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Comparison of RECIST version 1.0 and 1.1 in assessment of tumor response by computed tomography in advanced gastric cancer

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Chinese Journal of Cancer Research 2013年第6期25卷 689-694页

作者： Gil-Su Jang Min-Jeong Kim Hong-Il Ha Jung han Kim Hyeong Su Kim Sung bae Ju Dae young Zang Department of Internal Medicine Hallym University Sacred Heart Hospital Department of Diagnostic Radiology Hallym University Sacred Heart Hospital Department of Internal Medicine Kangnam Sacred Heart Hospital

Objective： Response Evaluation Criteria in Solid Tumors （RECIST） guideline version 1.0 （RECIST 1.0） was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure. With a number of issues being raised on RECIST 1.0, however, a revised RECIST guideline version 1.1 （RECIST 1.1） was proposed by the RECIST Working Group in 2009. This study was conducted to compare CT tumor response based on RECIST 1.1 vs. RECIST 1.0 in patients with advanced gastric cancer （AGC）. Methods： We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010. These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using the κ statistic. Results： The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0 （P〈0.0001）. However, there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0 0（κ=0.844）. The overall response rates （ORRs） according to RECIST 1.0 and RECIST 1.1 were 32.7% （20/61） and 34.5% （20/58）, respectively. One patient with partial response （PR） based on RECIST 1.0 was reclassified as stable disease （SD） by RECIST 1.1. Of two patients with SD by RECIST 1.0, one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1. Conclusions： RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC.

关键词： Response Evaluation Criteria in Solid Tumors guideline version 1.0 (RECIST 1.0) ResponseEvaluation Criteria in Solid Tumors guideline version 1.1 (RECIST 1.1) gastric cancer tumor response

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Development of a hand Exoskeleton System for Quantitative Analysis of hand Functions

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Journal of Bionic Engineering 2018年第5期15卷 783-794页

作者： Jeongsoo Lee Minhyuk Lee Joonbum bae Bio-Robotics and Control (BiRC) Laboratory Department of Mechanical Engineering UNIST Ulsan Republic of Korea

This paper proposes a hand exoskeleton system for evaluating hand functions. To evaluate hand functions, the hand exoskeleton system must be able to pull each finger joint, measure the finger joint angle and exerted force on the finger simultaneously. The proposed device uses serially connected 4-bar linkage structures, which have two embedded actuators with encoders and two loadcells per finger, to move each phalanx independently and measure the finger joint angles. A modular design was used for the exoskeleton, to facilitate the removal of unnecessary modules in different experiments and improve convenience. Silicon was used on the surface of the worn part to reduce the skin irritation that results from prolonged usage. This part was also designed to be compatible with various finger thicknesses. Using the proposed hand exoskeleton system, finger independence, multi-finger synergy, and finger joint stiffness were determined in five healthy subjects. The finger movement and force data collected in the experiments were used for analyzing three hand functions based on the physical and physiological phenomena.

关键词： evaluation of hand function hand rehabilitation wearable system exoskeleton

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Urgent ERCP for acute cholangitis reduces mortality and hospital stay in elderly and very elderly patients

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Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 619-625页

作者： Chan Sun Park Hee Seok Jeong Ki bae Kim Joung-Ho han Hee Bok Chae Sei Jin youn Seon Mee Park Department of Internal Medicine Chungbuk National University College of Medicine

BACKGROUND： Acute cholangitis in old people is a cause of mortality and prolonged hospital stay. We evaluated the effects of methods and timing of biliary drainage on the outcomes of acute cholangitis in elderly and very elderly patients. METHODS： We analyzed 331 patients who were older than 75 years and were diagnosed with acute calculous cholangitis. They were admitted to our hospital from 2009 to 2014. Patients＇ demographics, severity grading, methods and timing of biliary drainage, mortality, and hospital stay were retrospectively obtained from medical records. Clinical parameters and outcomes were compared between elderly （75-80 years, n= 156） and very elderly （≥81 years, n=175） patients. We analyzed the effects of methods [none, endoscopic retrograde cholangio- pancreatography （ERCP）, percutaneous transhepatic biliary drainage, or failure] and timing （urgent or early） of biliary drainage on mortality and hospital stay in these patients. RESULTS： Acute cholangitis in older patients manifested as atypical symptoms characterized as infrequent Charcot＇s triad （4.2%） and comorbidity in one-third of the patients. Patients were graded as mild, moderate, and severe cholangitis in 104 （31.4%）, 175 （52.9%）, and 52 （15.7%）, respectively. Urgent bili-ary drainage （≤24 hours） was performed for 80.5% （247/307） of patients. Very elderly patients tended to have more severe grades and were treated with sequential procedures of transient hiliary drainage and stone removal at different sessions. Hospital stay was related to methods and timing of biliary drainage. Mortality was very low （1.5%） and not related to patient age but rather to the success or failure of biliary drainage and severity grading of the acute cholangitis. CONCLUSIONS： The methods and timing used for biliary drainage and severity of cholangitis are the major determinants of mortality and hospital stay in elderly and very elderly patients with acute cholangitis. Urgent successful ERCP is mandatory for favorable

关键词： acute cholangitis biliary drainage prognosis elderly very elderly

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Analysis of Finger Muscular Forces using a Wearable hand Exoskeleton System

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Journal of Bionic Engineering 2017年第4期14卷 680-691页

作者： Suin Kim Jeongsoo Lee Joonbum bae Department of Mechanical Engineering UNIST Ulsan Korea

In this paper, the finger muscular forces were estimated and analyzed through the application of inverse dynamics-based static optimization, and a hand exoskeleton system was designed to pull the fingers and measure the dynamics of the hand. To solve the static optimization, a muscular model of the hand flexors was derived. The experimental protocol was devised to analyze finger flexors in order to evaluate spasticity of the clenched fingers; muscular forces were estimated while the flexed fingers were extended by the exoskeleton with external loads applied. To measure the finger joint angles, the hand exoskeleton system was designed using four-bar linkage structure and potentiometers. In addition, the external loads to the fingertips were generated by cable driven actuators and simultaneously measured by loadcells which were located at each phalanx. The ex- periments were performed with a normal person and the muscular forces estimation results were discussed with reference to the physical phenomena.

关键词： hand rehabilitation wearable system bionic exoskeleton musculoskeletal model inverse dynamics static opti-mization

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Measurement of alumina film induced ablation of internal insulator in solid rocket environment

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Defence Technology（防务技术） 2023年第11期29卷 181-192页

作者： Ji-Yeul bae In Sik Hwang Yoongoo Kang Agency for Defense Development 160488th Bukyuseong-streetDaejeonSouth Korea

This study investigates the ablation of internal insulation induced by the deposition of an alumina film with different lateral film speeds.A sub-scale test solid rocket motor(SRM)was designed in an impinging jet configuration to form an alumina film on the sample and to encourage the lateral movement of the film by a high-speed wall *** static fire tests of the test SRM were conducted with six different jet velocities(V_(jet)=100 m/s,150 m/s,200 m/s,268 m/s,330 m/s,and 450 m/s)that indirectly affected the velocity of the wall jet and the deposition rate of alumina *** ablation velocity was deduced from the difference in the sample thickness after a test using a coordinate measuring *** droplet deposition mass flux and wall jet velocity were obtained via two-phase flow simulation with the same jet velocity and effective *** a result,the characteristics of alumina-induced ablation and the changes in ablation with jet velocities were *** area within0.8×jet diameter was focused upon,where the ratio of ablation velocity to incoming alumina mass was constant for each jet velocity,and showed a similarity in jet *** the ablation velocity was increased from 2.05 to 9.98 mm/s with increasing jet velocity,the ratio of the ablation velocity and alumina mass flux decreased from 1.07×10^(-4)to 0.49×10^(-4)m^(3)/kg as Al_(2)O_(3)-C reactions became less efficient with a reduced residence time of the *** the decrease in residence time by the wall jet is more pronounced for slow reactions involved in Al_(2)O_(3)-C reactions,fast reactions in Al_(2)O_(3)-C reactions are less affected and result in a convergence of the volumetric rate of ablation per unit mass of alumina.

关键词： Internal insulation Solid rocket motor Ablation Alumina

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Effect of Cristobalite and Quartz on the Properties of Gypsum Bonded Investment

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Journal of Materials Science & Technology 2008年第1期24卷 143-144页

作者： Yun-Jong Kim Sang-bae Kim Hyun-Hye Park Myeong-Deok Seo Byoung-Cheon Lee Man-So han Taik-Nam Kim Sung-baek Cho Korea Institute of Geoscience and Mineral Resources (KIGAM) Gajeong-dong 30 Yuseong-kuDaejeon 305-350Korea Department of Materials Engineering Graduate School Paichai UniversityDaejeon 302-735Korea Dept.of Dental Laboratory Technology Daejeon Health Science College Korea

Generally the gold investment material consists of cristobalite,quartz and *** physical property of gold investment materials depends on its thermal expansion coefficients,compressive strength,and particles size *** the thermal expansion coefficient of cristobalite and quartz are 2.6×10^-6/℃and 2.32×10^-6/℃respectively,the composition ratio of each components influence the thermal and physical properties of gold investment *** the clinical applications,it is necessary to improve the properties of gold investment materials such as homogeneous size distribution and thermal expansion *** the present study,effect of inorganic fillers such as cristobalite and quartz on gold alloy investment was investigated to improve the properties of *** compressive strength and thermal expansion coefficients of the specimens were *** results showed that cristobalite and quartz were homogeneously distributed by milling. The optimum compressive strength was obtained at the ratio of 42：22 cristobalite and quartz,respectively.

关键词： Investment Cristobalite Quartz Thermal expansion coefficient Compressivestrength

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Use of oral contraceptives and risk of pancreatic cancer in women:A recalculated meta-analysis of prospective cohort studies

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World Journal of Gastroenterology 2021年第48期27卷 8374-8377页

作者： Jong-Myon bae Preventive Medicine Jeju National University College of MedicineJeju-si 63243Jeju ProvinceSouth Korea

In a recent systematic review and meta-analysis of observational studies,the author found potential errors in the selection and extraction *** recalculated summary relative risks and the results of a dose-response met... 详细信息

关键词： Pancreas neoplasms Oral contraceptives Risk factor Meta-analysis Risk assessment Systematic review

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Near-infrared fluorescence imaging guided surgery in colorectal surgery

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World Journal of Gastroenterology 2022年第12期28卷 1284-1287页

作者： Sung Uk bae Department of Surgery School of MedicineDongsan Medical CenterKeimyung UniversityDaegu 700-712South Korea

Near infrared fluorescence using indocyanine green is beneficial for visual assessment of blood vessels,blood flow,and tissue perfusion,sentinel lymph node biopsy,lymph node road mapping,identification of the vascular system round the major vessels,and the detection of ureters in order to reduce the risk of iatrogenic ureteral lesions in colorectal surgery.

关键词： Fluorescence Enhanced reality Anastomotic leak Lymph node Anastomosis

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Factors affecting photocatalytic performance through the evolution of the properties due to the phase transition from NaBiO_(3)·2H_(2)O to BiO_(2−x)

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Frontiers in Energy 2022年第3期16卷 471-482页

作者： Haoxuan Ma Yuefa Jia Jongseong bae Chunli Liu Department of Physics and Oxide Research Center Hankuk University of Foreign StudiesYongin17035Republic of Korea Busan Center Korea Basic Science InstituteBusan46742Republic of Korea

The phase transition process of a photocatalytic system from NaBiO_(3)·2H_(2)O to BiO_(2−x) has been investigated to understand the important factors that affect photocatalytic performance in a composite system. It is found that a proper amount of BiO2−x on the surface of NaBiO_(3)·2H_(2)O could effectively suppress the electron/hole recombination and increase the exposed reactive sites for photocatalytic reaction. A fully covered BiO2−x on NaBiO3·2H2O results in a dramatical decrease of photocatalytic degradation of dye. An over long hydrothermal process can result in BiO_(2−x) with reduced oxygen vacancies, which degrades the photocatalytic activity. Furthermore, the photocatalytic reduction ability of CO_(2) conversion has been investigated, indicating that the surface activity to different reactants also directly affects the catalytic performance. The investigation of the gradient phase transition process presents a clear guidance to construct a desired photocatalytic system, in addition to selecting gradient materials with suitable bandgap structure and a morphology with different fraction and distribution of each component. The defect evolution of each component during construction of a composite is also an important factor that should be optimized and considered in making a composite to achieve high photocatalytic efficiency.

关键词： composite construction distribution BiO2−x evolution of defects

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Suppression of Chaotic Behaviors in a Complex Biological System by Disturbance Observer-based Derivative-Integral Terminal Sliding Mode

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IEEE/CAA Journal of Automatica Sinica 2020年第1期7卷 126-135页

作者： Dianwei Qian Hui Ding SukGyu Lee Hyansu bae School of Control and Computer Engineering North China Electric Power UnverisityBeijing 102206China Department of Anesthesia Shaanxi Provincial People’s HospitalXi’anChina Department of Electrical Engineering Yeungnam UniversityGyeongsanRepublic of Korea

Coronary artery systems are a kind of complex biological systems. Their chaotic phenomena can lead to serious health problems and illness development. From the perspective of engineering, this paper investigates the chaos suppression problem. At first, nonlinear dynamics of coronary artery systems are presented. To suppress the chaotic phenomena, the method of derivative-integral terminal sliding mode control is adopted. Since coronary artery systems suffer from uncertainties, the technique of disturbance observer is taken into consideration. The stability of such a control system that integrates the derivative-integral terminal sliding mode controller and the disturbance observer is proven in the sense of Lyapunov. To verify the feasibility and effectiveness of the proposed strategy, simulation results are illustrated in comparison with a benchmark.

关键词： Biological systems chaos suppression coronary artery nonlinear dynamics sliding mode control(SMC)

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