检索结果-南通市图书馆

Topic Modeling Analysis of Chinese Medicine Literature on Gastroesophageal Reflux Disease: Insights into Potential Treatment

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CHINESE JOURNAL OF INTEGRATIVE MEDICINE 2024年第12期30卷 1128-1136页

作者： Qian, Jia-nan Kang, Yan-lan he, you-cheng Hu, Hong-yi Shanghai Univ Tradit Chinese Med Longhua Hosp Dept Gastroenterol Shanghai 200032 Peoples R China Shanghai Univ Tradit Chinese Med Longhua Hosp Inst Digest Dis Shanghai 200032 Peoples R China Fudan Univ Inst AI & Robot Acad Engn & Technol Shanghai 200433 Peoples R China Longhua Hosp Ctr Clin Evaluat Shanghai 200032 Peoples R China

ObjectiveTo analyze Chinese medicine (CM) prescriptions for gastroesophageal reflux disease (GERD), we model topics on GERD-related classical CM literature, providing insights into the potential *** guidelines were used to identify symptom terms for GERD, and CM literature from the database "Imedbooks" was retrieved for related prescriptions and their corresponding sources, indications, and other information. BERTopic was applied to identify the main topics and visualize the *** total of 36,207 entries are queried and 1,938 valid entries were acquired after manually filtering. Eight topics were identified by BERTopic, including digestion function abate, stomach flu, respiratory-related symptoms, gastric dysfunction, regurgitation and gastrointestinal dysfunction in pediatric patients, vomiting, stroke and alcohol accumulation are associated with the risk of GERD, vomiting and its causes, regurgitation, epigastric pain, and symptoms of *** modeling provides an unbiased analysis of classical CM literature on GERD in a time-efficient and scale-efficient manner. Based on this analysis, we present a range of treatment options for relieving symptoms, including herbal remedies and non-pharmacological interventions such as acupuncture and dietary therapy.

关键词： gastroesophageal reflux disease BERTopic prescription topic modeling Chinese medicine

Repetitive transcranial magnetic stimulation promotes neurological functional recovery in rats with traumatic brain injury by upregulating synaptic plasticity-related proteins

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Neural Regeneration Research 2023年第2期18卷 368-374页

作者： Fang-Fang Qian you-Hua he Xiao-Hui Du Hua-Xiang Lu Ren-Hong he Jian-Zhong Fan Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Comprehensive Ward Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Studies have shown that repetitive transcra nial magnetic stimulation(rTMS)can enhance synaptic plasticity and improve neurological *** r,the mechanism through which rTMS can improve moderate traumatic brain injury remains poorly *** this study,we established rat models of moderate traumatic brain injury using Feeney's weight-dropping method and treated them using *** help determine the mechanism of action,we measured levels of seve ral impo rtant brain activity-related proteins and their *** the injured side of the brain,we found that rTMS increased the protein levels and mRNA expression of brain-derived neurotrophic factor,tropomyosin receptor kinase B,N-methyl-D-aspartic acid receptor 1,and phosphorylated cAMP response element binding protein,which are closely associated with the occurrence of long-term *** also partially reve rsed the loss of synaptophysin after injury and promoted the remodeling of synaptic *** findings suggest that upregulation of synaptic plasticity-related protein expression is the mechanism through which rTMS promotes neurological function recovery after moderate traumatic brain injury.

关键词： brain-derived neurotrophic factor moderate traumatic brain injury neurological dysfunction neurological improvement N-methyl-D-aspartic acid receptor repetitive transcranial magnetic stimulation synaptic plasticity synaptophysin traumatic brain injury TrkB

Antibody response and therapy in COVID-19 patients: what can be learned for vaccine development?

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Science China(Life Sciences) 2020年第12期63卷 1833-1849页

作者： Ligong Lu Hui Zhang Meixiao Zhan Jun Jiang Hua Yin Danielle JDauphars Shi-you Li Yong Li you-Wen he Zhuhai Interventional Medical Center Zhuhai Precision Medical CenterZhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China First Affiliated Hospital China Medical UniversityShenyang 110001China tricision Biotherapeutic Inc. Zhuhai 519041China Department of Immunology Duke University Medical University Medical CenterDurhamNC 27710USA

The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has infected millions of people and caused tremendous morbidity and mortality worldwide. Effective treatment for coronavirus disease 2019(COVID-19) due to SARSCoV-2 infection is lacking, and different therapeutic strategies are under testing. Host humoral and cellular immunity to SARSCoV-2 infection is a critical determinant for patients’ outcomes. SARS-CoV-2 infection results in seroconversion and production of anti-SARS-CoV-2 antibodies. The antibodies may suppress viral replication through neutralization but might also participate in COVID-19 pathogenesis through a process termed antibody-dependent enhancement. Rapid progress has been made in the research of antibody response and therapy in COVID-19 patients, including characterization of the clinical features of antibody responses in different populations infected by SARS-CoV-2, treatment of COVID-19 patients with convalescent plasma and intravenous immunoglobin products, isolation and characterization of a large panel of monoclonal neutralizing antibodies and early clinical testing, as well as clinical results from several COVID-19 vaccine candidates. In this review, we summarize the recent progress and discuss the implications of these findings in vaccine development.

关键词： COVID-19 seroconversion neutralizing antibody spike protein SARS-CoV-2 convalescent plasma vaccine

Topology optimization of on-chip integrated laser-driven particle accelerator

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Nuclear Science and Techniques 2022年第9期33卷 126-136页

作者： Yang-Fan he Bin Sun Ming-Jiang Ma Wei Li Qiang-you he Zhi-Hao Cui Shao-Yi Wang Zong-Qing Zhao Laser Fusion Research Center CAEPP.O.Box 919986Mianyang 621900China The Sciences and Technology on Plasma Physics Laboratory CAEPMianyang 621900China Department of Plasma Physics and Fusion Engineering CAS Key Laboratory of Geospace EnvironmentUniversity of Science and Technology of ChinaHefei 230026China The Institute of Optics University of RochesterRochesterNY 14627USA

Particle accelerators are indispensable tools in both science and ***,the size and cost of conventional RF accelerators limits the utility and scope of this *** research has shown that a dielectric laser accelerator(DLA)made of dielectric structures and driven at optical frequencies can generate particle beams with energies ranging from MeV to GeV at the tabletop *** design DLA structures with a high acceleration gradient,we demonstrate topology optimization,which is a method used to optimize the material distribution in a specific area based on given load conditions,constraints,and performance *** demonstrate the effectiveness of this approach,we propose two schemes and design several acceleration structures based on *** optimization results demonstrate that the proposed method can be applied to structure optimization for on-chip integrated laser accelerators,producing manufacturable structures with significantly improved performance compared with previous size or shape optimization *** results provide new physical approaches to explore ultrafast dynamics in matter,with important implications for future laser particle accelerators based on photonic chips.

关键词： Laser-driven particle acceleration Dielectric grating accelerator Inverse Smith-Purcell effect Topology optimization

Spray Deposition Behavior and Numerical Simulation of Growth of Tubular Preform in Spray Forming Process

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Journal of Iron and Steel Research International 2012年第2期19卷 28-35页

作者： XIANG Jin-zong ZHANG Yin FAN Wen-jun WANG Ping he you-duo Inner Mongolia Key Laboratory for Utilization of Bayan Obo Multi-Metallic Resources： Elected State KeyLaboratory Inner Mongolia University of Science and Technology Baotou 014010 Inner Mongolia China Anhui Shoukuang-Dachang Metal Materials Co Ltd Luran 237400 Anhui China

Analysis on the deposition behavior of spray on deposition surface was made and an optimization method for the movement parameters （u, ω） of substrate was obtained. Simultaneously, a mathematical model of growth of tubular preform, specifically aimed at the kind of atomizer that is fixed and with a tilt angle was established. By in- tegrating the optimization method and the mathematical model, the growth process and shape of preform were simu- lated. The results show that the tilt angle of atomizer plays an important role on the dimensions and shapes of tubular preforms and it can provide a guidance for the development of spray forming equipment.

关键词： spray deposition behavior parameters optimization tubular preform~ growth process

Study on the Interaction between CdSe Quantum Dots and Bovine Serum Albumin with Ultraviolet Visible Absorption Spectroscopy

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Chinese Chemical Letters 2006年第7期17卷 961-964页

作者： he you HAN De Hong HU Jian Gong LIANG Zong Hai SheNG College of Science MOA Key Laboratory of Food Safety Evaluation Huazhong Agricultural University Wuhan 430070

The interaction of CdSe quantum dots （QDs） with bovine serum albumin （BSA） has been investigated with ultraviolet visible absorption spectroscopy （UVAS）. It was found that the absorption intensity of CdSe QDs significantly decreased after adding BSA solution, showing that CdSe QDs were bonded to BSA. The binding molar ratio was 1：1 and the binding constant was 9.7 × 10^6 L mol^-1.

关键词： CdSe quantum dots bovine serum albumin interaction.

Determination of Some CarbonylCarboxylic Acids Using Chemiluminescent Reaction of Ru (bipy)_3^(2+)-Ce (Ⅳ)

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Wuhan University Journal of Natural Sciences 1999年第3期4卷 326-330页

作者： Han he-you he Zhi-ke Li Xiao-yan Zeng Yun’e Wuhan University College of Chemistry Wuhan China (GRID:grid.49470.3e) (ISNI:***)

A coupled chemiluminescence method for the determination of some carhoxylic acids was devel-oped, based on their enhancement the chemiluminescence light emission of the reaction of tirs(2, 2'-bipyri-dine) ruthenium(Ⅱ) and Ce(Ⅳ) in sulfuric acid medium. The conditions for their determination were opti-mized. The following detection limits were obtained: oxalic acid, 2. 67×10-8 mol/L; propandioic acld, 1.20×10-6 mol/L; pyruvic acid, 1. 35 ×10-8 mol/L; citric acid, 5.10×10-8. mol/L; barbituric acid, 2.48×10-7,mol/L. The proposed method was successfully applied to determination or oxalic acid. The coupled chemilu-minescent reaction mechanism and rate equation are proposed.

关键词： chemiluminescence Ru(bipy)_3^(2+) carbonyl carboxylic acid Ce(Ⅳ)

Design and Implementation of Signal Generator and Real-time Analysis System

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Design and Implementation of Signal Generator and Real-time ...

Effect of parallel resonance on the electron energy distribution function in a 60 MHz capacitively coupled plasma

第25届中国控制与决策会议

作者： Song Jie Yuan Hang Guan Chengbin Long Teng he you School of Information and Electronics Beijing Institute of Technology Research Institute of Information Fusion Naval Aeronautical and Astronautical University

ISBN: (纸本)9781467355339

A FPGA-based two-channel low frequency signal generator and analysis system has been designed to analyze the occurrence and analysis of low frequency signal. It uses FPGA for low frequency signal producing control chip module and analysis module. Control signal is sent to the FPGA by keys, FPGA generates frequency range step adjustable low frequency signal. Through the adder, fast Fourier transform is used to extract frequency domain signal by analysis module FPGA, the oscilloscope measures frequency amplitude and other information, to achieve low frequency signal frequency domain analysis capabilities. The system whose encapsulation is compact has friendly interface and it is very easy to operate and demonstrate.

关键词： FPGA signal generation fast Fourier transform frequency domain analysis

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Plasma Science and Technology 2023年第4期25卷 69-78页

作者： you he Yeong-Min LIM Jun-Ho LEE Ju-Ho KIM Moo-young LEE Chin-Wook CHUNG Department of Electrical Engineering Hanyang University17 Haengdang-dongSeongdong-guSeoul 133-791Republic of Korea Department of Nanoscale Semiconductor Engineering Hanyang University17 Haengdang-dongSeongdong-guSeoul 133-791Republic of Korea

In general,as the radio frequency(RF)power increases in a capacitively coupled plasma(CCP),the power transfer efficiency decreases because the resistance of the CCP *** this work,a parallel resonance circuit is applied to improve the power transfer efficiency at high RF power,and the effect of the parallel resonance on the electron energy distribution function(EEDF)is investigated in a 60 MHz *** CCP consists of a power feed line,the electrodes,and *** reactance of the CCP is positive at 60 MHz and acts like an inductive load.A vacuum variable capacitor(VVC)is connected in parallel with the inductive load,and then the parallel resonance between the VVC and the inductive load can be *** the capacitance of the VVC approaches the parallel resonance condition,the equivalent resistance of the parallel circuit is considerably larger than that without the VVC,and the current flowing through the matching network is greatly ***,the power transfer efficiency of the discharge is improved from 76%,70%,and 68%to 81%,77%,and 76%at RF powers of 100 W,150 W,and 200 W,*** parallel resonance conditions,the electron heating in bulk plasma is enhanced,which cannot be achieved without the VVC even at the higher RF *** enhancement of electron heating results in the evolution of the shape of the EEDF from a biMaxwellian distribution to a distribution with the smaller temperature difference between high-energy electrons and low-energy *** to the parallel resonance effect,the electron density increases by approximately 4%,18%,and 21%at RF powers of 100 W,150 W,and 200 W,respectively.

关键词： capacitively coupled plasma parallel resonance electron energy distribution function