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High energy density physics research at IMP,Lanzhou, China

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High Power Laser Science and Engineering 2014年第4期2卷 17-21页

作者： Yongtao zhao Rui cheng yuyu Wang Xianming Zhou yu lei yuanbo Sun ge Xu Jieru Ren Lina Sheng Zimin Zhang Guoqing Xiao Institute of Modern Physics Chinese Academy of Sciences

Recent research activities relevant to high energy density physics(HEDP) driven by the heavy ion beam at the Institute of Modern Physics, Chinese Academy of Sciences are presented. Radiography of static objects with the fast extracted high energy carbon ion beam from the Cooling Storage Ring is discussed. Investigation of the low energy heavy ion beam and plasma interaction is reported. With HEDP research as one of the main goals, the project HIAF(High Intensity heavy-ion Accelerator Facility), proposed by the Institute of Modern Physics as the 12 th five-year-plan of China, is introduced.

关键词： heavy ion beam high energy density physics ion beam and plasma interaction radiography

Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction

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Signal Transduction and Targeted Therapy 2022年第2期7卷 502-518页

作者： Zhen Wang Fan-lian Zeng Ya-wen Hu Xiao-yan Wang Fu-lei zhao pei Zhou Jing Hu yuan-yuan Xiao Zhong-lan Hu Ming-feng Guo Xiao-qiong Wei Xiao Liu Nong-yu Huang Jun Zhang Shu-wen chen Juan cheng Hua-ping Zheng Hong Zhou Qi-xiang zhao chen Zhang Yan Hao Song Zou Yi-yue Gui Jia-dong yu Lin-na Gu cheng-cheng yue Hao-zhou Zhang Wen-ling Wu Yi-fan Zhou Xi-kun Zhou Guo-bo Shen Xiu Teng Jiong Li State Key Laboratory of Biotherapy and Cancer Center West China HospitalWest China Medical SchoolSichuan University and Collaborative Innovation Center for BiotherapyChengduSichuan 610041China Department of Liver Surgery&Liver Transplantation West China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuan 610041China Laboratory of Liver Surgery West China HospitalSichuan UniversityChengduSichuan 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengdu 610041China Department of Cardiovascular Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Laboratory of Human Disease and Immunotherapies West China HospitalSichuan UniversityChengduSichuan 610041China

Interleukin-37b(hereafter called IL-37)was identified as fundamental inhibitor of natural and acquired *** molecular mechanism and function of IL-37 in colorectal cancer(CRC)has been ***,we found that IL-37 transgenic(IL-37tg)mice were highly susceptible to colitis-associated colorectal cancer(CAC)and suffered from dramatically increased tumor burdens in ***,IL-37 is dispensable for intestinal mutagenesis,and CRC cell proliferation,apoptosis,and ***,IL-37 dampened protective cytotoxic T cell-mediated immunity in CAC and B16-OVA ***8^(+)T cell dysfunction is defined by reduced retention and activation as well as failure to proliferate and produce cytotoxic cytokines in IL-37tg mice,enabling tumor evasion of immune *** dysfunction led by IL-37 antagonizes IL-18–induced proliferation and effector function of CD8+T cells,which was dependent on SIGIRR(single immunoglobulin interleukin-1 receptor-related protein).Finally,we observed that IL-37 levels were significantly increased in CRC patients,and positively correlated with serum CRC biomarker CEA levels,but negatively correlated with the CD8+T cell infiltration in CRC *** findings highlight the role of IL-37 in harnessing antitumor immunity by inactivation of cytotoxic T cells and establish a new defined inhibitory factor IL-37/SIGIRR in cancerimmunity cycle as therapeutic targets in CRC.

关键词： immunity cytotoxic Interleukin

Distribution patterns of landslides triggered by the 2022 Ms 6.8 Luding earthquake,Sichuan,China

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Journal of Mountain Science 2023年第3期20卷 607-623页

作者： ZHANG Jian-qiang YANG Zong-ji MENG Qing-kai WANG Jiao HU Kai-heng ge Yong-gang SU Feng-huan zhao Bo ZHANG Bo JIANG Ning HUANG yu MING Zai-yang ZHANG Yi-fan LIU Zhen-xing WU Chun-hao ZHOU Wen-tao LIANG Xin-yue SUN yu-qing YANG Lian-bing YAO Hong-kun FENG pei-hua LIU Jia-li Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Bejing 100049China East China University of Technology Nanchang 330013China Institute of geographic Sciences and Natural Resources Research Beijing 100101China Chongqing Jiaotong University Chongqing 400074China

At 12:52 pm on September 5,2022,an Ms 6.8 earthquake occurred in Luding County,Sichuan Province,*** on high-resolution aerial photographs and satellite imageries obtained after the earthquake,as well as field investigation,a total of 8685 earthquake-triggered landslides(EQTLs)were *** landslides covered an area of 30.7km^(2),with a source area of 9.4 km^(2).These EQTLs were mainly distributed in areas with a seismic intensity of VIII and *** of the landslides were small and medium in size,and their types included landslide,rockfall,and rock *** landslide distributions were found,EQTLs were distributed along the Xianshuihe fault,landslide area decreased gradually with an increased distance to the fault;EQTLs were distributed along the Daduhe River and roads;besides,landslide distribution was associated with ground deformation caused by the ***’characteristics indicated that,a large number of EQTLs were located near the foot of the slope;the full area of EQTLs and their source area followed a power *** study concluded that Luding EQTLs were greater in number and area but relatively smaller in terms of affected *** on geo-hazards post-earthquake and risk assessment were proposed in the earthquake-stricken area to support the rehabilitation and reconstruction.

关键词： 2022 Luding earthquake Earthquaketriggered landslide Landslide inventory Distribution patterns

丝裂原活化蛋白激酶磷酸酶1与胰腺癌细胞获得性耐药的关系

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中华外科杂志 2006年第7期44卷 473-475页

作者：郭俊超赵玉沛廖泉陈革朱预中国医学科学院中国协和医科大学北京协和医院基本外科 100730

目的探讨丝裂原活化蛋白激酶(MAPK)磷酸酶1(MKP-1)在介导胰腺癌耐药细胞株SW 1990/Fu产生获得性耐药过程中的可能机制。方法采用Northern印迹杂交和W estern蛋白免疫印迹杂交方法,检测MKP-1在体外诱导建立的人胰腺癌耐药细胞株SW 1990/F... 详细信息

目的探讨丝裂原活化蛋白激酶(MAPK)磷酸酶1(MKP-1)在介导胰腺癌耐药细胞株SW 1990/Fu产生获得性耐药过程中的可能机制。方法采用Northern印迹杂交和W estern蛋白免疫印迹杂交方法,检测MKP-1在体外诱导建立的人胰腺癌耐药细胞株SW 1990/Fu、亲本细胞株SW 1990和胰腺癌细胞株M iaPaCa-2中的表达,分析MKP-1在SW 1990/Fu产生获得性耐药前后的变化。结果Northern印迹杂交结果显示,在SW 1990/Fu、SW 1990和M iaPaCa-2细胞株中均检测到2400 bp的MKP-1 mRNA,MKP-1在SW 1990/Fu的表达水平明显低于SW 1990和M iaPaCa-2。在蛋白水平上,W estern蛋白免疫印迹杂交结果也表明,与SW 1990和M iaPaCa-2相比,MKP-1蛋白在SW 1990/Fu细胞中的表达水平明显降低。结论MAPK家族的关键调节酶MKP-1可能参与SW 1990/Fu获得性耐药的产生,推测细胞信号转导系统的改变可能是导致胰腺癌细胞产生获得性耐药的机制之一。

关键词：胰腺肿瘤抗药性丝裂原活化蛋白激酶

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FeB_N(N≤6)团簇的结构与磁性

物理学报 2007年第5期56卷 2590-2595页

作者：杨致闫玉丽赵文杰雷雪玲葛桂贤罗有华河南大学理论物理研究所开封475001

利用密度泛函理论中的广义梯度近似(GGA),在考虑自旋多重度后,预测了FeBN(N≤6)团簇的基态结构.结果表明基态团簇的自旋多重度分别为4,3,2,1,2和1,其中FeB4团簇比较稳定.同时对FeBN(N≤6)基态团簇的磁性做了系统地研究,发现除了FeB5团簇... 详细信息

利用密度泛函理论中的广义梯度近似(GGA),在考虑自旋多重度后,预测了FeBN(N≤6)团簇的基态结构.结果表明基态团簇的自旋多重度分别为4,3,2,1,2和1,其中FeB4团簇比较稳定.同时对FeBN(N≤6)基态团簇的磁性做了系统地研究,发现除了FeB5团簇外,FeBN(N≤6)团簇的总磁矩和Fe原子磁矩随团簇尺寸的增大而减小.

关键词： FeBN团簇自旋多重度磁矩

Effect of edaravone in combined with rTMS on the free radicals and neurological function in patients with cerebral infarction

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Journal of Hainan Medical University 2017年第4期23卷 82-85页

作者： lei ge yu-Xiao zhao Yong-Xia Chang Wan-Sen Cui Xiu-Zhen Zhai Qiu-yun Ma The First Hospital Affiliated to Hebei North University 075000

Objective:To explore the effect of edaravone in combined with repetitive transcranial magnetic stimulation (rTMS) on the free radicals and neurological function in patients with cerebral ***: A total of 90 patients with acute cerebral infarction (ACI) who were admitted in our hospital from September, 2015 to March, 2016 were included in the study and randomized into the observation group and the control group. The patients in the control group were given blood pressure reduction, intracranial pressure reduction, blood lipid regulation, anti-platelet aggregation, symptomatic and supportive treatments, edaravone (30 mg) + normal saline (100 mL), ivdrip, 2 times/d, continuously for 14 d. On this basis, the patients in the observation group were given additional rTMS. 7 d-treatment was regarded as one course, and the patients were treated for 4 courses. The morning fasting venous blood before treatment, 7 d and 14 d after treatment in the two groups was collected to detect NO, NOS, SOD, MDA, S-100β, and NSE. NIHSS before treatment, 7 d, 14 d, and 28 d after treatment was ***:NO, NOS, and MDA levels after treatment in the observation group were significantly lower than those in the control group, while SOD level was significantly higher than that in the control group. S-100β and NSE levels after treatment in the observation group were significantly lower than those in the control group. NIHSS score after treatment in the observation group was significantly lower than that in the control ***:Edaravone in combined with rTMS in the treatment of ACI can significantly eliminate the free radicals, effectively improve the neurological function, and enhance the long-term efficacy.

关键词： Edaravone rTMS Cerebral infarction Free radical Neurological function

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海河流域河流富营养化程度总体评估

环境科学学报 2015年第8期35卷 2336-2344页

作者：张洪林超雷沛单保庆赵钰中国科学院生态环境研究中心环境水质学国家重点实验室北京100085 水利部海河水利委员会水资源保护局天津300170

以海河流域2009年地表水水质现状数据为基础,分别运用河流水体富营养化潜势和浮游植物表征河流富营养化水平.结果显示,流域河流水体中富营养盐含量相对较高,河流水体中TN、NH3-N平均含量分别为8.13、4.34 mg·L-1,分别超过《地表水环境... 详细信息

以海河流域2009年地表水水质现状数据为基础,分别运用河流水体富营养化潜势和浮游植物表征河流富营养化水平.结果显示,流域河流水体中富营养盐含量相对较高,河流水体中TN、NH3-N平均含量分别为8.13、4.34 mg·L-1,分别超过《地表水环境质量标准》(GB3838—2002)Ⅴ类限值(2 mg·L-1)4倍、2倍以上.北三河水系(北运河、潮白河、蓟运河)、子牙河水系和海河干流中TN浓度超过9 mg·L-1;海河流域河流水体中TP平均含量为0.87 mg·L-1,超过地表水Ⅴ类限值(0.4 mg·L-1)2倍以上.北三河水系、子牙河水系和黑龙港运东水系水中TP平均含量均超过1.0 mg·L-1.主要河流3%处于中或贫营养,44%处于极富营养化水平,主要分布在北三河水系、子牙河水系和漳卫河水系,表明流域河流总体呈现富营养化状态,平原段河流富营养化严重.河流治理要兼顾耗氧污染控制和营养盐控制,以改善河流水质.

关键词：海河流域河流富营养化氮磷

海河流域河流耗氧污染变化趋势及氧亏分布研究

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环境科学学报 2015年第8期35卷 2324-2335页

作者：张洪林超雷沛单保庆赵钰中国科学院生态环境研究中心环境水质学国家重点实验室北京100085 水利部海河水利委员会水资源保护局天津300170

耗氧污染是海河流域河流水污染的主要类型,耗氧污染物对河流溶氧的消耗产生的氧亏效应对水生生物产生重大影响.收集海河流域重点水功能区88个监测站点2000—2011年CODCr/CODMn、NH3-N指标,分析河流耗氧污染特征及演变趋势,并基于水质目... 详细信息

耗氧污染是海河流域河流水污染的主要类型,耗氧污染物对河流溶氧的消耗产生的氧亏效应对水生生物产生重大影响.收集海河流域重点水功能区88个监测站点2000—2011年CODCr/CODMn、NH3-N指标,分析河流耗氧污染特征及演变趋势,并基于水质目标(2 mg·L-1)下计算出海河流域河流氧亏量.结果表明,流域河流耗氧污染总体呈现好转趋势,耗氧污染指标(NH3-N、CODCr/CODMn)逐渐降低,I^III类水质站点比例增加,劣V类水质站点数和超标倍数减少;CODMn降低幅度大于NH3-N,主要污染物由COD向NH3-N转化.海河流域重点氧亏区域主要集中于中部平原段和下游滨海段,未氧亏区域多集中于上游山区段;北三河、黑龙港运东与徒骇马颊河水系中部平原段整体处于缺氧区域,子牙河水系中部平原区缺氧现象最为严重,氧亏区域位于石家庄洨河下游、滏阳河艾辛庄下游至献县段及石津总干以南;海河流域内中部平原段河流氧亏的主要贡献仍以COD为主,但氨氮的贡献显著,其中黑龙港运东水系、徒骇马颊河水系和北三河水系,COD耗氧均值都高于5 mg·L-1,在北三河和子牙河水系,氨氮耗氧均值达到了4 mg·L-1.

关键词：海河流域耗氧污染物氧亏

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大体积混凝土浇筑水化热分析

中国港湾建设 2007年第3期27卷 13-16页

作者：雷宇赵雷罗红革西南交通大学桥梁及结构工程系四川成都610031 西南科技大学土木工程学院四川绵阳621000

为了探求影响大体积混凝土温度场的因素,通过讨论考虑管冷和混凝土分批浇筑时混凝土的内部温度场的计算方法,对泰安长江大桥主塔承台浇筑全过程进行了温度场三维分析。结果表明:混凝土浇筑温度、水管冷却、外界气温、水温等因素的变化... 详细信息

为了探求影响大体积混凝土温度场的因素,通过讨论考虑管冷和混凝土分批浇筑时混凝土的内部温度场的计算方法,对泰安长江大桥主塔承台浇筑全过程进行了温度场三维分析。结果表明:混凝土浇筑温度、水管冷却、外界气温、水温等因素的变化对温度场都有重要的影响。应采取措施有效控制混凝土内部最高温度,降低混凝土内外温差,防止混凝土温度急剧变化。

关键词：斜拉桥承台管冷水化热