炎、抗肿瘤、调节免疫力等生理功能,在食品、药品和化妆品领域都有广泛的应用。但是,天然虾青素不稳定,在提取和储存及加工过程中容易降解。因此,提高虾青素的稳定性是当前该领域的研究热点之一。本文从虾青素自身结构、提取溶剂以及加工和储藏环境三个方面介绍了影响虾青素稳定性的因素和机理,并对比了现有的虾青素稳态化体系,如乳液、微胶囊、脂质体及纳米颗粒和纳米分散体的基本原理、效果及优缺点。多种虾青素稳态化体系能够不同程度地提高其水溶性、稳定性和生物利用度,但普遍存在工艺复杂、成本高等缺点。未来研究应聚焦各类稳态化技术的基础理论,借助分子模拟技术推动虾青素稳态化体系向更加高效、绿色和智能发展。

关键词：虾青素稳定性稳态化技术研究进展

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数据驱动研制发光材料的策略与挑战

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发光学报 2024年第8期45卷 1219-1231页

作者：黄霖解荣军厦门大学材料学院福建厦门361005

人工智能在高效处理数据、精准预测、自动化执行任务以及个性化服务等方面为人类的生产、生活和科学研究带来了极大的便利。机器学习与高通量计算在材料领域的广泛渗透与成功应用,也为发光材料的研制开辟了新路径——通过算法进行高效... 详细信息

人工智能在高效处理数据、精准预测、自动化执行任务以及个性化服务等方面为人类的生产、生活和科学研究带来了极大的便利。机器学习与高通量计算在材料领域的广泛渗透与成功应用,也为发光材料的研制开辟了新路径——通过算法进行高效挖掘和大规模数据处理,加速新材料的筛选与设计,进而推动材料的创新发现与应用进程。本文综述了近年来基于数据驱动发光材料研究的前沿进展,从相关研究案例出发,对数据驱动材料研究进行全流程梳理,详细阐述发光材料研制场景下数据获取阶段的重要性及实施策略,并对如何提取表征材料性能的核心特征进行分析,同时探讨发光材料领域适用的模型选择与优化方案。最后,就当前数据驱动式发光材料研究面临诸如高质量数据匮乏、复杂结构-性能关联模型构建困难的问题,从发光材料数据库平台的构建、高通量实验的实施以及相应数据生产规范的建立等方向提出突破设想。

关键词：数据驱动发光材料机器学习高通量计算发光材料数据工厂

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Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models

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Biomedical and Environmental Sciences 2024年第1期37卷 108-111页

作者： CHEN Qian Wei huang Xue Zan DING Yu ZHU Feng Ren WANG Jia ZOU Yuan Jie DU Yuan Zhen ZHANG Ya Jun HUI Zi Wen ZHU Feng Lin MU Min The Project was supported by Open Research Grant of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHefei 232001AnhuiChina School of Public Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Key Laboratory of Industrial Dust Prevention and Control Occupational Safety and HealthMinistry of EducationAnhui University of Science and TechnologyHefei 232001AnhuiChina Anhui Institute of Occupational Safety and Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Joint Research Center of Occupational Medicine and Health Institute of Grand HealthHefei Comprehensive National Science CenterAnhui University of Science and TechnologyHefei 232001AnhuiChina Department of Occupational&Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

Coal is one of the world’s main energy resources,accounting for approximately 68%of China’s current total power ***,several studies have demonstrated that dust,exhaust fumes,and other harmful factors in coal mines increase the risk of cardiovascular disease(CVD)among miners^([1]).Arterial stiffness(AS)is an independent risk factor of CVD,and epidemiological studies have shown that AS plays a vital role in assessing the risk of CVD^([2]).

关键词： Arterial cardiovascular assessing

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Effectiveness and safety of early lens extraction during par plana vitrectomy for proliferative diabetes retinopathy with mild cataract:a randomized clinical trial

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 528-536页

作者： Wei-Bo Feng Lei Zheng Ying-Qi Li Yong-Hao Li Guo-Ming Zhang Xian Wang Bing-Qian Liu Ling Jin Yi-Nuo huang Yang-Fan Yang Zi-Dong Chen Da-Hui Ma Qing-Shan Chen Chao-Jun Qin Bing-Min Feng Zhu-Min Yang Xing huang Cheng-Jie Yang Sheng-Hui Liu Ming-Xing Wu State Key Laboratory of Ophthalmology Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesZhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Shenzhen Eye Hospital Affiliated to Jinan University Shenzhen 518040Guangdong ProvinceChina The Affiliated Hospital of Guizhou Medical University Guiyang 550004Guizhou ProvinceChina Guangzhou Aier Eye Hospital Guangzhou 510000Guangdong ProvinceChina

●AIM:To evaluate the effectiveness and safety of early lens extraction during pars plana vitrectomy(PPV)for proliferative diabetic retinopathy(PDR)compared to those of PPV with subsequent cataract surgery.●METHODS:This multicenter randomized controlled trial was conducted in three Chinese hospitals on patients with PDR,aged>45y,with mild *** participants were randomly assigned to the combined(PPV combined with simultaneously cataract surgery,i.e.,phacovitrectomy)or subsequent(PPV with subsequent cataract surgery 6mo later)group and followed up for *** primary outcome was the change in best-corrected visual acuity(BCVA)from baseline to 6mo,and the secondary outcomes included complication rates and medical expenses.●RESULTS:In total,129 patients with PDR were recruited and equally randomized(66 and 63 in the combined and subsequent groups respectively).The change in BCVA in the combined group[mean,36.90 letters;95%confidence interval(CI),30.35–43.45]was significantly better(adjusted difference,16.43;95%CI,8.77–24.08;P<0.001)than in the subsequent group(mean,22.40 letters;95%CI,15.55–29.24)6mo after the PPV,with no significant difference between the two groups at *** overall surgical risk of two sequential surgeries was significantly higher than that of the combined surgery for neovascular glaucoma(17.65%vs 3.77%,P=0.005).No significant differences were found in the photocoagulation spots,surgical time,and economic expenses between two *** the subsequent group,the duration of work incapacity(22.54±9.11d)was significantly longer(P<0.001)than that of the combined group(12.44±6.48d).●CONCLUSION:PDR patients aged over 45y with mild cataract can also benefit from early lens extraction during PPV with gratifying effectiveness,safety and convenience,compared to sequential surgeries.

关键词： lens extraction pars plana vitrectomy proliferative diabetic retinopathy cataract simultaneously operations

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比特币价格风险、宏观经济波动与股市风险传染——基于分位数关联网络的分析

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中国管理科学 2024年第4期32卷 26-37页

作者：黄云洲黄炯豪夏晓华中国人民大学应用经济学院北京100872

本文以中国股市28个一级行业为研究样本,利用分位数关联方法量化各一级行业间的金融互联程度,进一步结合空间自回归模型,将比特币价格波动对中国股市造成的风险冲击分解为直接效应与间接效应,测度了比特币价格波动的风险传染效应,并从... 详细信息

本文以中国股市28个一级行业为研究样本,利用分位数关联方法量化各一级行业间的金融互联程度,进一步结合空间自回归模型,将比特币价格波动对中国股市造成的风险冲击分解为直接效应与间接效应,测度了比特币价格波动的风险传染效应,并从宏观经济层面分析了其影响因素。研究发现:比特币价格波动对股市行业收益率存在正向影响,且其可以通过行业间的分位数关联在不同行业之间扩散。此外,不同市场状态和不同频率的行业关联呈现出异质性的风险传染模式。具体而言,市场平稳状态、繁荣状态、低迷状态下的风险传染效应依次减弱;中期(周度)的比特币风险传染效应强于短期(日度)的风险传染效应;在市场平稳状态下,周度频率分位数关联网络下的风险传染效应更强。分组检验显示,较低的利率和价格水平能够显著减弱比特币价格冲击对中国股市的风险传染效应。本文的贡献有两点:第一,采用分位数关联方法构建了各一级行业收益率间的依赖结构,并描绘了不同频率和市场状态下的分位数关联网络;第二,使用空间自回归模型将风险冲击分解为直接效应和间接效应,这有助于了解分位数关联在风险传播中的作用,为制定防范比特币风险的相关政策提供了经验证据。

关键词：分位数关联比特币价格风险传染

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淤泥质海岸岬湾沙滩沙泥分界特征及机理

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河海大学学报（自然科学版） 2024年第4期52卷 78-84页

作者：黄君宝刘旭姚文伟黄世昌浙江省水利河口研究院(浙江省海洋规划设计研究院) 浙江杭州310012 浙江省河口海岸重点实验室浙江杭州310012

以浙江省淤泥质海岸岬湾沙滩为研究对象,剖析了影响沙泥分界点位置的主要因素和沙泥分界的影响机理,并提出了岬湾沙滩沙泥分界点高程计算公式。结果表明:潮位、滩前波高、沙滩坡度和潮差是影响沙泥分界点位置的主要因素;沙泥分界点深度... 详细信息

以浙江省淤泥质海岸岬湾沙滩为研究对象,剖析了影响沙泥分界点位置的主要因素和沙泥分界的影响机理,并提出了岬湾沙滩沙泥分界点高程计算公式。结果表明:潮位、滩前波高、沙滩坡度和潮差是影响沙泥分界点位置的主要因素;沙泥分界点深度与滩前1/10大波平均波高和大潮平均潮差呈正相关关系,与沙滩坡度呈负相关关系;沙泥分界点位置呈现季节性变化和年际变化,夏季沙泥分界点位置向海外移且高程下降、冬季分界点向岸上溯,2020年比2019年的沙泥分界点位置呈现向海外移、高程下降的趋势。

关键词：岬湾沙滩沙泥分界淤泥质海岸演化机理经验公式

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Algorithm of automatic identification of diabetic retinopathy foci based on ultra-widefield scanning laser ophthalmoscopy

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 610-615页

作者： Jie Wang Su-Zhen Wang Xiao-Lin Qin Meng Chen Heng-Ming Zhang Xin Liu Meng-Jun Xiang Jian-Bin Hu Hai-Yu huang Chang-Jun Lan Aier Eye Hospital(East of Chengdu) Chengdu 610051Sichuan ProvinceChina Department of Ophthalmology Chengdu First People’s HospitalChengdu 610095Sichuan ProvinceChina School of Computer and Artificial Intelligence Southwest Jiaotong UniversityChengdu 610097Sichuan ProvinceChina Chengdu Aier Eye Hospital Chengdu 610041Sichuan ProvinceChina

AIM:To propose an algorithm for automatic detection of diabetic retinopathy(DR)lesions based on ultra-widefield scanning laser ophthalmoscopy(SLO).METHODS:The algorithm utilized the FasterRCNN(Faster Regions with CNN features)+ResNet50(Residua Network 50)+FPN(Feature Pyramid Networks)method for detecting hemorrhagic spots,cotton wool spots,exudates,and microaneurysms in DR ultra-widefield *** segmentation combined with a deeper residual network FasterRCNN+ResNet50 was employed for feature extraction to enhance intelligent learning *** fusion was carried out by the feature pyramid network FPN,which significantly improved lesion detection rates in SLO fundus ***:By analyzing 1076 ultra-widefield SLO images provided by our hospital,with a resolution of 2600×2048 dpi,the accuracy rates for hemorrhagic spots,cotton wool spots,exudates,and microaneurysms were found to be 87.23%,83.57%,86.75%,and 54.94%,***:The proposed algorithm demonstrates intelligent detection of DR lesions in ultra-widefield SLO,providing significant advantages over traditional fundus color imaging intelligent diagnosis algorithms.

关键词： diabetic retinopathy ultra-widefield scanning laser ophthalmoscopy intelligent diagnosis system

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SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

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Current Medical Science 2024年第1期44卷 134-143页

作者： Yan-ni MA Yun-ding ZOU Zhi-long LIU Gui-xian WU Yuan-ze ZHOU Cheng-xin LUO Xiang-tao huang Ming-ling XIE Shuang-nian XU Xi LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hematology the Third Affiliated Hospital(Daping Hospital)Third Military Medical University(Army Medical University)Chongqing 400042China

Objective SUMO-specific protease 3(SENP3),a member of the SUMO-specific protease family,reverses the SUMOylation of SUMO-2/3 *** of SENP3 has been proven to be involved in the development of various ***,its role in mantle cell lymphoma(MCL),a highly aggressive lymphoma,remains *** study was aimed to elucidate the effect of SENP3 in *** The expression of SENP3 in MCL cells and tissue samples was detected by RT-qPCR,Western blotting or *** cells with stable SENP3 knockdown were constructed using short hairpin *** proliferation was assessed by CCK-8 assay,and cell apoptosis was determined by flow *** sequencing(mRNA-seq)was used to investigate the underlying mechanism of SENP3 knockdown on MCL development.A xenograft nude mouse model was established to evaluate the effect of SENP3 on MCL growth in *** SENP3 was upregulated in MCL patient samples and *** of SENP3 in MCL cells inhibited cell proliferation and promoted cell ***,the canonical Wnt signaling pathway and the expression of Wnt10a were suppressed after SENP3 ***,the growth of MCL cells in vivo was significantly inhibited after SENP3 knockdown in a xenograft nude mouse *** SENP3 participants in the development of MCL and may serve as a therapeutic target for MCL.

关键词： mantle cell lymphoma SENP3 cell proliferation apoptosis

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